Mark Seielstad, PhD
Professor
Laboratory Medicine
School of Medicine

Research in my lab is at the interface of genetic epidemiology and population/anthropological genetics. The main goal is to identify human genetic variation altering the risk of complex human diseases involving immunity (e.g., autoimmunity and susceptibility to infectious diseases) and metabolism (e.g., type 2 diabetes).

Show full bio (100 words) Hide full bio

This puts an emphasis on genomic technologies such as genome-wide SNP genotyping, and next-generation sequencing to reveal and characterize polymorphisms in whole exome and whole genome data. Much of this work is carried out in geographically diverse human populations, which are also the subject of anthropological investigations that seek to characterize the global distribution of genetic variation. A particular emphasis is placed on sequencing and coalescence analysis of the Y chromosome and mtDNA, as well as cultural practices that alter demographic and selective regimes acting on the sex-specific lineages of these two DNA molecules.

Awards

Show all (6) Hide

• Editor-in-Chief, Human Molecular Genetics, Oxford University Press, 2025
• Jefferson Science Fellow (USAID), National Academy of Sciences, 2022-2023
• Elected Member At-Large, Sigma Xi, 2021
• Fellow, Biological Sciences, American Association for the Advancement of Science (AAAS), 2020
• Taiwan, Fulbright Scholar, 2019-2020
• Monash University, The Sir John Monash Lecture, 2016

Education & Training

Show all (4) Hide

• Diversity, Equity, and Inclusion Champion Training University of California 11/2020
• Ph.D. Biology Harvard University 1998
• B.S. Biological Sciences (w/Honors) Stanford University 1992
• A.B. Classics Stanford University 1992

Publications (113)

Top publication keywords:
Fetomaternal TransfusionHaplotypesPolymorphism, Single NucleotideGene FrequencyGenetic VariationGenetic LociGenome-Wide Association StudyGenetic Predisposition to DiseaseGenetics, PopulationHepatitis B VaccinesE2F7 Transcription FactorTuberculosis, PulmonaryDiabetes Mellitus, Type 2Y ChromosomeChromosomes, Human, Y

• Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP.
  Human molecular genetics 2019 Albao DS, Cutiongco-de la Paz EM, Mercado ME, Lirio A, Mariano M, Kim S, Yangco A, Melegrito J, Wad-Asen K, Gauran II, Francisco MA, Santos-Acuin C, David-Padilla C, Murphy EJ, Paz-Pacheco E, …
• A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency Virus.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Rajan JV, Semitala FC, Mehta T, Seielstad M, Montalvo L, Andama A, Asege L, Nakaye M, Katende J, Mwebe S, Kamya MR, Yoon C, Cattamanchi A
• 1524-P: Discordance between A1C and Glucose for the Diagnosis of Prediabetes in a Filipino-American Population.
  Diabetes 2019 MARIA ELIZABETH P. MERCADO, SARAH KIM, MARIA C EVA, CUTIONGCO DE LA PAZ, MARK SEIELSTAD, ELIZABETH PAZ-PACHECO, ELIZABETH MURPHY
• Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
  Nature 2019 Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, …
• Development and evaluation of a transfusion medicine genome wide genotyping array.
  Transfusion 2018 Guo Y, Busch MP, Seielstad M, Endres-Dighe S, Westhoff CM, Keating B, Hoppe C, Bordbar A, Custer B, Butterworth AS, Kanias T, Mast AE, Kleinman S, Lu Y, Page GP, National Heart, Lung, and Blood …

