Liusheng Huang, PhD
Co-Dir, Drug Research Unit
Clinical Pharmacy
School of Pharmacy
Education & Training
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- Postdoctoral Studies Pharmaceutical Chemistry University of California, San Francisco 04/2007
- Ph.D Pharmaceutical Sciences Wayne State University 02/2003
- MS Medicinal Chemistry Peking Union Medical College 07/1998
- BS Pharmaceutical Sciences/Medicinal Chemistry Beijing Medical University 07/1992
Interests
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- Antimalarials
- Tandem Mass Spectrometry
- Drug-Drug-Interaction
- Bioanalysis
Publications (69)
Top publication keywords:
NevirapineChromatography, High Pressure LiquidQuinolinesAntimalarialsTandem Mass SpectrometryHorseradish PeroxidaseFluorenesMalariaChromatography, LiquidArtemisininsVidarabineEthanolaminesHemeMalaria, FalciparumPeroxidases
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Determination of sulfadoxine and pyrimethamine in microvolume human plasma using ultra high performance liquid chromatography-tandam mass spectrometry.
Journal of Chromatography B 2024 Vong Sok, Florence Marzan, Michelle Roh, Kevin Guo, Jenny Legac, Norah Mwebaza, Grant Dorsey, Philip Rosenthal, Francesca T. Aweeka, Liusheng Huang -
Pharmacokinetics (PK) of Deferasirox in Transfusion Dependent Thalassemia.
Blood 2023 Beth Apsel Winger, Felicity Usac, Liusheng Huang, Ashutosh Lal, Janel R. Long-Boyle -
Efavirenz-Based Antiretroviral Therapy but Not Pregnancy Increased Unbound Piperaquine Exposure in Women during Malaria Chemoprevention.
Antimicrobial agents and chemotherapy 2023 Hong H, Aslam-Mir U, Kajubi R, Wallender E, Mwebaza N, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L -
The Impact of Extended Treatment With Artemether-lumefantrine on Antimalarial Exposure and Reinfection Risks in Ugandan Children With Uncomplicated Malaria: A Randomized Controlled Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Whalen ME, Kajubi R, Goodwin J, Orukan F, Colt M, Huang L, Richards K, Wang K, Li F, Mwebaza N, Aweeka FT, Parikh S -
Prospective Validation and Refinement of a Population Pharmacokinetic Model of Fludarabine in Children and Young Adults Undergoing Hematopoietic Cell Transplantation.
Pharmaceutics 2022 Brooks JT, Solans BP, Lu Y, Kharbanda S, Dvorak CC, Lalefar N, Long S, Gupta AO, Horn B, Lamba JK, Huang L, Apsel-Winger B, Keizer RJ, Savic R, Long-Boyle J
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Impact of Drug Exposure on Resistance Selection Following Artemether-Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda.
Clinical pharmacology and therapeutics 2022 Kay K, Goodwin J, Ehrlich H, Ou J, Freeman T, Wang K, Li F, Wade M, French J, Huang L, Aweeka F, Mwebaza N, Kajubi R, Riggs M, Ruiz-Garcia A, Parikh S -
Quantification of N, N' N"-triethylenethiophosphoramide, N, N"-triethylenephosphoramide, cyclophosphamide, and 4-hydroxy-cyclophosphamide in microvolume human plasma to support neonatal and pediatric drug studies.
Journal of chromatography open 2022 Huang L, Winger BA, Cheah V, Gingrich D, Marzan F, Lu Y, Cooper JC, Aweeka F, Long-Boyle J -
Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry.
Journal of chromatography open 2022 Huang L, Sok V, Aslam-Mir U, Marzan F, Whalen M, Rosenthal PJ, Aweeka F -
Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs.
Communications biology 2022 Bieber JM, Sanman LE, Sun X, Hammerlindl H, Bao F, Roth MA, Koleske ML, Huang L, Aweeka F, Wu LF, Altschuler SJ -
Loss of GdpP Function in Staphylococcus aureus Leads to β-Lactam Tolerance and Enhanced Evolution of β-Lactam Resistance.
Antimicrobial agents and chemotherapy 2021 Poon R, Basuino L, Satishkumar N, Chatterjee A, Mukkayyan N, Buggeln E, Huang L, Nair V, Argudín MA, Datta SK, Chambers HF, Chatterjee SS -
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.
Nature communications 2021 Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M, Huang L, Duvalsaint M, Legac J, Kamya MR, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM -
Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasma.
PloS one 2021 Sok V, Marzan F, Gingrich D, Aweeka F, Huang L -
Methotrexate Decreases Tenofovir Exposure in Antiretroviral-Suppressed Individuals Living With HIV.
Journal of acquired immune deficiency syndromes (1999) 2020 Gingrich D, Deitchman AN, Kantor A, Huang L, Stein JH, Currier JS, Hsue PY, Ribaudo HJ, Aweeka FT, ACTG 5314 Protocol Team -
Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women.
Antimicrobial agents and chemotherapy 2020 Hughes E, Imperial M, Wallender E, Kajubi R, Huang L, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N, Clark TD, Opira B, Nakalembe M, Havlir D, Kamya M, Rosenthal PJ, … -
Therapeutic Efficacy of Artemether-Lumefantrine for Uncomplicated Falciparum Malaria in Northern Zambia.
The American journal of tropical medicine and hygiene 2020 Ippolito MM, Pringle JC, Siame M, Katowa B, Aydemir O, Oluoch PO, Huang L, Aweeka FT, Bailey JA, Juliano JJ, Meshnick SR, Shapiro TA, Moss WJ, Thuma PE -
Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations.
PloS one 2020 Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L -
Efavirenz-Based Antiretroviral Therapy Reduces Artemether-Lumefantrine Exposure for Malaria Treatment in HIV-Infected Pregnant Women.
Journal of acquired immune deficiency syndromes (1999) 2020 Hughes E, Mwebaza N, Huang L, Kajubi R, Nguyen V, Nyunt MM, Orukan F, Mwima MW, Parikh S, Aweeka F -
Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention.
Clinical pharmacology and therapeutics 2019 Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT -
Population Pharmacokinetics of Clofarabine as Part of Pretransplantation Conditioning in Pediatric Subjects before Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 Wang H, Jones AK, Dvorak CC, Huang L, Orchard P, Ivaturi V, Long-Boyle J -
Determination of melphalan in human plasma by UPLC-UV method.
Cancer chemotherapy and pharmacology 2019 Huang L, Cheah V, Chan D, Marzan F, Dvorak CC, Aweeka FT, Long-Boyle J -
Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT -
Strong correlation of lumefantrine concentrations in capillary and venous plasma from malaria patients.
PloS one 2018 Huang L, Mwebaza N, Kajubi R, Marzan F, Forsman C, Parikh S, Aweeka FT -
Determination of Tobramycin in M9 Medium by LC-MS/MS: Signal Enhancement by Trichloroacetic Acid.
Journal of analytical methods in chemistry 2018 Huang L, Haagensen JAJ, Verotta D, Cheah V, Spormann AM, Aweeka F, Yang K -
Semi-quantitative measurement of the antimalarial lumefantrine from untreated dried blood spots using LC-MS/MS.
Journal of pharmaceutical and biomedical analysis 2018 Ippolito MM, Huang L, Siame M, Thuma P, Shapiro TA, Aweeka FT -
Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz.
The Journal of infectious diseases 2018 Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM -
Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms.
The Journal of antimicrobial chemotherapy 2017 Haagensen J, Verotta D, Huang L, Engel J, Spormann AM, Yang K -
Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda.
The Journal of infectious diseases 2017 Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ -
Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children.
PloS one 2017 Huang L, Carey V, Lindsey JC, Marzan F, Gingrich D, Graham B, Barlow-Mosha L, Ssemambo PK, Kamthunzi P, Nachman S, Parikh S, Aweeka FT, IMPAACT P1079 protocol team -
Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Ivaturi V, Dvorak CC, Chan D, Liu T, Cowan MJ, Wahlstrom J, Stricherz M, Jennissen C, Orchard PJ, Tolar J, Pai SY, Huang L, Aweeka F, Long-Boyle J -
Parasite Clearance and Artemether Pharmacokinetics Parameters Over the Course of Artemether-Lumefantrine Treatment for Malaria in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Ugandan Children.
