Lorriana Leard, MD
Professor
Medicine
School of Medicine

She completed an additional subspecialty fellowship in Lung Transplantation at the University of California San Francisco and joined the faculty in 2006. She pursued further training in medical education in the UCSF Teaching Scholars program and was selected to join the Academy of Medical Educators in 2011.

Dr. Leard is Associate Dean for Continuing Medical Education for the UCSF School of Medicine and Vice Chief of Clinical Operations for the UCSF Division of Pulmonary, Critical Care, Allergy and Sleep Medicine. Her major academic interests include Medical Education, Lung Transplantation and Lung Cancer. She cares for patients on the Advanced Lung Disease Service at UCSF Moffitt-Long Hospital, and sees patients at the Mt. Zion Comprehensive Cancer Center.

She is a past president of the California Thoracic Society. She serves on Item Review Committees for the National Board of Medical Educators and is an Editorial Board Consultant for the Journal of Heart and Lung Transplantation. She is Vice Chair (2023-2024) of the Committee on Academic Personnel -Gold Committee.

• The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision.
  American journal of respiratory and critical care medicine 2023 Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T
• CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2022.
  Journal of the National Comprehensive Cancer Network : JNCCN 2022 Wood DE, Kazerooni EA, Aberle D, Berman A, Brown LM, Eapen GA, Ettinger DS, Ferguson JS, Hou L, Kadaria D, Klippenstein D, Kumar R, Lackner RP, Leard LE, Lennes IT, Leung ANC, Mazzone P, Merritt RE, …
• Response to selection of lung transplant candidates: A pediatric perspective on the ISHLT consensus document.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Solomon M, Willemse BWM, Ramos KJ, Leard LE
• Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction.
  Thorax 2022 Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden JA, Venado A, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Kukreja J, Blanc PD, Smith PJ, Singer JP
• Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival.
  Clinical transplantation 2022 Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR
• A survey of use of mTOR inhibitors in patients with lymphangioleiomyomatosis listed for lung transplant.
  Respiratory medicine 2022 Warrior K, Leard LE, Nair AR, Gries CJ, Fisher AJ, Johnson SR, McCormack FX, Dilling DF
• What's in a name: The importance of lung transplant at Cystic Fibrosis Foundation Accredited Care Centers for patients with Cystic Fibrosis.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Perez AA, Leard LE
• Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.
  Frontiers in immunology 2021 Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR
• Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates.
  Annals of the American Thoracic Society 2021 Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, …
• Perceptions Around Lung Transplant-Associated Hypogammaglobulinemia.
  Journal of clinical immunology 2021 Lew J, Casey M, Leard LE, Hays S, Otani IM
• Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Leard LE, Holm AM, Valapour M, Glanville AR, Attawar S, Aversa M, Campos SV, Christon LM, Cypel M, Dellgren G, Hartwig MG, Kapnadak SG, Kolaitis NA, Kotloff RM, Patterson CM, Shlobin OA, Smith PJ, …
• The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.
  Clinical transplantation 2021 DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J
• Lung transplantation from swimming pool drowning victims: A case series.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Tsou S, Chen J, Brzezinski M, Hays S, Leard L, Singer JP, Trinh B, Kukreja J
• Type-1 immunity and endogenous immune regulators predominate in the airway transcriptome during chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Iasella CJ, Hoji A, Popescu I, Wei J, Snyder ME, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Ellen …
• Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Dugger DT, Fung M, Hays SR, Singer JP, Kleinhenz ME, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR
• Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not disability or depression.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden J, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Venado A, Kukreja J, Blanc PD, Singer JP
• Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.
  Cell reports. Medicine 2020 Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR
• Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
  Thorax 2020 Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD,…
• Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis.
  Pediatric pulmonology 2020 Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP
• Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction.
  American journal of respiratory cell and molecular biology 2020 Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, …
• Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients.
  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2019 Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, …
• Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience.
  Transplant infectious disease : an official journal of the Transplantation Society 2019 Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR
• Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.
  Clinical transplantation 2019 Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD
• Frailty trajectories in adult lung transplantation: A cohort study.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP
• Wildfires Disaster Guidance: Tips for Staying Healthy during Wildfires.
  American journal of respiratory and critical care medicine 2019 Jamil S, Carlos WG, Leard L, Wang A, Santhosh L, Balmes J, Seam N, Dela Cruz CS
• Pirfenidone-Induced Sarcoid-Like Reaction: A Novel Complication.
  Chest 2018 Kolaitis NA, Kukreja J, Jones KD, Hays SR, Leard LE
• Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Hachem RR, Kamoun M, Budev MM, Askar M, Ahya VN, Lee JC, Levine DJ, Pollack MS, Dhillon GS, Weill D, Schechtman KB, Leard LE, Golden JA, Baxter-Lowe L, Mohanakumar T, Tyan DB, Yusen RD
• Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology.
  Journal of the National Comprehensive Cancer Network : JNCCN 2018 Wood DE, Kazerooni EA, Baum SL, Eapen GA, Ettinger DS, Hou L, Jackman DM, Klippenstein D, Kumar R, Lackner RP, Leard LE, Lennes IT, Leung ANC, Makani SS, Massion PP, Mazzone P, Merritt RE, Meyers BF, …
• Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation.
  The Journal of thoracic and cardiovascular surgery 2018 Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP
• ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018 Crespo MM, McCarthy DP, Hopkins PM, Clark SC, Budev M, Bermudez CA, Benden C, Eghtesady P, Lease ED, Leard L, D'Cunha J, Wigfield CH, Cypel M, Diamond JM, Yun JJ, Yarmus L, Machuzak M, Klepetko W, …
• Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness.
  Annals of the American Thoracic Society 2017 Baldwin MR, Singer JP, Huang D, Sell J, Gonzalez WC, Pollack LR, Maurer MS, D'Ovidio FF, Bacchetta M, Sonett JR, Arcasoy SM, Shah L, Robbins H, Hays SR, Kukreja J, Greenland JR, Shah RJ, Leard L, …
• Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
  Transplantation 2016 Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q
• Lung transplantation after prior cardiothoracic surgery: To transplant or not to transplant.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2016 Leard LE
• Acquired acanthosis nigricans with tripe palms in a patient with interstitial lung disease.
  JAAD case reports 2016 Danesh MJ, Saylor DK, Leard LE, North JP, Fox LP
• Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation.
  American journal of respiratory and critical care medicine 2015 Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, …
• Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report.
  Transplantation proceedings 2015 Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP
• Lung transplantation for hypersensitivity pneumonitis.
  Chest 2015 Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD
• Clinical outcomes of lung transplant recipients with telomerase mutations.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2015 Tokman S, Singer JP, Devine MS, Westall GP, Aubert JD, Tamm M, Snell GI, Lee JS, Goldberg HJ, Kukreja J, Golden JA, Leard LE, Garcia CK, Hays SR
• Lung cancer screening, version 1.2015: featured updates to the NCCN guidelines.
  Journal of the National Comprehensive Cancer Network : JNCCN 2015 Wood DE, Kazerooni E, Baum SL, Dransfield MT, Eapen GA, Ettinger DS, Hou L, Jackman DM, Klippenstein D, Kumar R, Lackner RP, Leard LE, Leung AN, Makani SS, Massion PP, Meyers BF, Otterson GA, Peairs K…
• The feasibility of lung transplantation in HIV-seropositive patients.
  Annals of the American Thoracic Society 2014 Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP
• Development and validation of a lung transplant-specific disability questionnaire.
  Thorax 2013 Singer JP, Blanc PD, Dean YM, Hays S, Leard L, Kukreja J, Golden J, Katz PP
• A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Singer JP, Chen J, Blanc PD, Leard LE, Kukreja J, Chen H
• Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis.
  Transplant infectious disease : an official journal of the Transplantation Society 2013 Sayah DM, Schwartz BS, Kukreja J, Singer JP, Golden JA, Leard LE
• Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection.
  Clinical transplantation 2012 Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP
• Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptives.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012 Urisman A, Leard LE, Nathan M, Elicker BM, Hoopes C, Kukreja J, Jones KD
• Lung cancer screening.
  Journal of the National Comprehensive Cancer Network : JNCCN 2012 Wood DE, Eapen GA, Ettinger DS, Hou L, Jackman D, Kazerooni E, Klippenstein D, Lackner RP, Leard L, Leung AN, Massion PP, Meyers BF, Munden RF, Otterson GA, Peairs K, Pipavath S, Pratt-Pozo C, Reddy C…
• Use of sublingual tacrolimus in lung transplant recipients.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011 Watkins KD, Boettger RF, Hanger KM, Leard LE, Golden JA, Hoopes CW, Singer JP
• An analysis of potential risk factors for early complications from fiberoptic bronchoscopy in lung transplant recipients.
  Transplant international : official journal of the European Society for Organ Transplantation 2011 Smith L, Singer JP, Hayes M, Golden JA, Leard LE
• The impact of pretransplant mechanical ventilation on short- and long-term survival after lung transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011 Singer JP, Blanc PD, Hoopes C, Golden JA, Koff JL, Leard LE, Cheng S, Chen H
• Management of recurrent airway strictures in lung transplant recipients using AERO covered stents.
  Journal of vascular and interventional radiology : JVIR 2010 Tan JH, Fidelman N, Durack JC, Hays SR, Leard LL, Laberge JM, Kerlan RK, Golden JA, Gordon RL
• Supratherapeutic anticoagulation from low-molecular-weight heparin in lung transplant recipients.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010 Singer JP, Huang MY, Hui C, Blanc PD, Boettger RF, Golden J, Watkins K, Hoopes C, Leard LE
• Progression of native lung fibrosis in lung transplant recipients with idiopathic pulmonary fibrosis.
  Respiratory medicine 2009 Elicker BM, Golden JA, Ordovas KG, Leard L, Golden TR, Hays SR
• Lung transplantation in patients with connective tissue disorders and esophageal dysmotility.
  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2008 Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG
• Fatal diffuse alveolar damage in two lung transplant patients treated with cetuximab.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Leard LE, Cho BK, Jones KD, Hays SR, Tope WD, Golden JA, Hoopes CW
• Antireflux surgery for patients with end-stage lung disease before and after lung transplantation.
  Surgical endoscopy 2007 Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG
• Lung transplantation for pulmonary metastases and radiation-induced pulmonary fibrosis after radioactive iodine ablation of extensive lung metastases from papillary thyroid carcinoma.
  Thyroid : official journal of the American Thyroid Association 2007 Lee J, Sogutlu G, Leard L, Zarnegar R, Bailey J, Golden J, Hays S, Kebebew E, Duh QY, Clark O
• Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation.
  The Journal of thoracic and cardiovascular surgery 2007 Sweet MP, Patti MG, Leard LE, Golden JA, Hays SR, Hoopes C, Theodore PR
• Prevalence of delayed gastric emptying and gastroesophageal reflux in patients with end-stage lung disease.
  The Annals of thoracic surgery 2006 Sweet MP, Hoopes C, Golden J, Hays S, Leard L, Patti M
• The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation.
  Annals of surgery 2006 Sweet MP, Herbella FA, Leard L, Hoopes C, Golden J, Hays S, Patti MG
• Mesothelial cell proliferation and apoptosis.
  Respirology (Carlton, Vic.) 2004 Leard LE, Broaddus VC