Mark McCormick
Program Associate
Medicine
School of Medicine

Education & Training

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• BA Sociology University of California 1988

Websites

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• TargetHIV (targethiv.org)
• AETC NCRC (aidsetc.org)
• Center for HIV Information (chi.ucsf.edu)

Publications (20)

Top publication keywords:
Enzyme InhibitorsSaccharomyces cerevisiae ProteinsProtein BiosynthesisNuclear Pore Complex ProteinsCaloric RestrictionGene Expression Regulation, FungalAmino Acyl-tRNA SynthetasesBasic-Leucine Zipper Transcription FactorsUbiquitinLongevityAutophagySaccharomyces cerevisiaeCaenorhabditis elegansSystems BiologyHuntington Disease

• Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux in C. elegans.
  Biomolecules 2026 Heath OC, Otero MP, Achusim AT, Karr DS, Leger AW, McCormick MA
• Diverse Patterns of Allele-Specific Expression in Healthy Human Tissues.
  bioRxiv : the preprint server for biology 2025 Mariner BL, Sands B, Yun S, Jones T, Swisher EM, McCormick MA, Mendenhall AR
• Spermidine is essential for fasting-mediated autophagy and longevity.
  Nature cell biology 2024 Hofer SJ, Daskalaki I, Bergmann M, Frišcic J, Zimmermann A, Mueller MI, Abdellatif M, Nicastro R, Masser S, Durand S, Nartey A, Waltenstorfer M, Enzenhofer S, Faimann I, Gschiel V, Bajaj T, Niemeyer C…
• Multiomics of GCN4-Dependent Replicative Lifespan Extension Models Reveals Gcn4 as a Regulator of Protein Turnover in Yeast.
  International journal of molecular sciences 2023 Mariner BL, Felker DP, Cantergiani RJ, Peterson J, McCormick MA
• Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality.
  Frontiers in toxicology 2023 Scieszka D, Bolt AM, McCormick MA, Brigman JL, Campen MJ

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• Easy C. elegans Worm Lifespan Plotting and Statistics with WLSplot.
  microPublication biology 2023 Mariner BL, Peterson J, Taylor JC, Achusim AT, McCormick MA
• Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors.
  GeroScience 2023 Mariner BL, Rodriguez AS, Heath OC, McCormick MA
• Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice.
  Journal of neuroinflammation 2023 Scieszka D, Jin Y, Noor S, Barr E, Garcia M, Begay J, Herbert G, Hunter RP, Bhaskar K, Kumar R, Gullapalli R, Bolt A, McCormick MA, Bleske B, Gu H, Campen MJ
• Neuroinflammatory and Metabolomic Temporal Dynamics Following Wood Smoke Inhalation.
  Research square 2023 Scieszka D, Jin Y, Noor S, Barr E, Garcia M, Begay J, Herbert G, Hunter RP, Bhaskar K, Kumar R, Gullapalli R, Bolt A, McCormick MA, Bleske B, Gu H, Campen M
• Cytosolic and mitochondrial tRNA synthetase inhibitors increase lifespan in a GCN4/atf-4-dependent manner.
  iScience 2022 Robbins CE, Patel B, Sawyer DL, Wilkinson B, Kennedy BK, McCormick MA
• Single-cell RNA-seq reveals early heterogeneity during aging in yeast.
  Aging cell 2022 Wang J, Sang Y, Jin S, Wang X, Azad GK, McCormick MA, Kennedy BK, Li Q, Wang J, Zhang X, Zhang Y, Huang Y
• SPOCK, an R based package for high-throughput analysis of growth rate, survival, and chronological lifespan in yeast.
  Translational medicine of aging 2020 Small EM, Felker DP, Heath OC, Cantergiani RJ, Osley MA, McCormick MA
• Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.
  Science advances 2020 Zou K, Rouskin S, Dervishi K, McCormick MA, Sasikumar A, Deng C, Chen Z, Kaeberlein M, Brem RB, Polymenis M, Kennedy BK, Weissman JS, Zheng J, Ouyang Q, Li H
• A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways.
  Cell metabolism 2020 Molenaars M, Janssens GE, Williams EG, Jongejan A, Lan J, Rabot S, Joly F, Moerland PD, Schomakers BV, Lezzerini M, Liu YJ, McCormick MA, Kennedy BK, van Weeghel M, van Kampen AHC, Aebersold R, …
• Automation of C. elegans lifespan measurement.
  Translational medicine of aging 2019 Felker DP, Robbins CE, McCormick MA
• Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms.
  eLife 2018 Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M
• Recent Advances in the Systems Biology of Aging.
  Antioxidants & redox signaling 2017 McCormick MA, Promislow DEL
• The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.
  Aging cell 2017 Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR
• Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice.
  Cell reports 2016 Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Academia EC, Wilson JA, Pongkietisak C, Thompson MA, Lagmay EP, Miller DM, Hsu YM, McCormick MA, O'Leary MN, Kennedy BK
• A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
  Cell metabolism 2015 McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, …