Luke Bonham, MD
Resident
Radiology
School of Medicine

Publications (54)

Top publication keywords:
Optic DiskApolipoprotein E4KCNQ2 Potassium ChannelAlzheimer DiseaseGTP-Binding Protein gamma SubunitsMagnetic Resonance Imaging, InterventionalComplement C3Receptors, CXCR4Amyotrophic Lateral SclerosisPrimary Progressive Nonfluent AphasiaDenervationPolymorphism, Single NucleotideFrontotemporal DementiaSural NerveNeurodegenerative Diseases

• C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types.
  Frontiers in neuroscience 2024 Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller BL, Castruita PA, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS
• Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.
  bioRxiv : the preprint server for biology 2024 Sirkis DW, Solsberg CW, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS
• FTLD targets brain regions expressing recently evolved genes.
  medRxiv : the preprint server for health sciences 2023 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
  Alzheimer's & dementia (Amsterdam, Netherlands) 2023 Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH…
• C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types.
  bioRxiv : the preprint server for biology 2023 Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller B, Castruita P, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS

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• Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.
  Genome medicine 2023 Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Sturm VE, Lee SE, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Miller BL, Geier EG, Yokoyama JS
• Genetic overlap between cortical brain morphometry and frontotemporal dementia risk.
  Cerebral cortex (New York, N.Y. : 1991) 2023 Diaz-Torres S, Ogonowski N, García-Marín LM, Bonham LW, Duran-Aniotz C, Yokoyama JS, Rentería ME
• Association of Optic Nerve Head and Macular Optical Coherence Tomography Measures With Glaucoma-Related Disability.
  Journal of glaucoma 2023 Bonham LW, Mihailovic A, Xiao G, West SK, Friedman DS, Ramulu PY
• Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia.
  JAMA neurology 2023 Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Illán-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind…
• Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Bonham LW, Geier EG, Sirkis DW, Leong JK, Ramos EM, Wang Q, Karydas A, Lee SE, Sturm VE, Sawyer RP, Friedberg A, Ichida JK, Gitler AD, Sugrue L, Cordingley M, Bee W, Weber E, Kramer JH, Rankin KP, …
• Case Report: Novel CSF1R Variant in a Patient With Behavioral Variant Frontotemporal Dementia Syndrome With Prodromal Repetitive Scratching Behavior.
  Frontiers in neurology 2022 Friedberg A, Ramos EM, Yang Z, Bonham LW, Yokoyama JS, Ljubenkov PA, Younes K, Geschwind DH, Miller BL
• Dissecting the clinical heterogeneity of early-onset Alzheimer's disease.
  Molecular psychiatry 2022 Sirkis DW, Bonham LW, Johnson TP, La Joie R, Yokoyama JS
• The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia.
  The application of clinical genetics 2021 Sirkis DW, Bonham LW, Yokoyama JS
• A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.
  Science translational medicine 2020 Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris …
• Diagnostic and interventional magnetic resonance neurography diagnosis of brachytherapy seed-mediated pudendal nerve injury: a case report.
  Translational andrology and urology 2020 Bonham LW, Herati AS, McCarthy EF, Dellon AL, Fritz J
• Needle Heating During Interventional Magnetic Resonance Imaging at 1.5- and 3.0-T Field Strengths.
  Investigative radiology 2020 Khodarahmi I, Bonham LW, Weiss CR, Fritz J
• Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.
  American journal of human genetics 2020 Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS, Alzheimer’s Disease …
• Exploring Patient Motivations and Impact of Asian Blepharoplasty.
  Facial plastic surgery : FPS 2019 Huynh PP, Ishii M, Juarez M, Fung N, Bater K, Darrach H, Nellis JC, Bonham LW, Lay PC, Ishii LE
• The Radiogenomics of Late-onset Alzheimer Disease.
  Topics in magnetic resonance imaging : TMRI 2019 Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS
• Evidence-Based Criteria for Determining Peripapillary OCT Reliability.
  Ophthalmology 2019 Yohannan J, Cheng M, Da J, Chapagain S, Sotimehin A, Bonham LW, Mihailovic A, Boland M, Ramulu P
• Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
  Scientific reports 2019 Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, …
• Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites.
  Alzheimer disease and associated disorders 2019 Fan J, Tse M, Carr JS, Miller BL, Kramer JH, Rosen HJ, Bonham LW, Yokoyama JS
• The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease.
  Frontiers in immunology 2019 Bonham LW, Sirkis DW, Yokoyama JS
• Immunological signatures in frontotemporal lobar degeneration.
  Current opinion in neurology 2019 Sirkis DW, Bonham LW, Karch CM, Yokoyama JS
• Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.
  Brain : a journal of neurology 2019 Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, …
• Recent advances in the genetics of frontotemporal dementia.
  Current genetic medicine reports 2019 Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS
• Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
  Acta neuropathologica 2018 Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW…
• Frequency of frontotemporal dementia gene variants in C9ORF72, MAPT, and GRN in academic versus commercial laboratory cohorts.
  Advances in genomics and genetics 2018 Steele NZ, Bright AR, Lee SE, Fong JC, Bonham LW, Karydas A, Karbassi ID, Pribadi M, Meservey MA, Gallen MC, Ramos EM, Liaquat K, Hoffman CC, Krasner MR, Dodge W, L Miller B, Coppola G, Rankin KP, …
• Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.
  Neurology. Genetics 2018 Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, Desikan RS, Ferrari R, Yokoyama JS, …
• MR Imaging-Guided Cryoneurolysis of the Sural Nerve.
  Journal of vascular and interventional radiology : JVIR 2018 Bonham LW, Phelps A, Rosson GD, Fritz J
• Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.
  Scientific reports 2018 Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, …
• Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease.
  Frontiers in neuroscience 2018 Carr JS, Bonham LW, Morgans AK, Ryan CJ, Yokoyama JS, Geier EG, Alzheimer’s Disease Neuroimaging Initiative
• Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice.
  Frontiers in neuroscience 2018 Bonham LW, Geier EG, Steele NZR, Holland D, Miller BL, Dale AM, Desikan RS, Yokoyama JS, Alzheimer’s Disease Neuroimaging Initiative
• Comparative Analysis of Body Radiologist to Neuroradiologist Evaluation of the Spine in Trauma Settings.
  Journal of the American College of Radiology : JACR 2018 Zhou AL, Bonham LW, Verde F
• CXCR4 involvement in neurodegenerative diseases.
  Translational psychiatry 2018 Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller …
• Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
  PLoS medicine 2018 Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, …
• Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes.
  American journal of Alzheimer's disease and other dementias 2018 Bonham LW, Evans DS, Liu Y, Cummings SR, Yaffe K, Yokoyama JS
• Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
  PLoS medicine 2018 Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, …
• Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
  Acta neuropathologica 2017 Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK,…
• Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.
  Brain imaging and behavior 2017 Yokoyama JS, Marx G, Brown JA, Bonham LW, Wang D, Coppola G, Seeley WW, Rosen HJ, Miller BL, Kramer JH, Dubal DB
• Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
  PLoS medicine 2017 Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS
• Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
  PLoS medicine 2017 Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen …
• Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
  Acta neuropathologica 2017 Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, International FTD-Genomics Consortium (IFGC), Momeni P, Sugrue LP, …
• Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease.
  Neurocase 2017 Bonham LW, Sirkis DW, Fan J, Aparicio RE, Tse M, Ramos EM, Wang Q, Coppola G, Rosen HJ, Miller BL, Yokoyama JS
• Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
  Journal of neurology, neurosurgery, and psychiatry 2016 Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, International FTD-Genomics Consortium (IFGC),, International Parkinson's Disease Genomics Consortium (…
• Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.
  Acta neuropathologica communications 2016 Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS
• Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.
  Annals of clinical and translational neurology 2016 Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS
• The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease.
  Acta neuropathologica communications 2016 Bonham LW, Desikan RS, Yokoyama JS, Alzheimer’s Disease Neuroimaging Initiative
• Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.
  JAMA neurology 2016 Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen…
• The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia.
  NeuroImage. Clinical 2015 Yokoyama JS, Bonham LW, Sturm VE, Adhimoolam B, Karydas A, Coppola G, Miller BL, Rankin KP
• Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer's disease.
  BMC neurology 2015 Yokoyama JS, Bonham LW, Sears RL, Klein E, Karydas A, Kramer JH, Miller BL, Coppola G
• Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults.
  PloS one 2015 Yokoyama JS, Lee AK, Takada LT, Busovaca E, Bonham LW, Chao SZ, Tse M, He J, Schwarz CG, Carmichael OT, Matthews BR, Karydas A, Weiner MW, Coppola G, DeCarli CS, Miller BL, Rosen HJ
• Variation in longevity gene KLOTHO is associated with greater cortical volumes.
  Annals of clinical and translational neurology 2015 Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB
• APOE Genotype Affects Cognitive Training Response in Healthy Shanghai Community-Dwelling Elderly Individuals.
  Journal of Alzheimer's disease : JAD 2015 Feng W, Yokoyama JS, Yu S, Chen Y, Cheng Y, Bonham LW, Wang D, Shen Y, Wu W, Li C