Mark Looney, MD
Professor
Medicine
School of Medicine

He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

Research Interests

My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

• CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.
  JCI insight 2023 Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier …
• B-075 Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis.
  Clinical Chemistry 2023 M Sorrells, Y Seo, M Magnen, R Sheybani, A M Shah, H T Tse, M R Looney, H O'Neal
• Optimizing anesthesia and delivery approaches for dosing into lungs of mice.
  American journal of physiology. Lung cellular and molecular physiology 2023 Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ
• Optimizing anesthesia and delivery approaches for dosing into lungs of mice.
  bioRxiv : the preprint server for biology 2023 Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ
• Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis.
  Diagnostics (Basel, Switzerland) 2023 Sorrells MG, Seo Y, Magnen M, Broussard B, Sheybani R, Shah AM, O'Neal HR, Tse HTK, Looney MR, Di Carlo D
• CCR5 Mediates Natural Killer Cell Airway Trafficking in Lung Ischemia Reperfusion Injury.
  The Journal of Heart and Lung Transplantation 2023 J. Santos, S. Cleary, P. Wang, A. Shemesh, T. Tsao, E. Aminian, M.R. Looney, J.R. Greenland, D.R. Calabrese
• SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
  Stem cell reports 2023 Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, …
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• Is neutrophilic inflammation treatable in COVID-19?
  The Lancet. Respiratory medicine 2022 Conrad C, Looney MR
• New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
  American journal of respiratory cell and molecular biology 2022 Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).
  Annals of the American Thoracic Society 2022 Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA
• Bronchoalveolar Lavage MICB is Associated with Severe Primary Graft Dysfunction, Prolonged Mechanical Ventilation, and Low Post-Transplant FEV1 in Lung Transplant Recipients.
  The Journal of Heart and Lung Transplantation 2022 D.R. Calabrese, J.P. Singer, S.R. Hays, L.E. Leard, J.A. Golden, N.A. Kolaitis, M. Kleinhenz, R. Shah, A. Venado, J. Kukreja, J.A. Belperio, S.S. Weigt, J.R. Greenland, M.R. Looney
• Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression.
  The Journal of clinical investigation 2022 Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Méndez-Ferrer S, Swirski FK, Looney MR
• GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
  Cell 2022 De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG
• CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
  Science (New York, N.Y.) 2022 Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG
• GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
  Cell 2022 De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG
• ADAM8 signaling drives neutrophil migration and ARDS severity.
  JCI insight 2022 Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet…
• Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
  American journal of respiratory cell and molecular biology 2022 Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy …
• In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.
  ACS central science 2021 Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS
• Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S
• Natural Killer Cells Recognize Pulmonary Epithelial Stress Molecules during Primary Graft Dysfunction.
  The Journal of Heart and Lung Transplantation 2021 E. Aminian, B. Mallavia, F. Liu, S. Cleary, P. Wang, J.P. Singer, S.R. Hays, J.A. Golden, J. Kukreja, D. Dugger, M. Nakamura, L.L. Lanier, M.R. Looney, J.R. Greenland, D.R. Calabrese
• Chewing the fat on TRALI.
  Blood 2021 Cleary SJ, Looney MR
• Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.
  The Journal of clinical investigation 2021 Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR
• β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction.
  Circulation research 2021 Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath KE, Morrell CN
• Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Lung megakaryocytes are immune modulatory cells.
  The Journal of clinical investigation 2021 Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders J, Georas SN, Veazey J, Madere F, Santos LT, Arne A, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons C, …
• Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation.
  Science advances 2020 Hyun YM, Seo SU, Choi WS, Kwon HJ, Kim DY, Jeong S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS
• Complement activation on endothelium initiates antibody-mediated acute lung injury.
  The Journal of clinical investigation 2020 Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR
• Update on animal models for COVID-19 research.
  British journal of pharmacology 2020 Cleary SJ, Magnen M, Looney MR, Page CP
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  bioRxiv : the preprint server for biology 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  Research square 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose.
  Archives of toxicology 2020 Zhao Y, Magaña LC, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L
• NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.
  Transfusion 2020 Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (…
• Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.
  British journal of pharmacology 2020 Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP
• Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
  The Journal of experimental medicine 2020 Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, …
• Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.
  The Journal of clinical investigation 2020 Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR
• Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction.
  American journal of respiratory cell and molecular biology 2020 Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, …
• Platelet Biogenesis in the Lung Circulation.
  Physiology (Bethesda, Md.) 2019 Lefrançais E, Looney MR
• Modulating Pathogenesis with Mobile-CRISPRi.
  Journal of bacteriology 2019 Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS
• LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin.
  American journal of respiratory cell and molecular biology 2019 Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC
• An update of the transfusion-related acute lung injury (TRALI) definition.
  Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2019 Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S
• Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
  American journal of respiratory and critical care medicine 2019 Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, …
• A consensus redefinition of transfusion-related acute lung injury.
  Transfusion 2019 Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S
• Live imaging of the pulmonary immune environment.
  Cellular immunology 2018 Looney MR, Headley MB
• The incomparable platelet: holy alveoli!
  Blood 2018 Looney MR
• Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.
  Research and practice in thrombosis and haemostasis 2018 Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg …
• Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.
  Critical care medicine 2018 Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, National Heart, Lung, and Blood Institute (…
• Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.
  JCI insight 2018 Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR
• Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway.
  American journal of respiratory and critical care medicine 2017 Lefrançais E, Looney MR
• Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice.
  PloS one 2017 Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney MR
• Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.
  JCI insight 2017 Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, …
• Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
  Transfusion 2017 Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group
• The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.
  Science immunology 2017 Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P
• Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training.
  Annals of the American Thoracic Society 2017 Santhosh L, Babik J, Looney MR, Hollander H
• The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.
  Nature 2017 Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR
• Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.
  Thorax 2017 Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM
• Lung Imaging in Animal Models.
  Acute Lung Injury and Repair 2017 Emma Lefrançais, Beñat Mallavia, Mark R. Looney
• Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies.
  Shock (Augusta, Ga.) 2017 Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR
• Proposed revised nomenclature for transfusion-related acute lung injury.
  Transfusion 2016 Toy P, Kleinman SH, Looney MR
• Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.
  Vox sanguinis 2016 Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (…
• Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response.
  Nature communications 2016 Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A
• CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.
  The Journal of experimental medicine 2016 Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, …
• Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules.
  Annals of the American Thoracic Society 2016 Henry TS, Naeger DM, Looney MR, Elicker BM
• Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis.
  JCI insight 2016 Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ
• Reply to concerns regarding dropping the term "possible TRALI".
  Transfusion 2016 Toy P, Kleinman SH, Looney MR
• Visualization of immediate immune responses to pioneer metastatic cells in the lung.
  Nature 2016 Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF
• Inhibiting Integrin αvβ5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016 Mallavia B, Liu F, Sheppard D, Looney MR
• Current concepts in TRALI pathogenesis.
  ISBT Science Series 2016 M. R. Looney
• Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice.
  PloS one 2015 Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR
• Selectin' for NETs.
  Blood 2015 Looney MR
• Non-invasive Intratracheal Instillation in Mice.
  Bio-protocol 2015 Ortiz-Muñoz G, Looney MR
• Two-event Transfusion-related Acute Lung Injury Mouse Model.
  Bio-protocol 2015 Ortiz-Muñoz G, Looney MR
• Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation.
  American journal of respiratory and critical care medicine 2015 Sayah DM, Mallavia B, Looney MR
• Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.
  PloS one 2015 Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF
• Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.
  Transfusion 2015 Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group
• Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.
  American journal of respiratory and critical care medicine 2015 Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A, Lung Transplant Outcomes Group Investigators, Ware LB, Christie JD, Belperio JA, …
• Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.
