Mark Segal, PhD, MS
Professor
Epidemiology & Biostatistics
School of Medicine

Grants and Projects

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• Reconstruction of 3D Genome Architecture from Chromatin Conformation Capture Data, NIH, 2013-2021
• General Clinical Research Center, NIH, 1977-2011
• Analytical Aspects of Molecular Epidemiology, NIH, 1998-2002
• Tree-structured Survival Analysis--Methods and Software, NIH, 1993-1997
• Tree-structured Methods for Longitudinal &Survival Data, NIH, 1991-1996

Publications (210)

Top publication keywords:
AlgorithmsRenal DialysisLong-Term PotentiationGenomicsCluster AnalysisChromosomesGenome, FungalMolecular ConformationGene Expression Regulation, FungalNucleosomesBiometryChromatinSaccharomyces cerevisiaeOligonucleotide Array Sequence AnalysisGenome

• Evaluation of a large-scale aptamer proteomics platform among patients with kidney failure on dialysis.
  PloS one 2023 Ren Y, Ruan P, Segal M, Dobre M, Schelling JR, Banerjee U, Shafi T, Ganz P, Dubin RF, CRIC Study Investigators
• Proteomics of CKD progression in the chronic renal insufficiency cohort.
  Nature communications 2023 Dubin RF, Deo R, Ren Y, Wang J, Zheng Z, Shou H, Go AS, Parsa A, Lash JP, Rahman M, Hsu CY, Weir MR, Chen J, Anderson A, Grams ME, Surapaneni A, Coresh J, Li H, Kimmel PL, Vasan RS, Feldman H, Segal …
• Assessing chromatin relocalization in 3D using the patient rule induction method.
  Biostatistics (Oxford, England) 2023 Segal MR
• Proteomic cardiovascular risk assessment in chronic kidney disease.
  European heart journal 2023 Deo R, Dubin RF, Ren Y, Murthy AC, Wang J, Zheng H, Zheng Z, Feldman H, Shou H, Coresh J, Grams M, Surapaneni AL, Bhat Z, Cohen JB, Rahman M, He J, Saraf SL, Go AS, Kimmel PL, Vasan RS, Segal MR, Li H…
• Analytical and Biological Variability of a Commercial Modified Aptamer Assay in Plasma Samples of Patients with Chronic Kidney Disease.
  The journal of applied laboratory medicine 2023 Dubin RF, Deo R, Ren Y, Lee H, Shou H, Feldman H, Kimmel P, Waikar SS, Rhee EP, Tin A, Chen J, Coresh J, Go AS, Kelly T, Rao PS, Chen TK, Segal MR, Ganz P

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• Does multi-way, long-range chromatin contact data advance 3D genome reconstruction?
  BMC bioinformatics 2023 Olshen AB, Segal MR
• National Treatment Patterns and Outcomes for Hospitalized Patients with Chronic Limb-Threatening Ischemia and End-Stage Kidney Disease.
  Vascular and endovascular surgery 2022 Shah SK, Neal D, Berceli SA, Segal M, Cooper MA, Huber TS, Upchurch GR, Scali ST
• Can 3D diploid genome reconstruction from unphased Hi-C data be salvaged?
  NAR genomics and bioinformatics 2022 Segal MR
• Principal curve approaches for inferring 3D chromatin architecture.
  Biostatistics (Oxford, England) 2022 Tuzhilina E, Hastie TJ, Segal MR
• Longitudinal Assessment of Body Composition and Its Association With Survival Among Participants of the ACTIVE/ADIPOSE Study.
  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2021 Delgado C, Chiang JM, Kittiskulnam P, Sheshadri A, Grimes B, Segal M, Kaysen GA, Johansen KL
• Indoor Air Pollution and Susceptibility to Tuberculosis Infection in Urban Vietnamese Children.
  American journal of respiratory and critical care medicine 2021 Blount RJ, Phan H, Trinh T, Dang H, Merrifield C, Zavala M, Zabner J, Comellas AP, Stapleton EM, Segal MR, Balmes J, Nhung NV, Nahid P
• Increased rates of secondary bacterial infections, including Enterococcus bacteremia, in patients hospitalized with coronavirus disease 2019 (COVID-19).
  Infection control and hospital epidemiology 2021 DeVoe C, Segal MR, Wang L, Stanley K, Madera S, Fan J, Schouest J, Graham-Ojo R, Nichols A, Prasad PA, Ghale R, Love C, Abe-Jones Y, Kangelaris KN, Patterson SL, Yokoe DS, Langelier CR
• Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.
  Scientific reports 2021 Huie JR, Ferguson AR, Kyritsis N, Pan JZ, Irvine KA, Nielson JL, Schupp PG, Oldham MC, Gensel JC, Lin A, Segal MR, Ratan RR, Bresnahan JC, Beattie MS
• Composition and origin of lung fluid proteome in premature infants and relationship to respiratory outcome.
