Marc Simon, MD, MS
Professor
Medicine
School of Medicine

RESEARCH INTERESTS: Dr. Simon’s research primary research focus involves developing new therapies for pulmonary hypertension and better understanding right-sided heart failure in pulmonary hypertension (PH). Notably, right-sided heart failure and PH are associated with poor outcomes and in particular have been noted to occur in another type of heart failure, called heart failure with preserved ejection fraction or HFpEF, in which the heart seems to function normally but causes difficulty breathing due to a stiffening of the heart and blood vessels.

• Refraction-corrected backscatter tensor imaging of excised porcine ventricular myocardium.
  JASA express letters 2022 Cormack JM, Simon MA, Kim K
• Anticoagulation in pulmonary arterial hypertension - association with mortality, healthcare utilization, and quality of life: The Pulmonary Hypertension Association Registry (PHAR).
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Garry JD, Kolaitis NA, Kronmal R, Thenappan T, Hemnes A, Grinnan D, Bull T, Chakinala MM, Horn E, Simon MA, De Marco T, Pulmonary Hypertension Association Registry Investigators
• HIV-associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry.
  American journal of respiratory and critical care medicine 2022 Kolaitis NA, Lammi M, Mazimba S, Feldman J, McConnell W, Sager JS, Raval AA, Simon MA, De Marco T
• Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension?
  American journal of respiratory and critical care medicine 2022 Vizza CD, Lang IM, Badagliacca R, Benza RL, Rosenkranz S, White RJ, Adir Y, Andreassen AK, Balasubramanian V, Bartolome S, Blanco I, Bourge RC, Carlsen J, Camacho REC, D'Alto M, Farber HW, Frantz RP, …
• Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations With Clinical Outcome Submitted for Publication.
  Journal of biomechanical engineering 2022 Xu J, Desmond EL, Wong TC, Neill CG, Simon MA, Brigham JC
• Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation
  JACC: Basic to Translational Science 2022 Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen P-S, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C,…
• Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.
  JACC. Basic to translational science 2022 Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, …
• An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension.
  Pulmonary circulation 2022 Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S
• The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study.
  Frontiers in medicine 2022 Sharifi Kia D, Shen Y, Bachman TN, Goncharova EA, Kim K, Simon MA
• An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension
  Pulmonary Circulation 2021 Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S
• A clinically applicable strategy to estimate the in vivo distribution of mechanical material properties of the right ventricular wall.
  International journal for numerical methods in biomedical engineering 2021 Xu J, Wong TC, Simon MA, Brigham JC
• Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations with Clinical Outcome Submitted for Publication
  J Biomech Eng 2021 Xu J, Desmond EL, Wong T C, Neill CG, Simon MA, Brigham JC
• A Clinically Applicable Strategy to Estimate the In Vivo Distribution of Mechanical Material Properties of the Right Ventricular Wall
  Int J Numer Meth Biomed Engng 2021 Xu J, Wong T C, Simon MA, Brigham JC
• Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.
  Journal of the American College of Cardiology 2021 Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN,…
• Role of Internal Jugular Venous Ultrasound in suspected or confirmed Heart Failure: A Systematic Review.
  Journal of cardiac failure 2021 Chaudhary R, Sukhi A, Simon MA, Villanueva FS, Pacella JJ
• Pulmonary Hypertension in the Context of Heart Failure With Preserved Ejection Fraction.
  Chest 2021 Inampudi C, Silverman D, Simon MA, Leary PJ, Sharma K, Houston BA, Vachiéry JL, Haddad F, Tedford RJ
• Gender Differences in Mortality After Left Ventricular Assist Device Implant: A Causal Mediation Analysis Approach.
  ASAIO journal (American Society for Artificial Internal Organs : 1992) 2021 Nayak A, Hu Y, Ko YA, Mehta A, Liu C, Pennington J, Xie R, Cowger J, Kirklin JK, Kormos RL, Simon MA, Morris AA
• A Pilot Study of Dimethyl Fumarate in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis.
  Journal of scleroderma and related disorders 2021 Kong K, Koontz D, Morse C, Roth E, Domsic RT, Simon MA, Stratton E, Buchholz C, Tobin-Finch K, Simms R, George MP, Hassoun PM, Farber H, Lafyatis R
• Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.
  Frontiers in physiology 2021 Sharifi Kia D, Kim K, Simon MA
• Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry.
  Pulmonary circulation 2021 DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani …
• Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
  Genome medicine 2021 Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, …
• Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting
  IEEE Open Journal of Engineering in Medicine and Biology 2021 Bachman TN, Kim K, Simon MA
• Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF: Results of the Randomized Placebo-Controlled HELP Trial.
  JACC. Heart failure 2021 Burkhoff D, Borlaug BA, Shah SJ, Zolty R, Tedford RJ, Thenappan T, Zamanian RT, Mazurek JA, Rich JD, Simon MA, Chung ES, Raza F, Majure DT, Lewis GD, Preston IR, Rich S
• Clinical Differences and Outcomes between Methamphetamine-associated and Idiopathic Pulmonary Arterial Hypertension in the Pulmonary Hypertension Association Registry.
  Annals of the American Thoracic Society 2021 Kolaitis NA, Zamanian RT, de Jesus Perez VA, Badesch DB, Benza RL, Burger CD, Chakinala MM, Elwing JM, Feldman J, Lammi MR, Mathai SC, McConnell JW, Presberg KW, Robinson JC, Sager J, Shlobin OA, …
• Creation and Validation of a Novel Sex-Specific Mortality Risk Score in LVAD Recipients.
  Journal of the American Heart Association 2021 Nayak A, Hu Y, Ko YA, Steinberg R, Das S, Mehta A, Liu C, Pennington J, Xie R, Kirklin JK, Kormos RL, Cowger J, Simon MA, Morris AA
• The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2021 Hasselberg NE, Kagiyama N, Soyama Y, Sugahara M, Goda A, Ryo-Koriyama K, Batel O, Chakinala M, Simon MA, Gorcsan J
• Prediction of Health-related Quality of Life and Hospitalization in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry.
  American journal of respiratory and critical care medicine 2021 Min J, Badesch D, Chakinala M, Elwing J, Frantz R, Horn E, Klinger J, Lammi M, Mazimba S, Sager J, Shlobin O, Simon M, Thenappan T, Grinnan D, Ventetuolo C, Al-Naamani N, PHAR Investigators
• Association between Preoperative Dynamic Measures of Vascular Load and Postoperative Hemodynamics in Patients with Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Thromboendarterectomy.
  Annals of the American Thoracic Society 2021 Contijoch F, Wong D, Igata S, Mizzell AM, Auger W, DeMaria AN, Blanchard D, Waheed A, Bachman TN, Simon MA, Pinsky MR, Madani M
• The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic?
  Transplantation 2021 Dew MA, Hollenberger JC, Obregon LL, Hickey GW, Sciortino CM, Lockard KL, Kunz NM, Mathier MA, Ramani RN, Kilic A, McNamara DM, Simon MA, Keebler ME, Kormos RL
• Right ventricular load and contractility in HIV-associated pulmonary hypertension.
  PloS one 2021 Rajaratnam A, Rehman S, Sharma P, Singh VK, Saul M, Vanderpool RR, Gladwin MT, Simon MA, Morris A
• An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload.
  Scientific reports 2021 Sharifi Kia D, Fortunato R, Maiti S, Simon MA, Kim K
• A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension.
  Therapeutic advances in respiratory disease 2021 Coons JC, Crisamore K, Adams S, Modany A, Simon MA, Zhao W, Shaik IH, Venkataramanan R, Empey PE
• Shape-based strategy for inverse estimation of soft tissue mechanical material properties from untagged medical imaging data
  J Eng Mech 2021 Xu J, Zupan R, Simon M, Wong T, Brigham JC
• Induced bioresistance via BNP detection for machine learning-based risk assessment.
