Ma Somsouk, MD, MAS
Professor
Medicine
School of Medicine

2. Translational program in GI mucosal biology. The gastrointestinal compartment is a window to studies of viral reservoirs and their impact on persistence, immune activation, and chronic disease (e.g., HIV, COVID-19). Approaches employed: organoid models, isolation of epithelial cells and lymphocytes, single-cell, spatial transcriptomic analysis, microbial profiling, and blood-based profiling.

• Barriers to Timely Colonoscopy Completion Following Abnormal Fecal Immunochemical Test Results in a Safety-net System.
  Journal of general internal medicine 2026 Avilez L, Wong J, Olazo K, Patel S, Pasick R, Somsouk M, Sarkar U
• Influence of Comorbidities on Colorectal Cancer Screening Participation and Mortality.
  American journal of medicine open 2025 Corren R, La S, Corona E, Martinez D, Sarkar U, Gregory B, Ladabaum U, Somsouk M
• CLINICAL DIAGNOSIS CODES IDENTIFY PATIENTS UNLIKELY TO RECEIVE ORDERS FOR FECAL IMMUNOCHEMICAL TESTS.
  medRxiv : the preprint server for health sciences 2025 Li AT, Burns S, Martinez D, Wang P, Aggarwal S, Potter M, Sarkar U, Somsouk M
• Multilevel intervention for follow-up of abnormal FIT in the safety-net: IMProving Adherence to Colonoscopy through Teams and Technology (IMPACTT).
  Contemporary clinical trials 2025 Wang K, Wong J, Avilez L, Olazo K, Olanrewaju S, McCulloch CE, Pasick R, Patel S, Somsouk M, Sarkar U
• Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.
  Science translational medicine 2024 Peluso MJ, Ryder D, Flavell RR, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez AE, Buitrago M, Tai V, Shrestha U, Lu S, …
• Colorectal Cancer Screening: A Multicomponent Intervention to Increase Uptake in Patients Aged 45-49.
  Journal of the American Board of Family Medicine : JABFM 2024 McClellan SP, Patel S, Uy-Smith E, Gregory B, Neuhaus JM, Potter MB, Somsouk M
• Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data.
  Anesthesiology 2024 Colquhoun DA, Somsouk M, Chen CL
• The effect of mailed outreach on FIT completion among patients aged 45-50 in a safety net healthcare system.
  Cancer causes & control : CCC 2024 McClellan SP, Khan T, Rafferty H, Wong J, La S, Patel S, Somsouk M
• Electronic Coding for Abnormal Fecal Immunochemical Test Is Associated With Increased Colonoscopy Completion.
  The American journal of gastroenterology 2024 Burns S, Griffith M, Patel S, Sarkar U, Somsouk M
• Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center.
  Inflammatory bowel diseases 2024 Odufalu FD, Sewell JL, Rudrapatna V, Somsouk M, Mahadevan U
• Intestinal Metaplasia Associated with Symptoms of Dyspepsia.
  Research square 2023 Viramontes O, Martinez D, Somsouk M
• Delivering High-Quality, Efficient Gastroenterology Care to Vulnerable and Underserved Populations: Special Considerations and Possible Solutions.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023 Patel S, Sewell JL, Bhuket T, Somsouk M
• Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
  medRxiv : the preprint server for health sciences 2023 Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, …
• Implementation of a novel program to support colorectal cancer screening in a community health center consortium before and after the onset of COVID-19: a qualitative study of stakeholders' perspectives.
  Implementation science communications 2023 Santiago-Rodríguez EJ, Hoeft KS, Lugtu K, McGowen M, Ofman D, Adler J, Somsouk M, Potter MB
• The human microbiome and gut-liver axis in people living with HIV.
  Current HIV/AIDS reports 2023 Duarte MJ, Tien PC, Somsouk M, Price JC
• Effect of Mailed Fecal Immunochemical Test Outreach for Patients Newly Eligible for Colorectal Cancer Screening.
  Digestive diseases and sciences 2023 Burns S, Wang J, Somsouk M
• Neighborhood socioeconomic status and the effectiveness of colorectal cancer screening outreach with mailed fecal immunochemical tests within a safety net healthcare system in San Francisco, CA: A subgroup analysis of a randomized controlled trial.
  Preventive medicine 2022 McClellan SP, Canchola AJ, Potter MB, Gomez SL, Somsouk M
• Durability of FIT Screening After Cessation of a Screening Outreach Intervention.
  Digestive diseases and sciences 2022 Burns S, Somsouk M
• LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients.
  Biomarkers in medicine 2022 Altinbas A, Holmes JA, Salloum S, Lidofsky A, Alatrakchi N, Somsouk M, Hunt P, Deeks S, Chew KW, Lauer G, Kruger A, Lin W, Chung RT
• Extent of Follow-Up on Abnormal Cancer Screening in Multiple California Public Hospital Systems: A Retrospective Review.
  Journal of general internal medicine 2022 Khoong EC, Rivadeneira NA, Pacca L, Schillinger D, Lown D, Babaria P, Gupta N, Pramanik R, Tran H, Whitezell T, Somsouk M, Sarkar U
• Determinants of Colorectal Cancer Screening among South Asian Americans.
  Journal of Asian health 2022 Mukherjea A, Shariff-Marco S, Yang J, Tseng W, Palaniappan L, Li J, Ivey SL, Somsouk M, Gomez SL
• From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center.
  Current epidemiology reports 2022 Hiatt RA, Sibley A, Venkatesh B, Cheng J, Dixit N, Fox R, Ling P, Nguyen T, Oh D, Palmer NR, Pasick RJ, Potter MB, Somsouk M, Vargas RA, Vijayaraghavan M, Ashworth A
• Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host‒Microbe Associations.
  JID innovations : skin science from molecules to population health 2022 Chang HW, Yan D, Singh R, Bui A, Lee K, Truong A, Milush JM, Somsouk M, Liao W
• A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems.
  Journal of patient safety 2022 Sharma AE, Lyson HC, Cherian R, Somsouk M, Schillinger D, Sarkar U
• Asian American/Pacific Islander and Hispanic Ethnic Enclaves, Neighborhood Socioeconomic Status, and Hepatocellular Carcinoma Incidence in California: An Update.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Sangaramoorthy M, Yang J, Guan A, DeRouen MC, Tana MM, Somsouk M, Thompson CA, Gibbons J, Ho C, Chu JN, Cheng I, Gomez SL, Shariff-Marco S
• Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response.
  The Journal of infectious diseases 2021 Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ
• Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
  Cell reports. Medicine 2021 Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh …
• Increased Colorectal Cancer Screening Sustained with Mailed Fecal Immunochemical Test Outreach.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2021 Lee B, Keyes E, Rachocki C, Grimes B, Chen E, Vittinghoff E, Ladabaum U, Somsouk M
• LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis.
  Scandinavian journal of gastroenterology 2021 Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR
• A Methodology to Generate Longitudinally Updated Acute-On-Chronic Liver Failure Prognostication Scores From Electronic Health Record Data.
  Hepatology communications 2021 Ge J, Najafi N, Zhao W, Somsouk M, Fang M, Lai JC
• Selection of patients for large mailed fecal immunochemical test colorectal cancer screening outreach programs: A systematic review.
  Journal of medical screening 2021 Wang A, Lee B, Patel S, Whitaker E, Issaka RB, Somsouk M
• Colorectal Cancer Screening and COVID-19.
  The American journal of gastroenterology 2021 Patel S, Issaka RB, Chen E, Somsouk M
• Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
  Journal of virology 2020 Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S
• Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.
  AIDS (London, England) 2020 Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA
• Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.
  eLife 2020 Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA,…
• Distinct viral reservoirs in individuals with spontaneous control of HIV-1.
  Nature 2020 Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo …
• Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial.
  Journal of general internal medicine 2020 Lee B, Patel S, Rachocki C, Issaka R, Vittinghoff E, Shapiro JA, Ladabaum U, Somsouk M
• Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.
  AIDS (London, England) 2020 SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC
• Obesity and metabolic outcomes in a safety-net health system.
  Biodemography and social biology 2020 Huynh MP, Bradshaw PT, Tana MM, Rachocki C, Somsouk M
• Colorectal Cancer Screening and Prevention in the COVID-19 Era.
  JAMA health forum 2020 Issaka RB, Somsouk M
• Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.
  Journal of acquired immune deficiency syndromes (1999) 2020 Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM
• Standardized Workflows Improve Colonoscopy Follow-Up After Abnormal Fecal Immunochemical Tests in a Safety-Net System.
  Digestive diseases and sciences 2020 Issaka RB, Rachocki C, Huynh MP, Chen E, Somsouk M
• Effectiveness and Cost of Organized Outreach for Colorectal Cancer Screening: A Randomized, Controlled Trial.
  Journal of the National Cancer Institute 2020 Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U
• Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.
  The Journal of infectious diseases 2020 Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU…
• HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.
  Nature immunology 2020 Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM,…
• Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.
  Journal of virology 2020 Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, …
• Disparities in Hepatocellular Carcinoma Incidence in California: An Update.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019 Sangaramoorthy M, Yang J, DeRouen MC, Ho C, Somsouk M, Tana MM, Thompson CA, Gibbons J, Gomez SL, Shariff-Marco S
• TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.
  Nature communications 2019 Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR
• Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study.
  Digestive diseases and sciences 2019 Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T, Kassam Z, Beck K, Lewin S, Ma A, Somsouk M, Lynch SV, El-Nachef N
• HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration.
  Current HIV/AIDS reports 2019 Vujkovic-Cvijin I, Somsouk M
• CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
  Pathogens & immunity 2019 Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ
• Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART.
  Pathogens & immunity 2019 Utay NS, Somasunderam A, Hinkle JE, Petschow BW, Detzel CJ, Somsouk M, Fichtenbaum CJ, Weaver EM, Shaw AL, Asmuth DM
• Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile.
  United European gastroenterology journal 2019 Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, LaMere B, Terdiman J, Ma A, Somsouk M, Lynch S, El-Nachef N
• Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.
  PLoS pathogens 2019 Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR
• Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice.
  Viruses 2019 Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA
• Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018 Wang A, Rachocki C, Shapiro JA, Issaka RB, Somsouk M
• Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.
  PLoS pathogens 2018 Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA
• Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review.
  Preventive medicine 2018 Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M
• Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection.
  The Journal of infectious diseases 2018 Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N
• Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S
• Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.
  Autoimmunity 2018 Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM
• Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018 Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M
• A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
  PLoS pathogens 2018 Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM
• Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.
  PLoS pathogens 2018 Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, …
• Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans.
  The American journal of gastroenterology 2018 Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM
• Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.
  Journal of immunology (Baltimore, Md. : 1950) 2018 Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL
• Missed Opportunities in Colorectal Cancer Prevention in Patients With Inadequate Bowel Preparations.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018 Issaka RB, Singh MH, Rachocki C, Day LW, Horton C, Somsouk M
• Colorectal Cancer Screening Among South Asians: Focus Group Findings on Attitudes, Knowledge, Barriers and Facilitators.
  Journal of health care for the poor and underserved 2018 Ivey SL, Mukherjea A, Patel A, Kapoor N, Rau S, Kazi E, Bhatia J, Somsouk M, Tseng W
• The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer.
  Health affairs (Project Hope) 2018 Hiatt RA, Sibley A, Fejerman L, Glantz S, Nguyen T, Pasick R, Palmer N, Perkins A, Potter MB, Somsouk M, Vargas RA, van 't Veer LJ, Ashworth A
• Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications.
  Gastrointestinal endoscopy 2017 Lin D, Soetikno RM, McQuaid K, Pham C, Doan G, Mou S, Shergill AK, Somsouk M, Rouse RV, Kaltenbach T
• Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection.
  Mucosal immunology 2017 Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL
• An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.
  AIDS research and human retroviruses 2017 Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S
• Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea.
  HIV clinical trials 2017 Asmuth DM, Hinkle JE, LaMarca A, Fichtenbaum CJ, Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM
• A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.
  Pathogens & immunity 2017 Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, …
• Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection.
  Pathogens & immunity 2017 Seang S, Somasunderam A, Nigalye M, Somsouk M, Schacker TW, Sanchez JL, Hunt PW, Utay NS, Lake JE
• Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals.
  Gut microbes 2017 Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M
• Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy.
  The Journal of infectious diseases 2017 Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR
• Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction.
  PLoS pathogens 2017 Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA
• Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells.
  PLoS pathogens 2017 Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, …
• Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis.
  Gastrointestinal endoscopy 2017 Kouanda AM, Somsouk M, Sewell JL, Day LW
• Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System.
  The American journal of gastroenterology 2016 Issaka RB, Singh MH, Oshima SM, Laleau VJ, Rachocki CD, Chen EH, Day LW, Sarkar U, Somsouk M
• Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.
  Mucosal immunology 2016 Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL
• Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection.
  Mucosal immunology 2016 Paquin-Proulx D, Ching C, Vujkovic-Cvijin I, Fadrosh D, Loh L, Huang Y, Somsouk M, Lynch SV, Hunt PW, Nixon DF, SenGupta D
• Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer.
  Gastrointestinal endoscopy 2015 Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M
• Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
  The Journal of infectious diseases 2015 von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, …
• Gut epithelial barrier and systemic inflammation during chronic HIV infection.
