Luika Timmerman, PhD
Associate Researcher
HDF Comprehensive Cancer Ctr
School of Medicine

Education & Training

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• Postdoctoral Studies Graduate Division University of California, San Francisco

Publications (10)

Top publication keywords:
Cell Transformation, NeoplasticTriple Negative Breast NeoplasmsPoly(ADP-ribose) Polymerase InhibitorsGlutamineMesodermDNA Modification MethylasesRecombinational DNA RepairAmino Acid Transport System y+GlutathioneHeartGene Expression Regulation, DevelopmentalEstrogen Receptor alphaEpithelial CellsEnzyme InhibitorsGene Expression Regulation, Neoplastic

• Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors.
  Breast cancer research : BCR 2025 Pacaud R, Thomas S, Chaudhuri S, Lazar A, Timmerman LA, Munster PN
• Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.
  PloS one 2023 Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E
• xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction.
  Oncotarget 2018 Cobler L, Zhang H, Suri P, Park C, Timmerman LA
• Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells.
  BMC cancer 2017 Padró M, Louie RJ, Lananna BV, Krieg AJ, Timmerman LA, Chan DA
• Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
  Cancer cell 2013 Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW

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• Lipoprotein lipase links dietary fat to solid tumor cell proliferation.
  Molecular cancer therapeutics 2011 Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, Pettus JR, Froehlich HM, Memoli VA, Morganelli PM, Swinnen JV, Timmerman LA, Chaychi L, Fricano CJ, Eisenberg BL, Coleman WB, …
• PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.
  Cancer research 2008 Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F
• Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw.
  Cell cycle (Georgetown, Tex.) 2004 Grego-Bessa J, Díez J, Timmerman L, de la Pompa JL
• Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway.
  The American journal of pathology 2004 Maldonado JL, Timmerman L, Fridlyand J, Bastian BC
• Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
  Genes & development 2003 Timmerman LA, Grego-Bessa J, Raya A, Bertrán E, Pérez-Pomares JM, Díez J, Aranda S, Palomo S, McCormick F, Izpisúa-Belmonte JC, de la Pompa JL