Lynda Frassetto, MD
Professor
Medicine
School of Medicine

She trained as a nephrologist at UCSF and was in private practice in San Francisco before returning to UCSF to start her research career with Drs. Anthony Sebastian and R. Curtis Morris Jr. Over approximately 20 years, the group published papers on regulation of acid base balance in healthy and aging people and dietary influences on acid-base balance in healthy people and those with diabetes.

Dr. Frassetto also collaborates with Dr. Leslie Z Benet, past chair of the Department of Biopharmaceutical Sciences at UCSF. Dr. Benet has pioneered a novel model predicting drug interactions in vivo, depending on the degree of in vitro membrane transporter and intracellular metabolizing enzyme interactions with a specific drug, xenobiotic or toxin. These predictions are then tested in clinical trials in healthy people and those with kidney disease, diabetes or HIV before and after transplantation.

In addition to research, Dr. Frassetto was the director of the adult Clinical Research Center at the Parnassus Campus in UCSF’s Clinical and Translational Science Institute, and still supervises inpatient and outpatient care at three of the University’s hospital campuses. For the last several years, she has also been participating in and teaching programs that teach UC students and faculty better communication and behavioral stress modification techniques.

• Association of Diet-dependent Systemic Acid Load, Renal Function, and Serum Albumin Concentration.
  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2023 Banerjee T, Sebastian A, Frassetto L
• Dietary Contributions to Metabolic Acidosis.
  Advances in chronic kidney disease 2022 Frassetto L, Remer T, Banerjee T
• Diagnosis of acute intermittent porphyria in a renal transplant patient: A case report.
  World journal of transplantation 2022 Sirch C, Khanna N, Frassetto L, Bianco F, Artero ML
• Diet-dependent acid load is associated with mean arterial pressure in a cohort of non-obese, non-black, postmenopausal women.
  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Banerjee T, Sebastian A, Frassetto L
• Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers.
  Clinical pharmacology and therapeutics 2021 Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ
• Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients.
  European journal of clinical nutrition 2020 Angeloco LRN, Arces de Souza GC, Romão EA, Frassetto L, Chiarello PG
• How metabolic acidosis and kidney disease may accelerate the aging process.
  European journal of clinical nutrition 2020 Frassetto LA, Sebastian A, DuBose TD
• Performance of Predictive Equations and Biochemical Measures Quantifying Net Endogenous Acid Production and the Potential Renal Acid Load.
  Kidney international reports 2020 Parmenter BH, Dymock M, Banerjee T, Sebastian A, Slater GJ, Frassetto LA
• Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial.
  Pharmaceutical research 2019 Surofchy DD, Frassetto LA, Benet LZ
• Corrigendum to "Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base" [Nutrition 31 (2015) 1-13].
  Nutrition (Burbank, Los Angeles County, Calif.) 2019 Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, …
• Aging, metabolic acidosis and renal failure: Interactive accelerating processes.
  Medical hypotheses 2019 Frassetto LA, Sebastian A
• Med Hypotheses
  Aging, metabolic acidosis and renal failure: Interactive accelerating processes 2019 Frassetto LA, Sebastian A. .
• Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs.
  Clinical pharmacology and therapeutics 2019 Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ
• Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in daily selection of foods in respect of their potassium and sodium content resulting in oxidative stress-induced dysfunction of the vascular endothelium, vascular smooth muscle, and perivascular tissues.
  Medical hypotheses 2018 Sebastian A, Cordain L, Frassetto L, Banerjee T, Morris RC
• Another strategy to help counter the effects of low gravity?
  The American journal of clinical nutrition 2018 Frassetto L
• Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject.
  Nutrients 2018 Frassetto L, Banerjee T, Powe N, Sebastian A
• Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling.
  Nutrients 2018 Hietavala EM, Ihalainen JK, Frassetto LA, Schumann M, Eklund D, Pitkänen H, Häkkinen K, Mero AA
• Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex.
  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017 Hietavala EM, Stout JR, Frassetto LA, Puurtinen R, Pitkänen H, Selänne H, Suominen H, Mero AA
• Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.
  Journal of pharmaceutical sciences 2017 Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ
• 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.
  Annals of nuclear medicine 2017 Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF
• Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.
  Pharmaceutical research 2016 Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ
• Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database.
  Nutrition & dietetics: the journal of the Dietitians Association of Australia 2016 Parmenter BH, Slater GJ, Frassetto LA
• Spot-testing urine pH, a novel dietary biomarker? A randomised cross-over trial.
  Nutrition & dietetics: the journal of the Dietitians Association of Australia 2016 Parmenter BH, Slater GJ, Frassetto LA
• Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient.
