Mandar Aras, MD, PhD
Assistant Professor
Medicine
School of Medicine

In addition to my expertise in heart failure and cardiomyopathies, I developed a specific focus in cardio-oncology (management of cardiovascular issues in cancer patients).

My research interests focus on cardiac amyloidosis and in understanding risk predictors and outcomes of cancer patients with heart disease.

• Daratumumab Plus Bortezomib and Dexamethasone in Newly Diagnosed Systemic Light Chain Amyloidosis.
  Current problems in cancer 2023 Kennedy VE, Natsuhara K, Maringanti SA, Shah ND, Arora S, Wolf J, Martin TG, Aras MA, Chung A, Wong SW
• Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning.
  Journal of cardiac failure 2023 Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH
• Post-transplant ejection fraction and renal failure in cardiac transplant recipients: An analysis of the OPTN database.
  Clinical transplantation 2022 Lai M, Aras MA, Park M
• Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design.
  Respiratory research 2022 Benza RL, Franco V, Aras MA, Spikes L, Grinnan D, Satler C
• Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis.
  JAMA network open 2022 Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
• Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry.
  European journal of cancer (Oxford, England : 1990) 2022 Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Itzhaki …
• Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report.
  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2021 Banerjee R, Lo M, Klein L, Aras M, Logan AC
• Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review.
  JAMA cardiology 2021 Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, …
• Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis.
  Circulation 2021 Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehman L, Ederhy S, …
• Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis.
  Current Cardiovascular Risk Reports 2021 Gabriela Spencer-Bonilla, Joyce N. Njoroge, Keon Pearson, Ronald M. Witteles, Mandar A. Aras, Kevin M. Alexander
• Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors.
  Clinical science (London, England : 1979) 2021 Baik AH, Tsai KK, Oh DY, Aras MA
• Predictors of steroid-refractory immune checkpoint inhibitor associated myocarditis.
  European Heart Journal 2020 J Power, W Meijers, C Fenioux, Y Tamura, A Asnani, J Alexandre, J Cautela, M Aras, L Lehmann, M Perl, A Narezkina, L Gilstrap, S Ederhy, J Moslehi, J Salem
• Inflammatory Biomarkers to Detect Immune Checkpoint Inhibitor-Associated Cardiotoxicity in Lung Cancer Patients: Ready for Prime Time?
  JACC. CardioOncology 2020 Aras MA, Power JR, Moslehi JJ
• Echo-Strain to Check Up on Checkpoint Inhibitors.
  Journal of the American College of Cardiology 2020 Abraham TP, Aras MA
• Heart-lung transplantation: A viable option for connective tissue diseases.
  Clinical transplantation 2020 Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T
• Noninvasive estimation of pulmonary vascular resistance improves portopulmonary hypertension screening in liver transplant candidates.
  Clinical transplantation 2019 DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T
• Pulmonary Hypertension Due to Left Heart Disease: an Update.
  Current cardiology reports 2019 Aras MA, Psotka MA, De Marco T
• Fully Automated Echocardiogram Interpretation in Clinical Practice.
  Circulation 2018 Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC
• Lung ultrasound: a 'B-line' to the prediction of decompensated heart failure.
  European heart journal 2016 Aras MA, Teerlink JR
• Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons.
  Antioxidants & redox signaling 2011 Aras MA, Aizenman E
• Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia.
  The European journal of neuroscience 2009 Aras MA, Saadi RA, Aizenman E
• Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling.
  The Journal of physiology 2009 Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E
• Intracellular zinc inhibits KCC2 transporter activity.
  Nature neuroscience 2009 Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E
• Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.
  Journal of neurochemistry 2009 Aras MA, Hara H, Hartnett KA, Kandler K, Aizenman E
• Assessment of cell viability in primary neuronal cultures.
  Current protocols in neuroscience 2008 Aras MA, Hartnett KA, Aizenman E
• Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis.
  Neuropathology : official journal of the Japanese Society of Neuropathology 2005 Chalovich EM, Koike MA, Aras MA, Murphey-Corb M, Wiley CA, Jordan-Sciutto KL
• Obligatory role of ASK1 in the apoptotic surge of K+ currents.
  Neuroscience letters 2005 Aras MA, Aizenman E