Margaux Pinney, PhD
Assistant Researcher
Biochemistry and Biophysics
School of Medicine

Publications (8)

Top publication keywords:
Crystallography, X-RayThermodynamicsEnzyme StabilityHydroxyl RadicalBacterial ProteinsKetosteroidsAdaptation, PhysiologicalCatalytic DomainFree RadicalsPhotoreceptors, MicrobialSalicylatesProton Magnetic Resonance SpectroscopyHydrogen BondingEvolution, MolecularSteroid Isomerases

• Ensemble-function relationships to dissect mechanisms of enzyme catalysis.
  Science advances 2022 Yabukarski F, Doukov T, Pinney MM, Biel JT, Fraser JS, Herschlag D
• Parallel molecular mechanisms for enzyme temperature adaptation.
  Science (New York, N.Y.) 2021 Pinney MM, Mokhtari DA, Akiva E, Yabukarski F, Sanchez DM, Liang R, Doukov T, Martinez TJ, Babbitt PC, Herschlag D
• Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Yabukarski F, Biel JT, Pinney MM, Doukov T, Powers AS, Fraser JS, Herschlag D
• Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation.
  Free radical biology & medicine 2019 Komaki Y, Simpson AM, Choe JK, Pinney MM, Herschlag D, Chuang YH, Mitch WA
• Structural Coupling Throughout the Active Site Hydrogen Bond Networks of Ketosteroid Isomerase and Photoactive Yellow Protein.
  Journal of the American Chemical Society 2018 Pinney MM, Natarajan A, Yabukarski F, Sanchez DM, Liu F, Liang R, Doukov T, Schwans JP, Martinez TJ, Herschlag D
• Hydrogen Bonds: Simple after All?
  Biochemistry 2018 Herschlag D, Pinney MM
• Evaluation of the Catalytic Contribution from a Positioned General Base in Ketosteroid Isomerase.
  Journal of the American Chemical Society 2016 Lamba V, Yabukarski F, Pinney M, Herschlag D
• Electron transfer and proton-coupled electron transfer reactivity and self-exchange of synthetic [2Fe-2S] complexes: models for Rieske and mitoNEET clusters.
  Inorganic chemistry 2014 Saouma CT, Pinney MM, Mayer JM