  Case reports in nephrology 2016 Frassetto LA, Gibson S
• A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton's base reservoir with net base-producing diets.
  Medical hypotheses 2016 Sebastian A, Frassetto LA
• Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet.
  European journal of clinical nutrition 2015 Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A
• A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2015 Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM
• Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.
  European journal of clinical nutrition 2015 Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L
• The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015 Lambert H, Frassetto L, Moore JB, Torgerson D, Gannon R, Burckhardt P, Lanham-New S
• Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ
• The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.
  The AAPS journal 2014 Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA
• Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base.
  Nutrition (Burbank, Los Angeles County, Calif.) 2014 Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, …
• Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR
• Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients.
  Transplantation 2014 Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ
• A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study--Alimentation and Diabetes in Lanzarote--ADILAN.
  Trials 2014 Fontes-Villalba M, Jönsson T, Granfeldt Y, Frassetto LA, Sundquist J, Sundquist K, Carrera-Bastos P, Fika-Hernándo M, Picazo Ó, Lindeberg S
• Hip fractures in hemodialysis patients.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2013 Delgado C, Frassetto L
• Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.
  Biopharmaceutics & drug disposition 2013 Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L
• Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.
  Molecular pharmaceutics 2013 Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ
• Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets.
  European journal of clinical nutrition 2013 Frassetto LA, Shi L, Schloetter M, Sebastian A, Remer T
• Commentary to accompany the paper entitled 'nutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney', by Jean-Philippe Bonjour.
  The British journal of nutrition 2013 Frassetto LA, Sebastian A
• Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation.
  Transplantation proceedings 2013 Chakkera HA, Chang YH, Bodner JK, Behmen S, Heilman RL, Reddy KS, Mulligan DC, Moss AA, Khamash H, Katariya N, Hewitt WR, Pitta TL, Frassetto LA
• Potassium.
  Advances in nutrition (Bethesda, Md.) 2012 Lanham-New SA, Lambert H, Frassetto L
• No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake.
  European journal of clinical nutrition 2012 Frassetto LA, Hardcastle AC, Sebastian A, Aucott L, Fraser WD, Reid DM, Macdonald HM
• How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects.
  Medical hypotheses 2012 Frassetto LA, Sebastian A
• Effects of modality change on health-related quality of life.
  Hemodialysis international. International Symposium on Home Hemodialysis 2012 Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen K
• Long term higher urinary calcium excretion within the normal physiologic range predicts impaired bone status of the proximal radius in healthy children with higher potential renal acid load.
  Bone 2012 Shi L, Libuda L, Schönau E, Frassetto L, Remer T
• Treatment and prevention of kidney stones: an update.
  American family physician 2011 Frassetto L, Kohlstadt I
• Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients.
  Drug metabolism and disposition: the biological fate of chemicals 2011 Grover A, Frassetto LA, Benet LZ, Chakkera HA
• Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.
  Transplantation 2010 Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG
• Improving the reporting of adverse drug reactions in the hospital setting.
  Postgraduate medicine 2010 Pushkin R, Frassetto L, Tsourounis C, Segal ES, Kim S
• Effects of modality change and transplant on peak oxygen uptake in patients with kidney failure.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2010 Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen KL
• Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.
  Clinical pharmacology and therapeutics 2010 Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ
• Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG
• Management of osteoporosis in CKD Stages 3 to 5.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2010 Gordon PL, Frassetto LA
• Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease.
  Clinical pharmacology and therapeutics 2010 Sun H, Frassetto LA, Huang Y, Benet LZ
• Clinical islet transplantation at the University of California, San Francisco.
  Clinical transplants 2010 Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG
• Diet-induced acidosis: is it real and clinically relevant?
  The British journal of nutrition 2009 Pizzorno J, Frassetto LA, Katzinger J
• Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: case report and review of the literature.
  International urology and nephrology 2009 Tuot D, Gibson S, Caughey AB, Frassetto LA
• Liver and kidney transplantation in HIV-infected patients.
  AIDS reviews 2009 Tan-Tam CC, Frassetto LA, Stock PG
• Renal transplantation in patients with HIV.
  Nature reviews. Nephrology 2009 Frassetto LA, Tan-Tam C, Stock PG
• Metabolic acidosis and progression of chronic kidney disease.
  Journal of the American Society of Nephrology : JASN 2009 Frassetto LA, Hsu CY
• Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet.
  European journal of clinical nutrition 2009 Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A
• Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite.
  Clinical pharmacology and therapeutics 2008 Zheng HX, Huang Y, Frassetto LA, Benet LZ
• Renal net acid excretion capacity is comparable in prepubescence, adolescence, and young adulthood but falls with aging.
