Mark Ansel, PhD
Professor
Microbiology and Immunology
School of Medicine
MicroRNAs, transcription factors, and epigenetic regulation shape the gene expression programs that determine cell identity and function. The Ansel lab studies how these molecular mechanisms work together to control lymphocyte development, differentiation, and function in immunity.
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We use in vitro cell differentiation systems, mouse genetics, disease models, and high dimensional cellular and molecular analyses in human biospecimens to unravel the regulatory networks that underlie immunity and immune pathology, especially allergy and asthma.
Lymphocyte lineage decisions and the deployment of their effector functions are critical for the development of protective immunity against a great diversity of pathogens. However, improper or exaggerated responses underlie the pathogenesis of autoimmune diseases, chronic inflammation, allergy, and asthma. Our primary experimental system is the differentiation of helper T cells, the central coordinators of adaptive immune responses. Upon immune activation, naïve CD4+ T cells can differentiate into several different helper T cell effectors subtypes (e.g. Th1, Th2, Th17, iTreg, Tfh, etc.). These lineages are defined by their characteristic gene expression programs and mediate distinct immune functions. These gene expression programs are controlled by external factors that derive from other cells or the environment, signaling-induced and lineage-specific transcription factors, epigenetic regulation of transcriptional responses, and posttranscriptional mechanisms, including RNA-binding proteins and miRNAs. The depth of our knowledge about the networks that control helper T cells makes them an attractive model for studying basic mechanisms of gene regulation.
Active projects in the laboratory mostly focus on RNA regulation of immune cell programming. We study how individual miRNA families regulate lymphocyte differentiation and immune function, and the regulation of the miRNA pathway itself during immune responses. Naive CD4+ T cells that cannot produce any miRNAs exhibit reduced cell division and survival in response to immune stimuli. Surprisingly, they also undergo rapid unrestrained differentiation into effector cells. We have developed a screening technology that allows us to rapidly determine which specific miRNAs regulate each of these T cell behaviors, and pipelines for determining miRNA expression patterns in very small clinical samples (such as sorted T cell subsets from the airways of human asthmatic subjects, serum, sputum, and other sources of extracellular miRNAs, etc.). In addition, we discovered that T cells rapidly reset their small RNA repertoire upon activation. This process involves ubiquitination and degradation of Argonaute proteins and the release of RNAs in extracellular vesicles, but the signaling mechanisms and the fate of associated RNAs remains unknown. Activation-induced changes in regulatory RNA expression affects T cell differentiation and the development of immune effector functions.
The major research goals of our laboratory are:
1) To define the molecular mechanisms that control miRNA homeostasis and extracellular release by lymphocytes, and determine how the miRNA repertoire is so dramatically remodeled during activation.
2) To characterize the function of RBPs and individual miRNAs that regulate T cell differentiation and immune effector functions.
3) To determine how the expression and function of miRNAs contributes to the pathogenic properties of T cells and other immune cells in human asthma.
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 12/2020
- Ph.D. Graduate Division (Biomedical Sciences) University of California, San Francisco 2001
Interests
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- Immunology
- Allergy
- Gene expression
- RNA
- Asthma
- Cell differentiation
Websites
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- The Ansel Lab at UCSF (ansel.ucsf.edu)
Grants and Projects
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- Predoctrol Training in Biomedical Sciences, NIH, 2020-2025
- Exploring the biology of persistent type 2 airway niches in asthma, NIH, 2012-2024
- Predoctoral Training in Biomedical Sciences, NIH, 1995-2020
- Global analysis of T cell post-transcriptional regulatory elements, NIH, 2018-2020
- MicroRNA directed pathway discovery in helper T cell driven airway inflammation, NIH, 2011-2020
- In Vivo Regulated Release and Function of Extracellular Small RNAs, NIH, 2013-2019
Publications (103)
Top publication keywords:
HypersensitivityRNAAsthmaRNA, Long NoncodingImmunoglobulin Class SwitchingGerminal CenterExoribonucleasesB-LymphocytesT-Lymphocytes, Helper-InducerLymphocyte ActivationAdaptive ImmunityNeurogenic InflammationTh2 CellsInterleukin-4MicroRNAs
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miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
Cell reports 2019 Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, … -
Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes.