Show all (108 more) Hide

• Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R…
• Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
  Scientific data 2017 Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW,…
• Genomewide association study of HLA alloimmunization in previously pregnant blood donors.
  Transfusion 2017 Seielstad M, Page GP, Gaddis N, Lanteri M, Lee TH, Kakaiya R, Barcellos LF, Criswell LA, Triulzi D, Norris PJ, Busch MP, NHLBI REDS-III Study Investigators
• Y chromosomal evidence on the origin of northern Thai people.
  PloS one 2017 Brunelli A, Kampuansai J, Seielstad M, Lomthaisong K, Kangwanpong D, Ghirotto S, Kutanan W
• A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
  Diabetes 2017 Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, …
• Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction.
  The Journal of infectious diseases 2017 Ferreira LR, Ferreira FM, Nakaya HI, Deng X, Cândido DD, de Oliveira LC, Billaud JN, Lanteri MC, Rigaud VO, Seielstad M, Kalil J, Fernandes F, Ribeiro AL, Sabino EC, Cunha-Neto E
• The genetic architecture of type 2 diabetes.
  Nature 2016 Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani…
• Identification of genetic variants associated with susceptibility to West Nile virus neuroinvasive disease.
  Genes and immunity 2016 Long D, Deng X, Singh P, Loeb M, Lauring AS, Seielstad M
• Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.
  Nature genetics 2016 Khor CC, Do T, Jia H, Nakano M, George R, Abu-Amero K, Duvesh R, Chen LJ, Li Z, Nongpiur ME, Perera SA, Qiao C, Wong HT, Sakai H, Barbosa de Melo M, Lee MC, Chan AS, Azhany Y, Dao TL, Ikeda Y, Perez-…
• Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
  Human molecular genetics 2016 Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, Choi S, Chen H, Kaur I, Takeuchi F, …
• Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
  Nature communications 2015 Yin X, Low HQ, Wang L, Li Y, Ellinghaus E, Han J, Estivill X, Sun L, Zuo X, Shen C, Zhu C, Zhang A, Sanchez F, Padyukov L, Catanese JJ, Krueger GG, Duffin KC, Mucha S, Weichenthal M, Weidinger S, Lieb…
• Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
  PLoS genetics 2015 Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N, Im HK, Cingolani P, Flannick J, Fontanillas P, Fuchsberger C, Gaulton KJ, Teslovich TM, Rayner NW, Robertson NR, Beer NL,…
• Admixed origin of the Kayah (Red Karen) in Northern Thailand revealed by biparental and paternal markers.
  Annals of human genetics 2015 Kutanan W, Srikummool M, Pittayaporn P, Seielstad M, Kangwanpong D, Kumar V, Prombanchachai T, Chantawannakul P
• Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases.
  Genes and immunity 2014 Nititham J, Taylor KE, Gupta R, Chen H, Ahn R, Liu J, Seielstad M, Ma A, Bowcock AM, Criswell LA, Stahle M, Liao W
• Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
  Human molecular genetics 2014 He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D…
• Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
  Diabetes 2014 Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Ong RT, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Katsuya T, …
• Whole genome sequencing to identify host genetic risk factors for severe outcomes of hepatitis a virus infection.
  Journal of medical virology 2014 Long D, Fix OK, Deng X, Seielstad M, Lauring AS, Acute Liver Failure Study Group
• Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
  Human molecular genetics 2014 Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, …
• Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study.
  PloS one 2014 Chen Z, Pereira MA, Seielstad M, Koh WP, Tai ES, Teo YY, Liu J, Hsu C, Wang R, Odegaard AO, Thyagarajan B, Koratkar R, Yuan JM, Gross MD, Stram DO
• Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
  Nature genetics 2014 DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican …
• Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
  PloS one 2013 Deng X, Sabino EC, Cunha-Neto E, Ribeiro AL, Ianni B, Mady C, Busch MP, Seielstad M, REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component Internatio
• Genome-wide association study of retinopathy in individuals without diabetes.
  PloS one 2013 Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, Eiriksdottir G, Harris TB, Jonasson F, Klein BE, Launer LJ, Smith AV, Boerwinkle E, Cheung N, Hewitt AW, Liew G, Mitchell P, Wang JJ, Attia J, …
• Association of cardiovascular and metabolic disease genes with psoriasis.
  The Journal of investigative dermatology 2012 Lu Y, Chen H, Nikamo P, Qi Low H, Helms C, Seielstad M, Liu J, Bowcock AM, Stahle M, Liao W
• Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations.
  Human Molecular Genetics 2012 Belinda K. Cornes, Chiea Chuen Khor, Monisha E. Nongpiur, Liang Xu, Wan-Ting Tay, Yingfeng Zheng, Raghavan Lavanya, Yang Li, Renyi Wu, Xueling Sim, Ya-Xing Wang, Peng Chen, Yik Ying Teo, Kee-Seng Chia…
• Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis.
  PloS one 2012 Ottenhoff TH, Dass RH, Yang N, Zhang MM, Wong HE, Sahiratmadja E, Khor CC, Alisjahbana B, van Crevel R, Marzuki S, Seielstad M, van de Vosse E, Hibberd ML
• Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
  Nature genetics 2012 Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim SC, Wong TY, Liu J, Young TL, Aung T, Seielstad M, Teo YY, Kim YJ, Lee JY, Han BG, Kang D, Chen CH, Tsai FJ…
• Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.
  PLoS genetics 2012 Fan Q, Barathi VA, Cheng CY, Zhou X, Meguro A, Nakata I, Khor CC, Goh LK, Li YJ, Lim W, Ho CE, Hawthorne F, Zheng Y, Chua D, Inoko H, Yamashiro K, Ohno-Matsui K, Matsuo K, Matsuda F, Vithana E, …
• Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians.
  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2012 Png E, Alisjahbana B, Sahiratmadja E, Marzuki S, Nelwan R, Adnan I, van de Vosse E, Hibberd M, van Crevel R, Ottenhoff TH, Seielstad M
• Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
  PLoS genetics 2012 Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L,…
• Meta-analysis identifies common variants associated with body mass index in east Asians.
  Nature genetics 2012 Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, Gu D, Zhu D, Haiman CA, Mo Z, Gao YT, Saw SM, Go MJ, Takeuchi F, Chang LC, Kokubo Y, Liang J, Hao M, Le …
• A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians.
  BMC medical genetics 2012 Png E, Alisjahbana B, Sahiratmadja E, Marzuki S, Nelwan R, Balabanova Y, Nikolayevskyy V, Drobniewski F, Nejentsev S, Adnan I, van de Vosse E, Hibberd ML, van Crevel R, Ottenhoff TH, Seielstad M
• Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
  Nature genetics 2011 Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ…
• Genetic determinants of hepatitis B vaccine response.
  BMC Proceedings 2011 Eileen Png, Anbupalam Thalamuthu, Rick TH Ong, Harm Snippe, Herawati Sudoyo, David H Muljono, Sangkot Marzuki, Greet J Boland, Mark Seielstad
• Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
  PLoS genetics 2011 Fan Q, Zhou X, Khor CC, Cheng CY, Goh LK, Sim X, Tay WT, Li YJ, Ong RT, Suo C, Cornes B, Ikram MK, Chia KS, Seielstad M, Liu J, Vithana E, Young TL, Tai ES, Wong TY, Aung T, Teo YY, Saw SM
• A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.
  PloS one 2011 Sivakumaran TA, Igo RP, Kidd JM, Itsara A, Kopplin LJ, Chen W, Hagstrom SA, Peachey NS, Francis PJ, Klein ML, Chew EY, Ramprasad VL, Tay WT, Mitchell P, Seielstad M, Stambolian DE, Edwards AO, Lee KE,…
• Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations.
  Human molecular genetics 2011 Cornes BK, Khor CC, Nongpiur ME, Xu L, Tay WT, Zheng Y, Lavanya R, Li Y, Wu R, Sim X, Wang YX, Chen P, Teo YY, Chia KS, Seielstad M, Liu J, Hibberd ML, Cheng CY, Saw SM, Tai ES, Jonas JB, Vithana EN, …
• SgD-CNV, a database for common and rare copy number variants in three Asian populations.
  Human mutation 2011 Xu H, Poh WT, Sim X, Ong RT, Suo C, Tay WT, Khor CC, Seielstad M, Liu J, Aung T, Tai ES, Wong TY, Chia KS, Teo YY
• Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
  Nature 2011 International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, …
• Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
  Nature genetics 2011 Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, Been LF, Chia KS, Dimas AS, Hassanali N, Jafar T, Jowett JB, Li X, Radha V, Rees SD, Takeuchi F, Young R, Aung T, Basit A, Chidambaram M, …
• A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.
  Human molecular genetics 2011 Png E, Thalamuthu A, Ong RT, Snippe H, Boland GJ, Seielstad M
• Copy number polymorphisms in new HapMap III and Singapore populations.
  Journal of human genetics 2011 Ku CS, Teo SM, Naidoo N, Sim X, Teo YY, Pawitan Y, Seielstad M, Chia KS, Salim A
• Genetic structure of the Mon-Khmer speaking groups and their affinity to the neighbouring Tai populations in Northern Thailand.
  BMC genetics 2011 Kutanan W, Kampuansai J, Fuselli S, Nakbunlung S, Seielstad M, Bertorelle G, Kangwanpong D
• Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
  Human molecular genetics 2011 Han S, Chen P, Fan Q, Khor CC, Sim X, Tay WT, Ong RT, Suo C, Goh LK, Lavanya R, Zheng Y, Wu R, Seielstad M, Vithana E, Liu J, Chia KS, Lee JJ, Tai ES, Wong TY, Aung T, Teo YY, Saw SM
• Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
  Nature genetics 2011 Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, …
• Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
  PLoS genetics 2011 Sim X, Ong RT, Suo C, Tay WT, Liu J, Ng DP, Boehnke M, Chia KS, Wong TY, Seielstad M, Teo YY, Tai ES
• Multi-platform segmentation for joint detection of copy number variants.
  Bioinformatics (Oxford, England) 2011 Teo SM, Pawitan Y, Kumar V, Thalamuthu A, Seielstad M, Chia KS, Salim A
• Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
  Human molecular genetics 2011 Khor CC, Ramdas WD, Vithana EN, Cornes BK, Sim X, Tay WT, Saw SM, Zheng Y, Lavanya R, Wu R, Wang JJ, Mitchell P, Uitterlinden AG, Rivadeneira F, Teo YY, Chia KS, Seielstad M, Hibberd M, Vingerling JR,…
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
  Nature genetics 2011 Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless …
• Pathway-based analysis using reduced gene subsets in genome-wide association studies.
  BMC bioinformatics 2011 Zhao J, Gupta S, Seielstad M, Liu J, Thalamuthu A
• A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
  Annals of the rheumatic diseases 2010 Padyukov L, Seielstad M, Ong RT, Ding B, Rönnelid J, Seddighzadeh M, Alfredsson L, Klareskog L, Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group
• Genetic affinity and admixture of northern Thai people along their migration route in northern Thailand: evidence from autosomal STR loci.
  Journal of human genetics 2010 Kutanan W, Kampuansai J, Colonna V, Nakbunlung S, Lertvicha P, Seielstad M, Bertorelle G, Kangwanpong D
• Collagen-related genes influence the glaucoma risk factor, central corneal thickness.
  Human molecular genetics 2010 Vithana EN, Aung T, Khor CC, Cornes BK, Tay WT, Sim X, Lavanya R, Wu R, Zheng Y, Hibberd ML, Chia KS, Seielstad M, Goh LK, Saw SM, Tai ES, Wong TY
• Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese.
  Ophthalmology 2010 Li YJ, Goh L, Khor CC, Fan Q, Yu M, Han S, Sim X, Ong RT, Wong TY, Vithana EN, Yap E, Nakanishi H, Matsuda F, Ohno-Matsui K, Yoshimura N, Seielstad M, Tai ES, Young TL, Saw SM
• Identification of new genetic risk variants for type 2 diabetes.
  PLoS genetics 2010 Shu XO, Long J, Cai Q, Qi L, Xiang YB, Cho YS, Tai ES, Li X, Lin X, Chow WH, Go MJ, Seielstad M, Bao W, Li H, Cornelis MC, Yu K, Wen W, Shi J, Han BG, Sim XL, Liu L, Qi Q, Kim HL, Ng DP, Lee JY, Kim …
• Biological, clinical and population relevance of 95 loci for blood lipids.
  Nature 2010 Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis …
• Support for TGFB1 as a susceptibility gene for high myopia in individuals of Chinese descent.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2010 Khor CC, Fan Q, Goh L, Tan D, Young TL, Li YJ, Seielstad M, Goh DL, Saw SM
• Genomic copy number variations in three Southeast Asian populations.
  Human mutation 2010 Ku CS, Pawitan Y, Sim X, Ong RT, Seielstad M, Lee EJ, Teo YY, Chia KS, Salim A
• Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
  Inflammatory bowel diseases 2010 Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
  Nature genetics 2010 Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, …
• Genetic evidence supports linguistic affinity of Mlabri--a hunter-gatherer group in Thailand.
  BMC genetics 2010 Xu S, Kangwanpong D, Seielstad M, Srikummool M, Kampuansai J, Jin L, HUGO Pan-Asian SNP Consortium
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Genes and immunity 2010 Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
• Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
  Nature genetics 2010 McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, …
• Comparative analyses of seven algorithms for copy number variant identification from single nucleotide polymorphism arrays.
  Nucleic acids research 2010 Dellinger AE, Saw SM, Goh LK, Seielstad M, Young TL, Li YJ
• Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese.
  Ophthalmology 2010 Khor CC, Fan Q, Goh LK, Wong TY, Li YJ, Cheung N, Seielstad M, Goh DL, Young TL, Tai ES, Saw SM
• Mapping human genetic diversity in Asia.
  Science (New York, N.Y.) 2009 HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, …
• Genetic structure of the Han Chinese population revealed by genome-wide SNP variation.
  American journal of human genetics 2009 Chen J, Zheng H, Bei JX, Sun L, Jia WH, Li T, Zhang F, Seielstad M, Zeng YX, Zhang X, Liu J
• Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore.
  Endocrinology 2009 Jonathan T. Tan, Daniel P. K. Ng, Siti Nurbaya, Sandra Ye, Xiu Li Lim, Helen Leong, Lin Tze Seet, Wei Fong Siew, Winston Kon, Tien Yin Wong, Seang Mei Saw, Tin Aung, Kee Seng Chia, Jeannette Lee, Suok…
• Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore.
  Endocrine reviews 2009 Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL, Leong H, Seet LT, Siew WF, Kon W, Wong TY, Saw SM, Aung T, Chia KS, Lee J, Chew SK, Seielstad M, Tai ES
• Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
  Nature genetics 2009 Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, …
• Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.
  The Journal of clinical endocrinology and metabolism 2009 Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL, Leong H, Seet LT, Siew WF, Kon W, Wong TY, Saw SM, Aung T, Chia KS, Lee J, Chew SK, Seielstad M, Tai ES
• Differential association of cataract sub-types with obesity and FTO polymorphisms.
