Lucas Wachsmuth, MD, PhD
RESIDENT
Surgery
School of Medicine

Lucas Wachsmuth is a General Surgery resident at UCSF. He earned his B.S. from the University of Georgia, where he double majored in Biochemistry and Biology, and his M.D./Ph.D. from Duke in 2025. His research interests center on development of the pediatric immune system, pediatric solid tumor immunology, and developing immunotherapeutic platforms specifically for pediatric oncology patients.

Education & Training

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• MD, PhD Tumor Immunology Duke University 05/2025
• BS Biochemistry, Biology University of Georgia 05/2014

Publications (18)

Top publication keywords:
Aldehyde DehydrogenaseT-Lymphocytes, RegulatoryBiologyLymphocyte ActivationAttitudeCyclophosphamideLaser TherapyHemangiosarcomaGraft vs Host DiseaseHemangioendothelioma, EpithelioidAntigen PresentationHematopoietic Stem Cell TransplantationMathematicsStudentsMyeloid-Derived Suppressor Cells

• Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Mariani CL, Wachsmuth LP, Bramall AN, Meritet DM, Hatfield J, Tsvankin V, Keenihan EK, Tokarz DA, Tyc R, Nolan MW, Fecci PE
• Autonomic modulation of the immune response and implications for CNS malignancies.
  NPJ precision oncology 2025 Wachsmuth LP, Srinivasan ES, Puviindran BJ, Haskell-Mendoza AP, DeSpenza T, Fecci PE
• Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion.
  Immunity 2024 Waibl Polania J, Hoyt-Miggelbrink A, Tomaszewski WH, Wachsmuth LP, Lorrey SJ, Wilkinson DS, Lerner E, Woroniecka K, Finlay JB, Ayasoufi K, Fecci PE
• Combination checkpoint blockade and laser interstitial thermal therapy in radiographically progressive non-small cell lung cancer brain metastases.
  Neuro-oncology advances 2024 Haskell-Mendoza AP, Srinivasan ES, Gonzalez AT, Reason EH, Jackson JD, Flusche AM, Wachsmuth LP, Lerner E, Underwood D, Buckley ED, Zaidi SE, Herndon JE, Fecci PE
• The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies.
  Journal of neuro-oncology 2024 Haskell-Mendoza AP, Gonzalez AT, Reason EH, Flusche AM, Chongsathidkiet P, Wachsmuth LP, Goodwin CR, Fecci PE

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• Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Srinivasan ES, Liu Y, Odion RA, Chongsathidkiet P, Wachsmuth LP, Haskell-Mendoza AP, Edwards RM, Canning AJ, Willoughby G, Hinton J, Norton SJ, Lascola CD, Maccarini PF, Mariani CL, Vo-Dinh T, Fecci …
• CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.
  Nature cancer 2023 Lerner EC, Woroniecka KI, D'Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD, Cui X, Raj JA, Tomaszewski WH, Cook SL, Sampson JH, Patel AP, …
• Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution.
  Development (Cambridge, England) 2023 Li J, Wachsmuth LP, Xiao S, Condie BG, Manley NR
• Posttransplantation cyclophosphamide expands functional myeloid-derived suppressor cells and indirectly influences Tregs.
  Blood advances 2023 Fletcher RE, Nunes NS, Patterson MT, Vinod N, Khan SM, Mendu SK, Li X, de Paula Pohl A, Wachsmuth LP, Choo-Wosoba H, Eckhaus MA, Venzon DJ, Kanakry CG
• Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege.
  Neuro-oncology advances 2023 Lorrey SJ, Waibl Polania J, Wachsmuth LP, Hoyt-Miggelbrink A, Tritz ZP, Edwards R, Wolf DM, Johnson AJ, Fecci PE, Ayasoufi K
• Erratum to "E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054."
  Advances in radiation oncology 2023 Lerner EC, Srinivasan ES, Broadwater G, Haskell-Mendoza AP, Vaios EJ, Edwards RM, Wachsmuth LP, Huie D, Floyd SR, Adamson JD, Fecci PE
• Efflux capacity and aldehyde dehydrogenase both contribute to CD8+ T-cell resistance to posttransplant cyclophosphamide.
  Blood advances 2022 Patterson MT, Nunes NS, Wachsmuth LP, Panjabi A, Fletcher RE, Khan SM, Dimitrova D, Kanakry JA, Luznik L, Kanakry CG
• Grief in Medical Students: The Short and Long-Term Impacts on Health and Well-Being.
  The American journal of hospice & palliative care 2021 Price MJ, Wachsmuth LP, Ferguson KA, Robbins-Welty GA, Riordan PA, Pieper CF, Galanos A
• Hepatic vascular malignancies in children are associated with increased rates of surgical resection and improved overall survival compared with adults.
  Pediatric blood & cancer 2021 Commander SJ, Cerullo M, Leraas HJ, Reed CR, Achey MA, Wachsmuth LP, Schooler GR, Tracy ET
• Optimized Timing of Post-Transplantation Cyclophosphamide in MHC-Haploidentical Murine Hematopoietic Cell Transplantation.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Kanakry CG
• Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.
  The Journal of clinical investigation 2019 Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG
• Do Biology Students Really Hate Math? Empirical Insights into Undergraduate Life Science Majors' Emotions about Mathematics.
  CBE life sciences education 2017 Wachsmuth LP, Runyon CR, Drake JM, Dolan EL
• The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.
  PLoS genetics 2015 Tucker JM, Larango ME, Wachsmuth LP, Kannan N, Garfinkel DJ