  PloS one 2020 Ballard PL, Oses-Prieto J, Chapin C, Segal MR, Ballard RA, Burlingame AL
• Correlates and Consequences of High Serum Irisin Concentration in Patients on Hemodialysis: A Longitudinal Analysis.
  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2020 Chiang JM, Delgado C, Kaysen GA, Segal MR, Chertow GM, Johansen KL
• Predialysis fluid overload and gait speed: a repeated measures analysis among patients on chronic dialysis.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2020 Carlos C, Grimes B, Segal M, Johansen K
• Assessing stationary distributions derived from chromatin contact maps.
  BMC bioinformatics 2020 Segal MR, Fletez-Brant K
• Low testosterone is associated with frailty, muscle wasting and physical dysfunction among men receiving hemodialysis: a longitudinal analysis.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2019 Chiang JM, Kaysen GA, Segal M, Chertow GM, Delgado C, Johansen KL
• The Rabl configuration limits topological entanglement of chromosomes in budding yeast.
  Scientific reports 2019 Pouokam M, Cruz B, Burgess S, Segal MR, Vazquez M, Arsuaga J
• Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk.
  Epigenetics 2019 Gonseth S, Shaw GM, Roy R, Segal MR, Asrani K, Rine J, Wiemels J, Marini NJ
• Frailty Among Patients Receiving Hemodialysis: Evolution of Components and Associations With Mortality.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Johansen KL, Delgado C, Kaysen GA, Chertow GM, Chiang J, Dalrymple LS, Segal MR, Grimes BA
• Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment.
  Pediatric research 2018 Ballard PL, Keller RL, Truog WE, Chapin C, Horneman H, Segal MR, Ballard RA, Tolsurf Investigators
• Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
  Frontiers in immunology 2018 Hawkins RB, Raymond SL, Stortz JA, Horiguchi H, Brakenridge SC, Gardner A, Efron PA, Bihorac A, Segal M, Moore FA, Moldawer LL
• Improved accuracy assessment for 3D genome reconstructions.
  BMC bioinformatics 2018 Segal MR, Bengtsson HL
• Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis.
  PloS one 2018 Nahid P, Jarlsberg LG, Kato-Maeda M, Segal MR, Osmond DH, Gagneux S, Dobos K, Gold M, Hopewell PC, Lewinsohn DM
• Associations of lipoproteins with cardiovascular and infection-related outcomes in patients receiving hemodialysis.
  Journal of clinical lipidology 2017 Kaysen GA, Grimes B, Dalrymple LS, Chertow GM, Ishida JH, Delgado C, Segal M, Chiang J, Dwyer T, Johansen KL
• Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ
• Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial.
  EBioMedicine 2017 Sigal GB, Segal MR, Mathew A, Jarlsberg L, Wang M, Barbero S, Small N, Haynesworth K, Davis JL, Weiner M, Whitworth WC, Jacobs J, Schorey J, Lewinsohn DM, Nahid P
• Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
  Circulation 2017 Williams SA, Murthy AC, DeLisle RK, Hyde C, Malarstig A, Ostroff R, Weiss SJ, Segal MR, Ganz P
• Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California.
  Environmental health perspectives 2017 Blount RJ, Pascopella L, Catanzaro DG, Barry PM, English PB, Segal MR, Flood J, Meltzer D, Jones B, Balmes J, Nahid P
• Using Organizational Philosophy to Create a Self-Sustaining Compensation Plan Without Harming Academic Missions.
  Academic medicine : journal of the Association of American Medical Colleges 2017 Leverence R, Nuttall R, Palmer R, Segal M, Wood A, Yancey F, Shuster J, Brantly M, Hromas R
• Factors Associated with Frailty and Its Trajectory among Patients on Hemodialysis.
  Clinical journal of the American Society of Nephrology : CJASN 2017 Johansen KL, Dalrymple LS, Delgado C, Chertow GM, Segal MR, Chiang J, Grimes B, Kaysen GA
• Immune Response and Mortality Risk Relate to Distinct Lung Microbiomes in Patients with HIV and Pneumonia.
  American journal of respiratory and critical care medicine 2017 Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV
• Antiinflammatory Effects of Budesonide in Human Fetal Lung.
  American journal of respiratory cell and molecular biology 2016 Barrette AM, Roberts JK, Chapin C, Egan EA, Segal MR, Oses-Prieto JA, Chand S, Burlingame AL, Ballard PL
• HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis.
  PloS one 2016 Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L
• Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease.
  JAMA 2016 Ganz P, Heidecker B, Hveem K, Jonasson C, Kato S, Segal MR, Sterling DG, Williams SA
• Discovering hotspots in functional genomic data superposed on 3D chromatin configuration reconstructions.
  Nucleic acids research 2016 Capurso D, Bengtsson H, Segal MR
• Chromosome position determines the success of double-strand break repair.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Lee CS, Wang RW, Chang HH, Capurso D, Segal MR, Haber JE
• Reconstruction of 3D genome architecture via a two-stage algorithm.
  BMC bioinformatics 2015 Segal MR, Bengtsson HL
• Current theoretical models fail to predict the topological complexity of the human genome.
