Lynn Pulliam, PhD
Professor
Laboratory Medicine
School of Medicine
Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She has begun to study how extracellular vesicles from activated cells can influence inflammation in recipient cells.
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Also, isolation of blood neuron-derived exosomes can be a window into the health of brain neurons and can be used as biomarkers for cognitive impairment in HIV, Alzheimer's and post COVID sequelae. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.
Awards
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- Pioneer in Neurovirology, International Society for Neurovirology, 2019
- Prize in Neurovirology, Drexel College of Medicine, 2017
- Most Influential Women in Business, San Francisco Business Times, 2012
- President, Society for Neurovirology, 2010-2013
- Outstanding Women in Neuroscience, International Society for Neurovirology, 2009
Education & Training
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- Ph.D. Graduate Division (Experimental Pathology) University of California, San Francisco 1983
- M.S. Microbiology California State University, Long Beach 1977
- BA Biology Northwestern University, Evanston 1969
Interests
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- HIV
- neuroinflammation
- cognitive impairment
- extracellular vesicles/exosomes
- biomarkers
Grants and Projects
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- Neural and cognitive consequences of COVID-19 survival, Veterans Affairs Merit Award, 2021-2025
- Plasma neuronal-derived exosomes are biomarkers of HIV cognitive impairment, NIH, 2020-2025
- Engineered exosomes target inflammation in HIV, NIH, 2018-2020
- Hepatitis C Drives Neuropathogenesis in HIV/HCV Coinfection Patients, NIH, 2008-2019
- Brain-derived exosomes as blood markers of HIV cognitive impairment, NIH, 2016-2019
- Exosomes from HIV-activated monocytes induce endothelial cell activation, NIH, 2015-2017
- Interferon-a drives peripheral activation and brain injury in chronic HIV, NIH, 2012-2017
- Role of PreS2 Mutants in Pathogenesis of Chronic Hepatitis B, NIH, 1992-2012
- Predicting HAD using Monocyte Profiling and Neuroimaging, NIH, 2005-2010
- HIV-1 Infection Increases Brain Amyloid Beta, NIH, 2003-2008
- Role of Inflammation in HIV Dementia, NIH, 2002-2006
- Monocyte Subsets and Aids Dementia, NIH, 1997-2002
- Apoptosis Inhibitors--Therapy for Neurotoxicity, NIH, 1996-1997
- Hiv-associated Neurotoxin and Aids Dementia, NIH, 1991-1996
Publications (24)
Top publication keywords:
Toll-Like Receptor 4Myeloid Differentiation Factor 88Nervous System DiseasesInterferon-alphaHepatitis C, ChronicAIDS Dementia ComplexAmyloid beta-PeptidesExosomesHMGB1 ProteinCoinfectionHIV InfectionsCognition DisordersExtracellular VesiclesMonocytesNeurofilament Proteins
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Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations.
Cells 2021 Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L -
Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease.
Journal of neurovirology 2019 Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D -
Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV.
AIDS (London, England) 2017 Sun B, Dalvi P, Abadjian L, Tang N, Pulliam L -
Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway.
Scientific reports 2017 Dalvi P, Sun B, Tang N, Pulliam L -
Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Tang N, Sun B, Gupta A, Rempel H, Pulliam L
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Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS.
Current topics in behavioral neurosciences 2021 Fernandes N, Pulliam L -
Using neuronal extracellular vesicles and machine learning to predict cognitive deficits in HIV.
Journal of neurovirology 2020 Pulliam L, Liston M, Sun B, Narvid J -
Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms.
The Journal of infectious diseases 2020 Sun B, Abadjian L, Monto A, Freasier H, Pulliam L -
Human plasma platelet-derived exosomes: effects of aspirin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L -
Modulation of cellular function through immune-activated exosomes.
DNA and cell biology 2015 Pulliam L, Gupta A -
Monocyte activation from interferon-α in HIV infection increases acetylated LDL uptake and ROS production.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H -
Exosomes as mediators of neuroinflammation.
Journal of neuroinflammation 2014 Gupta A, Pulliam L -
Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection.
Current HIV research 2014 Pulliam L -
Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment.
PloS one 2013 Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L -
Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection.
Journal of acquired immune deficiency syndromes (1999) 2013 Sun B, Abadjian L, Rempel H, Monto A, Pulliam L -
Global NeuroAIDS roundtable.
Journal of neurovirology 2013 Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, … -
Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling.
PloS one 2012 Wang Q, Na B, Ou JH, Pulliam L, Yen TS -
A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations.
AIDS (London, England) 2011 Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ -
Transcriptional control of monocyte gene expression in post-traumatic stress disorder.
Disease markers 2011 O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T -
Suppressed monocyte gene expression profile in men versus women with PTSD.
Brain, behavior, and immunity 2010 Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L -
Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection.
AIDS (London, England) 2010 Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L -
Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection.
Journal of neurovirology 2010 Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L -
Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection
Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection 2010 Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam -
HIV regulation of amyloid beta production.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009 Pulliam L