ImmunoHorizons 2019 Wigton EJ, DeFranco AL, Ansel KM -
A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.
Genome research 2019 Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM -
Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses.
Cell reports 2019 Pua HH, Happ HC, Gray CJ, Mar DJ, Chiou NT, Hesse LE, Ansel KM -
Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.
Cell reports 2018 Chiou NT, Kageyama R, Ansel KM -
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
The Journal of experimental medicine 2017 Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM -
MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production.
Immunity 2016 Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM -
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
Nature immunology 2014 Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM
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The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation.
eLife 2023 Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DS, Li Z, DeBarge R, Spitzer MH, Marson A, Ansel KM -
GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins.
Genome biology 2023 Zhu WS, Litterman AJ, Sekhon HS, Kageyama R, Arce MM, Taylor KE, Zhao W, Criswell LA, Zaitlen N, Erle DJ, Ansel KM -
An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
Cell reports 2023 Johansson K, Gagnon JD, Zhou SK, Fassett MS, Schroeder AW, Kageyama R, Bautista RA, Pham H, Woodruff PG, Ansel KM -
IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.
Science immunology 2023 Fassett MS, Braz JM, Castellanos CA, Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J, Munoz-Sandoval P, Roy S, Lazarevsky S, Mar DJ, Zhou CJ, Shin JS, Basbaum AI, Ansel KM -
RNA circuits and RNA-binding proteins in T cells.
Trends in immunology 2023 Zhu WS, Wheeler BD, Ansel KM -
The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue.
Cell reports 2023 Sprenkle NT, Winn NC, Bunn KE, Zhao Y, Park DJ, Giese BG, Karijolich JJ, Ansel KM, Serezani CH, Hasty AH, Pua HH -
The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation.
bioRxiv : the preprint server for biology 2023 Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DR, Li Z, Debarge R, Spitzer MH, Marson A, Ansel KM -
Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.
American journal of human genetics 2023 Guo L, Salian S, Xue JY, Rath N, Rousseau J, Kim H, Ehresmann S, Moosa S, Nakagawa N, Kuroda H, Clayton-Smith J, Wang J, Wang Z, Banka S, Jackson A, Zhang YM, Wei ZJ, Hüning I, Brunet T, Ohashi H, … -
Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.
Proceedings of the National Academy of Sciences of the United States of America 2023 Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A -
An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
bioRxiv : the preprint server for biology 2023 Johansson K, Gagnon JD, Zhou S, Fassett MS, Schroeder AW, Kageyama R, Bautista RA, Pham H, Woodruff PG, Ansel KM -
Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells.
iScience 2022 Dölz M, Hasiuk M, Gagnon JD, Kornete M, Marone R, Bantug G, Kageyama R, Hess C, Ansel KM, Seyres D, Roux J, Jeker LT -
Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
Immunity 2022 Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, … -
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ… -
MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.
Proceedings of the National Academy of Sciences of the United States of America 2022 Stelekati E, Cai Z, Manne S, Chen Z, Beltra JC, Buchness LA, Leng X, Ristin S, Nzingha K, Ekshyyan V, Niavi C, Abdel-Hakeem MS, Ali MA, Drury S, Lau CW, Gao Z, Ban Y, Zhou SK, Ansel KM, Kurachi M, … -
Obesity alters pathology and treatment response in inflammatory disease.
Nature 2022 Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, … -
A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, … -
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, … -
RNA regulation in immunity.
Immunological reviews 2021 Pua H, Ansel KM -
MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
The Journal of experimental medicine 2021 Wigton EJ, Mikami Y, McMonigle RJ, Castellanos CA, Wade-Vallance AK, Zhou SK, Kageyama R, Litterman A, Roy S, Kitamura D, Dykhuizen EC, Allen CDC, Hu H, O'Shea JJ, Ansel KM -
PICS2: next-generation fine mapping via probabilistic identification of causal SNPs.