  Biosensors & bioelectronics 2020 So S, Khalaf A, Yi X, Herring C, Zhang Y, Simon MA, Akcakaya M, Lee S, Yun M
• SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension.
  JACC. Basic to translational science 2020 Sun W, Tang Y, Tai YY, Handen A, Zhao J, Speyer G, Al Aaraj Y, Watson A, Romanelli ME, Sembrat J, Rojas M, Simon MA, Zhang Y, Lee J, Xiong Z, Dutta P, Vasamsetti SB, McNamara D, McVerry B, McTiernan …
• Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR).
  Annals of the American Thoracic Society 2020 Min J, Feng R, Badesch D, Berman-Rosenzweig E, Burger C, Chakinala M, De Marco T, Feldman J, Hemnes A, Horn EM, Lammi MR, Mathai S, McConnell JW, Presberg K, Robinson J, Sager J, Shlobin OA, Simon M, …
• Nationwide variability in the use of induction immunosuppression for adult heart transplantation.
  Journal of cardiac surgery 2020 Diaz-Castrillon CE, Seese L, Mathier MA, Keebler ME, Hickey GW, McNamara D, Simon MA, Horn E, Kilic A
• PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure.
  American heart journal 2020 Mentz RJ, Xu H, O'Brien EC, Thomas L, Alexy T, Gupta B, Vilaro J, Lala A, DeVore AD, Dhingra R, Briasoulis A, Simon MA, Stehlik J, Rodgers JE, Dunlay SM, Abshire M, Wells QS, Barringhaus KG, Eckman PM…
• Diversity, Equity, and Inclusiveness in Medicine and Cardiology: Next Steps for JAHA.
  Journal of the American Heart Association 2020 London B, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Simon MA, Sullivan LM, Weinberg JM
• Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care.
  Journal of the American Heart Association 2020 Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM
• J Am Heart Assoc
  Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care 2020 Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM
• United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics.
  Chest 2020 Badlam JB, Badesch DB, Austin ED, Benza RL, Chung WK, Farber HW, Feldkircher K, Frost AE, Poms AD, Lutz KA, Pauciulo MW, Yu C, Nichols WC, Elliott CG, USPHSR Investigators
• Metformin in Pulmonary Hypertension in Left Heart Disease.
  Frontiers in medicine 2020 Mulkareddy V, Simon MA
• Clearing Our Vision for Discerning Precapillary From Postcapillary Pulmonary Hypertension With the OPTICS Risk Score.
  Journal of the American Heart Association 2020 Simon MA, Vachiéry JL
• Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension.
  Journal of the American Heart Association 2020 Sharifi Kia D, Benza E, Bachman TN, Tushak C, Kim K, Simon MA
• The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients With Pulmonary Hypertension Associated with Heart Failure With Preserved Ejection Fraction.
  Journal of cardiac failure 2020 Bashline MJ, Bachman TN, Helbling NL, Nouraie M, Gladwin MT, Simon MA
• mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling?
  American journal of respiratory and critical care medicine 2020 Goncharova EA, Simon MA, Yuan JX
• Outcomes of Pulmonary Arterial Hypertension Are Improved in a Specialty Care Center.
  Chest 2020 Pi H, Kosanovich CM, Handen A, Tao M, Visina J, Vanspeybroeck G, Simon MA, Risbano MG, Desai A, Mathier MA, Rivera-Lebron BN, Nguyen Q, Kliner J, Nouraie M, Chan SY
• Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach.
  The International journal of artificial organs 2019 Bellavia D, Iacovoni A, Agnese V, Falletta C, Coronnello C, Pasta S, Novo G, di Gesaro G, Senni M, Maalouf J, Sciacca S, Pilato M, Simon M, Clemenza F, Gorcsan SJ
• Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension.
