Mark Schumacher, MD, PhD
Professor
Anesthesia
School of Medicine

Dr. Schumacher is also the Director of the UCSF Pain and Addiction Research Center (PARC) and served on the National Academies of Science Engineering and Medicine Committee, co-authoring the report on “Pain Management and the Opioid Epidemic.” Scientifically, following his collaboration in the cloning of the Capsaicin Receptor (TRPV1), he has led a laboratory dedicated to non-addictive strategies to block the transition from acute to chronic pain through transcriptional blockade.

His NIH-funded research includes: Study of painful Chemotherapy-Induced Peripheral Neuropathy (CIPN) with the aim to develop novel non-opioid therapeutics and studying Neuro-immune Mechanisms of Analgesia of the Minor Cannabinoids such as CBD and CBN. He is also investigating novel sensory neuron receptors that mediate neuropathic pain. Throughout his career, he has sought ways to integrate the science and practice of pain medicine including previously directing an NIH Center of Excellence in Pain Education at UCSF.

• Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes.
  Pain 2025 Franco-Enzástiga Ú, Inturi NN, Natarajan K, Mwirigi JM, Mazhar K, Schlachetzki JCM, Schumacher M, Price TJ
• Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes.
  bioRxiv : the preprint server for biology 2024 Franco-Enzástiga Ú, Inturi NN, Natarajan K, Mwirigi JM, Mazhar K, Schlachetzki JCM, Schumacher M, Price TJ
• N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.
  Journal of neuroinflammation 2022 Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J
• Occurrence and perceived effectiveness of activities used to decrease chemotherapy-induced peripheral neuropathy symptoms in the feet.
  European journal of oncology nursing : the official journal of European Oncology Nursing Society 2021 Ogle T, Alexander K, Yates P, Paul SM, Kober KM, Conley YP, Schumacher M, Levine JD, Miaskowski C
• Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014.
  Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2020 Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA
• Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain.
  Molecular pain 2020 Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C
• AAAPT Diagnostic Criteria for Acute Pain Following Breast Surgery.
  The journal of pain 2019 Schreiber KL, Belfer I, Miaskowski C, Schumacher M, Stacey BR, Van De Ven T
• Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.
  Journal of neuroimmunology 2019 Miaskowski C, Topp K, Conley YP, Paul SM, Melisko M, Schumacher M, Chesney M, Abrams G, Levine JD, Kober KM
• Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors.
  Journal of pain and symptom management 2019 Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C
• Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors.
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C
• Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients.
  The Clinical journal of pain 2019 Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Schumacher M, Conley YP, Hammer M, Cheung S, Borsook D, Levine JD
• Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors.
  Molecular pain 2018 Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C
• Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors.
  Journal of pain and symptom management 2018 Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C
• Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report.
  A&A practice 2018 Peniche A, Poree L, Schumacher M, Yu X
• Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors.
  Journal of pain and symptom management 2018 Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD
• Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life.
  Journal of cancer survivorship : research and practice 2017 Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD
• Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy.
  European journal of oncology nursing : the official journal of European Oncology Nursing Society 2017 Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD
• America's Opioid Epidemic: Supply and Demand Considerations.
  Anesthesia and analgesia 2017 Clark DJ, Schumacher MA
• N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K
• The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.
  The journal of pain 2017 Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, …
• The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.
  Pain medicine (Malden, Mass.) 2017 Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, …
• (431) Characteristics of chemotherapy induced neuropathy (CIN) in cancer survivors who received taxol.
  Journal of Pain 2017 K. Kober, J. Mastick, S. Paul, K. Topp, B. Smoot, G. Abrams, L. Chen, Y. Conley, M. Chesney, K. Bolla, G. Mausisa, M. Azor, M. Wong, M. Schumacher, J. Levine, C. Miaskowski
• The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons.
  Neuroscience letters 2014 Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA
• Topical capsaicin formulations in the management of neuropathic pain.
  Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 2014 Schumacher M, Pasvankas G
• Back pain and the mineralocorticoid receptor: is there a connection?
  Anesthesiology 2012 Schumacher MA
• Pain Management for the Obese Sleep Apnea Patient.
  ICU Director 2012 Mark A. Schumacher
• Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma.
  Journal of pain and symptom management 2011 Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA
• Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.
  Anesthesiology 2010 Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW
• TRPV1 splice variants: structure and function.
  Frontiers in bioscience (Landmark edition) 2010 Schumacher MA, Eilers H
• Transient receptor potential channels in pain and inflammation: therapeutic opportunities.
  Pain practice : the official journal of World Institute of Pain 2010 Schumacher MA
• The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation.
  Neuroreport 2007 Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA
• Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.
  The Journal of biological chemistry 2007 Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP
• Isolation of an mRNA binding protein homologue that is expressed in nociceptors.
  The European journal of neuroscience 2004 Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA
• Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure?
  Molecular interventions 2004 Eilers H, Schumacher MA
• Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures.
  Experimental dermatology 2004 Ständer S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D, Steinhoff M
• The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.
  Anesthesia and analgesia 2001 Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA
• The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat.
  Neuroscience letters 2000 Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD
• ISOLATION OF NERVE GROWTH FACTOR (NGF) REGULATED GENES IN PRIMARY AFFERENT NEURONS.
  Anesthesiology 1998 Mark A. Schumacher, Irene Moff, Jon D. Levine
• ATP receptors in sickness, pain and death.
  Chemistry & biology 1996 Brake A, Schumacher M, Julius D
• Multiple messenger RNA species give rise to the structural diversity in acetylcholinesterase.
  The Journal of biological chemistry 1988 Schumacher M, Maulet Y, Camp S, Taylor P
• Primary structure of acetylcholinesterase: implications for regulation and function.
  Federation proceedings 1986 Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P
• Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence.
  Nature 1986 Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P
• Hepatic (Na+,K+)-ATPase: a current view of its structure, function and localization in rat liver as revealed by studies with monoclonal antibodies.
  Hepatology (Baltimore, Md.) 1985 Leffert HL, Schenk DB, Hubert JJ, Skelly H, Schumacher M, Ariyasu R, Ellisman M, Koch KS, Keller GA
• Mechanisms of whole blood-induced cerebral arterial contraction.
  Neurosurgery 1981 Schumacher MA, Alksne JF