Loren Frank, PhD
Professor
Physiology
School of Medicine
Research Overview
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The ability to store experiences and then use them to guide behavior is one of the most remarkable abilities of the brain. Our goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. In particular, our laboratory focuses on the circuitry of the hippocampus and anatomically related regions. We use a combination of techniques, including large scale multielectrode recording, targeted optogenetic interventions and behavioral manipulations of awake, behaving animals to understand how the brain learns and remembers.
Learning in the Hippocampus and Cortex
Previous studies have shown that neurons throughout the hippocampal formation show place specific firing patterns, where a given neuron is active only in a subregion of the animal's environment. Most of these studies focused on describing patterns of activity during well learned tasks, and we therefore know little about neural processing during learning. We have developed a spatial alternation task that animals can learn over the course of a few days of exposure. We have shown that rapid learning in this task requires an intact hippocampus, and thus this task provides a powerful paradigm for examining the relationship between dynamic patterns of neural activity and changes in behavior.
Although the hippocampus is essential for spatial learning, storing and retrieving new information requires complex networks spread throughout the brain. One prominent hypothesis states that learning takes place first in the hippocampus and over time information is transferred to neocortical regions in a process known as consolidation. We are therefore recording both in the hippocampus and in downstream areas to understand how hippocampal and cortical circuits could support learning, consolidation and memory guided behavior.
These studies continue to provide important new insights into how the brain changes as animals learn and how memory retrieval might occur, but these insights are fundamentally correlational in nature. We have therefore been developing and apply new techniques, including optogenetic manipulations, to take these correlational hypothesis and turn them into causal understanding. We can now express optically activated channels in specific subpopulations of neurons in the rat hippocampus and activate these channels with an implanted fiber optic. We have also combined this optical activation with large scale multielectrode recording, allowing us to manipulate the circuit and record the results both locally and in more distant brain regions. Anatomical Organization of the Hippocampus
The hippocampal formation has a unique anatomical organization in that the connectivity between adjacent hippocampal regions is almost exclusively unidirectional. The majority of neocortical input to the hippocampus comes in through the superficial layers of the entorhinal cortex and connections proceed through the dentate gyrus, to CA3 and on to CA1 (the hippocampus proper), and then to the subiculum. Nearly all neocortically bound outputs from the hippocampus originate in CA1 and the subiculum and target cells in the deep layers of the entorhinal cortex, which projects both to numerous neocortical regions as well as to back to the superficial layers of the entorhinal cortex. Our research uses that organization to compare patterns of activity across regions and to use the similarities and differences among the patterns to identify the transformations that occur in the hippocampal circuit.
An Animal Model for Hippocampal Function
Numerous researchers have shown that a human without a hippocampus is unable to form new memories of facts or events. In rodents these same structures play an essential role in animal's abilities to learn about and remember complex associations, including tasks where the animal must learn and remember information about a set of spatial cues in order to navigate through an environment. Event/fact memory in humans and spatial memory in rodents both require learning complex relationships, and that parallel strongly suggests that qualitatively similar processing occurs in the human and the rat hippocampus.
Websites
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- The Frank Laboratory (keck.ucsf.edu)
Videos
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- Mission in a Minute (youtube.com)
Grants and Projects
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- Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordings, NIH, 2020-2024
- Modular systems for large scale, long lasting measurements of brain activity, NIH, 2018-2021
- Real-time analysis of memories and decisions, NIH, 2014-2020
- Computational and circuit mechanisms for information transmission in the brain, NIH, 2015-2019
- Modular systems for measuring and manipulating brain activity, NIH, 2014-2018
- The role of cholinergic modulation in hippocampal information processing, NIH, 2013-2016
- The role of hippocampal replay in memory formation and retrieval, NIH, 2011-2016
- Dynamic Analysis of Neural Plasticity in the Hippocampal Circuit, NIH, 2007-2013
- Learning in neural circuits: applied optogenetics in non-genetic models, NIH, 2009-2012
- Variation as a Neural Code, NIH, 2006-2012
- Adaptive Analysis of Neural Receptive Field Dynamics, NIH, 2002-2003
Publications (115)
Top publication keywords:
HippocampusRats, Long-EvansMemoryNeuronsSpatial BehaviorNerve NetSpatial NavigationCA1 Region, HippocampalAction PotentialsBrain WavesLearningMemory ConsolidationSpace PerceptionWakefulnessElectrodes, Implanted
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Spyglass: a framework for reproducible and shareable neuroscience research.
bioRxiv : the preprint server for biology 2024 Lee KH, Denovellis EL, Ly R, Magland J, Soules J, Comrie AE, Gramling DP, Guidera JA, Nevers R, Adenekan P, Brozdowski C, Bray SR, Monroe E, Bak JH, Coulter ME, Sun X, Broyles E, Shin D, Chiang S, … -
Regional specialization manifests in the reliability of neural population codes.
bioRxiv : the preprint server for biology 2024 Guidera JA, Gramling DP, Comrie AE, Joshi A, Denovellis EL, Lee KH, Zhou J, Thompson P, Hernandez J, Yorita A, Haque R, Kirst C, Frank LM -
Dual credit assignment processes underlie dopamine signals in a complex spatial environment.
Neuron 2023 Krausz TA, Comrie AE, Kahn AE, Frank LM, Daw ND, Berke JD -
Resolving Non-identifiability Mitigates Bias in Models of Neural Tuning and Functional Coupling.
bioRxiv : the preprint server for biology 2023 Sachdeva P, Bak JH, Livezey J, Kirst C, Frank L, Bhattacharyya S, Bouchard KE -
Dynamic synchronization between hippocampal representations and stepping.
Nature 2023 Joshi A, Denovellis EL, Mankili A, Meneksedag Y, Davidson TJ, Gillespie AK, Guidera JA, Roumis D, Frank LM
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Dual credit assignment processes underlie dopamine signals in a complex spatial environment.
bioRxiv : the preprint server for biology 2023 Krausz TA, Comrie AE, Frank LM, Daw ND, Berke JD -
Cortical-hippocampal coupling during manifold exploration in motor cortex.
Nature 2022 Kim J, Joshi A, Frank L, Ganguly K -
Imagination as a fundamental function of the hippocampus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2022 Comrie AE, Frank LM, Kay K -
A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations.
Nature communications 2022 Liu AA, Henin S, Abbaspoor S, Bragin A, Buffalo EA, Farrell JS, Foster DJ, Frank LM, Gedankien T, Gotman J, Guidera JA, Hoffman KL, Jacobs J, Kahana MJ, Li L, Liao Z, Lin JJ, Losonczy A, Malach R, van… -
The Neurodata Without Borders ecosystem for neurophysiological data science.
eLife 2022 Rübel O, Tritt A, Ly R, Dichter BK, Ghosh S, Niu L, Baker P, Soltesz I, Ng L, Svoboda K, Frank L, Bouchard KE -
Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents.
Nature biomedical engineering 2022 Zhao Z, Zhu H, Li X, Sun L, He F, Chung JE, Liu DF, Frank L, Luan L, Xie C -
Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task.
Cell reports 2022 Kastner DB, Miller EA, Yang Z, Roumis DK, Liu DF, Frank LM, Dayan P -
A Variable Clock Underlies Internally Generated Hippocampal Sequences.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Deng X, Chen S, Sosa M, Karlsson MP, Wei XX, Frank LM -
Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1.
Cell reports 2021 Aery Jones EA, Rao A, Zilberter M, Djukic B, Bant JS, Gillespie AK, Koutsodendris N, Nelson M, Yoon SY, Huang K, Yuan H, Gill TM, Huang Y, Frank LM -
The impact of reducing signal acquisition specifications on neuronal spike sorting.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2021 Hermiz J, Joseph E, Hyun Lee K, Baldacci IA, Chung JE, Frank LM, Bouchard KE, Denes P -
Hippocampal replay of experience at real-world speeds.
eLife 2021 Denovellis EL, Gillespie AK, Coulter ME, Sosa M, Chung JE, Eden UT, Frank LM -
Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
PLoS biology 2021 Yu JY, Frank LM -
Rats use memory confidence to guide decisions.
Current biology : CB 2021 Joo HR, Liang H, Chung JE, Geaghan-Breiner C, Fan JL, Nachman BP, Kepecs A, Frank LM -
Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice.
Neuron 2021 Gillespie AK, Astudillo Maya DA, Denovellis EL, Liu DF, Kastner DB, Coulter ME, Roumis DK, Eden UT, Frank LM -
Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants.
Scientific reports 2020 Kastner DB, Kharazia V, Nevers R, Smyth C, Astudillo-Maya DA, Williams GM, Yang Z, Holobetz CM, Santina LD, Parkinson DY, Frank LM -
Real-Time Point Process Filter for Multidimensional Decoding Problems Using Mixture Models.
Journal of neuroscience methods 2020 Rezaei MR, Arai K, Frank LM, Eden UT, Yousefi A -
Memory Alone Does Not Account for the Way Rats Learn a Simple Spatial Alternation Task.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Kastner DB, Gillespie AK, Dayan P, Frank LM -
A consensus statement: defining terms for reactivation analysis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2020 Genzel L, Dragoi G, Frank L, Ganguly K, de la Prida L, Pfeiffer B, Robertson E -
Robust and replicable measurement for prepulse inhibition of the acoustic startle response.
Molecular psychiatry 2020 Miller EA, Kastner DB, Grzybowski MN, Dwinell MR, Geurts AM, Frank LM -
HDMF: Hierarchical Data Modeling Framework for Modern Science Data Standards.
Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data 2020 Tritt AJ, Rübel O, Dichter B, Ly R, Kang D, Chang EF, Frank LM, Bouchard K -
Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.
Cell 2020 Kay K, Chung JE, Sosa M, Schor JS, Karlsson MP, Larkin MC, Liu DF, Frank LM -
Dorsal and Ventral Hippocampal Sharp-Wave Ripples Activate Distinct Nucleus Accumbens Networks.
Neuron 2019 Sosa M, Joo HR, Frank LM -
Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model.
Cell reports 2019 Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y -
A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain.
Journal of neural engineering 2019 Joo HR, Fan JL, Chen S, Pebbles JA, Liang H, Chung JE, Yorita AM, Tooker AC, Tolosa VM, Geaghan-Breiner C, Roumis DK, Liu DF, Haque R, Frank LM -
BRAIN Initiative: Cutting-Edge Tools and Resources for the Community.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Litvina E, Adams A, Barth A, Bruchez M, Carson J, Chung JE, Dupre KB, Frank LM, Gates KM, Harris KM, Joo H, William Lichtman J, Ramos KM, Sejnowski T, Trimmer JS, White S, Koroshetz W -
Chronic Implantation of Multiple Flexible Polymer Electrode Arrays.
Journal of visualized experiments : JoVE 2019 Chung JE, Joo HR, Smyth CN, Fan JL, Geaghan-Breiner C, Liang H, Liu DF, Roumis D, Chen S, Lee KY, Pebbles JA, Tooker AC, Tolosa VM, Frank LM -
Chronic Implantation of Multiple Flexible Polymer Electrode Arrays.
Journal of Visualized Experiments 2019 Jason E Chung, Hannah R Joo, Clay N Smyth, Jiang Lan Fan, Charlotte Geaghan-Breiner, Hexin Liang, Daniel Fan Liu, Demetris Roumis, Supin Chen, Kye Y Lee, Jeanine A Pebbles, Angela C Tooker, Vanessa M … -
Efficient Decoding of Multi-Dimensional Signals From Population Spiking Activity Using a Gaussian Mixture Particle Filter.
IEEE transactions on bio-medical engineering 2019 Yousefi A, Gillespie AK, Guidera JA, Karlsson M, Frank LM, Eden UT -
Three brain states in the hippocampus and cortex.
Hippocampus 2019 Kay K, Frank LM -
The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation.
Nature reviews. Neuroscience 2018 Joo HR, Frank LM -
High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays.
Neuron 2018 Chung JE, Joo HR, Fan JL, Liu DF, Barnett AH, Chen S, Geaghan-Breiner C, Karlsson MP, Karlsson M, Lee KY, Liang H, Magland JF, Pebbles JA, Tooker AC, Greengard LF, Tolosa VM, Frank LM -
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Cell 2018 Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, … -
Are We There Yet? Identification of Reward-Selective Cells in the Hippocampus.
Neuron 2018 Sosa M, Frank LM -
A Comparison Study of Point-Process Filter and Deep Learning Performance in Estimating Rat Position Using an Ensemble of Place Cells.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2018 Rezaei MR, Gillespie AK, Guidera JA, Nazari B, Sadri S, Frank LM, Eden UT, Yousefi A -
Specific hippocampal representations are linked to generalized cortical representations in memory.
Nature communications 2018 Yu JY, Liu DF, Loback A, Grossrubatscher I, Frank LM -
International Neuroscience Initiatives through the Lens of High-Performance Computing.