Bioinformatics (Oxford, England) 2021 Taylor KE, Ansel KM, Marson A, Criswell LA, Farh KK -
Regulation of airway immunity by epithelial miRNAs.
Immunological reviews 2021 Johansson K, Woodruff PG, Ansel KM -
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, … -
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson… -
Epithelial miR-141 regulates IL-13-induced airway mucus production.
JCI insight 2021 Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG -
Noncoding RNAs in B cell responses.
RNA biology 2021 Wigton EJ, Ansel KM -
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, … -
miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.
Cell reports 2020 Hines MJ, Coffre M, Mudianto T, Panduro M, Wigton EJ, Tegla C, Osorio-Vasquez V, Kageyama R, Benhamou D, Perez O, Bajwa S, McManus MT, Ansel KM, Melamed D, Koralov SB -
Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing.
Nature communications 2020 Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S -
An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020 Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV -
Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing.
Nature communications 2020 Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S -
Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma.
The Journal of allergy and clinical immunology 2020 Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE… -
Universal Principled Review: A Community-Driven Method to Improve Peer Review.
Cell 2019 Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M, Future Immunology Consortium -
RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.
Cell reports 2019 Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW -
MicroRNA regulation of CD8+ T cell responses.
Non-coding RNA investigation 2019 Gagnon JD, Ansel KM -
The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
Cell 2019 Das S, Extracellular RNA Communication Consortium, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, … -
Bacterial biogeography of adult airways in atopic asthma.
Microbiome 2018 Durack J, Huang YJ, Nariya S, Christian LS, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, King TS, White SR, Denlinger LC, Holguin F, Lazarus SC, … -
Identification of Functionally Relevant microRNAs in the Regulation of Allergic Inflammation.
Methods in molecular biology (Clifton, N.J.) 2018 Fassett MS, Pua HH, Simpson LJ, Steiner DF, Ansel KM -
Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Nature 2017 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, … -
A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2017 Montoya MM, Maul J, Singh PB, Pua HH, Dahlström F, Wu N, Huang X, Ansel KM, Baumjohann D -
Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation.
Journal of visualized experiments : JoVE 2017 Montoya MM, Ansel KM -
Alternative splicing of interleukin-33 and type 2 inflammation in asthma.
Proceedings of the National Academy of Sciences of the United States of America 2016 Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, … -
IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.
American journal of respiratory and critical care medicine 2016 Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL -
Biogenesis, delivery, and function of extracellular RNA.
Journal of extracellular vesicles 2015 Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, … -
MicroRNA regulation of allergic inflammation and asthma.
Current opinion in immunology 2015 Pua HH, Ansel KM -
mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function.
Journal of immunology (Baltimore, Md. : 1950) 2015 Schaffert SA, Loh C, Wang S, Arnold CP, Axtell RC, Newell EW, Nolan G, Ansel KM, Davis MM, Steinman L, Chen CZ -
MicroRNA regulation of lymphocyte tolerance and autoimmunity.
The Journal of clinical investigation 2015 Simpson LJ, Ansel KM -
Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.
Cancer cell 2015 Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan… -
Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation.
The EMBO journal 2015 Warth SC, Hoefig KP, Hiekel A, Schallenberg S, Jovanovic K, Klein L, Kretschmer K, Ansel KM, Heissmeyer V -
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Immunity 2015 Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A -
Tracking early T follicular helper cell differentiation in vivo.
Methods in molecular biology (Clifton, N.J.) 2015 Baumjohann D, Ansel KM -
Editorial overview: Allergy and hypersensitivity.
Current opinion in immunology 2014 Sperling AI, Ansel KM -
Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.
Nature immunology 2014 Seumois G, Chavez L, Gerasimova A, Lienhard M, Omran N, Kalinke L, Vedanayagam M, Ganesan AP, Chawla A, Djukanovic R, Ansel KM, Peters B, Rao A, Vijayanand P -
Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.
Trends in genetics : TIG 2014 Thomas MF, L'Etoile ND, Ansel KM -
MicroRNA regulation of the germinal center response.
