Mallar Bhattacharya, MD
Associate Professor
Medicine
School of Medicine

These interactions drive the development of scarring and progressive loss of lung function and therefore represent an opportunity for discovery of novel therapies.

• IL10 trains macrophage profibrotic function after lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2022 Bhattacharyya A, Boostanpour K, Bouzidi M, Magee L, Chen TY, Wolters R, Torre P, Pillai SK, Bhattacharya M
• Molecular programs of fibrotic change in aging human lung.
  Nature communications 2021 Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, …
• Invariant Natural Killer T cells coordinate removal of senescent cells.
  Med (New York, N.Y.) 2021 Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A
• Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.
  Cell reports 2020 Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M
• Fibroblast Gap-closure Assay-Microscopy-based in vitro Assay Measuring the Migration of Murine Fibroblasts.
  Bio-protocol 2019 Looney AP, Bhattacharya M
• Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage.
  Nature immunology 2019 Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M
• Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.
  JCI insight 2018 Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M
• Could a coffee a day keep the inflammasome away?
  Science translational medicine 2017 Bhattacharya M
• Mesenchymal metamorphosis.
  Science translational medicine 2016 Bhattacharya M
• Macrophages build a wall and the host pays for it.
  Science Translational Medicine 2016 Mallar Bhattacharya
• Stiff discipline for cells in pulmonary hypertension.
  Science Translational Medicine 2016 Mallar Bhattacharya
• Airway architect Adam33 in asthma.
  Science Translational Medicine 2016 Mallar Bhattacharya
• The gut takes a “Toll” on the lung.
  Science Translational Medicine 2016 Mallar Bhattacharya
• Unwanted guests: Bacterial microbiome in COPD.
  Science Translational Medicine 2016 Mallar Bhattacharya
• H5N1 stems the alveolar tide: MSCs to the rescue!.
  Science Translational Medicine 2016 Mallar Bhattacharya
• Negative-Pressure Pulmonary Edema.
  Chest 2016 Bhattacharya M, Kallet RH, Ware LB, Matthay MA
• IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.
  The Journal of clinical investigation 2014 Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D
• Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5.
  Critical care medicine 2013 Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D
• IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
  American journal of physiology. Lung cellular and molecular physiology 2012 Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D
• Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.
  American journal of respiratory and critical care medicine 2012 Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D
• CHAPTER 188 Acute Respiratory Distress Syndrome and the Kidney: Lung and Kidney Crosstalk.
  2009 Mallar Bhattacharya, Michael A. Matthay, Hamid Rabb
• Case 81.
  Radiology 2004 Mallar Bhattacharya, Benjamin M. Yeh, Aliya Qayyum, Fergus V. Coakley
• Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.
  Journal of cell science 2004 Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG