Mark Rubinstein, MD
Professor Emeritus
Pediatrics
School of Medicine

Education & Training

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• M.D. School of Medicine Yale-New Haven 1997

Interests

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• Nicotine addiction
• nicotine metabolism
• adolescent smoking

Websites

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• Posts on X Dr_Mark_R (X.com)

Videos

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• NBC World News interview (twitter.com)

Grants and Projects

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• Adolescent ENDS Use, Nicotine Metabolism and Toxicant Exposure, NIH, 2016-2019
• Nicotine Metabolism and the Development of Addiction in Adolescent Light Smokers, NIH, 2009-2015
• Nicotine Metabolism and the Development of Addiction in Adolescent Light Smokers, NIH, 2009-2014
• Nicotine Replacement and Counseling In Adolescents, NIH, 2003-2009

Publications (37)

Top publication keywords:
VapingVolatile Organic CompoundsSubstance Withdrawal SyndromeSalivaNicotineSmoking CessationBehavior, AddictiveSmokingCotinineTobacco ProductsElectronic Nicotine Delivery SystemsCigarette SmokingTobacco Use DisorderSmoking PreventionAdolescent Behavior

• Effects of Social Media on Adolescents' Willingness and Intention to Use E-Cigarettes: An Experimental Investigation.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2021 Vogel EA, Ramo DE, Rubinstein ML, Delucchi KL, Darrow SM, Costello C, Prochaska JJ
• Effect of varenicline for smoking cessation in adolescents - Authors' reply.
  The Lancet. Child & adolescent health 2021 Gray KM, Rubinstein ML, Prochaska JJ, DuBrava SJ, Holstein AR, Samuels L, McRae TD
• Abuse liability assessment of the JUUL system in two nicotine concentrations compared to combustible cigarette, nicotine gum and comparator electronic nicotine delivery system.
  Drug and alcohol dependence 2020 Goldenson NI, Buchhalter AR, Augustson EM, Rubinstein ML, Van Hoof D, Henningfield JE
• Abuse liability assessment of the JUUL system in four flavors relative to combustible cigarette, nicotine gum and a comparator electronic nicotine delivery system among adult smokers.
  Drug and alcohol dependence 2020 Goldenson NI, Buchhalter AR, Augustson EM, Rubinstein ML, Henningfield JE
• Neural Correlates of Smartphone Dependence in Adolescents.
  Frontiers in human neuroscience 2020 Tymofiyeva O, Yuan JP, Kidambi R, Huang CY, Henje E, Rubinstein ML, Jariwala N, Max JE, Yang TT, Xu D

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• High-dose and low-dose varenicline for smoking cessation in adolescents: a randomised, placebo-controlled trial.
  The Lancet. Child & adolescent health 2020 Gray KM, Rubinstein ML, Prochaska JJ, DuBrava SJ, Holstein AR, Samuels L, McRae TD
• Online patient-provider cannabis consultations.
  Preventive medicine 2020 Gali K, Narode R, Young-Wolff KC, Rubinstein ML, Rutledge G, Prochaska JJ
• Adolescents' E-Cigarette Use: Increases in Frequency, Dependence, and Nicotine Exposure Over 12 Months.
  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2019 Vogel EA, Prochaska JJ, Ramo DE, Andres J, Rubinstein ML
• Measuring e-cigarette addiction among adolescents.
  Tobacco control 2019 Vogel EA, Prochaska JJ, Rubinstein ML
• Adolescents’ E-Cigarette Use: Increases in Frequency, Dependence, and Nicotine Exposure over 12 Months
  Journal of Adolescent Health 2019 Vogel EA, Prochaska JJ, Ramo DE, Jerome A, Rubinstein ML
• Measuring E-cigarette Addiction among Adolescents
  Tobacco Control 2019 Vogel EA, Prochaska JJ, Rubinstein ML
• Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing.
  Journal of hematology & oncology 2018 Li Z, Song W, Rubinstein M, Liu D
• Associations between marijuana use and tobacco cessation outcomes in young adults.
  Journal of substance abuse treatment 2018 Vogel EA, Rubinstein ML, Prochaska JJ, Ramo DE
• Author Response.
  Pediatrics 2018 Rubinstein ML
• Prevalence and correlates of adolescents' e-cigarette use frequency and dependence.
  Drug and alcohol dependence 2018 Vogel EA, Ramo DE, Rubinstein ML
• Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes.
  Pediatrics 2018 Rubinstein ML, Delucchi K, Benowitz NL, Ramo DE
• Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products.
  Neuroscience and biobehavioral reviews 2016 England LJ, Aagaard K, Bloch M, Conway K, Cosgrove K, Grana R, Gould TJ, Hatsukami D, Jensen F, Kandel D, Lanphear B, Leslie F, Pauly JR, Neiderhiser J, Rubinstein M, Slotkin TA, Spindel E, Stroud L, …
• Polydrug use among urban adolescent cigarette smokers.
  Addictive behaviors 2016 McKelvey KL, Ramo DE, Delucchi K, Rubinstein ML
• Eating Disorders in Adolescent and Young Adult Males: Presenting Characteristics.
  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2016 Vo M, Lau J, Rubinstein M
• Recruitment of adolescents for a smoking study: use of traditional strategies and social media.
  Translational behavioral medicine 2015 Rait MA, Prochaska JJ, Rubinstein ML
• Reporting of cigar use among adolescent tobacco smokers.
  Addictive behaviors 2015 Rait MA, Prochaska JJ, Rubinstein ML
• Scanning the brain for answers about effectiveness of graphic warning labels.
  Tobacco control 2015 Rubinstein ML
• Exploration of the Effect of Tobacco Smoking on Metabolic Measures in Young People Living with HIV.
  AIDS research and treatment 2014 Rubinstein ML, Harris DR, Rudy BJ, Kapogiannis BG, Aldrovandi GM, Mulligan K
• Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers.
  Drug and alcohol dependence 2014 Rubinstein ML, Rait MA, Prochaska JJ
• Characteristics of adolescent intermittent and daily smokers.
  Addictive behaviors 2014 Rubinstein ML, Rait MA, Sen S, Shiffman S
• Race, gender, and nicotine metabolism in adolescent smokers.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2012 Rubinstein ML, Shiffman S, Rait MA, Benowitz NL
• Nicotine metabolism and addiction among adolescent smokers.
  Addiction (Abingdon, England) 2012 Rubinstein ML, Shiffman S, Moscicki AB, Rait MA, Sen S, Benowitz NL
• Adolescent smokers show decreased brain responses to pleasurable food images compared with nonsmokers.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2011 Rubinstein ML, Luks TL, Dryden WY, Rait MA, Simpson GV
• Smoking-related cue-induced brain activation in adolescent light smokers.
  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2011 Rubinstein ML, Luks TL, Moscicki AB, Dryden W, Rait MA, Simpson GV
• Withdrawal in adolescent light smokers following 24-hour abstinence.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2009 Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB
• A randomized trial of nicotine nasal spray in adolescent smokers.
  Pediatrics 2008 Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB
• Rate of nicotine metabolism and withdrawal symptoms in adolescent light smokers.
  Pediatrics 2008 Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB
• Who's Smoking? Cotinine versus self-report in adolescent populations.
  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2008 Rubinstein ML
• Cotinine levels in relation to smoking behavior and addiction in young adolescent smokers.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2007 Rubinstein ML, Thompson PJ, Benowitz NL, Shiffman S, Moscicki AB
• Clear the air: adolescents' perceptions of the risks associated with secondhand smoke.
  Preventive medicine 2004 Halpern-Felsher BL, Rubinstein ML
• Perceived risks and benefits of smoking: differences among adolescents with different smoking experiences and intentions.
  Preventive medicine 2004 Halpern-Felsher BL, Biehl M, Kropp RY, Rubinstein ML
• An evaluation of the use of the transdermal contraceptive patch in adolescents.
  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2004 Rubinstein ML, Halpern-Felsher BL, Irwin CE