  Acta Ophthalmologica 2009 L LIM, E TAI, T AUNG, W TAY, SM SAW, M SEIELSTAD, TY WONG
• Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations.
  Genome research 2009 Teo YY, Sim X, Ong RT, Tan AK, Chen J, Tantoso E, Small KS, Ku CS, Lee EJ, Seielstad M, Chia KS
• The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
  Arthritis and rheumatism 2009 Lee YC, Raychaudhuri S, Cui J, De Vivo I, Ding B, Alfredsson L, Padyukov L, Costenbader KH, Seielstad M, Graham RR, Klareskog L, Gregersen PK, Plenge RM, Karlson EW
• Relation of age-related cataract with obesity and obesity genes in an Asian population.
  American journal of epidemiology 2009 Lim LS, Tai ES, Aung T, Tay WT, Saw SM, Seielstad M, Wong TY
• Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
  Arthritis and rheumatism 2009 Ding B, Padyukov L, Lundström E, Seielstad M, Plenge RM, Oksenberg JR, Gregersen PK, Alfredsson L, Klareskog L
• Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.
  PLoS pathogens 2008 Thuong NT, Dunstan SJ, Chau TT, Thorsson V, Simmons CP, Quyen NT, Thwaites GE, Thi Ngoc Lan N, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR
• Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
  Journal of lipid research 2008 Tai ES, Sim XL, Ong TH, Wong TY, Saw SM, Aung T, Kathiresan S, Orho-Melander M, Ordovas JM, Tan JT, Seielstad M
• Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.
  PLoS genetics 2008 Davila S, Hibberd ML, Hari Dass R, Wong HE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F, van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff TH, Seielstad M
• Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
  Nature genetics 2008 Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J,…
• Association of skin barrier genes within the PSORS4 locus is enriched in Singaporean Chinese with early-onset psoriasis.
  The Journal of investigative dermatology 2008 Chen H, Toh TK, Szeverenyi I, Ong RT, Theng CT, McLean WH, Seielstad M, Lane EB
• FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
  Diabetes 2008 Tan JT, Dorajoo R, Seielstad M, Sim XL, Ong RT, Chia KS, Wong TY, Saw SM, Chew SK, Aung T, Tai ES
• The Singapore Genome Variation Project.
  European Journal of Cancer Supplements 2008 Y.Y. Teo, X.L. Sim, C.S. Ku, R.T.H. Ong, A. Tan, E. Tantoso, Y. Pawitan, M. Seielstad, E.J.D. Lee, K.S. Chia
• Whole genome-amplified DNA: insights and imputation.
  Nature methods 2008 Teo YY, Inouye M, Small KS, Fry AE, Potter SC, Dunstan SJ, Seielstad M, Barroso I, Wareham NJ, Rockett KA, Kwiatkowski DP, Deloukas P
• Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
  Nature genetics 2008 Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff TH, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD
• OR.103. Combined Analysis of Three Genome-wide Scans Reveals Additional Loci Associated with Rheumatoid Arthritis.
  Clinical Immunology 2008 Mark Seielstad, Leonid Padyukov, Xiayi Ke, Bo Ding, Erwin Tantoso, Twee Hee Rick Ong, Lars Alfredsson, Robert Plenge, Peter Gregersen, Jane Worthington, Lars Klareskog
• TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
  The New England journal of medicine 2007 Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, …
• Genetic variation in Northern Thailand Hill Tribes: origins and relationships with social structure and linguistic differences.
  BMC evolutionary biology 2007 Besaggio D, Fuselli S, Srikummool M, Kampuansai J, Castrì L, Tyler-Smith C, Seielstad M, Kangwanpong D, Bertorelle G
• On the usage of HWE for identifying genotyping errors.
  Annals of human genetics 2007 Teo YY, Fry AE, Clark TG, Tai ES, Seielstad M
• A whole genome long-range haplotype (WGLRH) test for detecting imprints of positive selection in human populations.
  Bioinformatics (Oxford, England) 2006 Zhang C, Bailey DK, Awad T, Liu G, Xing G, Cao M, Valmeekam V, Retief J, Matsuzaki H, Taub M, Seielstad M, Kennedy GC
• Twin births in Singapore: a population-based study using the National Birth Registry.
  Annals of the Academy of Medicine, Singapore 2004 Chia KS, Lee JJ, Cheung P, Cheung KH, Seielstad M, Wilcox MM, Liu E
• A novel Y-chromosome variant puts an upper limit on the timing of first entry into the Americas.
  American journal of human genetics 2003 Seielstad M, Yuldasheva N, Singh N, Underhill P, Oefner P, Shen P, Wells RS
• Allele frequency and genotype distribution of polymorphisms within disease-related genes is influenced by ethnic population sub-structuring in Sudan.
  Genetica 2003 Bereir RE, Mohamed HS, Seielstad M, El Hassani AM, Khalil EA, Peacock CS, Blackwell JM, Ibrahim ME
• Testing for population subdivision and association in four case-control studies.
  American journal of human genetics 2002 Ardlie KG, Lunetta KL, Seielstad M
• Patterns of linkage disequilibrium in the human genome.
  Nature reviews. Genetics 2002 Ardlie KG, Kruglyak L, Seielstad M
• Detection of novel ALAD gene polymorphisms using denaturing high-performance liquid chromatography.
  Human biology 2001 Niu T, Seielstad M, Zeng X, Apffel A, Li G, Hahnenberger K, Xu X
• African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes.
  Science (New York, N.Y.) 2001 Ke Y, Su B, Song X, Lu D, Chen L, Li H, Qi C, Marzuki S, Deka R, Underhill P, Xiao C, Shriver M, Lell J, Wallace D, Wells RS, Seielstad M, Oefner P, Zhu D, Jin J, Huang W, Chakraborty R, Chen Z, Jin L
• Y chromosome haplotypes reveal prehistorical migrations to the Himalayas.
  Human genetics 2000 Su B, Xiao C, Deka R, Seielstad MT, Kangwanpong D, Xiao J, Lu D, Underhill P, Cavalli-Sforza L, Chakraborty R, Jin L
• Y chromosome sequence variation and the history of human populations.
  Nature genetics 2000 Underhill PA, Shen P, Lin AA, Jin L, Passarino G, Yang WH, Kauffman E, Bonné-Tamir B, Bertranpetit J, Francalacci P, Ibrahim M, Jenkins T, Kidd JR, Mehdi SQ, Seielstad MT, Wells RS, Piazza A, Davis RW…
• Asymmetries in the maternal and paternal genetic histories of Colombian populations.
  American journal of human genetics 2000 Seielstad M
• Whiffs of selection.
  Nature genetics 2000 Seielstad M
• The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data.
  American journal of human genetics 2000 Jorde LB, Watkins WS, Bamshad MJ, Dixon ME, Ricker CE, Seielstad MT, Batzer MA
• Population growth of human Y chromosomes: a study of Y chromosome microsatellites.
  Molecular biology and evolution 1999 Pritchard JK, Seielstad MT, Perez-Lezaun A, Feldman MW
• A view of modern human origins from Y chromosome microsatellite variation.
  Genome research 1999 Seielstad M, Bekele E, Ibrahim M, Touré A, Traoré M
• Genetic evidence for a higher female migration rate in humans.
  Nature genetics 1998 Seielstad MT, Minch E, Cavalli-Sforza LL
• Population genetics of Y-chromosome short tandem repeats in humans.
  Journal of molecular evolution 1997 Pérez-Lezaun A, Calafell F, Seielstad M, Mateu E, Comas D, Bosch E, Bertranpetit J
• Cw*1701 defines a divergent african HLA-C allelic lineage.
  Immunogenetics 1997 Wells RS, Seielstad MT, Bunce M, Tyan DB, Bekele E, Parham P
• Geographic clustering of human Y-chromosome haplotypes.
  Annals of human genetics 1996 Ruiz Linares A, Nayar K, Goldstein DB, Hebert JM, Seielstad MT, Underhill PA, Lin AA, Feldman MW, Cavalli Sforza LL
• Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition.
  Human molecular genetics 1994 Seielstad MT, Hebert JM, Lin AA, Underhill PA, Ibrahim M, Vollrath D, Cavalli-Sforza LL