  Frontiers in molecular biosciences 2015 Arsuaga J, Jayasinghe RG, Scharein RG, Segal MR, Stolz RH, Vazquez M
• Identification of Discrete Prognostic Groups in Ewing Sarcoma.
  Pediatric blood & cancer 2015 Karski EE, McIlvaine E, Segal MR, Krailo M, Grier HE, Granowetter L, Womer RB, Meyers PA, Felgenhauer J, Marina N, DuBois SG
• Location is everything: evaluating the effects of terrestrial and marine resource subsidies on an estuarine bivalve.
  PloS one 2015 Harding JM, Segal MR, Reynolds JD
• Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis.
  Tuberculosis (Edinburgh, Scotland) 2015 Jayakumar A, Vittinghoff E, Segal MR, MacKenzie WR, Johnson JL, Gitta P, Saukkonen J, Anderson J, Weiner M, Engle M, Yoon C, Kato-Maeda M, Nahid P, Tuberculosis Trials Consortium
• Distance-based assessment of the localization of functional annotations in 3D genome reconstructions.
  BMC genomics 2014 Capurso D, Segal MR
• Development of a database for translational spinal cord injury research.
  Journal of neurotrauma 2014 Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, …
• Common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms.
  Journal of neurology, neurosurgery, and psychiatry 2014 Bendjilali N, Nelson J, Weinsheimer S, Sidney S, Zaroff JG, Hetts SW, Segal M, Pawlikowska L, McCulloch CE, Young WL, Kim H
• The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients.
  PloS one 2014 Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV
• Reproducibility of 3D chromatin configuration reconstructions.
  Biostatistics (Oxford, England) 2014 Segal MR, Xiong H, Capurso D, Vazquez M, Arsuaga J
• Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.
  The Journal of infectious diseases 2013 Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM
• 13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation.
  Anesthesiology 2013 Liu J, Segal MR, Kelly MJ, Pelton JG, Kim M, James TL, Litt L
• Global RNA structure analysis of poliovirus identifies a conserved RNA structure involved in viral replication and infectivity.
  Journal of virology 2013 Burrill CP, Westesson O, Schulte MB, Strings VR, Segal M, Andino R
• Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer.
  Diagnostic molecular pathology : the American journal of surgical pathology, part B 2013 Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ
• 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries.
  Pediatric research 2013 Liu J, Sheldon RA, Segal MR, Kelly MJ, Pelton JG, Ferriero DM, James TL, Litt L
• Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats.
  PloS one 2013 Ferguson AR, Irvine KA, Gensel JC, Nielson JL, Lin A, Ly J, Segal MR, Ratan RR, Bresnahan JC, Beattie MS
• A histone arginine methylation localizes to nucleosomes in satellite II and III DNA sequences in the human genome.
  BMC genomics 2012 Capurso D, Xiong H, Segal MR
• Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
  International journal of molecular imaging 2012 Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK
• Being 'underpowered' does not make a study unethical.
  Statistics in medicine 2012 Bacchetti P, McCulloch C, Segal MR
• A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.
  Lancet (London, England) 2012 Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones…
• Querying genomic databases: refining the connectivity map.
  Statistical applications in genetics and molecular biology 2012 Segal MR, Xiong H, Bengtsson H, Bourgon R, Gentleman R
• Sequence-based classification using discriminatory motif feature selection.
  PloS one 2011 Xiong H, Capurso D, Sen S, Segal MR
• Identifying polyglutamine protein species in situ that best predict neurodegeneration.
  Nature chemical biology 2011 Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, Osmand A, Gray M, Thulasiramin V, …
• Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.
  International journal of molecular sciences 2011 Liu J, Litt L, Segal MR, Kelly MJ, Pelton JG, Kim M
• Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study.
  Pediatric blood & cancer 2011 DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC
• Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
  Endocrinology 2011 McGuane JT, Debrah JE, Sautina L, Jarajapu YP, Novak J, Rubin JP, Grant MB, Segal M, Conrad KP
• Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.
  Clinical lung cancer 2011 Okamoto J, Kratz JR, Hirata T, Mikami I, Raz D, Segal M, Chen Z, Zhou HM, Pham P, Li H, Yagui-Beltran A, Beltran A, Ray MR, Koizumi K, Shimizu K, Jablons D, He B
• The relative importance of predictors of body mass index change, overweight and obesity in adolescent girls.
  International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity 2011 Rehkopf DH, Laraia BA, Segal M, Braithwaite D, Epel E
• Screening prevalence and incidence of colorectal cancer among American Indian/Alaskan natives in the Indian Health Service.
  Digestive diseases and sciences 2011 Day LW, Espey DK, Madden E, Segal M, Terdiman JP
• Clustering with exclusion zones: genomic applications.
  Biostatistics (Oxford, England) 2010 Segal MR, Xiao Y, Huffer FW
• Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.
  Protein science : a publication of the Protein Society 2010 Kelly L, Fukushima H, Karchin R, Gow JM, Chinn LW, Pieper U, Segal MR, Kroetz DL, Sali A
• Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Liu J, Litt L, Segal MR, Kelly MJ, Yoshihara HA, James TL
• Regulated gene expression in cultured type II cells of adult human lung.
  American journal of physiology. Lung cellular and molecular physiology 2010 Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA
• Prospective assessment of inpatient gastrointestinal consultation requests in an academic teaching hospital.
  The American journal of gastroenterology 2010 Day LW, Cello JP, Madden E, Segal M
• Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome.
  PloS one 2010 Cox MJ, Huang YJ, Fujimura KE, Liu JT, McKean M, Boushey HA, Segal MR, Brodie EL, Cabana MD, Lynch SV
• Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging.
  Radiology 2009 Barajas RF, Chang JS, Segal MR, Parsa AT, McDermott MW, Berger MS, Cha S
• Identification of yeast transcriptional regulation networks using multivariate random forests.
  PLoS computational biology 2009 Xiao Y, Segal MR
• Personalized prediction of tumor response and cancer progression on prostate needle biopsy.
  The Journal of urology 2009 Donovan MJ, Khan FM, Fernandez G, Mesa-Tejada R, Sapir M, Zubek VB, Powell D, Fogarasi S, Vengrenyuk Y, Teverovskiy M, Segal MR, Karnes RJ, Gaffey TA, Busch C, Haggman M, Hlavcak P, Freedland SJ, …
• A novel topology for representing protein folds.
  Protein science : a publication of the Protein Society 2009 Segal MR
• Distinguishing recurrent intra-axial metastatic tumor from radiation necrosis following gamma knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging.
  AJNR. American journal of neuroradiology 2008 Barajas RF, Chang JS, Sneed PK, Segal MR, McDermott MW, Cha S
• Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress.
  Neurochemistry international 2008 Liu J, Segal M, Yoo S, Yang GY, Kelly M, James TL, Litt L
• How safe is fructose for persons with or without diabetes?
  The American journal of clinical nutrition 2008 Sánchez-Lozada LG, Le M, Segal M, Johnson RJ
• A multigene assay is prognostic of survival in patients with early-stage lung adenocarcinoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Raz DJ, Ray MR, Kim JY, He B, Taron M, Skrzypski M, Segal M, Gandara DR, Rosell R, Jablons DM
• On E-values for tandem MS scoring schemes.
  Bioinformatics (Oxford, England) 2008 Segal MR
• Simple, defensible sample sizes based on cost efficiency.
  Biometrics 2008 Bacchetti P, McCulloch CE, Segal MR
• Re-cracking the nucleosome positioning code.
  Statistical applications in genetics and molecular biology 2008 Segal MR
• Biological sequence classification utilizing positive and unlabeled data.
  Bioinformatics (Oxford, England) 2008 Xiao Y, Segal MR
• The relationship between self-rated health and mortality in older black and white Americans.
  Journal of the American Geriatrics Society 2007 Lee SJ, Moody-Ayers SY, Landefeld CS, Walter LC, Lindquist K, Segal MR, Covinsky KE
• A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007 Nakagawa T, Segal M, Croker B, Johnson RJ
• A multi-array multi-SNP genotyping algorithm for Affymetrix SNP microarrays.
  Bioinformatics (Oxford, England) 2007 Xiao Y, Segal MR, Yang YH, Yeh RF
• Validation in genomics: CpG island methylation revisited.
  Statistical applications in genetics and molecular biology 2006 Segal MR
• Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.
  AIDS (London, England) 2006 Barbour JD, Hecht FM, Little SJ, Markowitz M, Daar ES, Kelleher AD, Routy JP, Campbell TB, Rosenberg ES, Segal MR, Weidler J, Grant RM
• Does familial non-medullary thyroid cancer adversely affect survival?
  World journal of surgery 2006 Triponez F, Wong M, Sturgeon C, Caron N, Ginzinger DG, Segal MR, Kebebew E, Duh QY, Clark OH
• Development and validation of a prognostic index for 4-year mortality in older adults.
  JAMA 2006 Lee SJ, Lindquist K, Segal MR, Covinsky KE
• Microarray gene expression data with linked survival phenotypes: diffuse large-B-cell lymphoma revisited.
  Biostatistics (Oxford, England) 2005 Segal MR
• Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing.
  PLoS computational biology 2005 Xiao Y, Yang YH, Burckin TA, Shiue L, Hartzog GA, Segal MR
• Prediction of genomewide conserved epitope profiles of HIV-1: classifier choice and peptide representation.
  Statistical applications in genetics and molecular biology 2005 Xiao Y, Segal MR
• Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
  Clinical immunology (Orlando, Fla.) 2005 Zhuang H, Narain S, Sobel E, Lee PY, Nacionales DC, Kelly KM, Richards HB, Segal M, Stewart C, Satoh M, Reeves WH
• DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
  The New England journal of medicine 2005 Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon …
• Stepwise normalization of two-channel spotted microarrays.
