Marc Levin, MD, PhD
Associate Professor
Ophthalmology
School of Medicine

Awards

Show all (5) Hide

• Editorial Board, Neurologic Ophthalmic and Otology, Current Treatment Option in Neurology, 2023
• Editorial Board, Clinical-Pathologic Case Studies, Journal of Neuro-ophthlamology, 2019
• Career Development Award, Research to Prevent Blindness, 2015
• Samuel J. Kimura Award for Outstanding Resident Teaching, UCSF Department of Ophthalmology, 2015
• Society of Heed Fellows, Heed Ophthalmic Foundation Fellow, 2012

Education & Training

Show all (6) Hide

• PhD Biophysics University of California, San Francisco 09/2026
• Neuro-ophthalmology (Fellowship) University of Pennsylvania 06/2013
• Ophthalmology (Residency) University of Pennsylvania 06/2012
• Internal Medicine (Internship) California Pacific Medical Center 06/2009
• MD Medicine University of California, San Francisco 06/2008
• BS Chemistry with Honors Stanford University 06/2001

Publications (46)

Top publication keywords:
Optic Nerve NeoplasmsBranchiomaOptic NerveNeuromyelitis OpticaTearsParaneoplastic Syndromes, OcularOcular Physiological PhenomenaConjunctivaAquaporinsAquaporin 4ScleraCystic Fibrosis Transmembrane Conductance RegulatorVisual AcuityOptic NeuritisDry Eye Syndromes

• Anterior segment ischemia following strabismus surgery in a young adult using gender-affirming estrogen hormone therapy.
  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2023 Al-Lozi A, Koo EB, Lambert SR, Levin MH, Velez FG, Do DV, Shue A
• Acute idiopathic blind spot enlargement syndrome (AIBSES) with retinal vasculitis.
  American journal of ophthalmology case reports 2022 Ishihara R, Khan Y, Halim MS, Akhavanrezayat A, Onghanseng N, Levin MH, Nguyen QD
• Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics.
  Annals of neurology 2022 Hinson SR, Honorat JA, Grund EM, Clarkson BD, Miske R, Scharf M, Zivelonghi C, Al-Lozi MT, Bucelli RC, Budhram A, Cho T, Choi E, Grell J, Lopez-Chiriboga AS, Levin M, Merati M, Montalvo M, Pittock SJ,…
• Diagnostic and Therapeutic Challenges.
  Retina (Philadelphia, Pa.) 2022 Gupta RR, Jiang S, Seamone ME, Iaboni DSM, Choudhry N, Levin MH
• Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport.
  Translational vision science & technology 2020 Pasricha ND, Smith AJ, Levin MH, Schallhorn JM, Verkman AS

