Mark Von Zastrow, MD, PhD
Professor
Psychiatry
School of Medicine

Websites

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• Profile at UCSF Department of Psychiatry (psych.ucsf.edu)

Grants and Projects

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• Mechanisms Regulating Endocytosis of Opioid Receptors, NIH, 1999-2021
• Membrane Trafficking of Opioid and Adrenergic Receptors, NIH, 1997-2019
• Presynaptic Mechanisms of Neural Plasticity, NIH, 1995-2018
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Membrane Trafficking of Opioid Receptors, NIH, 1997-2014
• Receptors and Second Messengers for Pain and Analgesia, NIH, 2007-2013
• Post-endocytic Sorting of Opioid Receptors, NIH, 1999-2010
• 2007 Molecular Pharmacology Gordon Research Conference, NIH, 2007
• Extracellular Matrix Protein enhancement of Phagocytosis, NIH, 1986-2007
• Membrane Trafficking of Opioid Receptors, NIH, 1997-2004
• Mechanisms of Receptor Internalization in Drug Addiction, NIH, 1994-1999

Publications (32)

Top publication keywords:
beta-ArrestinsEndosomesProtein TransportReceptors, G-Protein-CoupledPeptide HormonesIntracellular MembranesReceptors, Adrenergic, beta-2Cyclic AMPClass III Phosphatidylinositol 3-KinasesProteomeCell MembraneHeterotrimeric GTP-Binding ProteinsEndocytosisHEK293 CellsSignal Transduction

• Selective targeting of mu opioid receptors to primary cilia.
  Cell reports 2024 Fagan RR, Lee DF, Geron M, Scherrer G, von Zastrow M, Ehrlich AT
• Profiling the proximal proteome of the activated μ-opioid receptor.
  Nature chemical biology 2024 Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R
• β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.
  Nature chemical biology 2023 Blythe EE, von Zastrow M
• Endosomal cAMP production broadly impacts the cellular phosphoproteome.
  The Journal of biological chemistry 2021 Tsvetanova NG, Trester-Zedlitz M, Newton BW, Peng GE, Johnson JR, Jimenez-Morales D, Kurland AP, Krogan NJ, von Zastrow M
• A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling.
  The FASEB Journal 2020 Khairunnisa Mentari Semesta, Ruilin Tian, Martin Kampmann, Mark von Zastrow, Nikoleta G. Tsvetanova

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• Chemical Biology Approaches for Genome-Wide Screening of GPCR Trafficking.
  The FASEB Journal 2020 Braden Lobingier, Nikoleta Tsvetanova, Mark von Zastrow
• Catalytic activation of β-arrestin by GPCRs.
  Nature 2018 Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M
• Subcellular Organization of GPCR Signaling.
  Trends in pharmacological sciences 2018 Eichel K, von Zastrow M
• An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.
  Cell 2017 Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ
• Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
  Current biology : CB 2016 Varandas KC, Irannejad R, von Zastrow M
• Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling.
  Molecular pharmacology 2016 Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M
• Effects of endocytosis on receptor-mediated signaling.
  Current opinion in cell biology 2015 Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M
• G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
  The Journal of biological chemistry 2015 Tsvetanova NG, Irannejad R, von Zastrow M
• Retromer mediates a discrete route of local membrane delivery to dendrites.
  Neuron 2014 Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M
• Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors.
  Current opinion in cell biology 2014 Benovic JL, von Zastrow M
• Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
  Methods in enzymology 2014 Irannejad R, Kotowski SJ, von Zastrow M
• GPCR signaling along the endocytic pathway.
  Current opinion in cell biology 2013 Irannejad R, von Zastrow M
• Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.
  Neuron 2012 von Zastrow M, Williams JT
• Science Signaling Podcast: 9 August 2011.
  Science Signaling 2011 Mark von Zastrow, Annalisa M. VanHook
• Opioid Receptor Trafficking.
  The Opiate Receptors 2011 Mark von Zastrow
• Membrane traffic in the post-genomic era.
  Genome Biology 2010 Peter Hein, Mark von Zastrow
• Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.
  Drug and alcohol dependence 2010 von Zastrow M
• Chapter 27 Agonist-Induced Desensitization and Endocytosis of G-protein-Coupled Receptors.
  Handbook of Cell Signaling 2010 Michael Tanowitz, Mark von Zastrow
• Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens Junctions.
  Cell 2008 Robin M. Shaw, Alex J. Fay, Manojkumar A. Puthenveedu, Mark von Zastrow, Yuh-Nung Jan, Lily Y. Jan
• Signaling on the endocytic pathway.
  Current opinion in cell biology 2007 von Zastrow M, Sorkin A
• Endocytosis.
  Encyclopedia of Molecular Cell Biology and Molecular Medicine 2006 Hadiya A. Watson, Mark Von Zastrow, Beverly Wendland
• Regulated Membrane Trafficking and Proteolysis of GPCRs.
  The G Protein-Coupled Receptors Handbook 2005 James N. Hislop, Mark von Zastrow
• Identification of Protein Interactions by Yeast Two-Hybrid Screening and Coimmunoprecipitation.
  Receptor Signal Transduction Protocols 2004 Michael Tanowitz, Mark von Zastrow
• A walk on the wild side (of the synapse).
  Nature Cell Biology 2003 Mark von Zastrow
• Chapter 31 Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors.
  Handbook of Cell Signaling 2003 Mark von Zastrow
• Intracellular trafficking of epitope-tagged opioid receptors: Different effects of morphine and enkephalin.
  Peptides 1994 M von Zastrow, D Keith, P Zaki, C Evans
• An approach to the molecular biology of opiate tolerance: identification of opiate-regulated transcripts.
  NIDA research monograph 1991 vonZastrow M, Barchas JD, Eberwine JH