Marcus Muench, PhD
Professor
Laboratory Medicine
School of Medicine

Our work has helped to identify hematopoietic and hepatic progenitor populations in the liver and some of the cytokines that regulate their growth. A driving force behind my basic research efforts is a desire for the research to be clinically applicable, particularly in the field of fetal therapy. Fetal cellular therapy, the transplantation of cells into a fetus, has the potential of ameliorating or curing a large number of birth defects. However, the current practice of in utero stem cell transplantation is not yet effective enough to treat most hematopoietic or hepatic birth defects. Work in my laboratory is using mouse models of in utero transplantation to study methods of improving engraftment of foreign cells by prenatal transplantation.

• CD203c is expressed by human fetal hepatoblasts and distinguishes subsets of hepatoblastoma.
  Frontiers in oncology 2023 Muench MO, Fomin ME, Gutierrez AG, López-Terrada D, Gilfanova R, Nosworthy C, Beyer AI, Ostolaza G, Kats D, Matlock KL, Cairo S, Keller C
• Plasma transfusion-transmission of Zika virus in mice and macaques.
  Transfusion 2023 Van Rompay KKA, Coffey LL, Yee JL, Singapuri A, Stuart J, Lanteri MC, Santa Maria F, Lu K, Singh I, Bakkour S, Stone M, Williamson PC, Muench MO, Busch MP, Simmons G
• Antibody screening data of human midgestation liver cells with a focus on hematopoietic, liver sinusoidal endothelial, and hepatoblast cell-populations.
  BMC research notes 2022 Muench MO, Nosworthy C
• Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasma.
  The Journal of clinical investigation 2022 Saá P, Fink RV, Bakkour S, Jin J, Simmons G, Muench MO, Dawar H, Di Germanio C, Hui AJ, Wright DJ, Krysztof DE, Kleinman SH, Cheung A, Nester T, Kessler DA, Townsend RL, Spencer BR, Kamel H, Vannoy JM…
• Reduced dimethyl sulfoxide concentrations successfully cryopreserve human hematopoietic stem cells with multi-lineage long-term engraftment ability in mice.
  Cytotherapy 2021 Gilfanova R, Auclair KM, Hui A, Norris PJ, Muench MO
• A bioinspired and chemically defined alternative to dimethyl sulfoxide for the cryopreservation of human hematopoietic stem cells.
  Bone marrow transplantation 2021 Gilfanova R, Callegari A, Childs A, Yang G, Luarca M, Gutierrez AG, Medina KI, Mai J, Hui A, Kline M, Wei X, Norris PJ, Muench MO
• Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.
  Nature biotechnology 2021 Keating SM, Mizrahi RA, Adams MS, Asensio MA, Benzie E, Carter KP, Chiang Y, Edgar RC, Gautam BK, Gras A, Leong J, Leong R, Lim YW, Manickam VA, Medina-Cucurella AV, Niedecken AR, Saini J, Simons JF, …
• Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-β expression by cDCs and monocytes in mice.
  Blood advances 2020 Tran JQ, Muench MO, Jackman RP
• Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress.
  Transfusion 2020 Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T
• μ-Lat: A mouse model to evaluate human immunodeficiency virus eradication strategies.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sperber HS, Togarrati PP, Raymond KA, Bouzidi MS, Gilfanova R, Gutierrez AG, Muench MO, Pillai SK
• Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice.
  PloS one 2020 Blessinger SA, Tran JQ, Jackman RP, Gilfanova R, Rittenhouse J, Gutierrez AG, Heitman JW, Hazegh K, Kanias T, Muench MO
• A small allelic variant in donor class I MHC is sufficient to induce alloantibodies following transfusion of standard or pathogen-reduced platelets in mice.
  Vox sanguinis 2020 Jackman RP, Heitman JW, Muench MO
• Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes.
  Transfusion 2019 Tran JQ, Muench MO, Heitman JW, Jackman RP
• Potential of Membranes Surrounding the Fetus as Immunoprotective Cell-Carriers for Allogeneic Transplantations.
  Transplantation direct 2019 Togarrati PP, Dinglasan N, Yee E, Heitman JW, Jackman RP, Geisberg M, Norris PJ, Bárcena A, Muench MO
• Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice.
  Vox sanguinis 2019 Tran JQ, Muench MO, Heitman JW, Jackman RP
• Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.
  Development (Cambridge, England) 2018 May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM
• Minimal infectious dose and dynamics of Babesia microti parasitemia in a murine model.
  Transfusion 2018 Bakkour S, Chafets DM, Wen L, Muench MO, Telford SR, Erwin JL, Levin AE, Self D, Brès V, Linnen JM, Lee TH, Busch MP
• An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope.
  PLoS neglected tropical diseases 2018 Jin J, Sherman MB, Chafets D, Dinglasan N, Lu K, Lee TH, Carlson LA, Muench MO, Simmons G
• CD29 is highly expressed on epithelial, myoepithelial, and mesenchymal stromal cells of human salivary glands.
  Oral diseases 2018 Togarrati PP, Dinglasan N, Desai S, Ryan WR, Muench MO
• Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Tan YT, Ye L, Xie F, Beyer AI, Muench MO, Wang J, Chen Z, Liu H, Chen SJ, Kan YW
• SOX2 regulates acinar cell development in the salivary gland.
  eLife 2017 Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM
• Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands.
  Scientific reports 2017 Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO
• The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation.
  Development (Cambridge, England) 2017 Muench MO, Kapidzic M, Gormley M, Gutierrez AG, Ponder KL, Fomin ME, Beyer AI, Stolp H, Qi Z, Fisher SJ, Bárcena A
• A cost-effective software solution for vivarium management.
  Lab animal 2016 Muench MO
• Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice Are Associated With Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells.
  Cell medicine 2016 Fomin ME, Beyer AI, Publicover J, Lu K, Bakkour S, Simmons G, Muench MO
• Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood.
  Transfusion 2016 Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ
• Comparison of Human Hematopoietic Reconstitution in Different Strains of Immunodeficient Mice.
  Stem cells and development 2016 Beyer AI, Muench MO
• Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Ye L, Wang J, Tan Y, Beyer AI, Xie F, Muench MO, Kan YW
• Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets.
  Transfusion 2016 Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP
• Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets.
  Transfusion 2016 Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S
• The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function.
  Transfusion 2016 Baimukanova G, Miyazawa B, Potter DR, Gibb SL, Keating S, Danesh A, Beyer A, Dayter Y, Bruhn R, Muench MO, Cap AP, Norris PJ, Spinella P, Cohen M, Pati S
• TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.
  Molecular therapy. Nucleic acids 2016 Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M…
• A diverse group of small circular ssDNA viral genomes in human and non-human primate stools.
  Virus evolution 2015 Ng TF, Zhang W, Sachsenröder J, Kondov NO, da Costa AC, Vega E, Holtz LR, Wu G, Wang D, Stine CO, Antonio M, Mulvaney US, Muench MO, Deng X, Ambert-Balay K, Pothier P, Vinjé J, Delwart E
• Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis.
  Cell reports 2015 Jin J, Liss NM, Chen DH, Liao M, Fox JM, Shimak RM, Fong RH, Chafets D, Bakkour S, Keating S, Fomin ME, Muench MO, Sherman MB, Doranz BJ, Diamond MS, Simmons G
• A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros.
  Leukemia 2015 Wiemels JL, de Smith AJ, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM
• A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal-bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.
  BMC hematology 2015 Mahajan MM, Cheng B, Beyer AI, Mulvaney US, Wilkinson MB, Fomin ME, Muench MO
• Whole-genome fingerprint of the DNA methylome during human B cell differentiation.
  Nature genetics 2015 Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, …
• Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock.
  The journal of trauma and acute care surgery 2015 Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S
• Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
  Nucleic acids research 2015 Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL
• Potential role of increased oxygenation in altering perinatal adrenal steroidogenesis.
  Pediatric research 2014 Agrawal V, Tee MK, Qiao J, Muench MO, Miller WL
• Progress and challenges in the development of a cell-based therapy for hemophilia A.
  Journal of thrombosis and haemostasis : JTH 2014 Fomin ME, Togarrati PP, Muench MO
• Exposure of epitope residues on the outer face of the chikungunya virus envelope trimer determines antibody neutralizing efficacy.
  Journal of virology 2014 Fong RH, Banik SS, Mattia K, Barnes T, Tucker D, Liss N, Lu K, Selvarajah S, Srinivasan S, Mabila M, Miller A, Muench MO, Michault A, Rucker JB, Paes C, Simmons G, Kahle KM, Doranz BJ
• Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac.
  Genome research 2014 Xie F, Ye L, Chang JC, Beyer AI, Wang J, Muench MO, Kan YW
• Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW
• The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.
  PloS one 2014 Muench MO, Beyer AI, Fomin ME, Thakker R, Mulvaney US, Nakamura M, Suemizu H, Bárcena A
• Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro.
  Blood 2013 Danesh A, Inglis HC, Jackman RP, Wu S, Deng X, Muench MO, Heitman JW, Norris PJ
• A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.
  PLoS neglected tropical diseases 2013 Selvarajah S, Sexton NR, Kahle KM, Fong RH, Mattia KA, Gardner J, Lu K, Liss NM, Salvador B, Tucker DF, Barnes T, Mabila M, Zhou X, Rossini G, Rucker JB, Sanders DA, Suhrbier A, Sambri V, Michault A, …
• Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.
  The Journal of clinical investigation 2013 Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL
• Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors.
  Stem cells translational medicine 2013 Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW
• Identification of an astrovirus commonly infecting laboratory mice in the US and Japan.
  PloS one 2013 Ng TF, Kondov NO, Hayashimoto N, Uchida R, Cha Y, Beyer AI, Wong W, Pesavento PA, Suemizu H, Muench MO, Delwart E
• Immune modulation and lack of alloimmunization following transfusion with pathogen-reduced platelets in mice.
  Transfusion 2013 Jackman RP, Muench MO, Heitman JW, Inglis HC, Law JP, Marschner S, Goodrich RP, Norris PJ
• Filoviruses utilize glycosaminoglycans for their attachment to target cells.
  Journal of virology 2013 Salvador B, Sexton NR, Carrion R, Nunneley J, Patterson JL, Steffen I, Lu K, Muench MO, Lembo D, Simmons G
• A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.
  Nucleic acids research 2012 Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL
• Distinct roles of trauma and transfusion in induction of immune modulation after injury.
  Transfusion 2012 Jackman RP, Utter GH, Muench MO, Heitman JW, Munz MM, Jackman RW, Biswas HH, Rivers RM, Tobler LH, Busch MP, Norris PJ
• Expression of P450c17 in the human fetal nervous system.
  Endocrinology 2012 Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH
• Cellular therapies supplement: the peritoneum as an ectopic site of hematopoiesis following in utero transplantation.
  Transfusion 2011 Muench MO, Chen JC, Beyer AI, Fomin ME
• Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.
  Transfusion 2011 Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ
• Maternal microchimerism in pediatric inflammatory bowel disease.
  Chimerism 2011 Suskind DL, Kong D, Stevens A, Wahbeh G, Christie D, Baxter-Lowe LA, Muench MO
• Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver.
  Stem cells and development 2010 Fomin ME, Tai LK, Bárcena A, Muench MO
• Detection of human hematopoietic stem cell engraftment in the livers of adult immunodeficient mice by an optimized flow cytometric method.
  Stem Cell Studies 2010 Varga NL, Bárcena A, Fomin ME, Muench MO
• Characterization of tolerance induction through prenatal marrow transplantation: the requirement for a threshold level of chimerism to establish rather than maintain postnatal skin tolerance.
  Cell transplantation 2010 Chen JC, Kuo ML, Ou LS, Chang PY, Muench MO, Shen CR, Chang HL, Yu HY, Fu RH
• Barley as a green factory for the production of functional Flt3 ligand.
  Biotechnology journal 2010 Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdóttir SM, Jonsson A, Balmer Y, Mäntylä E, Orvar BL
• Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.
  Journal of virology 2009 Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S
• Characterization of Chikungunya pseudotyped viruses: Identification of refractory cell lines and demonstration of cellular tropism differences mediated by mutations in E1 glycoprotein.
  Virology 2009 Salvador B, Zhou Y, Michault A, Muench MO, Simmons G
• A new role for the human placenta as a hematopoietic site throughout gestation.
  Reproductive sciences (Thousand Oaks, Calif.) 2009 Bárcena A, Muench MO, Kapidzic M, Fisher SJ
• Transplantation NK'Oed in the first trimester.
  Blood 2008 Muench MO
• Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.
  Science (New York, N.Y.) 2008 Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM
• Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy FA, Bertozzi CR
• Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance.
  Cell transplantation 2008 Chen JC, Chang ML, Huang SF, Chang PY, Muench MO, Fu RH, Ou LS, Kuo ML
• Persistence of allografts in the peritoneal cavity after prenatal transplantation in mice.
