Luca Della Santina, PhD
Assistant Professor
Ophthalmology
School of Medicine

Education & Training

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• M.S. Medicinal Chemistry University of Pisa
• PhD Neuroscience University of Pisa
• PharmD Pharmacy University of Pisa
• PostDoc Neurodegeneration University of Washington

Grants and Projects

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• Trachoma Surveillance at Scale: Automatic Disease Grading of Eyelid Photos, NIH, 2021-2023

Publications (18)

Top publication keywords:
Presynaptic TerminalsNerve NetRetinal Bipolar CellsGABAergic NeuronsGlaucomaGlutamic AcidX-Ray MicrotomographyIntraocular PressureAmacrine CellsDisease Models, AnimalSynapsesRetinal Ganglion CellsOptic Nerve DiseasesOcular HypertensionBiolistics

• Impact of Photoreceptor Loss on Retinal Circuitry.
  Annual review of vision science 2021 Lee JY, Care RA, Della Santina L, Dunn FA
• Disassembly and rewiring of a mature converging excitatory circuit following injury.
  Cell reports 2021 Della Santina L, Yu AK, Harris SC, Soliño M, Garcia Ruiz T, Most J, Kuo YM, Dunn FA, Ou Y
• Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants.
  Scientific reports 2020 Kastner DB, Kharazia V, Nevers R, Smyth C, Astudillo-Maya DA, Williams GM, Yang Z, Holobetz CM, Santina LD, Parkinson DY, Frank LM
• Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.
  Translational vision science & technology 2020 Kong AW, Della Santina L, Ou Y
• A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse.
  eLife 2020 Maddox JW, Randall KL, Yadav RP, Williams B, Hagen J, Derr PJ, Kerov V, Della Santina L, Baker SA, Artemyev N, Hoon M, Lee A

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• Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.
  Cell reports 2020 Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA
• Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit.
  Cell reports 2019 Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA
• Biolistic Labeling of Retinal Ganglion Cells.
  Methods in molecular biology (Clifton, N.J.) 2018 Santina LD, Ou Y
• Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L
• Glutamatergic Monopolar Interneurons Provide a Novel Pathway of Excitation in the Mouse Retina.
  Current biology : CB 2016 Della Santina L, Kuo SP, Yoshimatsu T, Okawa H, Suzuki SC, Hoon M, Tsuboyama K, Rieke F, Wong ROL
• Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma.
  Experimental eye research 2016 Della Santina L, Ou Y
• Involvement of Autophagic Pathway in the Progression of Retinal Degeneration in a Mouse Model of Diabetes.
  Frontiers in cellular neuroscience 2016 Piano I, Novelli E, Della Santina L, Strettoi E, Cervetto L, Gargini C
• TMEM16A is associated with voltage-gated calcium channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit.
  Frontiers in cellular neuroscience 2015 Caputo A, Piano I, Demontis GC, Bacchi N, Casarosa S, Della Santina L, Gargini C
• Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry.
  Neuron 2014 Okawa H, Hoon M, Yoshimatsu T, Della Santina L, Wong ROL
• Functional architecture of the retina: development and disease.
  Progress in retinal and eye research 2014 Hoon M, Okawa H, Della Santina L, Wong RO
• Interplay of cell-autonomous and nonautonomous mechanisms tailors synaptic connectivity of converging axons in vivo.
  Neuron 2014 Okawa H, Della Santina L, Schwartz GW, Rieke F, Wong RO
• Sensory experience shapes the development of the visual system's first synapse.
  Neuron 2013 Dunn FA, Della Santina L, Parker ED, Wong RO
• Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Della Santina L, Inman DM, Lupien CB, Horner PJ, Wong RO