Margaret Lowe
Assistant Professor
Dermatology
School of Medicine
Publications (32)
Top publication keywords:
IntegrinsDermatitisTertiary Lymphoid StructuresInterleukinsHair FollicleOxazinesHidradenitis SuppurativaReceptors, Aryl HydrocarbonArginaseSkinTumor Necrosis Factor-alphaSkin TransplantationTh17 CellsT-Lymphocytes, RegulatoryTranscriptome
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Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.
JCI insight 2024 Lowe MM, Cohen JN, Moss MI, Clancy S, Adler JP, Yates AE, Naik HB, Yadav R, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM -
Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.
Science immunology 2024 Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD -
Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.
bioRxiv : the preprint server for biology 2023 Lowe MM, Cohen JN, Moss MI, Clancy S, Adler J, Yates A, Naik HB, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM -
Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.
JCI insight 2022 Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD -
Xenograft Skin Model to Manipulate Human Immune Responses In Vivo.
Journal of visualized experiments : JoVE 2022 Moss MI, Pauli M, Moreau JM, Cohen JN, Rosenblum MD, Lowe MM
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Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.
Nature 2021 Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD -
Layilin Anchors Regulatory T Cells in Skin.
Journal of immunology (Baltimore, Md. : 1950) 2021 Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus … -
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation.
Science immunology 2021 Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD -
B Home or You Are In Trouble: B Cell Integrin-Mediated Recruitment Attenuates Skin Inflammation.
The Journal of investigative dermatology 2021 Moreau JM, Lowe MM -
Single-cell analyses characterize circulating anti-tumor CD8+ T cells in mice and humans and identify markers for their enrichment.
The Journal of Immunology 2021 Kristen E Pauken, Osmaan Shahid, Kaitlyn A Lagattuta, Kelly M Mahuron, Jacob M Luber, Margaret M Lowe, Linglin Huang, Conor Delaney, Jaclyn Long, Megan E Fung, Kathleen Newcomer, Katy K Tsai, Melissa … -
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.
The Journal of experimental medicine 2021 Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, Burke KP, Schenkel JM, Rosenblum MD, Daud AI, … -
Abstract PO016: Single-cell analyses characterize circulating anti-tumor CD8 T cells and identify markers for their isolation.
Cancer Immunology Research 2021 Kristen E. Pauken, Osmaan Shahid, Kaitlyn A. Lagattuta, Kelly M. Mahuron, Jacob M. Luber, Margaret M. Lowe, Linglin Huang, Conor Delaney, Jaclyn M. Long, Megan E. Fung, Kathleen Newcomer, Katy K. Tsai… -
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Cell reports. Medicine 2020 Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC -
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.
JCI insight 2020 Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen ARJV, van der Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow… -
Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.
JCI insight 2020 Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD -
Layilin augments integrin activation to promote antitumor immunity.
The Journal of experimental medicine 2020 Mahuron KM, Moreau JM, Glasgow JE, Boda DP, Pauli ML, Gouirand V, Panjabi L, Grewal R, Luber JM, Mathur AN, Feldman RM, Shifrut E, Mehta P, Lowe MM, Alvarado MD, Marson A, Singer M, Wells J, Jupp R, … -
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
JCI insight 2019 Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, … -
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe 2019 Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC -
An Injectable Cytokine Trap for Local Treatment of Autoimmune Disease.
Biomaterials 2019 Zamecnik CR, Levy ES, Lowe MM, Zirak B, Rosenblum MD, Desai TA -
Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses.
Science immunology 2019 Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD -
868 Histologic progression of hidradenitis suppurativa: Implications for future therapeutic intervention.
Journal of Investigative Dermatology 2019 K. Salte, V. Todorovic, J. Wetter, V.E. Scott, K. Smith, M. Lowe, M. Rosenblum, J. Gudjonsson, P. Honore, R.W. Dunstan -
Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.
Immunity 2019 Mathur AN, Zirak B, Boothby IC, Tan M, Cohen JN, Mauro TM, Mehta P, Lowe MM, Abbas AK, Ali N, Rosenblum MD -
The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.
Science immunology 2018 Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD -
Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.
Microbiome 2018 Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W -
Injectable Polymeric Cytokine-Binding Nanowires Are Effective Tissue-Specific Immunomodulators.
ACS nano 2017 Zamecnik CR, Lowe MM, Patterson DM, Rosenblum MD, Desai TA -
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Cell 2017 Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, … -
041 Regulatory T cells drive stem cell differentiation during skin barrier repair.
Journal of Investigative Dermatology 2017 A. Mathur, B. Zirak, M. Lowe, A. Abbas, M. Rosenblum -
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe 2017 Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD -
Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages.
Viral immunology 2017 Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM -
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
PloS one 2014 Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM -
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate.
Biochemistry 2011 Soares J, Lowe MM, Jarstfer MB -
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Science translational medicine 2010 Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM