Mark Von Zastrow, MD, PhD
Professor
Psychiatry
School of Medicine

Websites

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• Profile at UCSF Department of Psychiatry (psych.ucsf.edu)

Grants and Projects

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• Mechanisms Regulating Endocytosis of Opioid Receptors, NIH, 1999-2021
• Membrane Trafficking of Opioid and Adrenergic Receptors, NIH, 1997-2019
• Presynaptic Mechanisms of Neural Plasticity, NIH, 1995-2018
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Membrane Trafficking of Opioid Receptors, NIH, 1997-2014
• Receptors and Second Messengers for Pain and Analgesia, NIH, 2007-2013
• Post-endocytic Sorting of Opioid Receptors, NIH, 1999-2010
• 2007 Molecular Pharmacology Gordon Research Conference, NIH, 2007
• Extracellular Matrix Protein enhancement of Phagocytosis, NIH, 1986-2007
• Membrane Trafficking of Opioid Receptors, NIH, 1997-2004
• Mechanisms of Receptor Internalization in Drug Addiction, NIH, 1994-1999

Publications (40)

Top publication keywords:
beta-ArrestinsEndosomesGTP-Binding Protein alpha Subunits, Gi-GoProtein TransportReceptors, Opioid, muReceptors, G-Protein-CoupledPeptide HormonesG-Protein-Coupled Receptor Kinase 2Cyclic AMPGTP-Binding ProteinsG-Protein-Coupled Receptor Kinase 3Cell MembraneEndocytosisHEK293 CellsSignal Transduction

• Conformational biosensors delineate endosomal G protein regulation by GPCRs.
  Nature communications 2026 Wysolmerski B, Fisher NM, Dates AN, Inoue A, Blythe EE, von Zastrow M
• GPCR-selective effects of endocytosis on cellular signaling through the cAMP / PKA cascade.
  The Journal of biological chemistry 2026 Blythe EE, Fagan RR, von Zastrow M
• GPR88 localization to primary cilia in neurons is cell-type specific.
  Life science alliance 2025 Li Guan YH, Kieffer BL, von Zastrow M, Ehrlich AT
• Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation.
  Proceedings of the National Academy of Sciences of the United States of America 2025 Fisher NM, von Zastrow M
• Intersection of GPCR trafficking and cAMP signaling at endomembranes.
  The Journal of cell biology 2025 Ripoll L, von Zastrow M, Blythe EE

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• Role of the G protein-coupled receptor kinase 2/3 N terminus in discriminating the endocytic effects of opioid agonist drugs.
  Molecular pharmacology 2024 Li J, Inoue A, Manglik A, von Zastrow M
• Unlocking opioid neuropeptide dynamics with genetically encoded biosensors.
  Nature neuroscience 2024 Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA…
• A proximity proteomics pipeline with improved reproducibility and throughput.
  Molecular systems biology 2024 Zhong X, Li Q, Polacco BJ, Patil T, Marley A, Foussard H, Khare P, Vartak R, Xu J, DiBerto JF, Roth BL, Eckhardt M, von Zastrow M, Krogan NJ, Hüttenhain R
• Selective targeting of mu opioid receptors to primary cilia.
  Cell reports 2024 Fagan RR, Lee DF, Geron M, Scherrer G, von Zastrow M, Ehrlich AT
• Profiling the proximal proteome of the activated μ-opioid receptor.
  Nature chemical biology 2024 Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R
• β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.
  Nature chemical biology 2023 Blythe EE, von Zastrow M
• Endosomal cAMP production broadly impacts the cellular phosphoproteome.
  The Journal of biological chemistry 2021 Tsvetanova NG, Trester-Zedlitz M, Newton BW, Peng GE, Johnson JR, Jimenez-Morales D, Kurland AP, Krogan NJ, von Zastrow M
• A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling.
  The FASEB Journal 2020 Khairunnisa Mentari Semesta, Ruilin Tian, Martin Kampmann, Mark von Zastrow, Nikoleta G. Tsvetanova
• Chemical Biology Approaches for Genome-Wide Screening of GPCR Trafficking.
  The FASEB Journal 2020 Braden Lobingier, Nikoleta Tsvetanova, Mark von Zastrow
• Catalytic activation of β-arrestin by GPCRs.
  Nature 2018 Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M
• Subcellular Organization of GPCR Signaling.
  Trends in pharmacological sciences 2018 Eichel K, von Zastrow M
• An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.
  Cell 2017 Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ
• Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
  Current biology : CB 2016 Varandas KC, Irannejad R, von Zastrow M
• Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling.
  Molecular pharmacology 2016 Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M
• Effects of endocytosis on receptor-mediated signaling.
  Current opinion in cell biology 2015 Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M
• G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
  The Journal of biological chemistry 2015 Tsvetanova NG, Irannejad R, von Zastrow M
• Retromer mediates a discrete route of local membrane delivery to dendrites.
  Neuron 2014 Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M
• Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors.
  Current opinion in cell biology 2014 Benovic JL, von Zastrow M
• Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
  Methods in enzymology 2014 Irannejad R, Kotowski SJ, von Zastrow M
• GPCR signaling along the endocytic pathway.
  Current opinion in cell biology 2013 Irannejad R, von Zastrow M
• Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.
  Neuron 2012 von Zastrow M, Williams JT
• Science Signaling Podcast: 9 August 2011.
  Science Signaling 2011 Mark von Zastrow, Annalisa M. VanHook
• Opioid Receptor Trafficking.
  The Opiate Receptors 2011 Mark von Zastrow
• Membrane traffic in the post-genomic era.
  Genome Biology 2010 Peter Hein, Mark von Zastrow
• Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.
  Drug and alcohol dependence 2010 von Zastrow M
• Chapter 27 Agonist-Induced Desensitization and Endocytosis of G-protein-Coupled Receptors.
  Handbook of Cell Signaling 2010 Michael Tanowitz, Mark von Zastrow
• Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens Junctions.
  Cell 2008 Robin M. Shaw, Alex J. Fay, Manojkumar A. Puthenveedu, Mark von Zastrow, Yuh-Nung Jan, Lily Y. Jan
• Signaling on the endocytic pathway.
  Current opinion in cell biology 2007 von Zastrow M, Sorkin A
• Endocytosis.
  Encyclopedia of Molecular Cell Biology and Molecular Medicine 2006 Hadiya A. Watson, Mark Von Zastrow, Beverly Wendland
• Regulated Membrane Trafficking and Proteolysis of GPCRs.
  The G Protein-Coupled Receptors Handbook 2005 James N. Hislop, Mark von Zastrow
• Identification of Protein Interactions by Yeast Two-Hybrid Screening and Coimmunoprecipitation.
  Receptor Signal Transduction Protocols 2004 Michael Tanowitz, Mark von Zastrow
• A walk on the wild side (of the synapse).
  Nature Cell Biology 2003 Mark von Zastrow
• Chapter 31 Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors.
  Handbook of Cell Signaling 2003 Mark von Zastrow
• Intracellular trafficking of epitope-tagged opioid receptors: Different effects of morphine and enkephalin.
  Peptides 1994 M von Zastrow, D Keith, P Zaki, C Evans
• An approach to the molecular biology of opiate tolerance: identification of opiate-regulated transcripts.
  NIDA research monograph 1991 vonZastrow M, Barchas JD, Eberwine JH