  Genome medicine 2019 Zhu N, Pauciulo MW, Welch CL, Lutz KA, Coleman AW, Gonzaga-Jauregui C, Wang J, Grimes JM, Martin LJ, He H, PAH Biobank Enrolling Centers’ Investigators, Shen Y, Chung WK, Nichols WC
• Use of Tricuspid Annular Plane Systolic Excursion/Pulmonary Artery Systolic Pressure As a Non-Invasive Method to Assess Right Ventricular-PA Coupling in Patients With Pulmonary Hypertension.
  Circulation. Cardiovascular imaging 2019 Bashline MJ, Simon MA
• Pulmonary Hypertension in Patients with Heart Failure with Preserved Ejection Fraction. Where to Draw the Line.
  American journal of respiratory and critical care medicine 2019 Simon MA, Maron BA
• Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients.
  PloS one 2019 Nguyen QL, Wang Y, Helbling N, Simon MA, Shiva S
• Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018.
  Annual review of biomedical engineering 2019 Simon MA, Bachman TN, Watson J, Baldwin JT, Wagner WR, Borovetz HS
• Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension.
  Pulmonary circulation 2019 Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY
• Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
  The Lancet. Respiratory medicine 2018 Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola…
• Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Macaca mulatta) Model of HIV Infection.
  Comparative medicine 2018 Tarantelli RA, Schweitzer F, Simon MA, Vanderpool RR, Christman I, Rayens E, Kling HM, Zullo T, Carney JP, Lopresti BJ, Bertero T, Chan SY, Norris KA
• Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction-Reply.
  JAMA cardiology 2018 Simon MA, Nouraie M, Gladwin MT
• Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.
  American journal of respiratory cell and molecular biology 2018 Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R
• Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.
  Trends in cardiovascular medicine 2018 Levine AR, Simon MA, Gladwin MT
• Right ventricle to pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation.
  Heart (British Cardiac Society) 2018 Sultan I, Cardounel A, Abdelkarim I, Kilic A, Althouse AD, Sharbaugh MS, Gupta A, Xu J, Fukui M, Simon MA, Schindler JT, Lee JS, Gleason TG, Cavalcante JL
• Bedside Ultrasound Assessment of Jugular Venous Compliance as a Potential Point-of-Care Method to Predict Acute Decompensated Heart Failure 30-Day Readmission.
  Journal of the American Heart Association 2018 Simon MA, Schnatz RG, Romeo JD, Pacella JJ
• Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction.
  JAMA cardiology 2018 Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA
• Impact of four times daily dosing of oral treprostinil on tolerability and daily dose achieved in pulmonary hypertension.
  Pulmonary circulation 2018 Coons JC, Bunner C, Ishizawar DC, Risbano MG, Rivera-Lebron B, Mathier MA, Chan SY, Simon MA
• Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension.
  APL bioengineering 2017 Avazmohammadi R, Hill M, Simon M, Sacks M
• Bosentan-based, treat-to-target therapy in patients with pulmonary arterial hypertension: results from the COMPASS-3 study.
  Pulmonary circulation 2017 Benza RL, Raina A, Gupta H, Murali S, Burden A, Zastrow MS, Park MH, Simon MA
• Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance.
  Journal of the American Heart Association 2017 Jang S, Vanderpool RR, Avazmohammadi R, Lapshin E, Bachman TN, Sacks M, Simon MA
• Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome.
  JAMA cardiology 2017 Schelbert EB, Fridman Y, Wong TC, Abu Daya H, Piehler KM, Kadakkal A, Miller CA, Ugander M, Maanja M, Kellman P, Shah DJ, Abebe KZ, Simon MA, Quarta G, Senni M, Butler J, Diez J, Redfield MM, …
• How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension.
  The European respiratory journal 2017 Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP
• Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity.
  JCI insight 2017 Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S
• Comprehensive Right-Sided Assessment for Transcatheter Aortic Valve Replacement Risk Stratification: Time for a Change.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2017 Cavalcante JL, Simon MA, Chan SY
• Chemokine receptor patterns and right heart failure in mechanical circulatory support.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2016 Nayak A, Neill C, Kormos RL, Lagazzi L, Halder I, McTiernan C, Larsen J, Inashvili A, Teuteberg J, Bachman TN, Hanley-Yanez K, McNamara DM, Simon MA
• Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction.
  JCI insight 2016 Simon MA, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J, Parsley EL, Gladwin MT
• Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing.
  PloS one 2016 Park DW, Sebastiani A, Yap CH, Simon MA, Kim K
• A novel constitutive model for passive right ventricular myocardium: evidence for myofiber-collagen fiber mechanical coupling.
  Biomechanics and modeling in mechanobiology 2016 Avazmohammadi R, Hill MR, Simon MA, Zhang W, Sacks MS
• Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.
  The Journal of clinical investigation 2016 Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, …
• Simple functional imaging of the right ventricle in pulmonary hypertension: Can right ventricular ejection fraction be improved?
  International journal of cardiology 2016 Vanderpool RR, Rischard F, Naeije R, Hunter K, Simon MA
• Update in Pulmonary Vascular Disease 2015.
  American journal of respiratory and critical care medicine 2016 Maron BA, Gladwin MT, Simon MA
• Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel.
  Journal of vascular and interventional radiology : JVIR 2016 Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, …
• The Prognostic Utility of a Simplified Biventricular Echocardiographic Index of Cardiac Remodeling in Patients with Pulmonary Hypertension.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2016 Goda A, Ryo K, Delgado-Montero A, Tayal B, Handa R, Simon MA, Gorcsan J
• Oral treprostinil for the treatment of pulmonary arterial hypertension in patients transitioned from parenteral or inhaled prostacyclins: case series and treatment protocol.
  Pulmonary circulation 2016 Coons JC, Miller T, Simon MA, Ishizawar DC, Mathier MA
• Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography.
  Circulation. Cardiovascular imaging 2015 Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J
• MY APPROACH to the patient with right ventricular failure.
  Trends in cardiovascular medicine 2015 Simon MA
• Methods for using 3-D ultrasound speckle tracking in biaxial mechanical testing of biological tissue samples.
  Ultrasound in medicine & biology 2015 Yap CH, Park DW, Dutta D, Simon M, Kim K
• Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.
  PloS one 2014 Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT
• Non-invasive screening for cardiac allograft vasculopathy: go small or go home?
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2014 Teuteberg JJ, Simon MA
• RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension.
  Heart (British Cardiac Society) 2014 Vanderpool RR, Pinsky MR, Naeije R, Deible C, Kosaraju V, Bunner C, Mathier MA, Lacomis J, Champion HC, Simon MA
• Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction.
  Annals of the American Thoracic Society 2014 Gomez-Arroyo J, Sandoval J, Simon MA, Dominguez-Cano E, Voelkel NF, Bogaard HJ
• Structural and mechanical adaptations of right ventricle free wall myocardium to pressure overload.
  Annals of biomedical engineering 2014 Hill MR, Simon MA, Valdez-Jasso D, Zhang W, Champion HC, Sacks MS
• A comparative analysis of global shape analysis methods for the assessment of the human right ventricle
  Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization 2014 Wu J, Simon MA, Brigham JC
• An implementation of independent component analysis for 3D statistical shape analysis
  Biomedical Signal Processing and Control 2014 Wu J, Brigham KG, Simon M, Brigham JC
• Biocompatibility Assessment of the CentriMag-Novalung Adult ECMO Circuit in a Model of Acute Pulmonary Hypertension.
  ASAIO journal (American Society for Artificial Internal Organs : 1992) 2014 Shankarraman V, Kocyildirim E, Olia SE, Kameneva MV, Dzadony RJ, Maul TM, Simon MA, Champion HC, Wagner WR, Bermudez CA
• Isolated right ventricular dysfunction in patients with human immunodeficiency virus.
  Journal of cardiac failure 2014 Simon MA, Lacomis CD, George MP, Kessinger C, Weinman R, McMahon D, Gladwin MT, Champion HC, Morris A
• Advances in Pulmonary Hypertension
  Nitric Oxide Therapeutics in Pulmonary Vascular Disease 2014 Simon MA
• First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease.
  Pulmonary circulation 2013 George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, …
• Matrix metalloproteinases in right ventricular failure.
  Nature reviews. Cardiology 2013 Simon MA
• Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission.
  European heart journal 2013 Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, Mulukutla SR, Simon MA, Shroff SG, Kuller LH, Schelbert EB
• A Novel Acquisition Technique to Utilize Swan-Ganz Catheter data as a Surrogate for High-fidelity Micromanometry within the Right Ventricle and Pulmonary Circuit.
  Cardiovascular engineering and technology 2013 Bachman TN, Bursic JJ, Simon MA, Champion HC
• Standing the test of time: exercise testing for heart failure prognosis in the beta-blocker era.
  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2013 Simon M, Soran O
• A new computational framework for anatomically consistent 3D statistical shape analysis with clinical imaging applications
  Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization 2013 Wu J, Wang Y, Simon MA, Sacks MS, Brigham JC
• Assessment and treatment of right ventricular failure.
  Nature reviews. Cardiology 2013 Simon MA
• Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography.
  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2013 Wong TC, Piehler K, Puntil KS, Moguillansky D, Meier CG, Lacomis JM, Kellman P, Cook SC, Schwartzman DS, Simon MA, Mulukutla SR, Schelbert EB
• Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension.
  American journal of respiratory cell and molecular biology 2012 George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA
• A new approach to kinematic feature extraction from the human right ventricle for classification of hypertension: a feasibility study.
  Physics in medicine and biology 2012 Wu J, Wang Y, Simon MA, Brigham JC
• Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality.
  Circulation 2012 Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, Shakesprere J, Kellman P, Shroff SG, Schwartzman DS, Mulukutla SR, Simon MA, Schelbert EB
• A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium.
  The Journal of physiology 2012 Valdez-Jasso D, Simon MA, Champion HC, Sacks MS
• Comparison of outcomes for patients with nonischemic cardiomyopathy taking intravenous inotropes versus those weaned from or never taking inotropes at cardiac resynchronization therapy.
  The American journal of cardiology 2012 Adelstein E, Bhattacharya S, Simon MA, Gorcsan J, Saba S
• Prognosis of right ventricular failure in patients with left ventricular assist device based on decision tree with SMOTE.
  IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society 2012 Wang Y, Simon M, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF
• Survival benefit of implantable cardioverter-defibrillators in left ventricular assist device-supported heart failure patients.
  Journal of cardiac failure 2011 Refaat MM, Tanaka T, Kormos RL, McNamara D, Teuteberg J, Winowich S, London B, Simon MA
• Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011 Wang Y, Simon MA, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF
• Impact of renal function before mechanical circulatory support on posttransplant renal outcomes.
  The Annals of thoracic surgery 2011 Singh M, Shullo M, Kormos RL, Lockard K, Zomak R, Simon MA, Bermudez C, Bhama J, McNamara D, Toyoda Y, Teuteberg JJ
• Left ventricular mechanical dyssynchrony in acute onset cardiomyopathy: association of its resolution with improvements in ventricular function.
  JACC. Cardiovascular imaging 2011 Tanaka H, Tanabe M, Simon MA, Starling RC, Markham D, Thohan V, Mather P, McNamara DM, Gorcsan J
• Right ventricular dysfunction and failure in chronic pressure overload.
  Cardiology research and practice 2011 Simon MA, Pinsky MR
• Role of cardiac resynchronization in end-stage heart failure patients requiring inotrope therapy.
  Journal of cardiac failure 2010 Bhattacharya S, Abebe K, Simon M, Saba S, Adelstein E
• Early adverse events as predictors of 1-year mortality during mechanical circulatory support.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010 Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL
• Right ventricular adaptation to pressure overload.
  Current opinion in critical care 2010 Simon MA
• Detection of elevated right atrial pressure using a simple bedside ultrasound measure.
  American heart journal 2010 Simon MA, Kliner DE, Girod JP, Moguillansky D, Villanueva FS, Pacella JJ
• Pulsatile left ventricular assist device support as a bridge to decision in patients with end-stage heart failure complicated by pulmonary hypertension.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010 Nair PK, Kormos RL, Teuteberg JJ, Mathier MA, Bermudez CA, Toyoda Y, Dew MA, Simon MA
• Left ventricular remodeling and myocardial recovery on mechanical circulatory support.
  Journal of cardiac failure 2009 Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan J, McNamara DM
• Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension.
  Congestive heart failure (Greenwich, Conn.) 2009 Simon MA, Rajagopalan N, Mathier MA, Shroff SG, Pinsky MR, López-Candales A
• Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation.
  The Annals of thoracic surgery 2009 Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Kay J, Siegenthaler MP, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL
• Identifying left ventricular dysfunction in pulmonary hypertension.
  Congestive heart failure (Greenwich, Conn.) 2009 Rajagopalan N, Simon MA, Edelman K, Mathier MA, López-Candales A
• Phenotyping the right ventricle in patients with pulmonary hypertension.
  Clinical and translational science 2009 Simon MA, Deible C, Mathier MA, Lacomis J, Goitein O, Shroff SG, Pinsky MR
• Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function.
  Pacing and clinical electrophysiology : PACE 2009 Johnson L, Simon MA, Pinsky MR, Shroff SG
• Noninvasive estimation of pulmonary vascular resistance in pulmonary hypertension.
  Echocardiography (Mount Kisco, N.Y.) 2008 Rajagopalan N, Simon MA, Suffoletto MS, Shah H, Edelman K, Mathier MA, López-Candales A
• Utility of right ventricular tissue Doppler imaging: correlation with right heart catheterization.
  Echocardiography (Mount Kisco, N.Y.) 2008 Rajagopalan N, Simon MA, Shah H, Mathier MA, López-Candales A
• Hemodynamic information and analysis of cardiac pumping
  Journal of Mechanics in Medicine and Biology 2008 Hung TK, Balasubramanian SR, Simon MA, Suffoletto M, Borovetz HS, Gorcsan J
• Current and future considerations in the use of mechanical circulatory support devices.
  Annual review of biomedical engineering 2008 Simon MA, Watson J, Baldwin JT, Wagner WR, Borovetz HS
• Identifying right ventricular dysfunction with tissue Doppler imaging in pulmonary hypertension.
  International journal of cardiology 2007 Rajagopalan N, Simon MA, Mathier MA, López-Candales A
• Right ventricular function following cardiac resynchronization therapy.
  The American journal of cardiology 2007 Rajagopalan N, Suffoletto MS, Tanabe M, Miske G, Thomas NC, Simon MA, Bazaz R, Gorcsan J, López-Candales A
• Correlation of tricuspid annular velocities with invasive hemodynamics in pulmonary hypertension.
  Congestive heart failure (Greenwich, Conn.) 2007 Rajagopalan N, Saxena N, Simon MA, Edelman K, Mathier MA, López-Candales A
• Right ventricular dyssynchrony in heart failure: a tissue Doppler imaging study.
  Journal of cardiac failure 2006 Rajagopalan N, Dohi K, Simon MA, Suffoletto M, Edelman K, Murali S, López-Candales A
• Differential exercise performance on ventricular assist device support.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005 Simon MA, Kormos RL, Gorcsan J, Dohi K, Winowich S, Stanford E, Carozza L, Murali S
• Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes.
  Circulation 2005 Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM
• Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers.
  Journal of cardiac failure 2004 Shakar SF, Lowes BD, Lindenfeld J, Zolty R, Simon M, Robertson AD, Bristow MR, Wolfel EE
• Inotropes in the beta-blocker era.
  Clinical cardiology 2000 Lowes BD, Simon MA, Tsvetkova TO, Bristow MR