Open forum infectious diseases 2016 Kajubi R, Huang L, Were M, Kiconco S, Li F, Marzan F, Gingrich D, Nyunt MM, Ssebuliba J, Mwebaza N, Aweeka FT, Parikh S -
Antiretroviral Choice for HIV Impacts Antimalarial Exposure and Treatment Outcomes in Ugandan Children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Parikh S, Kajubi R, Huang L, Ssebuliba J, Kiconco S, Gao Q, Li F, Were M, Kakuru A, Achan J, Mwebaza N, Aweeka FT -
Artemether-Lumefantrine Pharmacokinetics and Clinical Response Are Minimally Altered in Pregnant Ugandan Women Treated for Uncomplicated Falciparum Malaria.
Antimicrobial agents and chemotherapy 2015 Nyunt MM, Nguyen VK, Kajubi R, Huang L, Ssebuliba J, Kiconco S, Mwima MW, Achan J, Aweeka F, Parikh S, Mwebaza N -
Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children.
Malaria journal 2015 Sundell K, Jagannathan P, Huang L, Bigira V, Kapisi J, Kakuru MM, Savic R, Kamya MR, Dorsey G, Aweeka F -
Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy.
Antimicrobial agents and chemotherapy 2015 Parikh S, Fehintola F, Huang L, Olson A, Adedeji WA, Darin KM, Morse GD, Murphy RL, Taiwo BO, Akinyinka OO, Adewole IF, Aweeka FT, Scarsi KK -
Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data.
BMC medicine 2015 WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group -
New in vitro model to study the effect of human simulated antibiotic concentrations on bacterial biofilms.
Antimicrobial agents and chemotherapy 2015 Haagensen JA, Verotta D, Huang L, Spormann A, Yang K -
Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial.
AIDS (London, England) 2014 Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G -
Alteration in cytochrome P450 3A4 activity as measured by a urine cortisol assay in HIV-1-infected pregnant women and relationship to antiretroviral pharmacokinetics.
HIV medicine 2014 Aweeka FT, Hu C, Huang L, Best BM, Stek A, Lizak P, Burchett SK, Read JS, Watts H, Mirochnick M, Capparelli EV, International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1026s … -
Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial.
PLoS medicine 2014 Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G -
Determination of meropenem in bacterial media by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2014 Huang L, Haagensen J, Verotta D, Lizak P, Aweeka F, Yang K -
Simultaneous determination of fludarabine and clofarabine in human plasma by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2014 Huang L, Lizak P, Dvorak CC, Aweeka F, Long-Boyle J -
Plasma and Intracellular Population Pharmacokinetic Analysis of Fludarabine in Pediatric Allogeneic Hematopoietic Cell Transplant (alloHCT) Recipients.
Biology of Blood and Marrow Transplantation 2014 Janel Long-Boyle, Nancy Sambol, Christopher C. Dvorak, Morton J. Cowan, Shirley Lee, Liusheng Huang, Biljana Horn, Melisa Stricherz, Jakub Tolar, Paul Orchard, Pamala Jacobson, Francesca Aweeka -
Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS.
Bioanalysis 2014 Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L -
Determination of intracellular fludarabine triphosphate in human peripheral blood mononuclear cells by LC-MS/MS.
Journal of pharmaceutical and biomedical analysis 2013 Huang L, Lizak P, Aweeka F, Long-Boyle J -
Determination of artemether and dihydroartemisinin in human plasma with a new hydrogen peroxide stabilization method.
Bioanalysis 2013 Huang L, Olson A, Gingrich D, Aweeka FT -
Nevirapine inhibits the anti-HIV activity of CD8+ cells.
Journal of acquired immune deficiency syndromes (1999) 2013 Liu L, Wang L, Huang L, Siu V, Teque F, Aweeka FT, Levy JA -
Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2013 Gwaza L, Aweeka F, Greenblatt R, Lizak P, Huang L, Guglielmo BJ -
Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers.
