Mark Anderson, MD, PhD
Professor
Diabetes Center
School of Medicine

MD: MD, PhD, University of Chicago, 1994 Residency: University of Minnesota, MD, Internal Medicine, 1994-1997 Chief Resident, University of Minnesota 1997-1998 Fellowship: Massachusetts General Hospital, Adult Endocrinology, 1998-2001 Board Certification: Endocrinology and Metabolism, 2001, Renewed 2012

ACADEMIC INTERESTS The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).

Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.

CLINICAL INTERESTS: Type 1 diabetes and associated autoimmune disorders

Appointments: 415-353-2350

• Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy.
  medRxiv : the preprint server for health sciences 2023 Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena …
• Validation of a murine proteome-wide phage display library for identification of autoantibody specificities.
  JCI insight 2023 Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik CR, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS,…
• Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.
  Nature 2023 Le Voyer T, Parent AV, Liu X, Cederholm A, Gervais A, Rosain J, Nguyen T, Perez Lorenzo M, Rackaityte E, Rinchai D, Zhang P, Bizien L, Hancioglu G, Ghillani-Dalbin P, Charuel JL, Philippot Q, Gueye MS…
• Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
  Science immunology 2023 Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR
• Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin.
  Nature communications 2023 Xiao Q, Mears J, Nathan A, Ishigaki K, Baglaenko Y, Lim N, Cooney LA, Harris KM, Anderson MS, Fox DA, Smilek DE, Krueger JG, Raychaudhuri S
• T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS
• Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients.
  JCI insight 2023 Bodansky A, Wang CY, Saxena A, Mitchell A, Kung AF, Takahashi S, Anglin K, Huang B, Hoh R, Lu S, Goldberg SA, Romero J, Tran B, Kirtikar R, Grebe H, So M, Greenhouse B, Durstenfeld MS, Hsue PY, …
• A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.
  Scientific data 2023 Perry DJ, Shapiro MR, Chamberlain SW, Kusmartseva I, Chamala S, Balzano-Nogueira L, Yang M, Brant JO, Brusko M, Williams MD, McGrail KM, McNichols J, Peters LD, Posgai AL, Kaddis JS, Mathews CE, …
• Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.
  Diabetes care 2023 Russell WE, Bundy BN, Anderson MS, Cooney LA, Gitelman SE, Goland RS, Gottlieb PA, Greenbaum CJ, Haller MJ, Krischer JP, Libman IM, Linsley PS, Long SA, Lord SM, Moore DJ, Moore WV, Moran AM, Muir AB,…
• ABCC8-Related Monogenic Diabetes Presenting Like Type 1 Diabetes in an Adolescent.
  AACE clinical case reports 2023 Grier AE, McGill JB, Lord SM, Speake C, Greenbaum C, Chamberlain CE, German MS, Anderson MS, Hirsch IB
• Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities.
  bioRxiv : the preprint server for biology 2023 Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik C, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, …
• Case report: Discovery of a de novo FAM111B pathogenic variant in a patient with an APECED-like clinical phenotype.
  Frontiers in immunology 2023 Ferré EMN, Yu Y, Oikonomou V, Hilfanova A, Lee CR, Rosen LB, Burbelo PD, Vazquez SE, Anderson MS, Barocha A, Heller T, Soldatos A, Holland SM, Walkiewicz MA, Lionakis MS
• Autoantigen profiling reveals a shared post-COVID signature in fully recovered and Long COVID patients.
  medRxiv : the preprint server for health sciences 2023 Bodansky A, Wang CY, Saxena A, Mitchell A, Takahashi S, Anglin K, Huang B, Hoh R, Lu S, Goldberg SA, Romero J, Tran B, Kirtikar R, Grebe H, So M, Greenhouse B, Durstenfeld MS, Hsue PY, Hellmuth J, …
• Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs.
  The Journal of clinical investigation 2023 Casanova JL, Anderson MS
• Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.
  Diabetes 2023 Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, …
• Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure.
  Respiratory research 2022 Ghale R, Spottiswoode N, Anderson MS, Mitchell A, Wang G, Calfee CS, DeRisi JL, Langelier CR
• Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq.
  eLife 2022 Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Proekt I, Yu D, Mandel-Brehm C, Wang CY, Miao B, Sowa G, Zorn K, Chan AY…
• Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
  Cell reports 2022 VanDyke D, Iglesias M, Tomala J, Young A, Smith J, Perry JA, Gebara E, Cross AR, Cheung LS, Dykema AG, Orcutt-Jahns BT, Henclová T, Golias J, Balolong J, Tomasovic LM, Funda D, Meyer AS, Pardoll DM, …
• Publisher Correction: A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation.
  Nature 2022 Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, Laufer TM, Aifantis I, Bartleson JM, Allen PM, …
• Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes.
  JCI insight 2022 Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS…
• A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation.
  Nature 2022 Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, Laufer TM, Aifantis I, Bartleson JM, Allen PM, …
• The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja…
• Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq.
  bioRxiv : the preprint server for biology 2022 Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Mandel-Brehm C, Miao B, Sowa G, Zorn K, Chan AY, Shimizu C, Tremoulet A,…
• Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.
  Nature 2022 Lanz TV, Brewer RC, Ho PP, Moon JS, Jude KM, Fernandez D, Fernandes RA, Gomez AM, Nadj GS, Bartley CM, Schubert RD, Hawes IA, Vazquez SE, Iyer M, Zuchero JB, Teegen B, Dunn JE, Lock CB, Kipp LB, …
• Modeling human T1D-associated autoimmune processes.
  Molecular metabolism 2021 Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ
• Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium.
  Science immunology 2021 Wang J, Lareau CA, Bautista JL, Gupta AR, Sandor K, Germino J, Yin Y, Arvedson MP, Reeder GC, Cramer NT, Xie F, Ntranos V, Satpathy AT, Anderson MS, Gardner JM
• Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
  Science (New York, N.Y.) 2021 Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, …
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
  Science immunology 2021 Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja…
• Extrathymic Aire-expressing cells support maternal-fetal tolerance.
  Science immunology 2021 Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC
• Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.
  The Journal of experimental medicine 2021 Bastard P, Orlova E, Sozaeva L, Lévy R, James A, Schmitt MM, Ochoa S, Kareva M, Rodina Y, Gervais A, Le Voyer T, Rosain J, Philippot Q, Neehus AL, Shaw E, Migaud M, Bizien L, Ekwall O, Berg S, Beccuti…
• Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation.
  Diabetes care 2021 Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA
• A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.
  The Journal of experimental medicine 2021 Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS
• Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma.
  Journal of clinical immunology 2021 Vazquez SE, Bastard P, Kelly K, Gervais A, Norris PJ, Dumont LJ, Casanova JL, Anderson MS, DeRisi JL
• Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
  eLife 2021 Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, …
• Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
  bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
  Nature communications 2021 Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV
• Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
  Science (New York, N.Y.) 2021 Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, …
• More on STAT1 Gain of Function, Type 1 Diabetes, and JAK Inhibition. Reply.
  The New England journal of medicine 2021 Anderson MS, Chaimowitz NS, Forbes LR
• Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells.
  eLife 2020 Wells KL, Miller CN, Gschwind AR, Wei W, Phipps JD, Anderson MS, Steinmetz LM
• STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition.
  The New England journal of medicine 2020 Chaimowitz NS, Ebenezer SJ, Hanson IC, Anderson M, Forbes LR
• Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
  Science (New York, N.Y.) 2020 Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs…
• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
  Science (New York, N.Y.) 2020 Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, …
• Tolerance in the Age of Immunotherapy.
  The New England journal of medicine 2020 Bluestone JA, Anderson M
• Autoimmune Endocrinopathies: An Emerging Complication of Immune Checkpoint Inhibitors.
  Annual review of medicine 2020 Quandt Z, Young A, Perdigoto AL, Herold KC, Anderson MS
• Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
  Nature biotechnology 2020 Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong …
• High-resolution epitope mapping of anti-Hu and anti-Yo autoimmunity by programmable phage display.
  Brain communications 2020 O'Donovan B, Mandel-Brehm C, Vazquez SE, Liu J, Parent AV, Anderson MS, Kassimatis T, Zekeridou A, Hauser SL, Pittock SJ, Chow E, Wilson MR, DeRisi JL
• Test performance evaluation of SARS-CoV-2 serological assays.
  medRxiv : the preprint server for health sciences 2020 Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong …
• Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq.
  eLife 2020 Vazquez SE, Ferré EM, Scheel DW, Sunshine S, Miao B, Mandel-Brehm C, Quandt Z, Chan AY, Cheng M, German M, Lionakis M, DeRisi JL, Anderson MS
• GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen.
