Marc Steurer, MD, MHA
Professor
Anesthesia
School of Medicine

SFGH, as the only level 1 trauma hospital for San Francisco, is where the most severely injured trauma patients are treated. As the Director for Trauma Anesthesiology, I am engaged on multiple fronts to improve the individual treatment, systems-based care and the science of acute trauma care. I embrace the critical role of blood product and coagulation management and I have been introducing best practices and new techniques for this at a local and national level. Recognizing that this is a complex endeavor requiring multiple disciplines to work in synergy, I have taken on leadership, investigative and educational roles to fulfill my vision of delivering state of the art, multidisciplinary care to the severely injured patient.

Studies: PROPPR -Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as receiving 10 units or more RBCs within the first 24 hours). The goal of PROPPR is to improve the basis on which clinicians make decisions about transfusion protocols for massively bleeding patients.

PROPPR is a Resuscitation Outcomes Consortium (ROC) Protocol. ROC is funded by the National Heart, Lung, and Blood Institute (NHLBI), the United States' Department of Defense (DoD) and the Defence Research and Development Canada. PROPPR will be conducted as a Phase III trial at Level I Adult Trauma Centers in North America.

• Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial.
  Annals of emergency medicine 2018 Jones AR, Patel RP, Marques MB, Donnelly JP, Griffin RL, Pittet JF, Kerby JD, Stephens SW, DeSantis SM, Hess JR, Wang HE, PROPPR Study Group
• Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial.
  Journal of the American College of Surgeons 2018 Wei S, Gonzalez Rodriguez E, Chang R, Holcomb JB, Kao LS, Wade CE, PROPPR Study Group
• Endotracheal tube cuff pressure changes during manual cuff pressure control manoeuvres: An in-vitro assessment.
  Acta anaesthesiologica Scandinavica 2018 Aeppli N, Lindauer B, Steurer MP, Weiss M, Dullenkopf A
• Coagulation Monitoring of the Bleeding Trauma Patient.
  Essentials of Trauma Anesthesia 2017 Marc P. Steurer, Michael T. Ganter
• Post-discharge nausea and vomiting after total intravenous anaesthesia and standardised PONV prophylaxis for ambulatory surgery.
  Acta anaesthesiologica Scandinavica 2017 Bruderer U, Fisler A, Steurer MP, Steurer M, Dullenkopf A
• Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism.
  Journal of the American College of Surgeons 2017 McCully BH, Connelly CR, Fair KA, Holcomb JB, Fox EE, Wade CE, Bulger EM, Schreiber MA, PROPPR Study Group
• Factors influencing the level of patients using the internet to gather information before anaesthesia: a single-centre survey of 815 patients in Switzerland : The internet for patient information before anaesthesia.
  BMC anesthesiology 2017 Wieser T, Steurer MP, Steurer M, Dullenkopf A
• Midazolam plasma concentration after anesthesia premedication in clinical routine - an observational study : Midazolam plasma concentration after anesthesia premedication.
  BMC anesthesiology 2016 Steiner C, Steurer MP, Mueller D, Zueger M, Dullenkopf A
• Damage-control resuscitation and emergency laparotomy: Findings from the PROPPR study.
  The journal of trauma and acute care surgery 2016 Undurraga Perl VJ, Leroux B, Cook MR, Watson J, Fair K, Martin DT, Kerby JD, Williams C, Inaba K, Wade CE, Cotton BA, Del Junco DJ, Fox EE, Scalea TM, Tilley BC, Holcomb JB, Schreiber MA, PROPPR Study…
• Damage Control Resuscitation: More Than Just Transfusion Strategies.
  Current Anesthesiology Reports 2016 Catherine Heim, Marc P. Steurer, Karim Brohi
• Postoperative delirium assessed by post anesthesia care unit staff utilizing the Nursing Delirium Screening Scale: a prospective observational study of 1000 patients in a single Swiss institution.
  BMC anesthesiology 2015 Winter A, Steurer MP, Dullenkopf A
• Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial.
  Transfusion 2015 Novak DJ, Bai Y, Cooke RK, Marques MB, Fontaine MJ, Gottschall JL, Carey PM, Scanlan RM, Fiebig EW, Shulman IA, Nelson JM, Flax S, Duncan V, Daniel-Johnson JA, Callum JL, Holcomb JB, Fox EE, Baraniuk …
• Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
  JAMA 2015 Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, …
• Anesthetic management of patients undergoing bariatric surgery: two year experience in a single institution in Switzerland.
  BMC anesthesiology 2014 Lindauer B, Steurer MP, Müller MK, Dullenkopf A
• Trauma and Massive Blood Transfusions.
  Current Anesthesiology Reports 2014 Marc P. Steurer, Michael T. Ganter
• Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: design, rationale and implementation.
  Injury 2014 Baraniuk S, Tilley BC, del Junco DJ, Fox EE, van Belle G, Wade CE, Podbielski JM, Beeler AM, Hess JR, Bulger EM, Schreiber MA, Inaba K, Fabian TC, Kerby JD, Cohen MJ, Miller CN, Rizoli S, Scalea TM, O…
• Late pharmacologic conditioning with volatile anesthetics after cardiac surgery.
  Critical care (London, England) 2012 Steurer MP, Steurer MA, Baulig W, Piegeler T, Schläpfer M, Spahn DR, Falk V, Dreessen P, Theusinger OM, Schmid ER, Schwartz D, Neff TA, Beck-Schimmer B
• Anesthetic-induced improvement of the inflammatory response to one-lung ventilation.
  Anesthesiology 2009 De Conno E, Steurer MP, Wittlinger M, Zalunardo MP, Weder W, Schneiter D, Schimmer RC, Klaghofer R, Neff TA, Schmid ER, Spahn DR, Z'graggen BR, Urner M, Beck-Schimmer B
• The volatile anaesthetic sevoflurane attenuates lipopolysaccharide-induced injury in alveolar macrophages.
  Clinical and experimental immunology 2008 Steurer M, Schläpfer M, Steurer M, Z'graggen BR, Booy C, Reyes L, Spahn DR, Beck-Schimmer B
• Postconditioning with a volatile anaesthetic in alveolar epithelial cells in vitro.
  The European respiratory journal 2007 Yue T, Roth Z'graggen B, Blumenthal S, Neff SB, Reyes L, Booy C, Steurer M, Spahn DR, Neff TA, Schmid ER, Beck-Schimmer B
• Functional, electrophysiologic, and morphometric evaluation of nerve regeneration from coaptation on regenerated nerve fibers: experimental study in rabbits.
  Journal of reconstructive microsurgery 2004 Beer GM, Burg D, Zehnder A, Seifert B, Steurer M, Grimaldi H, Meyer VE