  Transfusion 2007 Chen JC, Chang ML, Muench MO
• Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland.
  The Journal of clinical endocrinology and metabolism 2006 Ishimoto H, Muench MO, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB
• Maintenance of proliferative capacity and retroviral transduction efficiency of human fetal CD38(-)/CD34(++) stem cells.
  Stem cells and development 2006 Muench MO, Ohkubo T, Smith CA, Suskind DL, Bárcena A
• In utero transplantation: baby steps towards an effective therapy.
  Bone marrow transplantation 2005 Muench MO
• Prevention of graft rejection by donor type II CD8(+) T cells (Tc2 cells) is not sufficient to improve engraftment in fetal transplantation.
  Fetal diagnosis and therapy 2005 Chen JC, Chang ML, Lee H, Muench MO
• Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation.
  British journal of haematology 2004 Chen JC, Chang ML, Lee H, Muench MO
• Maternal microchimerism in the livers of patients with biliary atresia.
  BMC gastroenterology 2004 Suskind DL, Rosenthal P, Heyman MB, Kong D, Magrane G, Baxter-Lowe LA, Muench MO
• Megakaryocyte growth and development factor is a potent growth factor for primitive hematopoietic progenitors in the human fetus.
  Pediatric research 2004 Muench MO, Bárcena A
• Stem cell transplantation in the fetus.
  Cancer control : journal of the Moffitt Cancer Center 2004 Muench MO, Bárcena A
• Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells.
  Journal of hepatology 2004 Suskind DL, Muench MO
• Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus.
  Developmental and comparative immunology 2003 Muench MO, Pott Bärtsch EM, Chen JC, Lopoo JB, Bárcena A
• A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling.
  Journal of immunological methods 2003 Chen JC, Chang ML, Muench MO
• Isolation of definitive zone and chromaffin cells based upon expression of CD56 (neural cell adhesion molecule) in the human fetal adrenal gland.
  The Journal of clinical endocrinology and metabolism 2003 Muench MO, Ratcliffe JV, Nakanishi M, Ishimoto H, Jaffe RB
• Isolation, growth and identification of colony-forming cells with erythroid, myeloid, dendritic cell and NK-cell potential from human fetal liver.
  Biological procedures online 2002 Muench MO, Suskind DL, Bárcena A
• Broad distribution of colony-forming cells with erythroid, myeloid, dendritic cell, and NK cell potential among CD34(++) fetal liver cells.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Muench MO, Bárcena A
• High-efficiency retroviral transduction of fetal liver CD38-CD34++ cells: implications for in utero and ex utero gene therapy.
  Fetal diagnosis and therapy 2001 Ohkubo T, Bárcena A, Smith CA, Harrison MR, Muench MO
• Disparate regulation of human fetal erythropoiesis by the microenvironments of the liver and bone marrow.
  Blood cells, molecules & diseases 2001 Muench MO, Namikawa R
• Antibodies to human fetal erythroid cells from a nonimmune phage antibody library.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Huie MA, Cheung MC, Muench MO, Becerril B, Kan YW, Marks JD
• Transplantation of a fetus with paternal Thy-1(+)CD34(+)cells for chronic granulomatous disease.
  Bone marrow transplantation 2001 Muench MO, Rae J, Bárcena A, Leemhuis T, Farrell J, Humeau L, Maxwell-Wiggins JR, Capper J, Mychaliska GB, Albanese CT, Martin T, Tsukamoto A, Curnutte JT, Harrison MR
• Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras.
  Blood cells, molecules & diseases 2001 Oppenheim SM, Muench MO, Gutiérrez-Adán A, Moyer AL, BonDurant RH, Rowe JD, Anderson GB
• Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors.
  Experimental hematology 2000 Muench MO, Humeau L, Paek B, Ohkubo T, Lanier LL, Albanese CT, Bárcena A
• Fetal bone marrow as a source of stem cells for in utero or postnatal transplantation.
  British journal of haematology 2000 Golfier F, Bárcena A, Harrison MR, Muench MO
• Mid-trimester fetal livers are a rich source of CD34+/++ cells for transplantation.
  Bone marrow transplantation 1999 Golfier F, Bárcena A, Cruz J, Harrison M, Muench M
• Role of CD95/Fas and its ligand in the regulation of the growth of human CD34(++)CD38(-) fetal liver cells.
  Experimental hematology 1999 Bárcena A, Muench MO, Song KS, Ohkubo T, Harrison MR
• Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse.
  Experimental hematology 1999 Namikawa R, Muench MO, Firpo MT, Humeau L, Xu Y, Menon S, Roncarolo MG
• Requirement of retinoids for the expression of CD38 on human hematopoietic progenitors in vitro.
  Cytotherapy 1999 Muench MO, Bárcena A, Ohkubo T, Harrison MR
• The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation.
  Journal of pediatric surgery 1998 Mychaliska GB, Muench MO, Rice HE, Leavitt AD, Cruz J, Harrison MR
• Colony-forming cells expressing high levels of CD34 are the main targets for granulocyte colony-stimulating factor and macrophage colony-stimulating factor in the human fetal liver.
  Experimental hematology 1997 Muench MO, Roncarolo MG, Rosnet O, Birnbaum D, Namikawa R
• Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver.
  Blood 1997 Muench MO, Roncarolo MG, Namikawa R
• Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
  Blood 1996 Bárcena A, Park SW, Banapour B, Muench MO, Mechetner E
• Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis.
  Stem cells (Dayton, Ohio) 1996 Namikawa R, Muench MO, Roncarolo MG
• The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro.
  Blood 1996 Namikawa R, Muench MO, de Vries JE, Roncarolo MG
• Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus.
  Leukemia & lymphoma 1995 Bárcena A, Muench MO, Roncarolo MG, Spits H
• FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver.
  Blood 1995 Muench MO, Roncarolo MG, Menon S, Xu Y, Kastelein R, Zurawski S, Hannum CH, Culpepper J, Lee F, Namikawa R
• Progress in the ex vivo expansion of hematopoietic progenitors.
  Leukemia & lymphoma 1994 Muench MO, Roncarolo MG, Namikawa R, Bárcena A, Moore MA
• Identification of a common T/natural killer cell progenitor in human fetal thymus.
  The Journal of experimental medicine 1994 Sánchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH
• Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture.
  The Journal of experimental medicine 1994 Bárcena A, Galy AH, Punnonen J, Muench MO, Schols D, Roncarolo MG, de Vries JE, Spits H
• Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential.
  Blood 1994 Muench MO, Cupp J, Polakoff J, Roncarolo MG
• Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.
  Nature 1994 Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J
• Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice.
  Experimental hematology 1994 Paul SR, Hayes LL, Palmer R, Morris GE, Neben TY, Loebelenz J, Pedneault G, Brooks J, Blue I, Moore MA
• In search of T-cell progenitors in the human foetal liver.
  Research in immunology 1994 Bárcena A, Muench MO, Roncarolo MG, Spits H
• Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development.
  Blood 1993 Bárcena A, Muench MO, Galy AH, Cupp J, Roncarolo MG, Phillips JH, Spits H
• Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential.
  Blood 1993 Muench MO, Firpo MT, Moore MA
• Development of a lacZ marked WEHI-3B D+ murine leukemic cell line as an in-vivo model of acute non-lymphocytic leukemia.
  Leukemia 1993 Smith C, Muench MO, Knizewski M, Gilboa E, Moore MA
• Ex vivo differentiation therapy as a method of leukemic cell purging in murine bone marrow expansion cultures.
  Cancer research 1992 Muench MO, Guy Z, Moore MA
• The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere.
  Cytokine 1992 Muench MO, Gasparetto C, Moore MA
• Accelerated recovery of peripheral blood cell counts in mice transplanted with in vitro cytokine-expanded hematopoietic progenitors.
  Experimental hematology 1992 Muench MO, Moore MA
• Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells.
  Experimental hematology 1992 Muench MO, Schneider JG, Moore MA
• Purification and partial characterization of a human hematopoietic precursor population.
  Blood 1991 Smith C, Gasparetto C, Collins N, Gillio A, Muench MO, O'Reilly RJ, Moore MA
• Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation.
  Ciba Foundation symposium 1990 Moore MA, Muench MO, Warren DJ, Laver J
• Radioprotection by murine and human tumor-necrosis factor: dose-dependent effects on hematopoiesis in the mouse.
  European journal of haematology 1989 Slørdal L, Muench MO, Warren DJ, Moore MA