Mark Schumacher, MD, PhD
Professor
Anesthesia
School of Medicine

He has a clinical, research and educational focus on pain medicine with an emphasis on the development of evidence – based pain care into general clinical practice that utilize non-addictive modalities to improve both the quality and safety of analgesic care. Dr. Schumacher is also the Director of the UCSF Pain and Addiction Research Center (PARC) and served on the National Academies of Science Engineering and Medicine Committee, co-authoring the report on “Pain Management and the Opioid Epidemic.” Scientifically, following his collaboration in the cloning of the Capsaicin Receptor (TRPV1), he has led a laboratory dedicated to non-addictive strategies to block the transition from acute to chronic pain through transcriptional blockade. His current NIH-funded research includes: Study of painful Chemotherapy-Induced Peripheral Neuropathy (CIPN) with the aim to develop novel therapeutics and studying Neuro-immune Mechanisms of Analgesia of the Minor Cannabinoids such as CBD as well as its developmental effects on sensory neurons. Throughout his career, he has sought ways to communicate the science and practice of pain medicine including previously directing an NIH Center of Excellence in Pain Education at UCSF.

• Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.
  Journal of neuroimmunology 2019 Miaskowski C, Topp K, Conley YP, Paul SM, Melisko M, Schumacher M, Chesney M, Abrams G, Levine JD, Kober KM
• Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors.
  Journal of pain and symptom management 2019 Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C
• Transcription factor Sp4 is required for hyperalgesic state persistence.
  PloS one 2019 Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M
• Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors.
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C
• Pain Management and Opioid Regulation: Continuing Public Health Challenges.
  American journal of public health 2019 Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS
• Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy.
  Molecular pain 2019 Kober KM, Schumacher M, Conley YP, Topp K, Mazor M, Hammer MJ, Paul SM, Levine JD, Miaskowski C
• Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors.
  Molecular pain 2018 Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C
• Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors.
  Journal of pain and symptom management 2018 Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C
• Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors.
  Journal of pain and symptom management 2018 Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD
• Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life.
  Journal of cancer survivorship : research and practice 2017 Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD
• Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy.
  European journal of oncology nursing : the official journal of European Oncology Nursing Society 2017 Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD
• America's Opioid Epidemic: Supply and Demand Considerations.
  Anesthesia and analgesia 2017 Clark DJ, Schumacher MA
• N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K
• (431) Characteristics of chemotherapy induced neuropathy (CIN) in cancer survivors who received taxol.
  Journal of Pain 2017 K. Kober, J. Mastick, S. Paul, K. Topp, B. Smoot, G. Abrams, L. Chen, Y. Conley, M. Chesney, K. Bolla, G. Mausisa, M. Azor, M. Wong, M. Schumacher, J. Levine, C. Miaskowski
• Chemotherapy-Induced Neuropathy in Cancer Survivors.
  Journal of pain and symptom management 2017 Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine JD
• Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways.
  F1000Research 2016 Guan Z, Hellman J, Schumacher M
• The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons.
  Neuroscience letters 2014 Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA
• Back pain and the mineralocorticoid receptor: is there a connection?
  Anesthesiology 2012 Schumacher MA
• Pain Management for the Obese Sleep Apnea Patient.
  ICU Director 2012 Mark A. Schumacher
• Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.
  Molecular pain 2011 Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA
• Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma.
  Journal of pain and symptom management 2011 Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA
• Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.
  Anesthesiology 2010 Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW
• TRPV1 splice variants: structure and function.
  Frontiers in bioscience (Landmark edition) 2010 Schumacher MA, Eilers H
• Transient receptor potential channels in pain and inflammation: therapeutic opportunities.
  Pain practice : the official journal of World Institute of Pain 2010 Schumacher MA
• The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation.
  Neuroreport 2007 Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA
• Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.
  The Journal of biological chemistry 2007 Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP
• Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor.
  Journal of neurochemistry 2007 Xue Q, Jong B, Chen T, Schumacher MA
• Isolation of an mRNA binding protein homologue that is expressed in nociceptors.
  The European journal of neuroscience 2004 Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA
• Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure?
  Molecular interventions 2004 Eilers H, Schumacher MA
• The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants.
  Genomics 2001 Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA
• The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.
  Anesthesia and analgesia 2001 Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA
• Room B, 10/16/2000 2: 00 PM - 4: 00 PM (PS) The Capsaicin Receptor Variant, Stretch-inactivated Channel, Is Expressed in Small-Diameter Sensory Neurons.
  Anesthesiology 2000 Mark A. Schumacher, Beverly E. Jong, Sharon L. Frey, Norman F. Capra, Jon D. Levine
• The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat.
  Neuroscience letters 2000 Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD
• Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes.
  The Journal of biological chemistry 2000 Schumacher MA, Moff I, Sudanagunta SP, Levine JD
• ISOLATION OF NERVE GROWTH FACTOR (NGF) REGULATED GENES IN PRIMARY AFFERENT NEURONS.
  Anesthesiology 1998 Mark A. Schumacher, Irene Moff, Jon D. Levine
• The capsaicin receptor: a heat-activated ion channel in the pain pathway.
  Nature 1997 Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D
• ATP receptors in sickness, pain and death.
  Chemistry & biology 1996 Brake A, Schumacher M, Julius D