  Statistical applications in genetics and molecular biology 2005 Xiao Y, Segal MR, Yang YH
• Ethics and sample size.
  American journal of epidemiology 2005 Bacchetti P, Wolf LE, Segal MR, McCulloch CE
• Identifying differentially expressed genes from microarray experiments via statistic synthesis.
  Bioinformatics (Oxford, England) 2004 Yang YH, Xiao Y, Segal MR
• Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
  Nature 2004 Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S
• Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis.
  BMC bioinformatics 2004 Cummings MP, Segal MR
• Biaxial testing of human annulus fibrosus and its implications for a constitutive formulation.
  Annals of biomedical engineering 2004 Bass EC, Ashford FA, Segal MR, Lotz JC
• Persistence of primary drug resistance among recently HIV-1 infected adults.
  AIDS (London, England) 2004 Barbour JD, Hecht FM, Wrin T, Liegler TJ, Ramstead CA, Busch MP, Segal MR, Petropoulos CJ, Grant RM
• Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection.
  The Journal of infectious diseases 2004 Barbour JD, Hecht FM, Wrin T, Segal MR, Ramstead CA, Liegler TJ, Busch MP, Petropoulos CJ, Hellmann NS, Kahn JO, Grant RM
• Plasticity of gene expression in injured human dorsal root ganglia revealed by GeneChip oligonucleotide microarrays.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2004 Rabert D, Xiao Y, Yiangou Y, Kreder D, Sangameswaran L, Segal MR, Hunt CA, Birch R, Anand P
• Management and outcomes of care of fever in early infancy.
  JAMA 2004 Pantell RH, Newman TB, Bernzweig J, Bergman DA, Takayama JI, Segal M, Finch SA, Wasserman RC
• Relating HIV-1 sequence variation to replication capacity via trees and forests.
  Statistical applications in genetics and molecular biology 2004 Segal MR, Barbour JD, Grant RM
• Novel stepwise normalization method for two-channel cDNA microarrays.
  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 Xiao Y, Hunt CA, Segal MR, Yang YH
• Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia.
  Genes, chromosomes & cancer 2003 Reiter A, Saussele S, Grimwade D, Wiemels JL, Segal MR, Lafage-Pochitaloff M, Walz C, Weisser A, Hochhaus A, Willer A, Reichert A, Büchner T, Lengfelder E, Hehlmann R, Cross NC
• Factors associated with future amputation among patients undergoing hemodialysis: results from the Dialysis Morbidity and Mortality Study Waves 3 and 4.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2003 O'Hare AM, Bacchetti P, Segal M, Hsu CY, Johansen KL, Dialysis Morbidity and Mortality Study Waves
• Regression approaches for microarray data analysis.
  Journal of computational biology : a journal of computational molecular cell biology 2003 Segal MR, Dahlquist KD, Conklin BR
• Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR
• Assessment of differential gene expression in human peripheral nerve injury.
  BMC genomics 2002 Xiao Y, Segal MR, Rabert D, Ahn AH, Anand P, Sangameswaran L, Hu D, Hunt CA
• Residual-based tree-structured survival analysis.
  Statistics in medicine 2002 Keles S, Segal MR
• Molecular characterization of genomic AML1-ETO fusions in childhood leukemia.
  Leukemia 2001 Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL
• Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma.
  The Journal of allergy and clinical immunology 2001 Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV
• Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro.
  Spine 2001 Chiu EJ, Newitt DC, Segal MR, Hu SS, Lotz JC, Majumdar S
• A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus.
  The New England journal of medicine 2001 Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, Gottwald MD, O'Neil N, Neuhaus JM, Segal MR, Lowenstein DH
• Relating amino acid sequence to phenotype: analysis of peptide-binding data.
  Biometrics 2001 Segal MR, Cummings MP, Hubbard AE
• Transcranial magnetic stimulation and antidepressive drugs share similar cellular effects in rat hippocampus.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001 Levkovitz Y, Grisaru N, Segal M
• Neurotrophins act at presynaptic terminals to activate synapses among cultured hippocampal neurons.
  The European journal of neuroscience 2001 Collin C, Vicario-Abejon C, Rubio ME, Wenthold RJ, McKay RD, Segal M
• Quantitative analysis of MR images in asphyxiated neonates: correlation with neurodevelopmental outcome.
  AJNR. American journal of neuroradiology 2001 Coskun A, Lequin M, Segal M, Vigneron DB, Ferriero DM, Barkovich AJ
• Validation of the American Association for the Surgery of Trauma organ injury severity scale for the kidney.
  The Journal of trauma 2001 Santucci RA, McAninch JW, Safir M, Mario LA, Service S, Segal MR
• Inhaled nitric oxide in neonates with persistent pulmonary hypertension.
  Lancet (London, England) 2001 Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR
• A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1.
  The Journal of cell biology 2001 Jensen S, Segal M, Clarke DJ, Reed SI
• Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networks.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Goldin M, Segal M, Avignone E
• Temporal lobe epilepsy: qualitative reading of 1H MR spectroscopic images for presurgical evaluation.
  Radiology 2001 Capizzano AA, Vermathen P, Laxer KD, Ende GR, Norman D, Rowley H, Matson GB, Maudsley AA, Segal MR, Weiner MW
• Brain and CSF entry of the novel non-nucleoside reverse transcriptase inhibitor, GW420867X.
  Neuroreport 2000 Thomas S, Cass L, Prince W, Segal M
• Predictors of late asthmatic response. Logistic regression and classification tree analyses.
  American journal of respiratory and critical care medicine 2000 Avila PC, Segal MR, Wong HH, Boushey HA, Fahy JV
• Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy.
  AJNR. American journal of neuroradiology 2000 Capizzano AA, Schuff N, Amend DL, Tanabe JL, Norman D, Maudsley AA, Jagust W, Chui HC, Fein G, Segal MR, Weiner MW
• Upregulation of GABA neurotransmission suppresses hippocampal excitability and prevents long-term potentiation in transgenic superoxide dismutase-overexpressing mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Levkovitz Y, Avignone E, Groner Y, Segal M
• Radiologic staging in patients with endometrial cancer: a meta-analysis.
  Radiology 1999 Kinkel K, Kaji Y, Yu KK, Segal MR, Lu Y, Powell CB, Hricak H
• Meta-analysis of exercise testing to detect coronary artery disease in women.
  The American journal of cardiology 1999 Kwok Y, Kim C, Grady D, Segal M, Redberg R
• Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities.
  JAMA 1998 Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, Brand R, Grady D
• Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Vicario-Abejón C, Collin C, McKay RD, Segal M
• Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Okabe S, Collin C, Auerbach JM, Meiri N, Bengzon J, Kennedy MB, Segal M, McKay RD
• The association of radiographically detected vertebral fractures with back pain and function: a prospective study.
  Annals of internal medicine 1998 Nevitt MC, Ettinger B, Black DM, Stone K, Jamal SA, Ensrud K, Segal M, Genant HK, Cummings SR
• Accommodating error analysis in comparison and clustering of molecular fingerprints.
  Emerging infectious diseases 1998 Salamon H, Segal MR, Ponce de Leon A, Small PM
• Methods development for epidemiologic investigations of the health effects of prolonged ozone exposure. Part II. An approach to retrospective estimation of lifetime ozone exposure using a questionnaire and ambient monitoring data (California sites).
  Research report (Health Effects Institute) 1998 Tager IB, Künzli N, Lurmann F, Ngo L, Segal M, Balmes J
• Radiological evaluation of lymph node metastases in patients with cervical cancer. A meta-analysis.
  JAMA 1997 Scheidler J, Hricak H, Yu KK, Subak L, Segal MR
• Maternal smoking during pregnancy and birth outcomes with weight gain adjustments via varying-coefficient models.
  Statistics in medicine 1997 Segal MR, Wight S, Hanrahan JP, Tager IB
• Temporal trends and factors associated with survival after Pneumocystis carinii pneumonia in California, 1983-1992.
  American journal of epidemiology 1997 Colford JM, Segal M, Tabnak F, Chen M, Sun R, Tager I
• Features of tree-structured survival analysis.
  Epidemiology (Cambridge, Mass.) 1997 Segal MR
• An empirical comparison of multivariable methods for estimating risk of death from coronary heart disease.
  Journal of cardiovascular risk 1997 Knuiman MW, Vu HT, Segal MR
• Dendritic spine density and LTP induction in cultured hippocampal slices.
  Journal of neurophysiology 1997 Collin C, Miyaguchi K, Segal M
• Association between lifetime ambient ozone exposure and pulmonary function in college freshmen--results of a pilot study.
  Environmental research 1997 Künzli N, Lurmann F, Segal M, Ngo L, Balmes J, Tager IB
• Dependence estimation for marginal models of multivariate survival data.
  Lifetime data analysis 1997 Segal MR, Neuhaus JM, James IR
• Examination of the role of cGMP in long-term potentiation in the CA1 region of the hippocampus.
  Learning & memory (Cold Spring Harbor, N.Y.) 1996 Selig DK, Segal MR, Liao D, Malenka RC, Malinow R, Nicoll RA, Lisman JE
• Reliability of lifetime residential history and activity measures as elements of cumulative ambient ozone exposure assessment.
  Journal of exposure analysis and environmental epidemiology 1996 Künzli N, Lurman F, Segal M, Ngo L, Balmes J, Tager IB
• Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus.
  The Journal of physiology 1996 Auerbach JM, Segal M
• Extending the elements of tree-structured regression.
  Statistical methods in medical research 1995 Segal MR
• Relation of FEV1 and peripheral blood leukocyte count to total mortality. The Normative Aging Study.
  American journal of epidemiology 1995 Weiss ST, Segal MR, Sparrow D, Wager C
• 0.0625% bupivacaine with 0.0002% fentanyl via patient-controlled epidural analgesia for pain of labor and delivery.
  The Clinical journal of pain 1995 Ferrante FM, Barber MJ, Segal M, Hughes NJ, Datta S
• Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS.