  Journal of immunology (Baltimore, Md. : 1950) 2020 Rausch MP, Meador LR, Metzger TC, Li H, Qiu S, Anderson MS, Hastings KT
• The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.
  Journal of graduate medical education 2020 Berger A, Matloubian M, Shah NP, Wachter RM, DeRisi JL, Anderson M
• New Frontiers in the Treatment of Type 1 Diabetes.
  Cell metabolism 2019 Warshauer JT, Bluestone JA, Anderson MS
• Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
  Diabetes care 2019 Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L,…
• Landscape of stimulation-responsive chromatin across diverse human immune cells.
  Nature genetics 2019 Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, …
• Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
  The Journal of clinical investigation 2019 Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA
• Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.
  eLife 2019 Landegren N, Rosen LB, Freyhult E, Eriksson D, Fall T, Smith G, Ferre EMN, Brodin P, Sharon D, Snyder M, Lionakis M, Anderson M, Kämpe O
• The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
  The Journal of experimental medicine 2019 Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR
• Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy.
  Cancer immunology research 2019 Su MA, Anderson MS
• The autoimmune targets in IPEX are dominated by gut epithelial proteins.
  The Journal of allergy and clinical immunology 2019 Eriksson D, Bacchetta R, Gunnarsson HI, Chan A, Barzaghi F, Ehl S, Hallgren Å, van Gool F, Sardh F, Lundqvist C, Laakso SM, Rönnblom A, Ekwall O, Mäkitie O, Bensing S, Husebye ES, Anderson M, Kämpe O,…
• A large CRISPR-induced bystander mutation causes immune dysregulation.
  Communications biology 2019 Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A
• A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
  Immunity 2019 Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA
• Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.
  Frontiers in immunology 2019 Fergusson JR, Morgan MD, Bruchard M, Huitema L, Heesters BA, van Unen V, van Hamburg JP, van der Wel NN, Picavet D, Koning F, Tas SW, Anderson MS, Marioni JC, Holländer GA, Spits H
• Thymic regulatory T cells arise via two distinct developmental programs.
  Nature immunology 2019 Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson …
• Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.
  Diabetes care 2018 Redondo MJ, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth JM, Atkinson MA, Pugliese A, Geyer S, Type 1 Diabetes TrialNet Study Group
• Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.
  Nature 2018 Wan X, Zinselmeyer BH, Zakharov PN, Vomund AN, Taniguchi R, Santambrogio L, Anderson MS, Lichti CF, Unanue ER
• Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
  Nature 2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, …
• Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
  Immunity 2018 Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J
• Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation.
  Nature 2018 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, …
• Autoimmune Polyendocrine Syndromes.
  The New England journal of medicine 2018 Husebye ES, Anderson MS, Kämpe O
• Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors.
  Diabetes 2018 Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC
• Thymic tolerance as a key brake on autoimmunity.
  Nature immunology 2018 Cheng M, Anderson MS
• Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.
  Immunity 2018 Perry JSA, Russler-Germain EV, Zhou YW, Purtha W, Cooper ML, Choi J, Schroeder MA, Salazar V, Egawa T, Lee BC, Abumrad NA, Kim BS, Anderson MS, DiPersio JF, Hsieh CS
• Revealing the specificity of regulatory T cells in murine autoimmune diabetes.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q
• Autoimmune Polyendocrine Syndromes.
  The New England journal of medicine 2018 Husebye ES, Anderson MS, Kämpe O
• Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens.
  Cell reports 2018 Cepeda S, Cantu C, Orozco S, Xiao Y, Brown Z, Semwal MK, Venables T, Anderson MS, Griffith AV
• Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet.
  Diabetologia 2017 Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M
• Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).
  Journal of autoimmunity 2017 Abbott JK, Huoh YS, Reynolds PR, Yu L, Rewers M, Reddy M, Anderson MS, Hur S, Gelfand EW
• Insights into immune tolerance from AIRE deficiency.
  Current opinion in immunology 2017 Proekt I, Miller CN, Lionakis MS, Anderson MS
• Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.
  JCI insight 2017 Bakhru P, Zhu ML, Wang HH, Hong LK, Khan I, Mouchess M, Gulati AS, Starmer J, Hou Y, Sailer D, Lee S, Zhao F, Kirkwood JM, Moschos S, Fong L, Anderson MS, Su MA
• Discovery of stimulation-responsive immune enhancers with CRISPR activation.
  Nature 2017 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, …
• Understanding and preventing type 1 diabetes through the unique working model of TrialNet.
  Diabetologia 2017 Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M
• Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.
  The Journal of clinical endocrinology and metabolism 2017 Li D, Streeten EA, Chan A, Lwin W, Tian L, Pellegrino da Silva R, Kim CE, Anderson MS, Hakonarson H, Levine MA
• The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development.
  Journal of autoimmunity 2016 Hardtke-Wolenski M, Dywicki J, Fischer K, Hapke M, Sievers M, Schlue J, Anderson MS, Taubert R, Noyan F, Manns MP, Jaeckel E
• Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS
• LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
  The Journal of clinical investigation 2016 Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL
• AIRE expands: new roles in immune tolerance and beyond.
  Nature reviews. Immunology 2016 Anderson MS, Su MA
• Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.
  Scientific reports 2016 Landegren N, Sharon D, Freyhult E, Hallgren Å, Eriksson D, Edqvist PH, Bensing S, Wahlberg J, Nelson LM, Gustafsson J, Husebye ES, Anderson MS, Snyder M, Kämpe O
• Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
  Nature immunology 2016 Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK
• Identification of a novel cis-regulatory element essential for immune tolerance.
  The Journal of experimental medicine 2015 LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS
• Central tolerance to self revealed by the autoimmune regulator.
  Annals of the New York Academy of Sciences 2015 Chan AY, Anderson MS
• Editorial overview: Autoimmunity.
  Current opinion in immunology 2015 Anderson MS, Mackay F
• Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.
  PloS one 2015 Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT
• Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D
• Transglutaminase 4 as a prostate autoantigen in male subfertility.
  Science translational medicine 2015 Landegren N, Sharon D, Shum AK, Khan IS, Fasano KJ, Hallgren Å, Kampf C, Freyhult E, Ardesjö-Lundgren B, Alimohammadi M, Rathsman S, Ludvigsson JF, Lundh D, Motrich R, Rivero V, Fong L, Giwercman A, …
• More than Meets the Eye: Monogenic Autoimmunity Strikes Again.
  Immunity 2015 Anderson MS, Casanova JL
• COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
  Nature genetics 2015 Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas …
• Autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model is directed against multiple autoantigens.
  Hepatology (Baltimore, Md.) 2015 Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, Falk CS, Ardesjö Lundgren B, Scott HS, Pich A, Anderson MS, Manns MP, Jaeckel E
• Too much of a good thing: NLRC4 and autoinflammation.
  The Journal of experimental medicine 2014 Anderson MS
• Breaking through the central tolerance ceiling to unleash anticancer immune responses.
  Oncoimmunology 2014 Su MA, Anderson MS
• Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance.
  The Journal of experimental medicine 2014 Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS
• Spontaneous development of autoimmune uveitis Is CCR2 dependent.
  The American journal of pathology 2014 Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara NA
• Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM
• Canonical microRNAs in thymic epithelial cells promote central tolerance.
  European journal of immunology 2014 Khan IS, Taniguchi RT, Fasano KJ, Anderson MS, Jeker LT
• The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
  Nature immunology 2014 Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS
• Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus.
  The Journal of clinical investigation 2013 Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, …
• Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.
  The Journal of experimental medicine 2013 Mohan JF, Calderon B, Anderson MS, Unanue ER
• BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
  Science translational medicine 2013 Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA,…
• Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population.
  Cell reports 2013 Metzger TC, Khan IS, Gardner JM, Mouchess ML, Johannes KP, Krawisz AK, Skrzypczynska KM, Anderson MS
• Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.
  Immunity 2013 Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS
• Insights into type 1 diabetes from the autoimmune polyendocrine syndromes.
  Current opinion in endocrinology, diabetes, and obesity 2013 Cheng MH, Anderson MS
• Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.
  Cell stem cell 2013 Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M
• Autoimmune retinopathy in a patient with autoimmune polyendocrine syndrome type I.