Journal of acquired immune deficiency syndromes (1999) 2012 Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT -
In vitro metabolism of piperaquine is primarily mediated by CYP3A4.
Xenobiotica; the fate of foreign compounds in biological systems 2012 Lee TM, Huang L, Johnson MK, Lizak P, Kroetz D, Aweeka F, Parikh S -
Determination of lumefantrine in small-volume human plasma by LC-MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation.
Bioanalysis 2012 Huang L, Li X, Marzan F, Lizak PS, Aweeka FT -
An Interim Evaluation of Systemic F-Ara-a Exposure in Pediatric Allogeneic Hematopoietic Cell Transplant (alloHCT) Recipients Using An Optimal Sampling Design.
Blood 2011 Janel R Long-Boyle, Shirley Yan, Christopher C. Dvorak, Biljana N. Horn, Morton Jerome Cowan, Liusheng Huang, Nancy Sambol, Lisa Musick, Francesca Aweeka -
A modified method for determination of lumefantrine in human plasma by HPLC-UV and combination of protein precipitation and solid-phase extraction: application to a pharmacokinetic study.
Analytical chemistry insights 2010 Huang L, Lizak PS, Jayewardene AL, Marzan F, Lee MN, Aweeka FT -
Development and validation of a high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemether and its active metabolite dihydroartemisinin in human plasma.
Journal of pharmaceutical and biomedical analysis 2009 Huang L, Jayewardene AL, Li X, Marzan F, Lizak PS, Aweeka FT -
Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for determination of isoniazid in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008 Huang L, Marzan F, Jayewardene AL, Lizak PS, Li X, Aweeka FT -
Arthromyces ramosus peroxidase produces two chlorinating species.
Biochemical and biophysical research communications 2007 Huang L, Ortiz de Montellano PR -
Different protein-binding selectivities for N-acyl heparin derivatives having N-phenylacetyl and heterocycle analogs of N-phenylacetyl substituted in place of N-sulfo groups.
Bioorganic & medicinal chemistry letters 2006 Huang L, Fernández C, Kerns RJ -
Role of heme-protein covalent bonds in mammalian peroxidases. Protection of the heme by a single engineered heme-protein link in horseradish peroxidase.
The Journal of biological chemistry 2006 Huang L, Wojciechowski G, Ortiz de Montellano PR -
Heme-protein covalent bonds in peroxidases and resistance to heme modification during halide oxidation.
Archives of biochemistry and biophysics 2005 Huang L, Ortiz de Montellano PR -
Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins.
Bioorganic & medicinal chemistry 2005 Huang L, Kerns RJ -
Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking.
Journal of the American Chemical Society 2005 Wojciechowski G, Huang L, Ortiz de Montellano PR -
Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase.
Journal of the American Chemical Society 2005 Huang L, Wojciechowski G, Ortiz de Montellano PR -
Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation.
Journal of the American Chemical Society 2004 Huang L, Colas C, Ortiz de Montellano PR -
Human heme oxygenase oxidation of 5- and 15-phenylhemes.
The Journal of biological chemistry 2004 Wang J, Niemevz F, Lad L, Huang L, Alvarez DE, Buldain G, Poulos TL, de Montellano PR -
Computer-aided molecular design of HIV-1 protease dissociative inhibitors
Acta Pharmaceutica Sinica (YaoXueXueBao) 1999 Huang L, Tao G, Li L, Chi H. -
Method for determination of total mercury in foods by atomic fluorescence spectrometry
J. Chinese Food Hygiene 1997 Huang L, Yang H. -
Monitoring of lead content in foodstuff in China
J. Chinese Preventive Medicine 1995 Yang H, Zou Z, Jin C, Yi F, Liang C, Xu X, Wang X, Huang, L -
Study on the tolerance limit for nitrite in Chinese foods
Hygiene Research 1995 Yang H, Huang L, Xie B. -
A study on cadmium content in foods of six provinces and cities
J. Chinese Prenentive Medicine 1994 Yang H, Zou Z, Jin C, Gu W, Liang C, Yi F, Xie B, Huang, L. -
Survey of mercury contamination of food in some areas of China
J. Hygiene Research 1994 Yang H, Han Y, Huang L.