Marco Conti, MD
Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

Grants and Projects

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• RNA binding protein networks and translational control in mammalian oocytes, NIH, 2016-2024
• Center for Research, Innovation and Training in Reproduction and Infertility, NIH, 2007-2023
• Wee Kinases and the Control of the Meiotic Cell Cycle, NIH, 2015-2019
• Origins and Biological Consequences of Human Infertility, NIH, 2007-2017
• The translational program in oocyte and early embryo development, NIH, 2011-2016
• Hormonal Regulation of Phosphodiestrases, NIH, 2008-2014
• Role of the EGF Network in Ovulation, NIH, 2007-2013
• Cyclic nucleotide signaling and the modulation of asthma inflammatory responses, NIH, 2010-2012
• Cyclic AMP and the Control of the Meiotic Cell Cycle, NIH, 2007-2011
• Role of Cyclic Nucleotides in Sperm Function, NIH, 1994-2011
• Hormonal Regulation of Phosphodiesterases, NIH, 1985-2008
• Gonadal and Endometrial Function in Human Reproduction, NIH, 1997-2008
• SCOR in Cellular and Molecular Mechanisms of Asthma, NIH, 2001-2006
• Modulation of Cellular Function in Seminiferous Tubules, NIH, 1986-1989

Publications (123)

Top publication keywords:
Adenylyl CyclasesOvarian FolliclemRNA Cleavage and Polyadenylation FactorsOogenesisOocytesRNA, Messenger, StoredCyclin B1Luteinizing Hormone3',5'-Cyclic-AMP PhosphodiesterasesCyclic Nucleotide Phosphodiesterases, Type 4Cyclin B2PolyadenylationCyclic AMPProtein BiosynthesisMeiosis

• Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts.
  Cells 2024 Kraft AE, Bork NI, Subramanian H, Pavlaki N, Failla AV, Zobiak B, Conti M, Nikolaev VO
• Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.
  Nucleic acids research 2024 Wang X, Leung FS, Bush JO, Conti M
• Multiple intersecting pathways are involved in the phosphorylation of CPEB1 to activate translation during mouse oocyte meiosis.
  bioRxiv : the preprint server for biology 2024 Kunitomi C, Romero M, Daldello EM, Schindler K, Conti M
• A genome-wide perspective of the maternal mRNA translation program during oocyte development.
  Seminars in cell & developmental biology 2023 Conti M, Kunitomi C
• Author Correction: CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging.
  Nature communications 2023 Takahashi N, Franciosi F, Daldello EM, Luong XG, Althoff P, Wang X, Conti M

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• CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging.
  Nature communications 2023 Takahashi N, Franciosi F, Daldello EM, Luong XG, Althoff P, Wang X, Conti M
• A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
  Science translational medicine 2022 Ghigo A, Murabito A, Sala V, Pisano AR, Bertolini S, Gianotti A, Caci E, Montresor A, Premchandar A, Pirozzi F, Ren K, Della Sala A, Mergiotti M, Richter W, de Poel E, Matthey M, Caldrer S, Cardone RA…
• The H3.3 chaperone Hira complex orchestrates oocyte developmental competence.
  Development (Cambridge, England) 2022 Smith R, Susor A, Ming H, Tait J, Conti M, Jiang Z, Lin CJ
• Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay.
  Journal of visualized experiments : JoVE 2021 Costermans NGJ, Daldello EM, Marathe RJ, Conti M
• Genome-wide analysis reveals a switch in the translational program upon oocyte meiotic resumption.
  Nucleic acids research 2020 Luong XG, Daldello EM, Rajkovic G, Yang CR, Conti M
• The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.
  Nature communications 2020 Yang CR, Rajkovic G, Daldello EM, Luong XG, Chen J, Conti M
• Cyclin B2 is required for progression through meiosis in mouse oocytes.
  Development (Cambridge, England) 2019 Daldello EM, Luong XG, Yang CR, Kuhn J, Conti M
• Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages.
  Innate immunity 2018 Yang JX, Hsiung TC, Weng FC, Ding SL, Wu CP, Conti M, Chuang TH, Catherine Jin SL
• Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events.
  Human reproduction update 2018 Conti M, Franciosi F
• Profiling Maternal mRNA Translation During Oocyte Development.
  Methods in molecular biology (Clifton, N.J.) 2018 Martins JPS, Conti M
• Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.
  Scientific reports 2017 Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO
• The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle.
  Scientific reports 2017 Han SJ, Martins JPS, Yang Y, Kang MK, Daldello EM, Conti M
• Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.
  The Journal of cell biology 2017 Zhang QH, Yuen WS, Adhikari D, Flegg JA, FitzHarris G, Conti M, Sicinski P, Nabti I, Marangos P, Carroll J
• Report from the 2016 University of California, San Francisco, Center for Reproductive Sciences retreat.
  Molecular reproduction and development 2017 Rinaudo PF, Conti M
• Maternal mRNAs with distinct 3' UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation.
  Genes & development 2017 Yang Y, Yang CR, Han SJ, Daldello EM, Cho A, Martins JPS, Xia G, Conti M
• Functional selectivity of GPCR-directed drug action through location bias.
  Nature chemical biology 2017 Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M
• Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
  Scientific reports 2017 Yang JX, Hsieh KC, Chen YL, Lee CK, Conti M, Chuang TH, Wu CP, Jin SC
• International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.
  Pharmacological reviews 2017 Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R
• Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M
• DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
  Journal of cell science 2016 Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M
• FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence.
  Endocrinology 2015 Franciosi F, Manandhar S, Conti M
• PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways.
  Cellular signalling 2015 Mika D, Conti M
• A CaMKII/PDE4D negative feedback regulates cAMP signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Mika D, Richter W, Conti M
• Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
  Developmental cell 2014 Lin CJ, Koh FM, Wong P, Conti M, Ramalho-Santos M
• The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).
  The Biochemical journal 2014 Xie M, Blackman B, Scheitrum C, Mika D, Blanchard E, Lei T, Conti M, Richter W
• Multiple pathways mediate luteinizing hormone regulation of cGMP signaling in the mouse ovarian follicle.
  Biology of reproduction 2014 Liu X, Xie F, Zamah AM, Cao B, Conti M
• Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
  Psychopharmacology 2014 Hansen RT, Conti M, Zhang HT
• Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.
  Cardiovascular research 2014 Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G
• PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.
  Journal of cell science 2014 Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M
• Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases.
  The Journal of general physiology 2014 Conti M, Mika D, Richter W
• Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
  Nature cell biology 2013 Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M
• Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W
• Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development.
  Development (Cambridge, England) 2013 Lin CJ, Conti M, Ramalho-Santos M
• PDE4 as a target for cognition enhancement.
  Expert opinion on therapeutic targets 2013 Richter W, Menniti FS, Zhang HT, Conti M
• β1-adrenergic receptor antagonists signal via PDE4 translocation.
  EMBO reports 2013 Richter W, Mika D, Blanchard E, Day P, Conti M
• Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
  Journal of cell science 2013 Oh JS, Susor A, Schindler K, Schultz RM, Conti M
• Analysis of signaling pathways controlling flagellar movements in mammalian spermatozoa.
  Methods in enzymology 2013 Xie F, Eddy EM, Conti M
• A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type.
  Human molecular genetics 2012 Geister KA, Brinkmeier ML, Hsieh M, Faust SM, Karolyi IJ, Perosky JE, Kozloff KM, Conti M, Camper SA
• Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.
  Circulation 2012 Ghigo A, Perino A, Mehel H, Zahradníková A, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G…
• Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias.
  Journal of the American College of Cardiology 2012 Molina CE, Leroy J, Richter W, Xie M, Scheitrum C, Lee IO, Maack C, Rucker-Martin C, Donzeau-Gouge P, Verde I, Llach A, Hove-Madsen L, Conti M, Vandecasteele G, Fischmeister R
• Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque.
  Human reproduction (Oxford, England) 2012 Peluffo MC, Ting AY, Zamah AM, Conti M, Stouffer RL, Zelinski MB, Hennebold JD
• Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.
  Molecular and cellular endocrinology 2011 Conti M, Hsieh M, Zamah AM, Oh JS
• Phosphodiesterases and regulation of female reproductive function.
  Current opinion in pharmacology 2011 Conti M
• Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
  Circulation research 2011 Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones P, Tian X, Wilson LS, Ahmad F, Chen SRW, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH
• Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation.
  PloS one 2011 Hsieh M, Thao K, Conti M
• When an egg is not an egg: compromised maternal mRNA storage and stabilization.
  Biology of reproduction 2011 Conti M
• Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.
  The Journal of clinical investigation 2011 Leroy J, Richter W, Mika D, Castro LR, Abi-Gerges A, Xie M, Scheitrum C, Lefebvre F, Schittl J, Mateo P, Westenbroek R, Catterall WA, Charpentier F, Conti M, Fischmeister R, Vandecasteele G
• Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP.
  Molecular pharmacology 2011 Xie M, Rich TC, Scheitrum C, Conti M, Richter W
• Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
  Genes & development 2011 Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M
• Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.
  Science (New York, N.Y.) 2011 Oh JS, Susor A, Conti M
• PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.
  The Journal of biological chemistry 2011 Blackman BE, Horner K, Heidmann J, Wang D, Richter W, Rich TC, Conti M
• Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT
• Conserved expression and functions of PDE4 in rodent and human heart.
  Basic research in cardiology 2010 Richter W, Xie M, Scheitrum C, Krall J, Movsesian MA, Conti M
• Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.
  The Journal of allergy and clinical immunology 2010 Jin SL, Goya S, Nakae S, Wang D, Bruss M, Hou C, Umetsu D, Conti M
• Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility.
  Biology of reproduction 2010 Nyegaard M, Overgaard MT, Su YQ, Hamilton AE, Kwintkiewicz J, Hsieh M, Nayak NR, Conti M, Conover CA, Giudice LC
• Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption.
  The Journal of cell biology 2010 Oh JS, Han SJ, Conti M
• The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis.
  Endocrinology 2010 Aghajanova L, Horcajadas JA, Weeks JL, Esteban FJ, Nezhat CN, Conti M, Giudice LC
• Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
  Circulation research 2009 Abi-Gerges A, Richter W, Lefebvre F, Mateo P, Varin A, Heymes C, Samuel JL, Lugnier C, Conti M, Fischmeister R, Vandecasteele G
• Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.
  Biology of reproduction 2009 Vaccari S, Weeks JL, Hsieh M, Menniti FS, Conti M
• Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation.
  Seminars in reproductive medicine 2009 Hsieh M, Zamah AM, Conti M
• Growth factors and the development and function of the reproductive organs.
  Seminars in reproductive medicine 2009 Guidice LC, Conti M
• From stem cells to germ cells and back again.
  Nature medicine 2008 Conti M, Giudice L
• Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.
  The Journal of biological chemistry 2008 Bruss MD, Richter W, Horner K, Jin SL, Conti M
• Soluble adenylyl cyclase is not required for axon guidance to netrin-1.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Moore SW, Lai Wing Sun K, Xie F, Barker PA, Conti M, Kennedy TE
• PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia.
  Schizophrenia research 2008 Fatemi SH, King DP, Reutiman TJ, Folsom TD, Laurence JA, Lee S, Fan YT, Paciga SA, Conti M, Menniti FS
• Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
  Circulation research 2008 Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechêne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G
• Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest.
  Developmental biology 2008 Vaccari S, Horner K, Mehlmann LM, Conti M
• Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.
  Molecular endocrinology (Baltimore, Md.) 2008 Panigone S, Hsieh M, Fu M, Persani L, Conti M
• Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4.
  The EMBO journal 2008 Richter W, Day P, Agrawal R, Bruss MD, Granier S, Wang YL, Rasmussen SG, Horner K, Wang P, Lei T, Patterson AJ, Kobilka B, Conti M
• The mouse polyubiquitin gene Ubb is essential for meiotic progression.
  Molecular and cellular biology 2007 Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, Kopito RR
• Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007 Zhang HT, Huang Y, Masood A, Stolinski LR, Li Y, Zhang L, Dlaboga D, Jin SL, Conti M, O'Donnell JM
• Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Peter D, Jin SL, Conti M, Hatzelmann A, Zitt C
• Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors.
  The Journal of biological chemistry 2007 Lee JH, Richter W, Namkung W, Kim KH, Kim E, Conti M, Lee MG
• Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling.
  Annual review of biochemistry 2007 Conti M, Beavo J
• Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation.
  Molecular and cellular biology 2006 Hsieh M, Lee D, Panigone S, Horner K, Chen R, Theologis A, Lee DC, Threadgill DW, Conti M
• Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.
  The EMBO journal 2006 Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, Conti M
• Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.
  American journal of physiology. Cell physiology 2006 Rich TC, Xin W, Mehats C, Hassell KA, Piggott LA, Le X, Karpen JW, Conti M
• Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.
  Developmental biology 2006 Xie F, Garcia MA, Carlson AE, Schuh SM, Babcock DF, Jaiswal BS, Gossen JA, Esposito G, van Duin M, Conti M
• A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes.
  Circulation research 2006 Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DM, Conti M, Fischmeister R, Vandecasteele G
• New pathways from PKA to the Cdc2/cyclin B complex in oocytes: Wee1B as a potential PKA substrate.
  Cell cycle (Georgetown, Tex.) 2006 Han SJ, Conti M
• Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists.
  Biology of reproduction 2005 Schuh SM, Carlson AE, McKnight GS, Conti M, Hille B, Babcock DF
• The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
  Developmental biology 2005 Hinckley M, Vaccari S, Horner K, Chen R, Conti M
• Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
  Cell 2005 Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR
• AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.
  Biology of reproduction 2005 Bajpai M, Fiedler SE, Huang Z, Vijayaraghavan S, Olson GE, Livera G, Conti M, Carr DW
• Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.
  Current biology : CB 2005 Han SJ, Chen R, Paronetto MP, Conti M
• G-protein-coupled receptor signaling and the EGF network in endocrine systems.
  Trends in endocrinology and metabolism: TEM 2005 Hsieh M, Conti M
• Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Jin SL, Lan L, Zoudilova M, Conti M
• Role of the epidermal growth factor network in ovarian follicles.
  Molecular endocrinology (Baltimore, Md.) 2005 Conti M, Hsieh M, Park JY, Su YQ
• Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.
  The Biochemical journal 2005 Richter W, Jin SL, Conti M
• Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B
• Generation of PDE4 knockout mice by gene targeting.
  Methods in molecular biology (Clifton, N.J.) 2005 Jin SL, Latour AM, Conti M
• Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Ariga M, Neitzert B, Nakae S, Mottin G, Bertrand C, Pruniaux MP, Jin SL, Conti M
• Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.
  The Journal of biological chemistry 2004 Barnes AP, Livera G, Huang P, Sun C, O'Neal WK, Conti M, Stutts MJ, Milgram SL
• Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation.
  Development (Cambridge, England) 2004 Nedachi T, Conti M
• A view into the catalytic pocket of cyclic nucleotide phosphodiesterases.
  Nature structural & molecular biology 2004 Conti M
• Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
  The Journal of clinical investigation 2004 Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, Nedachi T, Jin C, Conti M, Manganiello V
• The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.
  The Journal of biological chemistry 2004 Richter W, Conti M
• Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Esposito G, Jaiswal BS, Xie F, Krajnc-Franken MA, Robben TJ, Strik AM, Kuil C, Philipsen RL, van Duin M, Conti M, Gossen JA, Jaiswal BS
• EGF-like growth factors as mediators of LH action in the ovulatory follicle.
  Science (New York, N.Y.) 2004 Park JY, Su YQ, Ariga M, Law E, Jin SL, Conti M
• Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells.
  Developmental biology 2004 Xie F, Conti M
• PDE4D plays a critical role in the control of airway smooth muscle contraction.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Méhats C, Jin SL, Wahlstrom J, Law E, Umetsu DT, Conti M
• Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Jaiswal BS, Conti M
• Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells.
  Molecular endocrinology (Baltimore, Md.) 2003 Yoshida H, Beltran-Parrazal L, Butler P, Conti M, Charles AC, Weiner RI
• Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.
  Developmental biology 2003 Horner K, Livera G, Hinckley M, Trinh K, Storm D, Conti M
• IGF-I-induced differentiation of L6 myogenic cells requires the activity of cAMP-phosphodiesterase.
  Molecular biology of the cell 2003 De Arcangelis V, Coletti D, Conti M, Lagarde M, Molinaro M, Adamo S, Nemoz G, Naro F
• Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle.
  Molecular endocrinology (Baltimore, Md.) 2003 Park JY, Richard F, Chun SY, Park JH, Law E, Horner K, Jin SL, Conti M
• Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.
  The Journal of clinical endocrinology and metabolism 2003 Shinozaki H, Butnev V, Tao YX, Ang KL, Conti M, Segaloff DL
• Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.
  The Journal of biological chemistry 2002 Conti M, Richter W, Mehats C, Livera G, Park JY, Jin C
• Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Paruthiyil S, eL Majdoubi M, Conti M, Weiner RI
• Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).
  The Journal of biological chemistry 2002 Richter W, Conti M
• Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Jin SL, Conti M
• Role of cyclic nucleotide signaling in oocyte maturation.
  Molecular and cellular endocrinology 2002 Conti M, Andersen CB, Richard F, Mehats C, Chun SY, Horner K, Jin C, Tsafriri A
• Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling.
  Trends in endocrinology and metabolism: TEM 2002 Mehats C, Andersen CB, Filopanti M, Jin SL, Conti M
• Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis.
  Mechanisms of development 1998 Bhatia-Dey N, Taira M, Conti MA, Nooruddin H, Adelstein RS
• Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.
  The Journal of biological chemistry 1998 Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y
• Phosphorylation of vertebrate nonmuscle myosin heavy chains by protein kinase C.
  Advances in second messenger and phosphoprotein research 1990 Adelstein RS, Peleg I, Ludowyke R, Kawamoto S, Conti MA
• Phosphorylation by cyclic adenosine 3':5'-monophosphate-dependent protein kinase regulates myosin light chain kinase.
  Federation proceedings 1980 Conti MA, Adelstein RS
• Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase.
  The Journal of biological chemistry 1978 Adelstein RS, Conti MA, Hathaway DR, Klee CB