Liviu Klein, MD, MS
Professor
Medicine
School of Medicine

My clinical interests are heart failure and cardiac arrhythmias in patients with heart failure. Having advanced training in both heart failure and electrophysiology, I practice an integrated approach in treating patients with heart failure and cardiac arrhythmias. I am also interested in cardiac recovery using electrical (i.e. cardiac resynchronization) and mechanical (i.e. ventricular assist devices) therapies. I treat patients across the heart failure spectrum, from early diagnosis to heart transplantation. At UCSF, I am the Director of the Advanced Heart Failure Comprehensive Care Center and the Section Chief of Advanced Heart Failure, Mechanical Circulatory Support, Pulmonary Hypertension and Heart Transplant.

RESEARCH INTERESTS My research is aimed at developing new diagnostic sensors (including implantable hemodynamic sensors), therapeutic devices and artificial intelligence tools for patients with cardiovascular disease, including patients with heart failure. At UCSF, I am the Director of the Cardiology Clinical Research Unit.

• PROMIS: Physical, Mental and Social Health Outcomes Improve From Before to Early After LVAD Implant: Findings From the Mechanical Circulatory Support: Measures of Adjustment and Quality of Life (MCS A-QOL) Study.
  Journal of cardiac failure 2023 Hahn EA, Allen LA, Lee CS, Denfeld QE, Stehlik J, Cella D, Lindenfeld J, Teuteberg JJ, McIlvennan CK, Kiernan MS, Beiser DG, Walsh MN, Adler ED, Ruo B, Kirklin JK, Klein L, Bedjeti K, Cummings PD, …
• HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support.
  Journal of cardiac failure 2023 Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E
• Validity of Patient-Reported Outcomes Measurement Information System Physical, Mental, and Social Health Measures After Left Ventricular Assist Device Implantation and Implications for Patient Care.
  Circulation. Cardiovascular quality and outcomes 2023 Hahn EA, Walsh MN, Allen LA, Lee CS, Denfeld QE, Teuteberg JJ, Beiser DG, McIlvennan CK, Lindenfeld J, Klein L, Adler ED, Stehlik J, Ruo B, Bedjeti K, Cummings PD, Vela AM, Grady KL
• Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning.
  Journal of cardiac failure 2023 Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH
• Rationale and Design of the Proactive-HF Trial for Managing Patients With NYHA Class III Heart Failure by Using the Combined Cordella Pulmonary Artery Sensor and the Cordella Heart Failure System.
  Journal of cardiac failure 2022 Guichard JL, Cowger JA, Chaparro SV, Kiernan MS, Mullens W, Mahr C, Mullin C, Forouzan O, Hiivala NJ, Sauerland A, Leadley K, Klein L
• Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure.
  Current problems in cardiology 2022 Fudim M, Shahid I, Emani S, Klein L, Dupuy-McCauley KL, Zieroth S, Mentz RJ
• Estimation of Changes in Intracardiac Hemodynamics Using Wearable Seismocardiography and Machine Learning in Patients With Heart Failure: A Feasibility Study.
  IEEE transactions on bio-medical engineering 2022 Shandhi MMH, Fan J, Heller JA, Etemadi M, Klein L, Inan OT
• Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the REBALANCE-HF trial roll-in cohort.
  European journal of heart failure 2022 Fudim M, Fail PS, Litwin SE, Shaburishvili T, Goyal P, Hummel SL, Borlaug BA, Mohan RC, Patel RB, Mitter SS, Klein L, Rocha-Singh K, Patel MR, Reddy VY, Burkhoff D, Shah SJ
• Improving clinical trial efficiency using a machine learning-based risk score to enrich study populations.
  European journal of heart failure 2022 Jering KS, Campagnari C, Claggett B, Adler E, Klein L, Ahmad FS, Voors AA, Solomon S, Yagil A, Greenberg B
• Blood Pressure Variability and Heart Failure Hospitalization: Results From the Women's Health Initiative.
  American journal of preventive medicine 2022 Haring B, Hunt RP, Manson JE, LaMonte MJ, Klein L, Allison MA, Wild RA, Wallace RB, Shadyab AH, Breathett K, Eaton C, Wassertheil-Smoller S, Shimbo D
• Global best practices consensus: Long-term management of patients with hybrid centrifugal flow left ventricular assist device support.
  The Journal of thoracic and cardiovascular surgery 2022 Hayward C, Adachi I, Baudart S, Davis E, Feller ED, Kinugawa K, Klein L, Li S, Lorts A, Mahr C, Mathew J, Morshuis M, Müller M, Ono M, Pagani FD, Pappalardo F, Rich J, Robson D, Rosenthal DN, Saeed D,…
• Multiple cArdiac seNsors for mAnaGEment of Heart Failure (MANAGE-HF) - Phase I Evaluation of the Integration and Safety of the HeartLogic Multisensor Algorithm in Patients With Heart Failure.
  Journal of cardiac failure 2022 Hernandez AF, Albert NM, Allen LA, Ahmed R, Averina V, Boehmer JP, Cowie MR, Chien CV, Galvao M, Klein L, Kwan B, Lam CSP, Ruble SB, Stolen CM, Stein K, MANAGE-HF Study
• Novel Noninvasive Biosensors and Artificial Intelligence for Optimized Heart Failure Management.
  JACC. Basic to translational science 2022 Neill L, Etemadi M, Klein L, Inan OT
• Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report.
  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2021 Banerjee R, Lo M, Klein L, Aras M, Logan AC
• Is There a Logic in Using Device-Based Algorithms to Prevent Heart Failure Decompensations?
  Circulation. Heart failure 2021 Klein L
• Long-Term Electrocardiographic and Echocardiographic Progression of Arrhythmogenic Right Ventricular Cardiomyopathy and Their Correlation With Ventricular Tachyarrhythmias.
  Circulation. Heart failure 2021 Kalantarian S, Åström Aneq M, Svetlichnaya J, Sharma S, Vittinghoff E, Klein L, Scheinman MM
• Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA.
  International journal of cardiology 2021 Darden D, Ammirati E, Brambatti M, Lin A, Hsu JC, Shah P, Perna E, Cikes M, Gjesdal G, Potena L, Masetti M, Jakus N, Van De Heyning C, De Bock D, Brugts JJ, Russo CF, Veenis JF, Rega F, Cipriani M, …
• Predicting Incident Heart Failure in Women With Machine Learning: The Women's Health Initiative Cohort.
  The Canadian journal of cardiology 2021 Tison GH, Avram R, Nah G, Klein L, Howard BV, Allison MA, Casanova R, Blair RH, Breathett K, Foraker RE, Olgin JE, Parikh NI
• Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia.
  Women's health reports (New Rochelle, N.Y.) 2021 Quesada O, Shandhi MMH, Beach S, Dowling S, Tandon D, Heller J, Etemadi M, Roy S, Gonzalez Velez JM, Inan OT, Klein L
• Two-Year Follow Up of the LATERAL Clinical Trial: A Focus on Adverse Events.
  Circulation. Heart failure 2021 Wieselthaler GM, Klein L, Cheung AW, Danter MR, Strueber M, Mahr C, Mokadam NA, Maltais S, McGee EC
• Effect of preload reducing therapy on right ventricular size and function in patients with arrhythmogenic right ventricular cardiomyopathy.
  Heart rhythm 2021 Kalantarian S, Vittinghoff E, Klein L, Scheinman MM
• Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women.
  Circulation. Heart failure 2020 LaMonte MJ, Larson JC, Manson JE, Bellettiere J, Lewis CE, LaCroix AZ, Bea JW, Johnson KC, Klein L, Noel CA, Stefanick ML, Wactawski-Wende J, Eaton CB
• When the At-Risk Do Not Develop Heart Failure: Understanding Positive Deviance Among Postmenopausal African American and Hispanic Women.
  Journal of cardiac failure 2020 Breathett K, Kohler LN, Eaton CB, Franceschini N, Garcia L, Klein L, Martin LW, Ochs-Balcom HM, Shadyab AH, Cené CW
• Temporal Associations and Outcomes of Breast Cancer and Heart Failure in Postmenopausal Women.
  JACC. CardioOncology 2020 Lam PH, Barac A, Nohria A, Reding KW, Najjar SS, Fonarow GC, Pan K, Sheriff H, Morgan CJ, Chlebowski RT, Klein L, Eaton CB, Howard BV, Ahmed A, Mohammed SF
• Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA).
  International journal of cardiology 2020 Ammirati E, Brambatti M, Braun OÖ, Shah P, Cipriani M, Bui QM, Veenis J, Lee E, Xu R, Hong KN, Van de Heyning CM, Perna E, Timmermans P, Cikes M, Brugts JJ, Veronese G, Minto J, Smith S, Gjesdal G, …
• Cardiac Function Monitoring for Patients Undergoing Cancer Treatments Using Wearable Seismocardiography: A Proof-of-Concept Study.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2020 Hasan Shandhi MM, Aras M, Wynn S, Fan J, Heller JA, Etemadi M, Klein L, Inan OT
• Wearable Patch-Based Estimation of Oxygen Uptake and Assessment of Clinical Status during Cardiopulmonary Exercise Testing in Patients With Heart Failure.
  Journal of cardiac failure 2020 Shandhi MMH, Hersek S, Fan J, Sander E, De Marco T, Heller JA, Etemadi M, Klein L, Inan OT
• Detecting Suspected Pump Thrombosis in Left Ventricular Assist Devices via Acoustic Analysis.
  IEEE journal of biomedical and health informatics 2020 Semiz B, Hersek S, Pouyan MB, Partida C, Blazquez-Arroyo L, Selby V, Wieselthaler G, Rehg JM, Klein L, Inan OT
• Heart-lung transplantation: A viable option for connective tissue diseases.
  Clinical transplantation 2020 Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T
• Improving risk prediction in heart failure using machine learning.
  European journal of heart failure 2019 Adler ED, Voors AA, Klein L, Macheret F, Braun OO, Urey MA, Zhu W, Sama I, Tadel M, Campagnari C, Greenberg B, Yagil A
• Menopausal Hormone Therapy and Risks of First Hospitalized Heart Failure and its Subtypes During the Intervention and Extended Postintervention Follow-up of the Women's Health Initiative Randomized Trials.
  Journal of cardiac failure 2019 Liu L, Klein L, Eaton C, Panjrath G, Martin LW, Chae CU, Greenland P, Lloyd-Jones DM, Wactawski-Wende J, Manson JE
• Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.
  Journal of the American Heart Association 2019 Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham…
• Classification of Decompensated Heart Failure From Clinical and Home Ballistocardiography.
  IEEE transactions on bio-medical engineering 2019 Aydemir VB, Nagesh S, Shandhi MMH, Fan J, Klein L, Etemadi M, Heller JA, Inan OT, Rehg JM
• Internal Jugular Vein as Alternative Access for Implantation of a Wireless Pulmonary Artery Pressure Sensor.
  Circulation. Heart failure 2019 Abraham J, McCann P, Wang L, Schnell Heringer A, Paulsen J, Chappell J, Remick J, Westerdahl D, Lewis R, Callis K, Spinelli KJ, Klein L
• Atrial arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy: Prevalence, echocardiographic predictors, and treatment.
  Journal of cardiovascular electrophysiology 2019 Cardona-Guarache R, Åström-Aneq M, Oesterle A, Asirvatham R, Svetlichnaya J, Marcus GM, Gerstenfeld EP, Klein L, Scheinman MM
• Noninvasive estimation of pulmonary vascular resistance improves portopulmonary hypertension screening in liver transplant candidates.
  Clinical transplantation 2019 DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T
• Evaluation of a lateral thoracotomy implant approach for a centrifugal-flow left ventricular assist device: The LATERAL clinical trial.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 McGee E, Danter M, Strueber M, Mahr C, Mokadam NA, Wieselthaler G, Klein L, Lee S, Boeve T, Maltais S, Pretorius GV, Adler E, Vassiliades T, Cheung A
• Pregnancy complications and premature cardiovascular events among 1.6 million California pregnancies.
  Open heart 2019 Arnaout R, Nah G, Marcus G, Tseng Z, Foster E, Harris IS, Divanji P, Klein L, Gonzalez J, Parikh N
• Feasibility and utility of intraoperative epicardial scar characterization during left ventricular assist device implantation.
  Journal of cardiovascular electrophysiology 2018 Moss JD, Oesterle A, Raiman M, Flatley EE, Beaser AD, Jeevanandam V, Klein L, Ota T, Wieselthaler G, Uriel N, Tung R
• Physical Activity and Incidence of Heart Failure in Postmenopausal Women.
  JACC. Heart failure 2018 LaMonte MJ, Manson JE, Chomistek AK, Larson JC, Lewis CE, Bea JW, Johnson KC, Li W, Klein L, LaCroix AZ, Stefanick ML, Wactawski-Wende J, Eaton CB
• Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Women's Health Initiative.
  Circulation. Heart failure 2018 Breathett K, Leng I, Foraker RE, Abraham WT, Coker L, Whitfield KE, Shumaker S, Manson JE, Eaton CB, Howard BV, Ijioma N, Cené CW, Martin LW, Johnson KC, Klein L
• Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction.
  Circulation 2018 Pandey A, Omar W, Ayers C, LaMonte M, Klein L, Allen NB, Kuller LH, Greenland P, Eaton CB, Gottdiener JS, Lloyd-Jones DM, Berry JD
• (Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure.
  Journal of the American College of Cardiology 2017 Klein L
• Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative.
  Journal of the American College of Cardiology 2017 Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI
• Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure.
  Journal of the American College of Cardiology 2017 Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, Berry JD
• Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature.
  Transplant infectious disease : an official journal of the Transplantation Society 2017 Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM
• The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective.
  European journal of heart failure 2017 Cowie MR, Simon M, Klein L, Thokala P
• Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women.
  Circulation. Heart failure 2016 Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie-Smith G, Rosamond W, Breathett K, Klein L
• Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico.
  The International journal of artificial organs 2016 Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM
• Treating Hemodynamic Congestion Is the Key to Prevent Heart Failure Hospitalizations.
  JACC. Heart failure 2016 Klein L
• Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey.
  Journal of cardiac failure 2015 Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, de Marco T
• The importance of cognitive assessment before ventricular device placement: a teachable moment.
  JAMA internal medicine 2015 Rogers SE, Klein L, Perissinotto CM
• A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables.
  IEEE transactions on biomedical circuits and systems 2015 Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S
• Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative.
  Circulation. Heart failure 2014 Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE
• Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography.
  IEEE journal of biomedical and health informatics 2014 Wiens AD, Etemadi M, Roy S, Klein L, Inan OT
• Sudden cardiac death in heart failure.
  Cardiology clinics 2014 Klein L, Hsia H
• Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2014 Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT
• Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2014 Wiens A, Etemadi M, Klein L, Roy S, Inan OT
• Prognostic factors in patients hospitalized for heart failure.
  Current heart failure reports 2013 Sridharan L, Klein L
• Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study.
  Heart (British Cardiac Society) 2013 Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML
• Effects of postmenopausal hormone therapy on incident atrial fibrillation: the Women's Health Initiative randomized controlled trials.
  Circulation. Arrhythmia and electrophysiology 2012 Perez MV, Wang PJ, Larson JC, Virnig BA, Cochrane B, Curb JD, Klein L, Manson JE, Martin LW, Robinson J, Wassertheil-Smoller S, Stefanick ML
• ACP Journal Club. Review: new oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF.
  Annals of internal medicine 2012 Klein L
• Fine-mapping and initial characterization of QT interval loci in African Americans.
  PLoS genetics 2012 Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, …
• Racial and ethnic differences in incident hospitalized heart failure in postmenopausal women: the Women's Health Initiative.
  Circulation 2012 Eaton CB, Abdulbaki AM, Margolis KL, Manson JE, Limacher M, Klein L, Allison MA, Robinson JG, Curb JD, Martin LA, Liu S, Howard BV
• Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation.
  Annals of internal medicine 2012 Klein L
• Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF.
  Annals of internal medicine 2012 Klein L
• Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials.
  Journal of the American College of Cardiology 2011 Shah RU, Winkleby MA, Van Horn L, Phillips LS, Eaton CB, Martin LW, Rosal MC, Manson JE, Ning H, Lloyd-Jones DM, Klein L
• Quality of care and outcomes in women hospitalized for heart failure.
  Circulation. Heart failure 2011 Klein L, Grau-Sepulveda MV, Bonow RO, Hernandez AF, Williams MV, Bhatt DL, Fonarow GC
• Omnes viae Romam ducunt: Asymptomatic cardiac and noncardiac organ system dysfunction leads to heart failure.
  Circulation 2011 Klein L
• Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century.
  Expert review of cardiovascular therapy 2011 Svetlichnaya J, Klein L
• Clinical experience and patient outcomes associated with the TandemHeart percutaneous transseptal assist device among a heterogeneous patient population.
  ASAIO journal (American Society for Artificial Internal Organs : 1992) 2011 Tempelhof MW, Klein L, Cotts WG, Benzuly KH, Davidson CJ, Meyers SN, McCarthy PM, Malaisrie CS, McGee EC, Beohar N
• Characteristics and outcomes of very elderly patients after first hospitalization for heart failure.
  Circulation. Heart failure 2011 Shah RU, Tsai V, Klein L, Heidenreich PA
• ACP Journal Club. Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation.
  Annals of internal medicine 2010 Klein L
• Heart failure in women: epidemiology, biology and treatment.
  Women's health (London, England) 2009 Shah RU, Klein L, Lloyd-Jones DM
• Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF).
  Circulation. Heart failure 2008 Klein L, Massie BM, Leimberger JD, O'Connor CM, Piña IL, Adams KF, Califf RM, Gheorghiade M, OPTIME-CHF Investigators
• Thromboembolic risk in the patient with heart failure.
  Current treatment options in cardiovascular medicine 2007 Klein L, O'connell JB
• Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study.
  Circulation 2007 Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, Lewis CE, Savage P
• Acute heart failure syndromes: current state and framework for future research.
  Circulation 2005 Gheorghiade M, Zannad F, Sopko G, Klein L, Piña IL, Konstam MA, Massie BM, Roland E, Targum S, Collins SP, Filippatos G, Tavazzi L, International Working Group on Acute Heart Failure Syndromes
• Hyponatremia in patients with heart failure.
  The American journal of cardiology 2005 De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F, Gheorghiade M
• Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study.
  Circulation 2005 Klein L, O'Connor CM, Leimberger JD, Gattis-Stough W, Piña IL, Felker GM, Adams KF, Califf RM, Gheorghiade M, OPTIME-CHF Investigators
• Posting treatment recommendations to primary care physicians does not improve care for people with myocardial infarction or heart failure. Commentary.
  Evidence-based cardiovascular medicine 2005 Klein L
• Coronary artery disease and prevention of heart failure.
  The Medical clinics of North America 2004 Klein L, Gheorghiade M
• A predictive model for survival after in-hospital cardiopulmonary arrest.
  Resuscitation 2004 Danciu SC, Klein L, Hosseini MM, Ibrahim L, Coyle BW, Kehoe RF
• Warfarin-induced limb gangrene in the setting of lung adenocarcinoma.
  American journal of hematology 2004 Klein L, Galvez A, Klein O, Chediak J
• Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study.
  The American journal of cardiology 2004 Klein L, Gattis WA, Borrello F, Wu E, O'Connor CM, Gheorghiade M
• Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update.
  The American journal of medicine 2004 Klein L, Gheorghiade M
• New insights into diastolic heart failure: role of diabetes mellitus.
  The American journal of medicine 2004 Piccini JP, Klein L, Gheorghiade M, Bonow RO
• Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin.
  Italian heart journal : official journal of the Italian Federation of Cardiology 2004 Gheorghiade M, Klein L, Stone NJ, Bonow RO, Kim RJ
• Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations.
  The American journal of cardiology 2003 Klein L, O'Connor CM, Gattis WA, Zampino M, de Luca L, Vitarelli A, Fedele F, Gheorghiade M
• Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization.
  American heart journal 2003 Jain P, Massie BM, Gattis WA, Klein L, Gheorghiade M
• Therapeutic strategies for patients hospitalized with worsening heart failure.
  Italian heart journal : official journal of the Italian Federation of Cardiology 2003 Klein L, Gheorghiade M
• OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization.
  European journal of heart failure 2003 Gheorghiade M, Gattis WA, Klein L
• Reappraisal of beta-blocker therapy in the acute and chronic post-myocardial infarction period.
  Reviews in cardiovascular medicine 2003 Borrello F, Beahan M, Klein L, Gheorghiade M