Computer 2018 Kristofer E. Bouchard, James B. Aimone, Miyoung Chun, Thomas Dean, Michael Denker, Markus Diesmann, David D. Donofrio, Loren M. Frank, Narayanan Kasthuri, Christof Koch, Oliver Rubel, Horst D. Simon, … -
Characterizing Complex, Multi-Scale Neural Phenomena Using State-Space Models.
Dynamic Neuroscience 2018 Uri T. Eden, Loren M. Frank, Long Tao -
Neural Activity Patterns Underlying Spatial Coding in the Hippocampus.
Current topics in behavioral neurosciences 2018 Sosa M, Gillespie AK, Frank LM -
Hippocampal-Prefrontal Reactivation during Learning Is Stronger in Awake Compared with Sleep States.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Tang W, Shin JD, Frank LM, Jadhav SP -
A Fully Automated Approach to Spike Sorting.
Neuron 2017 Chung JE, Magland JF, Barnett AH, Tolosa VM, Tooker AC, Lee KY, Shah KG, Felix SH, Frank LM, Greengard LF -
Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility.
eLife 2017 Yu JY, Kay K, Liu DF, Grossrubatscher I, Loback A, Sosa M, Chung JE, Karlsson MP, Larkin MC, Frank LM -
A cortical-hippocampal-cortical loop of information processing during memory consolidation.
Nature neuroscience 2016 Rothschild G, Eban E, Frank LM -
Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.
Neuron 2016 Papale AE, Zielinski MC, Frank LM, Jadhav SP, Redish AD -
High-Performance Computing in Neuroscience for Data-Driven Discovery, Integration, and Dissemination.
Neuron 2016 Bouchard KE, Aimone JB, Chun M, Dean T, Denker M, Diesmann M, Donofrio DD, Frank LM, Kasthuri N, Koch C, Ruebel O, Simon HD, Sommer FT -
Cover Image, Volume 26, Issue 10.
Hippocampus 2016 Howard Eichenbaum, David G. Amaral, Elizabeth A. Buffalo, György Buzsáki, Neal Cohen, Lila Davachi, Loren Frank, Stephan Heckers, Richard G. M. Morris, Edvard I. Moser, Lynn Nadel, John O'Keefe, … -
Rapid classification of hippocampal replay content for real-time applications.
Journal of neurophysiology 2016 Deng X, Liu DF, Karlsson MP, Frank LM, Eden UT -
Hippocampus at 25.
Hippocampus 2016 Eichenbaum H, Amaral DG, Buffalo EA, Buzsáki G, Cohen N, Davachi L, Frank L, Heckers S, Morris RG, Moser EI, Nadel L, O'Keefe J, Preston A, Ranganath C, Silva A, Witter M -
Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples.
Neuron 2016 Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y -
Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.
Neuron 2016 Jadhav SP, Rothschild G, Roumis DK, Frank LM -
A hippocampal network for spatial coding during immobility and sleep.
Nature 2016 Kay K, Sosa M, Chung JE, Karlsson MP, Larkin MC, Frank LM -
Decoding position from multiunit activity using a marked point process filter.
BMC Neuroscience 2015 Xinyi Deng, Daniel F Liu, Kenneth Kay, Loren M Frank, Uri T Eden -
Hippocampal sharp-wave ripples in waking and sleeping states.
Current opinion in neurobiology 2015 Roumis DK, Frank LM -
Clusterless Decoding of Position from Multiunit Activity Using a Marked Point Process Filter.
Neural computation 2015 Deng X, Liu DF, Kay K, Frank LM, Eden UT -
Dynamic Hippocampal Circuits Support Learning- and Memory-Guided Behaviors.
Cold Spring Harbor symposia on quantitative biology 2015 Anderson EB, Grossrubatscher I, Frank L -
Reconceiving the hippocampal map as a topological template.
eLife 2014 Dabaghian Y, Brandt VL, Frank LM -
Hippocampal output area CA1 broadcasts a generalized novelty signal during an object-place recognition task.
Hippocampus 2014 Larkin MC, Lykken C, Tye LD, Wickelgren JG, Frank LM -
Hippocampal-cortical interaction in decision making.
Neurobiology of learning and memory 2014 Yu JY, Frank LM -
Memory Replay in the Hippocampus.
Space,Time and Memory in the Hippocampal Formation 2014 Shantanu P. Jadhav, Loren M. Frank -
Towards a large-scale recording system: demonstration of polymer-based penetrating array for chronic neural recording.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2014 Tooker A, Liu D, Anderson EB, Felix S, Shah KG, Lee KY, Chung JE, Pannu S, Frank L, Tolosa V -
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive.
Journal of Visualized Experiments 2013 Sarah H. Felix, Kedar G. Shah, Vanessa M. Tolosa, Heeral J. Sheth, Angela C. Tooker, Terri L. Delima, Shantanu P. Jadhav, Loren M. Frank, Satinderpall S. Pannu -
Insertion of flexible neural probes using rigid stiffeners attached with biodissolvable adhesive.
Journal of visualized experiments : JoVE 2013 Felix SH, Shah KG, Tolosa VM, Sheth HJ, Tooker AC, Delima TL, Jadhav SP, Frank LM, Pannu SS -
Rapid and continuous modulation of hippocampal network state during exploration of new places.
PloS one 2013 Kemere C, Carr MF, Karlsson MP, Frank LM -
Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task.
Neuron 2013 Singer AC, Carr MF, Karlsson MP, Frank LM -
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Nature 2012 Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K -
Transient slow gamma synchrony underlies hippocampal memory replay.
Neuron 2012 Carr MF, Karlsson MP, Frank LM -
Spatial information outflow from the hippocampal circuit: distributed spatial coding and phase precession in the subiculum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Kim SM, Ganguli S, Frank LM -
Awake hippocampal sharp-wave ripples support spatial memory.
Science (New York, N.Y.) 2012 Jadhav SP, Kemere C, German PW, Frank LM -
A single microcircuit with multiple functions: state dependent information processing in the hippocampus.
Current opinion in neurobiology 2012 Carr MF, Frank LM -
Optetrode: a multichannel readout for optogenetic control in freely moving mice.
Nature neuroscience 2011 Anikeeva P, Andalman AS, Witten I, Warden M, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K -
The structure of networks that produce the transformation from grid cells to place cells.
Neuroscience 2011 Cheng S, Frank LM -
Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Li JX, Medina JF, Frank LM, Lisberger SG -
Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval.
Nature neuroscience 2011 Carr MF, Jadhav SP, Frank LM -
Probability of repeating patterns in simultaneous neural data.
Neural computation 2010 Smith AC, Nguyen VK, Karlsson MP, Frank LM, Smith P -
Experience-dependent development of coordinated hippocampal spatial activity representing the similarity of related locations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Singer AC, Karlsson MP, Nathe AR, Carr MF, Frank LM -
Rewarded outcomes enhance reactivation of experience in the hippocampus.
Neuron 2009 Singer AC, Frank LM -
Reactivating memories for consolidation.
Neuron 2009 Jadhav SP, Frank LM -
Awake replay of remote experiences in the hippocampus.
Nature neuroscience 2009 Karlsson MP, Frank LM -
Hippocampal lesions impair rapid learning of a continuous spatial alternation task.
PloS one 2009 Kim SM, Frank LM -
Network dynamics underlying the formation of sparse, informative representations in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Karlsson MP, Frank LM -
Place Cells in Perspective SheriMizumoriHippocampal Place Fields: Relevance to Learning and Memory2008Oxford University Press432 pp., $98.50, hardcover.
Neuron 2008 Loren Frank -
New experiences enhance coordinated neural activity in the hippocampus.
Neuron 2008 Cheng S, Frank LM -
69: The role of primary human herpesvirus 6, 7 (HHV-6, HHV-7) infection in febrile status epilepticus.
Journal of Clinical Virology 2006 L. Epstein, D.R. Nordli, A. Hamidullah, J.M. Pellock, L.M. Frank, D.V. Lewis, D.C. Hesdorffer, A. Marmarou, C. O'Dell, S. Shinnar -
Hippocampal and cortical place cell plasticity: implications for episodic memory.
Hippocampus 2006 Frank LM, Brown EN, Stanley GB -
Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Law JR, Flanery MA, Wirth S, Yanike M, Smith AC, Frank LM, Suzuki WA, Brown EN, Stark CE -
An analysis of hippocampal spatio-temporal representations using a Bayesian algorithm for neural spike train decoding.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 2005 Barbieri R, Wilson MA, Frank LM, Brown EN -
Hippocampal plasticity across multiple days of exposure to novel environments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Frank LM, Stanley GB, Brown EN -
Dynamic analysis of neural encoding by point process adaptive filtering.
Neural computation 2004 Eden UT, Frank LM, Barbieri R, Solo V, Brown EN -
Dynamic analyses of information encoding in neural ensembles.
Neural computation 2004 Barbieri R, Frank LM, Nguyen DP, Quirk MC, Solo V, Wilson MA, Brown EN -
Dynamic analysis of learning in behavioral experiments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Smith AC, Frank LM, Wirth S, Yanike M, Hu D, Kubota Y, Graybiel AM, Suzuki WA, Brown EN -
A Bayesian decoding algorithm for analysis of information encoding in neural ensembles.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 Barbieri R, Frank LM, Nguyen DP, Quirk MC, Solo V, Wilson MA, Brown EN -
Consultant’s corner: the “breakthrough” seizure.
Clinical Pediatric Emergency Medicine 2003 Donald W Lewis, L.Matthew Frank, Larry White -
Making space for rats: from synapse to place code.
Neuron 2003 Nathe AR, Frank LM -
Persistent activity and memory in the entorhinal cortex.
Trends in neurosciences 2003 Frank LM, Brown EN -
Single neurons in the monkey hippocampus and learning of new associations.
Science (New York, N.Y.) 2003 Wirth S, Yanike M, Frank LM, Smith AC, Brown EN, Suzuki WA -
An application of reversible-jump Markov chain Monte Carlo to spike classification of multi-unit extracellular recordings.
Network (Bristol, England) 2003 Nguyen DP, Frank LM, Brown EN -
Construction and analysis of non-Gaussian spatial models of neural spiking activity.
Neurocomputing 2002 Riccardo Barbieri, Loren M. Frank, Michael C. Quirk, Victor Solo, Matthew A. Wilson, Emery N. Brown -
The time-rescaling theorem and its application to neural spike train data analysis.
Neural computation 2002 Brown EN, Barbieri R, Ventura V, Kass RE, Frank LM -
Entorhinal Place Cells: Trajectory Encoding.
The Neural Basis of Navigation 2002 Loren M. Frank, Emery N. Brown, Matthew A. Wilson -
An analysis of neural receptive field plasticity by point process adaptive filtering.
Proceedings of the National Academy of Sciences of the United States of America 2001 Brown EN, Nguyen DP, Frank LM, Wilson MA, Solo V -
A comparison of the firing properties of putative excitatory and inhibitory neurons from CA1 and the entorhinal cortex.
Journal of neurophysiology 2001 Frank LM, Brown EN, Wilson MA -
Diagnostic methods for statistical models of place cell spiking activity.
Neurocomputing 2001 Riccardo Barbieri, Loren M. Frank, Michael C. Quirk, Matthew A. Wilson, Emery N. Brown -
Construction and analysis of non-Poisson stimulus-response models of neural spiking activity.
Journal of neuroscience methods 2001 Barbieri R, Quirk MC, Frank LM, Wilson MA, Brown EN -
Trajectory encoding in the hippocampus and entorhinal cortex.
Neuron 2000 Frank LM, Brown EN, Wilson M -
A time-dependent analysis of spatial information encoding in the rat hippocampus.
Neurocomputing 2000 Riccardo Barbieri, Loren M Frank, Michael C Quirk, Matthew A Wilson, Emery N Brown -
REPLY.
Epilepsia 2000 L. Matthew Frank -
A Statistical Paradigm for Neural Spike Train Decoding Applied to Position Prediction from Ensemble Firing Patterns of Rat Hippocampal Place Cells.
Journal of Neuroscience 1998 Emery N. Brown, Loren M. Frank, Dengda Tang, Michael C. Quirk, Matthew A. Wilson -
A statistical paradigm for neural spike train decoding applied to position prediction from ensemble firing patterns of rat hippocampal place cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Brown EN, Frank LM, Tang D, Quirk MC, Wilson MA -
Spin-spin relaxation of brain tissues in systemic lupus erythematosus. A method for increasing the sensitivity of magnetic resonance imaging for neuropsychiatric lupus.
Arthritis and rheumatism 1995 Sibbitt WL, Brooks WM, Haseler LJ, Griffey RH, Frank LM, Hart BL, Sibbitt RR -
Prediction of chronic vegetative state with somatosensory evoked potentials.
Neurology 1986 L. M. Frank, T. L. Furgiuele, J. E. Etheridge -
PREDICTION OF CEREBRAL DEATH BY CRANIAL SECTOR SCAN.
Critical Care Medicine 1983 Terry L. Furquiele, L. Matthew Frank, Carolyn Riegle, Frederick Wirth, Linda C. Early