  Nature 2014 Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA
• Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
  Transfusion 2014 Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, …
• Platelets Induce Neutrophil Extracellular Traps in Transfusion-Related Acute Lung Injury.
  Blood 2014 Mark R. Looney
• Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.
  Blood 2014 Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR
• Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction.
  Respiratory research 2014 Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH
• Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
  Critical care medicine 2014 Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, …
• The spatiotemporal cellular dynamics of lung immunity.
  Trends in immunology 2014 Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF
• Live imaging of the lung.
  Annual review of physiology 2013 Looney MR, Bhattacharya J
• Risk factors and outcomes in transfusion-associated circulatory overload.
  The American journal of medicine 2013 Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group
• Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury.
  Critical care clinics 2012 Sayah DM, Looney MR, Toy P
• Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.
  The Journal of clinical investigation 2012 Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR
• Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
  The Journal of experimental medicine 2012 Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF
• Live imaging of the lung.
  Current protocols in cytometry 2012 Thornton EE, Krummel MF, Looney MR
• Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.
  Anesthesia and analgesia 2012 Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA
• Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury.
  Current pharmaceutical design 2012 Caudrillier A, Looney MR
• Transfusion-related acute lung injury: incidence and risk factors.
  Blood 2011 Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, …
• Reducing noninfectious risks of blood transfusion.
  Anesthesiology 2011 Gilliss BM, Looney MR, Gropper MA
• Lung surveillance revealed by two-photon live imaging (103.3).
  The Journal of Immunology 2011 Emily Thornton, Mark Looney, Debasish Sen, Dean Sheppard, Xiaozhu Huang, Matthew Krummel
• The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components.
  Transfusion 2011 Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM, National Heart, Lung, and Blood …
• Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.
  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011 Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA
• Experimental models of transfusion-related acute lung injury.
  Transfusion medicine reviews 2011 Gilliss BM, Looney MR
• Stabilized imaging of immune surveillance in the mouse lung.
  Nature methods 2010 Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF
• Pathophysiology of transfusion-related acute lung injury.
  Current opinion in hematology 2010 Looney MR, Gilliss BM, Matthay MA
• Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.
  American journal of physiology. Lung cellular and molecular physiology 2009 Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA
• Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2009 Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA
• Inhaled activated protein C: a novel therapy for acute lung injury?
  Critical care (London, England) 2009 Liu KD, Looney MR, Matthay MA
• Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2009 Su X, Looney MR, Gupta N, Matthay MA
• Neutrophil sandwiches injure the microcirculation.
  Nature medicine 2009 Looney MR, Matthay MA
• Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury.
  Thorax 2008 Looney MR, Esmon CT, Matthay MA
• Acute lung injury after blood product transfusion: are the times changing?
  Critical care medicine 2008 Looney MR
• CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Su X, Johansen M, Looney MR, Brown EJ, Matthay MA
• The role of protein C in sepsis.
  Current infectious disease reports 2007 Looney MR, Matthay MA
• Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.
  The FASEB Journal 2007 Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay
• Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza.
  Clinics in chest medicine 2006 Looney MR
• Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature.
  Transfusion medicine (Oxford, England) 2006 Church GD, Price C, Sanchez R, Looney MR
• Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2006 Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA
• Animal models of transfusion-related acute lung injury.
  Critical care medicine 2006 Looney MR, Matthay MA
• Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.
  Critical care (London, England) 2006 Looney MR, Matthay MA
• Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.
  American journal of physiology. Lung cellular and molecular physiology 2005 Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA
• Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice.
  Experimental lung research 2004 Su X, Looney M, Robriquet L, Fang X, Matthay MA
• Transfusion-related acute lung injury: a review.
  Chest 2004 Looney MR, Gropper MA, Matthay MA
• The Role of Protein C in Sepsis.
  Current infectious disease reports 2001 Looney MR, Matthay MA