  Lifetime data analysis 1995 Bacchetti P, Segal MR
• A novel cholinergic induction of long-term potentiation in rat hippocampus.
  Journal of neurophysiology 1994 Auerbach JM, Segal M
• Trees and tracking.
  Statistics in medicine 1993 Segal MR, Tager IB
• Design effects for binary regression models fitted to dependent data.
  Statistics in medicine 1993 Neuhaus JM, Segal MR
• Robust inference for multivariate survival data.
  Statistics in medicine 1993 Segal MR, Neuhaus JM
• Assessing selfcare status in quadriplegia: comparison of the quadriplegia index of function (QIF) and the functional independence measure (FIM).
  Paraplegia 1993 Marino RJ, Huang M, Knight P, Herbison GJ, Ditunno JF, Segal M
• Different AIDS incubation periods and their impacts on reconstructing human immunodeficiency virus epidemics and projecting AIDS incidence.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Bacchetti P, Segal MR, Hessol NA, Jewell NP
• Risk factors for ventilatory impairment among middle-aged and elderly men. The Normative Aging Study.
  Chest 1993 O'Connor GT, Sparrow D, Segal M, Weiss ST
• Correlates of knee pain among US adults with and without radiographic knee osteoarthritis.
  The Journal of rheumatology 1992 Davis MA, Ettinger WH, Neuhaus JM, Barclay JD, Segal MR
• The relationship of nasal disorders to lower respiratory tract symptoms and illness in a random sample of children.
  Pediatric pulmonology 1992 Barr MB, Weiss ST, Segal MR, Tager IB, Speizer FE
• A parametric family of correlation structures for the analysis of longitudinal data.
  Biometrics 1992 Muñoz A, Carey V, Schouten JP, Segal M, Rosner B
• Spontaneous recovery of deficits in spatial memory and cholinergic potentiation of NMDA in CA1 neurons during chronic lithium treatment.
  Hippocampus 1992 Richter-Levin G, Markram H, Segal M
• Serum beta 2-microglobulin and prediction of progression to AIDS in HIV infection.
  Lancet (London, England) 1992 Lifson AR, Hessol NA, Buchbinder SP, O'Malley PM, Barnhart L, Segal M, Katz MH, Holmberg SD
• The effect of maternal smoking during pregnancy on early infant lung function.
  The American review of respiratory disease 1992 Hanrahan JP, Tager IB, Segal MR, Tosteson TD, Castile RG, Van Vunakis H, Weiss ST, Speizer FE
• Living arrangements and survival among middle-aged and older adults in the NHANES I epidemiologic follow-up study.
  American journal of public health 1992 Davis MA, Neuhaus JM, Moritz DJ, Segal MR
• An annotated bibliography of methods for analysing correlated categorical data.
  Statistics in medicine 1992 Ashby M, Neuhaus JM, Hauck WW, Bacchetti P, Heilbron DC, Jewell NP, Segal MR, Fusaro RE
• Effects of asthma on pulmonary function in children. A longitudinal population-based study.
  The American review of respiratory disease 1992 Weiss ST, Tosteson TD, Segal MR, Tager IB, Redline S, Speizer FE
• Independent regulation of calcium revealed by imaging dendritic spines.
  Nature 1991 Guthrie PB, Segal M, Kater SB
• Temporal trends in chronic obstructive lung disease case fatality in hospitalized US veterans: 1970-1987.
  Chest 1991 Tager IB, Segal MR
• The influence of age and level of pulmonary function on nonspecific airway responsiveness. The Normative Aging Study.
  The American review of respiratory disease 1991 Sparrow D, O'Connor GT, Rosner B, Segal MR, Weiss ST
• Body fat distribution, blood pressure, and hypertension. A prospective cohort study of men in the normative aging study.
  Annals of epidemiology 1990 Cassano PA, Segal MR, Vokonas PS, Weiss ST
• Patterns of weight change and their relation to diet in a cohort of healthy women.
  The American journal of clinical nutrition 1990 Colditz GA, Willett WC, Stampfer MJ, London SJ, Segal MR, Speizer FE
• The relationship of body fat distribution to blood pressure in normotensive men: the normative aging study.
  International journal of obesity 1990 Troisi RJ, Weiss ST, Segal MR, Cassano PA, Vokonas PS, Landsberg L
• Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.
  Neuroscience letters 1990 Markram H, Segal M
• Pulmonary function measures in healthy infants. Variability and size correction.
  The American review of respiratory disease 1990 Hanrahan JP, Tager IB, Castile RG, Segal MR, Weiss ST, Speizer FE
• The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet.
  The New England journal of medicine 1990 Grimm RH, Neaton JD, Elmer PJ, Svendsen KH, Levin J, Segal M, Holland L, Witte LJ, Clearman DR, Kofron P
• The relationship of nonspecific airway responsiveness and atopy to the rate of decline of lung function. The Normative Aging Study.
  The American review of respiratory disease 1990 Parker DR, O'Connor GT, Sparrow D, Segal MR, Weiss ST
• Deficits in AIDS incidence.
  Journal of acquired immune deficiency syndromes 1990 Segal M, Bacchetti P
• Smoking, atopy, and methacholine airway responsiveness among middle-aged and elderly men. The Normative Aging Study.
  The American review of respiratory disease 1989 O'Connor GT, Sparrow D, Segal MR, Weiss ST
• Alcohol consumption and chronic obstructive pulmonary disease.
  The American review of respiratory disease 1989 Garshick E, Segal MR, Worobec TG, Salekin CM, Miller MJ
• Firefighting acutely increases airway responsiveness.
  The American review of respiratory disease 1989 Sherman CB, Barnhart S, Miller MF, Segal MR, Aitken M, Schoene R, Daniell W, Rosenstock L
• The relationship between longitudinal change in pulmonary function and nonspecific airway responsiveness in children and young adults.
  The American review of respiratory disease 1989 Redline S, Tager IB, Segal MR, Gold D, Speizer FE, Weiss ST
• A comparison of estimated proportional hazards models and regression trees.
  Statistics in medicine 1989 Segal MR, Bloch DA
• Comparison of questionnaire and diary methods in acute childhood respiratory illness surveillance.
  The American review of respiratory disease 1989 Gold DR, Weiss ST, Tager IB, Segal MR, Speizer FE
• Conventional cemented total hip arthroplasty. Assessment of clinical factors associated with revision for mechanical failure.
  Clinical orthopaedics and related research 1989 Schurman DJ, Bloch DA, Segal MR, Tanner CM
• A "state model" of renal function in systemic lupus erythematosus: its value in the prediction of outcome in 292 patients.
  The Journal of rheumatology 1989 Edworthy SM, Bloch DA, McShane DJ, Segal MR, Fries JF
• The natural history of forced expiratory volumes. Effect of cigarette smoking and respiratory symptoms.
  The American review of respiratory disease 1988 Tager IB, Segal MR, Speizer FE, Weiss ST
• Synaptic activation of a cholinergic receptor in rat hippocampus.
  Brain research 1988 Segal M
• Smoothing methods for epidemiologic analysis.
  Statistics in medicine 1988 Segal MR, Weiss ST, Speizer FE, Tager IB
• A retrospective cohort study of lung cancer and diesel exhaust exposure in railroad workers.
  The American review of respiratory disease 1988 Garshick E, Schenker MB, Muñoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, Speizer FE
• The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins.
  Nature 1988 Kozutsumi Y, Segal M, Normington K, Gething MJ, Sambrook J
• Postmarketing surveillance in rheumatology: analysis of purpura and upper abdominal pain.
  The Journal of rheumatology 1988 Fries JF, Bloch DA, Segal MR, Spitz PW, Williams C, Lane NE
• Analysis of dose-response curves to methacholine. An approach suitable for population studies.
  The American review of respiratory disease 1987 O'Connor G, Sparrow D, Taylor D, Segal M, Weiss S
• The effect of maternal cigarette smoking on the pulmonary function of children and adolescents. Analyses of data from two populations.
  The American review of respiratory disease 1987 Tager IB, Segal MR, Munoz A, Weiss ST, Speizer FE
• A case-control study of lung cancer and diesel exhaust exposure in railroad workers.
  The American review of respiratory disease 1987 Garshick E, Schenker MB, Muñoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, Speizer FE
• Interactions between grafted serotonin neurons and adult host rat hippocampus.
  Annals of the New York Academy of Sciences 1987 Segal M
• Rat hippocampal neurons in culture: responses to electrical and chemical stimuli.
  Journal of neurophysiology 1983 Segal M
• Amphotericin B selection of mutant Chinese hamster cells with defects in the receptor-mediated endocytosis of low density lipoprotein and cholesterol biosynthesis.
  Proceedings of the National Academy of Sciences of the United States of America 1983 Krieger M, Martin J, Segal M, Kingsley D
• On a method of mortality analysis incorporating age--year interaction, with application to prostate cancer mortality.
  Biometrics 1982 James IR, Segal MR
• Cyclic GMP in rat hippocampus: regulation by the septo-hippocampal pathway.
  Neuropharmacology 1981 Segal M, Guidotti A
• Recent trends in mortality from prostate cancer in male populations of Australia and England and Wales.
  British journal of cancer 1981 Holman CD, James IR, Segal MR, Armstrong BK
• Mechanisms of norepinephrine actions on hippocampal pyramidal cells in vitro.
  Brain research 1981 Langmoen IA, Segal M, Andersen P
• The actions of glutamic acid on neurons in the rat hippocampal slice.
  Advances in biochemical psychopharmacology 1981 Segal M
• A potent inhibitory monosynaptic hypothalamo-hippocampal connection.
  Brain research 1979 Segal M
• Lithium and the monoamine neurotransmitters in the rat hippocampus.
  Nature 1974 Segal M
• A case of penicillin allergy.
  Journal of the American Dental Association (1939) 1951 SEGAL MR