Show all (41 more) Hide

• Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye.
  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2020 Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS
• Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis.
  Journal of neuroinflammation 2019 Cruz-Herranz A, Dietrich M, Hilla AM, Yiu HH, Levin MH, Hecker C, Issberner A, Hallenberger A, Cordano C, Lehmann-Horn K, Balk LJ, Aktas O, Ingwersen J, von Gall C, Hartung HP, Zamvil SS, Fischer D, …
• Demyelinating Optic Neuritis and its Subtypes.
  International ophthalmology clinics 2019 Levin MH
• Mixed cranial neuropathies due to occult perineural invasion of basal cell carcinoma.
  American journal of ophthalmology case reports 2018 Ashraf DC, Kalin-Hajdu E, Levin MH, Kersten RC
• Advances in Neuromyelitis Optica: Take Them to the Clinic.
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2017 Levin MH
• Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders.
  Investigative ophthalmology & visual science 2017 Felix CM, Lee S, Levin MH, Verkman AS
• Evidence-based recommendations for the management of acne fulminans and its variants.
  Journal of the American Academy of Dermatology 2017 Greywal T, Zaenglein AL, Baldwin HE, Bhatia N, Chernoff KA, Del Rosso JQ, Eichenfield LF, Levin MH, Leyden JJ, Thiboutot DM, Webster GF, Friedlander SF
• Epstein-Barr Virus Neuroretinitis in a Lung Transplant Patient.
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2017 Hsia YC, Chin-Hong PV, Levin MH
• Recalcitrant Orbital Pain in a 50-Year-Old Woman.
  JAMA ophthalmology 2017 Kalin-Hajdu E, Vagefi MR, Levin MH
• Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.
  Journal of medicinal chemistry 2017 Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS
• Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS
• Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G.
  Journal of neuroinflammation 2016 Felix CM, Levin MH, Verkman AS
• Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Flores AM, Casey SD, Felix CM, Phuan PW, Verkman AS, Levin MH
• CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.
  Cellular and molecular gastroenterology and hepatology 2016 Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS
• The severe side of the IgG4-related hypertrophic pachymeningitis disease spectrum.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Schubert RD, Wood M, Levin MH, Perry A, Gelfand JM
• Risk of optic pathway glioma in children with neurofibromatosis type 1 and optic nerve tortuosity or nerve sheath thickening.
  The British journal of ophthalmology 2015 Levin MH, Armstrong GT, Broad JH, Zimmerman R, Bilaniuk LT, Feygin T, Li Y, Liu GT, Fisher MJ
• Second chances.
  Survey of ophthalmology 2015 Nagia L, Doyle JI, Hackney JR, Vaphiades MS, Kline LB, Levin MH
• In search of a treatment for radiation-induced optic neuropathy.
  Current treatment options in neurology 2015 Indaram M, Ali FS, Levin MH
• Systemic inflammatory pseudotumor and myasthenia gravis.
  JAMA ophthalmology 2014 Levin MH, Gopal PP, Galetta SL
• Varicella zoster virus vasculopathy in suspected giant cell arteritis.
  Survey of ophthalmology 2014 Levin MH
• Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G.
  Journal of neuroinflammation 2014 Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS
• Incidence of visual improvement in uveitis cases with visual impairment caused by macular edema.
  Ophthalmology 2013 Levin MH, Pistilli M, Daniel E, Gangaputra SS, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Kempen JH, Systemic Immunosuppressive Therapy for Eye Diseases …
• Optic neuritis in neuromyelitis optica.
  Progress in retinal and eye research 2013 Levin MH, Bennett JL, Verkman AS
• Orbital congestion complicating treatment of cerebral vascular anomalies.
  World neurosurgery 2013 Levin MH, Moss HE, Pineles SL, Bagley LJ, Heuer GG, Zager EL, Balcer LJ, Galetta SL, Vagefi MR
• Optic nerve biopsy in the management of progressive optic neuropathy.
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2012 Levin MH, Ney JJ, Venneti S, Moster ML, Balcer LJ, Volpe NJ, Gausas RE, Liu GT, Vagefi MR, Galetta SL
• A lack of delayed intraocular pressure elevation in patients treated with intravitreal injection of bevacizumab and ranibizumab.
  Retina (Philadelphia, Pa.) 2012 Wehrli SJ, Tawse K, Levin MH, Zaidi A, Pistilli M, Brucker AJ
• Intra-arterial chemotherapy for advanced retinoblastoma: is the time right for a prospective clinical trial?
  Archives of ophthalmology (Chicago, Ill. : 1960) 2011 Levin MH, Gombos DS, O'Brien JM
• Adult ovarian retinoblastoma genomic profile.
  JAMA 2011 Levin MH, O'Brien JM
• Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity.
  Journal of the neurological sciences 2010 Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena SC, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ
• Resident-performed prophylactic retinopexy and the risk of retinal detachment.
  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 2009 Levin M, Naseri A, Stewart JM
• In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency.
  Investigative ophthalmology & visual science 2009 Ruiz-Ederra J, Levin MH, Verkman AS
• Functions of aquaporins in the eye.
  Progress in retinal and eye research 2008 Verkman AS, Ruiz-Ederra J, Levin MH
• Comparative transport efficiencies of urea analogues through urea transporter UT-B.
  Biochimica et biophysica acta 2007 Zhao D, Sonawane ND, Levin MH, Yang B
• Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Levin MH, de la Fuente R, Verkman AS
• Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization.
  Investigative ophthalmology & visual science 2006 Levin MH, Verkman AS
• Aquaporins and CFTR in ocular epithelial fluid transport.
  The Journal of membrane biology 2006 Levin MH, Verkman AS
• Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins.
  The Journal of biological chemistry 2006 Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS
• Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model.
  Investigative ophthalmology & visual science 2006 Levin MH, Kim JK, Hu J, Verkman AS
• CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences.
  Investigative ophthalmology & visual science 2005 Levin MH, Verkman AS
• Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva.
  Investigative ophthalmology & visual science 2004 Levin MH, Verkman AS
• Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus.
  The Journal of biological chemistry 2001 Levin MH, Haggie PM, Vetrivel L, Verkman AS