  AIDS (London, England) 2015 Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW
• The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.
  PloS one 2014 Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW
• Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.
  The Journal of infectious diseases 2014 Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW
• The CD8⁺ memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection.
  Journal of virology 2014 Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Somsouk M, Hunt PW, Deeks SG, Nixon DF, SenGupta D
• HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
  PLoS pathogens 2014 Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, …
• Esophageal varices on computed tomography and subsequent variceal hemorrhage.
  Abdominal imaging 2014 Somsouk M, To'o K, Ali M, Vittinghoff E, Yeh BM, Yee J, Monto A, Inadomi JM, Aslam R
• Challenges and possible solutions to colorectal cancer screening for the underserved.
  Journal of the National Cancer Institute 2014 Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME
• Non-physician performance of lower and upper endoscopy: a systematic review and meta-analysis.
  Endoscopy 2014 Day LW, Siao D, Inadomi JM, Somsouk M
• Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis.
  Endoscopy international open 2014 Day LW, Lin L, Somsouk M
• Discordance between peripheral and colonic markers of inflammation during suppressive ART.
  Journal of acquired immune deficiency syndromes (1999) 2014 Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM
• A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.
  AIDS (London, England) 2014 Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H
• Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply.
  Alimentary pharmacology & therapeutics 2013 Sewell JL, Somsouk M, Shah SC, Day LW
• The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG…
• Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.
  PLoS pathogens 2013 Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, …
• Helicobacter pylori: evidence-based review with a focus on immigrant populations.
  Journal of general internal medicine 2013 Siao D, Somsouk M
• Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.
  AIDS (London, England) 2013 Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA
• Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth.
  Alimentary pharmacology & therapeutics 2013 Shah SC, Day LW, Somsouk M, Sewell JL
• Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.
  Science translational medicine 2013 Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM
• The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
  Blood 2013 Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, …
• Late presentation of colorectal cancer in a vulnerable population.
  The American journal of gastroenterology 2013 Ho C, Kornfield R, Vittinghoff E, Inadomi J, Yee H, Somsouk M
• Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
  PLoS pathogens 2013 Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'…
• Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.
  Blood 2012 Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK
• Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.
  AIDS research and human retroviruses 2012 Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL
• Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies.
  Archives of internal medicine 2012 Inadomi JM, Vijan S, Janz NK, Fagerlin A, Thomas JP, Lin YV, Muñoz R, Lau C, Somsouk M, El-Nachef N, Hayward RA
• Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis.
  Gastrointestinal endoscopy 2011 Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M
• Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test.
  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2011 Day LW, Cello JP, Somsouk M, Inadomi JM
• Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
  Journal of virology 2011 Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL
• Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2011 Somsouk M, Kornfield R, Vittinghoff E, Inadomi JM, Biggins SW
• Ascites improves upon [corrected] serum sodium plus [corrected] model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease.
  Alimentary pharmacology & therapeutics 2009 Somsouk M, Guy J, Biggins SW, Vittinghoff E, Kohn MA, Inadomi JM
• New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009 Guy J, Somsouk M, Shiboski S, Kerlan R, Inadomi JM, Biggins SW
• Understanding liver health using the National Center for Health Statistics.
  Digestive diseases and sciences 2009 Somsouk M, Yee HF, Biggins SW
• A cost-utility analysis of ablative therapy for Barrett's esophagus.
  Gastroenterology 2009 Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ
• Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008 Somsouk M, Gralnek IM, Inadomi JM
• Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA.
  Gastrointestinal endoscopy 2008 Somsouk M, Shergill AK, Grenert JP, Harris H, Cello JP, Shah JN
• A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients.
  Digestive diseases and sciences 2007 Somsouk M, Langfield DE, Inadomi JM, Yee HF
• Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening?
  Gastroenterology 2007 Inadomi JM, Somsouk MA
• Proton pump inhibitors and hip fracture: cause for alarm?
  Gastroenterology 2007 Inadomi JM, Somsouk MA
• Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints.
  Magnetic resonance in chemistry : MRC 2005 Steinmetz WE, Sparrow A, Somsouk M
• Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma.
  World journal of gastroenterology 2004 Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M
• Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation.
  Transplantation 2004 Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT
• Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2.
  Cancer research 2003 Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM
• Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.
  Gastroenterology 2003 Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT
• Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene.
  Mutation research 2000 Bouziane M, Miao F, Bates SE, Somsouk L, Sang BC, Denissenko M, O'Connor TR
• Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates.
  The Journal of biological chemistry 1998 Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B