  Journal of the American Geriatrics Society 2008 Berkemeyer S, Vormann J, Günther AL, Rylander R, Frassetto LA, Remer T
• Physical functioning in patients with chronic kidney disease.
  Journal of nephrology 2008 Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL, Painter P
• Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over.
  The British journal of nutrition 2008 Gannon RH, Millward DJ, Brown JE, Macdonald HM, Lovell DP, Frassetto LA, Remer T, Lanham-New SA
• Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets.
  The Journal of nutrition 2008 Frassetto LA, Morris RC, Sellmeyer DE, Sebastian A
• HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007 Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune …
• Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007 Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ
• Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system.
  The Journal of nutrition 2007 Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, Tylavsky FA
• Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet.
  American journal of physiology. Renal physiology 2007 Frassetto LA, Morris RC, Sebastian A
• Effects of uptake and efflux transporter inhibition on erythromycin breath test results.
  Clinical pharmacology and therapeutics 2007 Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ
• In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4.
  Journal of herbal pharmacotherapy 2007 Nicandro JP, Tsourounis C, Frassetto L, Guglielmo BJ
• effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.
  Clinical pharmacology and therapeutics 2006 Lau YY, Huang Y, Frassetto L, Benet LZ
• Solid organ transplantation: referral, management, and outcomes in HIV-infected patients.
  The AIDS reader 2006 Roland ME, Carlson LL, Frassetto LA, Stock PG
• The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes.
  Seminars in nephrology 2006 Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC
• Relationship and interaction between sodium and potassium.
  Journal of the American College of Nutrition 2006 Morris RC, Schmidlin O, Frassetto LA, Sebastian A
• A practical approach to the balance between acid production and renal acid excretion in humans.
  Journal of nephrology 2006 Frassetto LA, Morris RC, Sebastian A
• Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.
  Rapid communications in mass spectrometry : RCM 2006 Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET
• Effects of renal failure on drug transport and metabolism.
  Pharmacology & therapeutics 2005 Sun H, Frassetto L, Benet LZ
• Effects of short-term alendronate on bone mineral density in haemodialysis patients.
  Nephrology (Carlton, Vic.) 2005 Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L
• Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
  Transplantation 2005 Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ
• Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.
  The Journal of clinical endocrinology and metabolism 2004 Frassetto L, Morris RC, Sebastian A
• Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.
  Drug metabolism and disposition: the biological fate of chemicals 2004 Sun H, Huang Y, Frassetto L, Benet LZ
• Pharmacogenomics and transplantation: where are we?
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004 Frassetto LA, Benet LZ
• Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study.
  Transplantation 2003 Stock PG, Roland ME, Carlson L, Freise CE, Roberts JP, Hirose R, Terrault NA, Frassetto LA, Palefsky JM, Tomlanovich SJ, Ascher NL
• Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.
  Drug metabolism and pharmacokinetics 2003 Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC
• Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors.
  The American journal of clinical nutrition 2002 Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC
• Discrepancy in results between spine and hip scans of a woman with end stage renal disease.
  Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 2002 Sherman ME, Shepherd J, Frassetto L, Genant HK
• Solid organ transplantation in HIV-positive patients.
  Transplantation proceedings 2001 Stock P, Roland M, Carlson L, Freise C, Hirose R, Terrault N, Frassetto L, Coates T, Roberts J, Ascher N
• Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.
  European journal of nutrition 2001 Frassetto L, Morris RC, Sellmeyer DE, Todd K, Sebastian A
• The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.
  Clinical pharmacology and therapeutics 2001 Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U
• Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2000 Frassetto LA, Todd KM, Morris RC, Sebastian A
• Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion.
  Kidney international 2000 Frassetto LA, Nash E, Morris RC, Sebastian A
• Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications.
  Seminars in nephrology 1999 Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A
• Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents.
  The American journal of clinical nutrition 1998 Frassetto LA, Todd KM, Morris RC, Sebastian A
• Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women.
  The Journal of clinical endocrinology and metabolism 1997 Frassetto L, Morris RC, Sebastian A
• Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline.
  The American journal of physiology 1996 Frassetto LA, Morris RC, Sebastian A
• Age and systemic acid-base equilibrium: analysis of published data.
  The journals of gerontology. Series A, Biological sciences and medical sciences 1996 Frassetto L, Sebastian A
• Erythropoietin in pregnancies complicated by severe anemia of renal failure.
  Obstetrics and gynecology 1992 Yankowitz J, Piraino B, Laifer SA, Frassetto L, Gavin L, Kitzmiller JL, Crombleholme W
• Increasing incidence of human immunodeficiency virus-associated nephropathy at San Francisco General Hospital.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 1991 Frassetto L, Schoenfeld PY, Humphreys MH