Marina Lopez Alvarez, PhD
Postdoctoral Scholar
Radiology
School of Medicine

Education & Training

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• Ph.D Medical Microbiology University Medical Center Groningen 08/2021

Interests

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• Molecular Imaging
• Fluorecence
• Biomedical Imaging
• Infectious diseases
• Monoclonal antibodies
• Radiology

Websites

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• Linkedin (linkedin.com)

Publications (20)

Top publication keywords:
DiscitisAnti-Infective Agents, LocalProsthesis-Related InfectionsIodineMuramic AcidsBacteriaBiofilmsMicrococcal NucleaseFractures, BoneStaphylococcal InfectionsStaphylococcus aureusGranzymesOptical ImagingPeptidoglycanSepsis

• Correction to: A fluorogenic micrococcal nuclease-based probe for fast detection and optical imaging of Staphylococcus aureus in prosthetic joint and fracture-related infections.
  European journal of nuclear medicine and molecular imaging 2024 Schoenmakers JWA, López-Álvarez M, IJpma FFA, Wouthuyzen-Bakker M, McNamara JO, van Oosten M, Jutte PC, van Dijl JM
• Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens In Vivo Using Positron Emission Tomography.
  ACS infectious diseases 2024 Pandey A, Chopra S, Cleary SJ, López-Álvarez M, Quimby FM, Alanizi AAA, Sakhamuri S, Zhang N, Looney MR, Craik CS, Wilson DM, Evans MJ
• Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [18F]FB-sulfo-DBCO.
  Bioconjugate chemistry 2024 Alanizi AA, Sorlin AM, Parker MFL, López-Álvarez M, Qin H, Lee SH, Blecha J, Rosenberg OS, Engel J, Ohliger MA, Flavell RR, Wilson DM
• Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection.
  JACS Au 2024 Sorlin AM, López-Álvarez M, Biboy J, Gray J, Rabbitt SJ, Rahim JU, Lee SH, Bobba KN, Blecha J, Parker MFL, Flavell RR, Engel J, Ohliger M, Vollmer W, Wilson DM
• Imaging the Bacterial Cell Wall Using N-Acetyl Muramic Acid-Derived Positron Emission Tomography Radiotracers.
  ACS sensors 2023 Lee SH, Kim JM, López-Álvarez M, Wang C, Sorlin AM, Bobba KN, Pichardo-González PA, Blecha J, Seo Y, Flavell RR, Engel J, Ohliger MA, Wilson DM

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• A fluorogenic micrococcal nuclease-based probe for fast detection and optical imaging of Staphylococcus aureus in prosthetic joint and fracture-related infections.
  European journal of nuclear medicine and molecular imaging 2023 Schoenmakers JWA, López-Álvarez M, IJpma FFA, Wouthuyzen-Bakker M, McNamara JO, van Oosten M, Jutte PC, van Dijl JM
• Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.
  The Journal of infectious diseases 2023 Parker MFL, López-Álvarez M, Alanizi AA, Luu JM, Polvoy I, Sorlin AM, Qin H, Lee S, Rabbitt SJ, Pichardo-González PA, Ordonez AA, Blecha J, Rosenberg OS, Flavell RR, Engel J, Jain SK, Ohliger MA, …
• Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo.
  Journal of the American Chemical Society 2023 Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, …
• Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [ 18 F]FDG yield potent sensors of living bacteria in vivo.
  bioRxiv : the preprint server for biology 2023 Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, …
• New In Situ-Generated Polymer-Iodine Complexes with Broad-Spectrum Antimicrobial Activity.
  Microbiology spectrum 2022 López-Álvarez M, Ulmer H, Klay N, van Dijl JM
• Coating and Corruption of Human Neutrophils by Bacterial Outer Membrane Vesicles.
  Microbiology spectrum 2022 du Teil Espina M, Fu Y, van der Horst D, Hirschfeld C, López-Álvarez M, Mulder LM, Gscheider C, Haider Rubio A, Huitema M, Becher D, Heeringa P, van Dijl JM
• Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus.
  Frontiers in oral health 2022 du Teil Espina M, Haider Rubio A, Fu Y, López-Álvarez M, Gabarrini G, van Dijl JM
• Bacteria-targeted fluorescence imaging of extracted osteosynthesis devices for rapid visualization of fracture-related infections.
  European journal of nuclear medicine and molecular imaging 2022 López-Álvarez M, Heuker M, Sjollema KA, van Dam GM, van Dijl JM, IJpma FFA, van Oosten M
• Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections.
  Scientific reports 2021 Park HY, Zoller SD, Hegde V, Sheppard W, Burke Z, Blumstein G, Hamad C, Sprague M, Hoang J, Smith R, Romero Pastrana F, Czupryna J, Miller LS, López-Álvarez M, Bispo M, van Oosten M, van Dijl JM, …
• Double trouble: Bacillus depends on a functional Tat machinery to avoid severe oxidative stress and starvation upon entry into a NaCl-depleted environment.
  Biochimica et biophysica acta. Molecular cell research 2020 Prajapati B, Bernal-Cabas M, López-Álvarez M, Schaffer M, Bartel J, Rath H, Steil L, Becher D, Völker U, Mäder U, van Dijl JM
• Fighting Staphylococcus aureus infections with light and photoimmunoconjugates.
  JCI insight 2020 Bispo M, Anaya-Sanchez A, Suhani S, Raineri EJM, López-Álvarez M, Heuker M, Szymanski W, Romero Pastrana F, Buist G, Horswill AR, Francis KP, van Dam GM, van Oosten M, van Dijl JM
• The smart activatable P2&3TT probe allows accurate, fast, and highly sensitive detection of Staphylococcus aureus in clinical blood culture samples.
  Scientific reports 2020 López-Álvarez M, Heuker M, Schoenmakers JWA, van Dam GM, McNamara JO, van Dijl JM, van Oosten M
• Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections.
  European journal of nuclear medicine and molecular imaging 2020 Schoenmakers JWA, Heuker M, López-Álvarez M, Nagengast WB, van Dam GM, van Dijl JM, Jutte PC, van Oosten M
• A Facile and Reproducible Synthesis of Near-Infrared Fluorescent Conjugates with Small Targeting Molecules for Microbial Infection Imaging.
  ACS omega 2020 Reeßing F, Bispo M, López-Álvarez M, van Oosten M, Feringa BL, van Dijl JM, Szymanski W
• Bacterial FtsZ protein forms phase-separated condensates with its nucleoid-associated inhibitor SlmA.
  EMBO reports 2018 Monterroso B, Zorrilla S, Sobrinos-Sanguino M, Robles-Ramos MA, López-Álvarez M, Margolin W, Keating CD, Rivas G