Manu Hegde, MD, PhD
Associate Professor
Neurology
School of Medicine

Hegde is experienced at guiding patients who are interested in pursuing surgery for epilepsy, including looking at the option of implantable neurostimulation devices. Committed to helping patients improve their quality of life, he takes a holistic approach that aims to do more than just control seizures.

Hegde's research focuses on finding epilepsy biomarkers, factors that might predict the effectiveness of treatment before patients actually have a seizure. He is a principal investigator for the Human Epilepsy Project, a large multicenter observational study of people with epilepsy. His other research interests include the links between epilepsy and autoimmune disease, improving mental health care for people with seizures and improving patient safety.

Hegde earned his medical degree and a doctorate in neuroscience at the University of California, Davis. He completed a residency in neurology at UCSF, serving as a chief neurology resident for Moffitt Hospital in his final year. He then completed a fellowship in epilepsy and clinical neurophysiology at UCSF before joining the faculty. He is a fellow of the American Epilepsy Society and a member of the American Academy of Neurology.

• Differential sensitivity of structural, diffusion, and resting-state functional MRI for detecting brain alterations and verbal memory impairment in temporal lobe epilepsy.
  Epilepsia 2019 Chang YA, Marshall A, Bahrami N, Mathur K, Javadi SS, Reyes A, Hegde M, Shih JJ, Paul BM, Hagler DJ, McDonald CR
• Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities.
  Neurology 2019 Reyes A, Kaestner E, Bahrami N, Balachandra A, Hegde M, Paul BM, Hermann B, McDonald CR
• Beyond depression: The impact of executive functioning on quality of life in patients with temporal lobe epilepsy.
  Epilepsy research 2018 Ehrlich T, Reyes A, Paul BM, Uttarwar V, Hartman S, Mathur K, Chang YA, Hegde M, Shih JJ, McDonald CR
• Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy.
  Annals of neurology 2018 Winawer MR, Griffin NG, Samanamud J, Baugh EH, Rathakrishnan D, Ramalingam S, Zagzag D, Schevon CA, Dugan P, Hegde M, Sheth SA, McKhann GM, Doyle WK, Grant GA, Porter BE, Mikati MA, Muh CR, Malone CD,…
• Staff Response Times in the Epilepsy Monitoring Unit: A Study of Diurnal/Nocturnal Variability.
  The Neurodiagnostic journal 2017 Witek N, Cornes S, Hegde M
• Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection.
  Neurology 2014 Young AC, Yiannoutsos CT, Hegde M, Lee E, Peterson J, Walter R, Price RW, Meyerhoff DJ, Spudich S
• The search for circulating epilepsy biomarkers.
  Biomarkers in medicine 2014 Hegde M, Lowenstein DH
• Diagnostic yield of electroencephalography in the medical and surgical intensive care unit.
  Neurocritical care 2013 Kamel H, Betjemann JP, Navi BB, Hegde M, Meisel K, Douglas VC, Josephson SA
• Seizures and epileptiform activity in the early stages of Alzheimer disease.
  JAMA neurology 2013 Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L
• Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.
  Epilepsy & behavior : E&B 2012 Hegde M, Santos-Sanchez C, Hess CP, Kabir AA, Garcia PA
• Detection of atrial fibrillation after stroke and the risk of recurrent stroke.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2011 Kamel H, Johnson DR, Hegde M, Go AS, Sidney S, Sorel M, Hills NK, Johnston SC
• Cost-effectiveness of outpatient cardiac monitoring to detect atrial fibrillation after ischemic stroke.
  Stroke 2010 Kamel H, Hegde M, Johnson DR, Gage BF, Johnston SC
• Electroconvulsive therapy for refractory status epilepticus: a case series.
  Neurocritical care 2010 Kamel H, Cornes SB, Hegde M, Hall SE, Josephson SA