  Ocular immunology and inflammation 2013 Breunig A, Lee MS, Miller BS, Binstadt BA, Anderson MS, Montezuma S
• Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS
• Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum AK, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS
• Monogenic autoimmunity.
  Annual review of immunology 2012 Cheng MH, Anderson MS
• Autoimmunity's collateral damage: Immunodeficiency hints at autoreactivity to cytokines.
  Nature medicine 2011 Waterfield M, Anderson MS
• Control of central and peripheral tolerance by Aire.
  Immunological reviews 2011 Metzger TC, Anderson MS
• Myocarditis: a defect in central immune tolerance?
  The Journal of clinical investigation 2011 Metzger TC, Anderson MS
• Aire and T cell development.
  Current opinion in immunology 2010 Anderson MS, Su MA
• The role of Aire in clonal selection.
  Immunology and cell biology 2010 Taniguchi RT, Anderson MS
• Clues to immune tolerance: the monogenic autoimmune syndromes.
  Annals of the New York Academy of Sciences 2010 Waterfield M, Anderson MS
• Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis.
  Immunity 2010 Husebye ES, Anderson MS
• An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse.
  Journal of immunology (Baltimore, Md. : 1950) 2010 DeVoss JJ, LeClair NP, Hou Y, Grewal NK, Johannes KP, Lu W, Yang T, Meagher C, Fong L, Strauss EC, Anderson MS
• Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect.
  The New England journal of medicine 2010 Cheng MH, Fan U, Grewal N, Barnes M, Mehta A, Taylor S, Husebye ES, Murphy EJ, Anderson MS
• Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance.
  Science translational medicine 2009 Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS
• AIRE in the thymus and beyond.
  Current opinion in immunology 2009 Gardner JM, Fletcher AL, Anderson MS, Turley SJ
• The sickness unto Deaf.
  Nature immunology 2009 Gardner JM, Anderson MS
• An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.
  The Journal of clinical investigation 2009 Hou Y, DeVoss J, Dao V, Kwek S, Simko JP, McNeel DG, Anderson MS, Fong L
• Monogenic autoimmune diseases: insights into self-tolerance.
  Pediatric research 2009 Su MA, Anderson MS
• A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.
  The Journal of experimental medicine 2009 Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA
• The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.
  Clinical immunology (Orlando, Fla.) 2009 Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS
• Update in endocrine autoimmunity.
  The Journal of clinical endocrinology and metabolism 2008 Anderson MS
• Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS
• Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.
  The Journal of experimental medicine 2008 Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA
• Deletional tolerance mediated by extrathymic Aire-expressing cells.
  Science (New York, N.Y.) 2008 Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS
• Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.
  The Journal of clinical investigation 2008 Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS
• Expression of Aire and the early wave of apoptosis in spermatogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Schaller CE, Wang CL, Beck-Engeser G, Goss L, Scott HS, Anderson MS, Wabl M
• Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease.
  Investigative ophthalmology & visual science 2008 Li S, Nikulina K, DeVoss J, Wu AJ, Strauss EC, Anderson MS, McNamara NA
• A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1.
  Clinical immunology (Orlando, Fla.) 2007 Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS
• What's new in the Aire?
  Trends in immunology 2007 Cheng MH, Shum AK, Anderson MS
• Lessons on immune tolerance from the monogenic disease APS1.
  Current opinion in genetics & development 2007 DeVoss JJ, Anderson MS
• Spontaneous autoimmunity prevented by thymic expression of a single self-antigen.
  The Journal of experimental medicine 2006 DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi RR, Caspi R, Fong L, Anderson MS
• Modifier loci condition autoimmunity provoked by Aire deficiency.
  The Journal of experimental medicine 2005 Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C
• The cellular mechanism of Aire control of T cell tolerance.
  Immunity 2005 Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D
• The NOD mouse: a model of immune dysregulation.
  Annual review of immunology 2005 Anderson MS, Bluestone JA
• Aire: an update.
  Current opinion in immunology 2004 Su MA, Anderson MS
• Autoimmune endocrine disease.
  Current opinion in immunology 2002 Anderson MS
• Projection of an immunological self shadow within the thymus by the aire protein.
  Science (New York, N.Y.) 2002 Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D
• Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal.
  The Journal of experimental medicine 1993 Anderson MS, Swier K, Arneson L, Miller J
• Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Anderson MS, Miller J