Current opinion in immunology 2014 Baumjohann D, Ansel KM -
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Nature immunology 2013 Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC -
MicroRNA-mediated regulation of T helper cell differentiation and plasticity.
Nature reviews. Immunology 2013 Baumjohann D, Ansel KM -
The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
Nature immunology 2013 Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT -
RNA regulation of the immune system.
Immunological reviews 2013 Ansel KM -
Regulation of miRNA biogenesis and turnover in the immune system.
Immunological reviews 2013 Bronevetsky Y, Ansel KM -
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype.
Immunity 2013 Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F -
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of experimental medicine 2013 Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM -
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Nature structural & molecular biology 2012 Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V -
An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology 2012 Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM -
Airway epithelial miRNA expression is altered in asthma.
American journal of respiratory and critical care medicine 2012 Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG -
Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
Blood 2012 Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM -
Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.
Immunity 2012 Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM -
MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.
Immunity 2011 Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM -
Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development.
Journal of immunology (Baltimore, Md. : 1950) 2011 Baumjohann D, Okada T, Ansel KM -
Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011 Sofi MH, Qiao Y, Ansel KM, Kubo M, Chang CH -
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems.
PLoS pathogens 2010 Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D… -
Construction of small RNA cDNA libraries for deep sequencing.
Methods in molecular biology (Clifton, N.J.) 2010 Thomas MF, Ansel KM -
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.
Nature structural & molecular biology 2008 Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V -
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.
Journal of immunology (Baltimore, Md. : 1950) 2007 Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG -
The NFAT1 transcription factor is a repressor of cyclin A2 gene expression.
Cell cycle (Georgetown, Tex.) 2007 Carvalho LD, Teixeira LK, Carrossini N, Caldeira AT, Ansel KM, Rao A, Viola JP -
Regulation of the germinal center response by microRNA-155.
Science (New York, N.Y.) 2007 Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K -
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells.
Nature immunology 2006 Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM -
Regulation of Th2 differentiation and Il4 locus accessibility.
Annual review of immunology 2006 Ansel KM, Djuretic I, Tanasa B, Rao A -
MicroRNA profiling of the murine hematopoietic system.
Genome biology 2005 Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS -
Aberrant T cell differentiation in the absence of Dicer.
The Journal of experimental medicine 2005 Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K -
A plague of autoantibodies.
Nature immunology 2005 Heissmeyer V, Ansel KM, Rao A -
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.
Immunity 2005 Kabashima K, Banks TA, Ansel KM, Lu TT, Ware CF, Cyster JG -
Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes.
Novartis Foundation symposium 2005 Monticelli S, Ansel KM, Lee DU, Rao A -
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.
Nature immunology 2004 Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A -
Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA.
Nature immunology 2004 Nardone J, Lee DU, Ansel KM, Rao A -
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.
Nature immunology 2004 Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG -
An epigenetic view of helper T cell differentiation.
Nature immunology 2003 Ansel KM, Lee DU, Rao A -
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development.
The Journal of experimental medicine 2003 Luther SA, Ansel KM, Cyster JG -
CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity.
Immunity 2002 Ansel KM, Harris RB, Cyster JG -
Traffic patterns of B cells and plasma cells.
Advances in experimental medicine and biology 2002 Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT -
Chemokines in lymphopoiesis and lymphoid organ development.
Current opinion in immunology 2001 Ansel KM, Cyster JG -
Follicular stromal cells and lymphocyte homing to follicles.
Immunological reviews 2000 Cyster JG, Ansel KM, Reif K, Ekland EH, Hyman PL, Tang HL, Luther SA, Ngo VN -
A chemokine-driven positive feedback loop organizes lymphoid follicles.
Nature 2000 Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG -
In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines.
The Journal of experimental medicine 1999 Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG -
Chemokines and B-cell homing to follicles.
Current topics in microbiology and immunology 1999 Cyster JG, Ngo VN, Ekland EH, Gunn MD, Sedgwick JD, Ansel KM -
A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.
Nature 1998 Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT