Lucy Kornblith, MD
Associate Professor
Surgery
School of Medicine

lucy.kornblith@ucsf.edu 628-206-5977

Lucy Zumwinkle Kornblith, M.D., F.A.C.S. received her undergraduate degree from University of California Santa Barbara, her M.D.

from the University of Colorado, completed her General Surgery residency at the University of California San Francisco (UCSF), a Trauma and Critical Care Clinical Translational Research Fellowship at UCSF, and subspecialty training in Trauma and Acute Care Surgery and Surgical Critical Care at UCSF prior to joining the faculty at UCSF.

She clinically practices Trauma Surgery, Acute Care Surgery, and Surgical Critical Care. She has played a pivotal role in the translational study of blood system failure after injury, centrally focused on post-injury platelet biology. Her research program is multi-pronged, covering 1) Translational research to identify novel biology of blood system failure through the lens of platelets, 2) Large observational studies to identify predictors of bad outcomes after injury, and 3) Clinical trials investigating therapeutics and resuscitation strategies for injured patients. Her research program has been funded by the National Institutes of Health, the Department of Defense, the American College of Surgeons, the Eastern Association for the Surgery of Trauma, the UCSF School of Medicine Irene Perstein Award, and the Doris Duke Charitable Foundation. Dr. Kornblith is the co-chair of the UCSF Department of Surgery Muriel Steele Society, an inclusive community dedicated to inspiring, supporting, and promoting surgeons so they can thrive at all stages of their careers. In 2024, Dr. Kornblith became the Director of Research for the UCSF School of Medicine Vice Dean's Office at Zuckerberg San Francisco General Hospital, where she serves and represents approximately 300 investigators and 800 research staff. In 2025, Dr. Kornblith was appointed the Elsbach-Richards Endowed Chair in Surgery I at UCSF.

Awards

  • George H. A. Clowes Jr., MD, FACS, Memorial Research Career Development Award, The American College of Surgeons, 2023-2028
  • UCSF Holly Smith Award for Exceptional Service to the School of Medicine, University of California San Francisco, 2023
  • 40 under 40 female surgeons, The Association of Women Surgeons, The American Association for the Surgery of Trauma, 2022
  • Canizaro Award, The American Association for the Surgery of Trauma, The American Association for the Surgery of Trauma, 2021
  • UCSF Clinical and Translational Science Institute Mentor of the Year, University of California San Francisco, 2021
  • Department of Surgery Muriel Steele Society Honor Roll, University of California San Francisco, 2019-2022
  • Irene Perstein Award, University of California San Francisco, 2019
  • Department of Surgery Robert C Lim Jr. MD & Arthur N Thomas M, University of California San Francisco, 2019
  • Trauma Research Scholarship, Eastern Association for the Surgery of Trauma, 2018
  • Excellence in Research Award, Surgical Critical Care Program Directors Society Board of Directors, 2017
  • Fred H. & Esther E. Nusz Resident Achievement Award, University of California San Francisco, 2016
  • Haile T. Debas Resident Teaching Award, University of California San Francisco, 2016
  • Earl G Young First Place Winner, Western Trauma Association, 2014

Education & Training

  • Trauma Surgery University of California San Francisco 2018
  • Surgical Critical Care University of California San Francisco 2017
  • General Surgery Residency University of California San Francisco 2016
  • MD University of Colorado 2009
  • BS Biological Sciences University of California Santa Barbara 2005

Interests

  • Platelets
  • Acute Traumatic Coagulopathy
  • Critical Care
  • Functional Coagulation
  • Whole Blood
  • General Surgery
  • Tracheostomy
  • Transfusion
  • Trauma Surgery
  • Genomics
  • Lung Injury

Websites

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Grants and Projects

Publications (146)

Top publication keywords:
HemorrhageBrain Injuries, TraumaticThrombelastographyHemostasisPlasmaResuscitationCatecholaminesBlood PlateletsBlood Coagulation DisordersInjury Severity ScorePlatelet AggregationWounds and InjuriesFibrinogenBlood Component TransfusionTrauma Centers

  • Pathogen reduction diminishes the protective effects of platelets on endothelial barrier permeability in vitro.
    Blood Vessels Thrombosis & Hemostasis 2025 Alison B. Nair, Byron Miyazawa, Alpa Trivedi, Lindsay Vivona, Alex Fields, Kimberly Herrera, Lucy Z. Kornblith, Joseph Cuschieri, Shibani Pati
  • A Subset of Antibodies to the Spike Protein's Receptor-Binding Domain in Severe COVID-19 Activate Platelets.
    Blood 2024 Wen Zhu, Yongwei Zheng, Mei Yu, Nathan Witman, Anand Pabmanabhan, Lisa Baumann Kreuziger, Gilbert C. White, Tongjun Gu, Alexander Fields, Lucy Kornblith, Richard H. Aster, Weiguo Cui, Shawn M. Jobe, …
  • Regarding γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.
    Blood cells, molecules & diseases 2024 Kornblith LZ, Sadhanandhan B, Arun S, Long R, Johnson AJ, Noll J, Ramchand CN, Olynyk JK, Farrell DH
  • Abstract 13200: Changes in Thrombi-Inflammatory Biomarkers Associated With Therapeutic Heparin in Non-Critically Ill Patients Hospitalized With COVID-19: A Pre-Specified Secondary Analysis of the ACTIV4a and ATTACC Randomized Clinical Trial.
    Circulation 2023 Lana Wahid, Joshua Froess, Thomas L Ortel, Ryan Zarychanski, Michelle N Gong, Mary Cushman, Lucy Kornblith, Lana Castellucci, Michael E Farkouh, Ewan Gologher, Bryan J McVerry, Grant V Bochicchio, …
  • Abstract 14153: P2Y12 Inhibitors and Quality of Life Outcomes in Critically Ill Patients Hospitalized for COVID-19: A Pre-Specified Secondary Analysis of the ACTIV4a Randomized Clinical Trial.
    Circulation 2023 Lana Wahid, Erinn M Hade, Mary Cushman, Michelle N Gong, Valerie Renard, Emily R Ko, Tatyana Der, Lucy Z Kornblith, Patrick R Lawler, Harmony Reynolds, Chowdhury Ahsan, Grant Bochicchio, Carlos Carpio…
  • Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.
    JAMA network open 2023 Berger JS, Neal MD, Kornblith LZ, Gong MN, Reynolds HR, Cushman M, Althouse AD, Lawler PR, McVerry BJ, Kim KS, Baumann Kreuziger L, Solomon SD, Kosiborod MN, Berry SM, Bochicchio GV, Contoli M, …
  • γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.
    Blood cells, molecules & diseases 2023 Kornblith LZ, Sadhanandhan B, Arun S, Long R, Johnson AJ, Noll J, Ramchand CN, Olynyk JK, Farrell DH
  • Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.
    Frontiers in immunology 2023 Matthay ZA, Fields AT, Wick KD, Jones C, Lane HC, Herrera K, Nuñez-Garcia B, Gennatas E, Hendrickson CM, Kornblith AE, Matthay MA, Kornblith LZ, COVID-19 Associated Coagulopathy Inflammation …
  • Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.
    Frontiers in immunology 2023 Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nuñez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith…
  • Gamma' Fibrinogen Levels As a Biomarker of COVID-19 Severity.
    Blood 2022 Lucy Z Kornblith, Bindhya Sadhanandhan, Sreepriya Arun, Rebecca Long, Alicia J Johnson, Jamie Noll, CN Ramchand, John K Olynyk, David H Farrell
  • Abstract 14850: Effect of Therapeutic-Dose Heparin on Acute Kidney Injury in Non-Critically Ill Hospitalized Patients With Covid-19: The Activ4a and Attac Randomized Trial.
    Circulation 2022 Nathaniel Smilowitz, Erinn Hade, Lucy Kornblith, Lana Castellucci, Mary Cushman, Michael E Farkouh, Beverly Hunt, Keri Kim, Andrei Kindzelski, Patrick R Lawler, Eric Leifer, Bryan J McVerry, Harmony …
  • P2.02: Save the Environment: Liver Transplantation Restores A Circulating Environment That Supports Healthy Platelet Aggregation Within Two Hours of Reperfusion.
    Transplantation 2022 Hillary Braun, Alex T Fields, Kim Rodriguez, Zachary A Matthay, Rishi Kothari, Claus U Niemann, Dieter Adelmann, Nancy L Ascher, John P Roberts, Michael P Bokoch, Lucy Z Kornblith
  • Platelet Transfusion for Trauma Resuscitation.
    Current Trauma Reports 2022 Nichole Starr, Zachary Matthay, Alexander Fields, Matthew D. Neal, Lucy Zumwinkle Kornblith
  • Author Correction: Trauma-induced coagulopathy.
    Nature reviews. Disease primers 2022 Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
  • Impact of Transfusion Ratios on Mortality after Ultramassive Transfusion Across Nontrauma Surgical Specialties: An Eastern Association for the Surgery of Trauma Multicenter Study.
    Journal of the American College of Surgeons 2021 Zachary A. Matthay, Zane J. Hellmann, Brittany Robinson, Mary Kathryn Abel, Amanda Chipman, Rosemary A. Kozar, Alexandria Byskosh, Rachael A. Callcut, Lucy Z. Kornblith, EAST Multicenter Study Group …
  • Abstract 109: Platelets Amplify Endotheliopathy In Covid-19.
    Arteriosclerosis Thrombosis and Vascular Biology 2021 Tessa J Barrett, MacIntosh Cornwell, Khrystyna Myndzar, Christina Rolling, Yuhe Xia, Kamelia Drenkova, Antoine Biebuyck, Alexander Fields, Michael Tawil, Elliot Luttrell-Williams, Eugene Yuriditsky, …
  • Venous Thromboembolism After Vascular Surgery: Is More Aggressive Chemoprophylaxis Warranted?.
    Journal of Vascular Surgery 2021 Zachary A. Matthay, Colleen P. Flanagan, Katherine Sanders, Eric J. Smith, Elizabeth Lancaster, Warren Gasper, Lucy Z. Kornblith, Jade Hiramoto, Michael S. Conte, James C. Iannuzzi
  • Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
    The New England journal of medicine 2021 REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, …
  • Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
    The New England journal of medicine 2021 ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, …
  • Trauma-induced coagulopathy.
    Nature reviews. Disease primers 2021 Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
  • Platelets.
    2020 Zachary A. Matthay, Lucy Zumwinkle Kornblith
  • Platelet Contributions to Trauma-Induced Coagulopathy: Updates in Post-injury Platelet Biology, Platelet Transfusions, and Emerging Platelet-Based Hemostatic Agents.
    Current Trauma Reports 2019 Zachary A. Matthay, Lucy Zumwinkle Kornblith
  • Do Plasma Biomarkers Have Value in Identifying Hypoxemic Trauma Patients Who Will Develop ARDS?.
    Journal of the American College of Surgeons 2019 James T. Ross, Carolyn M. Hendrickson, Brenda Nunez-Garcia, Erin Ross, Amanda Conroy, Michael A. Matthay, Rachael A. Callcut, Lucy Z. Kornblith
  • Age-Related Alteration of the Fibrin Platelet Balance: The Impact of Age on Coagulation after Injury.
    Journal of the American College of Surgeons 2018 Anamaria J. Robles, Lucy Z. Kornblith, Amanda S. Conroy, Mitchell J. Cohen, Rachael A. Callcut
  • Post-Traumatic Complications as Preventable Events… Yes, No, or Maybe So?.
    Journal of the American College of Surgeons 2017 Anamaria J. Robles, Lucy Z. Kornblith, Benjamin M. Howard, Amanda S. Conroy, Ryan C. Kunitake, Mitchell J. Cohen, Rachael A. Callcut
  • Tired Platelet: Functional Anergy after Injury.
    Journal of the American College of Surgeons 2017 Lucy Z. Kornblith, Anamaria J. Robles, Amanda S. Conroy, Byron Y. Miyazawa, Rachael A. Callcut, Mitchell J. Cohen
  • Correlation between Factor (F)XIa, FIXa and Tissue Factor and Trauma Severity.
    Blood 2015 Saulius Butenas, Shannon M Prior, Amanda Conroy, Mary Nelson, Lucy Kornblith, Benjamin Howard, Mitchell Jay Cohen
  • Exposing the Bidirectional Effects of Alcohol on Coagulation after Injury.
    Journal of the American College of Surgeons 2014 Benjamin M. Howard, Lucy Z. Kornblith, Brittney J. Redick, Mary F. Nelson, Rachael A. Callcut, Mitchell J. Cohen
  • Prothrombin Function: Critical Role in Hemostasis after Injury.
    Journal of the American College of Surgeons 2014 Lucy Z. Kornblith, Benjamin M. Howard, Brittney J. Redick, Ryan F. Vilardi, Mary F. Nelson, Mitchell J. Cohen
  • Functional fibrinogen in coagulopathy, transfusion, and mortality after injury.
    Journal of the American College of Surgeons 2013 Lucy Z. Kornblith, Matthew E. Kutcher, Brittney J. Redick, Ryan F. Vilardi, Mary F. Nelson, Mitchell J. Cohen
  • Normalization of coagulation after traumatic brain injury: When to initiate deep venous thrombosis prophylaxis.
    Journal of the American College of Surgeons 2013 Cassandra A. Ligh, Fangfang Xing, Lucy Z. Kornblith, Brittney J. Redick, Mary Nelson, Tomoo Inoue, Geoffrey T. Manley, Mitchell J. Cohen
  • Untitled Publication
    Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, Mitchell Jay Cohen. “Chapter 128. Multitrauma Derangement in Hemostasis and Thrombosis.” In: Marder et al: Hemostasis and Thrombosis: Basic …
  • Untitled Publication
    Rochelle Dicker, Lucy Z. Kornblith. “Chapter 26. Acute Abdominal Pain.” In: Vincent et al: Textbook of Critical Care, 7th eds. 2017.
  • Untitled Publication
    Anamaria J. Robles, Lucy Z. Kornblith. “Coagulopathy in Trauma”. In: Dynamed Plus, 2017.
  • Untitled Publication
    Zachary Matthay, Lucy Z. Kornblith. “Platelets.” In: Trauma Induced Coagulopathy, 2nd eds. 2019.