Lisa McConlogue, PhD
Professor
Biochemistry and Biophysics
School of Medicine

We are particularly interested in understanding the pathogenic role and functional perturbation of intrinsically disordered proteins (IDP) that, due to their unique structural characteristics and key functional roles, lead to diseases of amyloid-type misfolding including cancer and neurodegenerative diseases. Our current focus is on understanding and blocking the pathogenic processes of α-Synuclein (α-Syn), an IDP that plays a central role in PD and also contributes to AD. We are developing small molecules that act as chaperones restoring the native structure and function of α-Syn under disease conditions to both probe the pathogenic mechanisms of α-Syn misfolding and malfunction, and to develop therapies to treat PD, AD and related diseases.

• Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.
  PloS one 2011 Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D
• Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
  The Journal of biological chemistry 2008 Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock…
• Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
  The Journal of biological chemistry 2007 McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S
• BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.
  Neurobiology of aging 2007 Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, Freedman S, Morris RG, Chen KS
• Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells.
  The Journal of biological chemistry 2003 Basi G, Frigon N, Barbour R, Doan T, Gordon G, McConlogue L, Sinha S, Zeller M
• Key signaling pathways regulate the biological activities and accumulation of amyloid-beta.
  Neurobiology of aging 2001 Wyss-Coray T, McConlogue L, Kindy M, Schmidt AM, Du Yan S, Stern DM
• BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
  Human molecular genetics 2001 Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols…
• TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
  Nature medicine 2001 Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L
• Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.
  The Journal of biological chemistry 2001 Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L
• Alzheimer’s Disease:Advances in Etiology, Pathogenesis and Therapeutics
  Functional analysis of β-secretase using mutagenesis and structural homology modeling. 2001 41 Gwen Tatsuno, John Anderson , Jin Hong, David A. Agard, Nobuyuki Ota, Sukanto Sinha, Guriqbal Basi, Lisa McConlogue
• A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease.
  Nature 2000 Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG
• Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.
  The American journal of pathology 2000 Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E
• High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L
• Recent advances in the understanding of the processing of APP to beta amyloid peptide.
  Annals of the New York Academy of Sciences 2000 Sinha S, Anderson J, John V, McConlogue L, Basi G, Thorsett E, Schenk D
• Purification and cloning of amyloid precursor protein beta-secretase from human brain.
  Nature 1999 Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, …
• Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors.
  The American journal of pathology 1999 Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L
• Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L
• Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.
  Biochimica et biophysica acta 1998 Tan Y, Hong J, Doan T, McConlogue L, Maltese WA
• Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
  Nature 1997 Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L
• Individual isoforms of the amyloid beta precursor protein demonstrate differential adhesive potentials to constituents of the extracellular matrix.
  Journal of neuroscience research 1997 Gillian AM, McFarlane I, Lucy FM, Overly C, McConlogue L, Breen KC
• Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L
• Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes.
  The Journal of biological chemistry 1996 Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L
• Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein.
  The Journal of biological chemistry 1996 McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA
• Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.
  The Journal of biological chemistry 1995 Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L
• The potential utility of transgenic mice harboring beta-amyloid precursor protein.
  Neurobiology of aging 1995 Schenk D, Games KD, McConlogue L
• The Ras-related GTP-binding protein, Rab1B, regulates early steps in exocytic transport and processing of beta-amyloid precursor protein.
  The Journal of biological chemistry 1995 Dugan JM, deWit C, McConlogue L, Maltese WA
• Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases.
  The Journal of biological chemistry 1995 Knops J, Suomensaari S, Lee M, McConlogue L, Seubert P, Sinha S
• Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
  Nature 1995 Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F
• Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells.
  Cell motility and the cytoskeleton 1994 Kosik KS, McConlogue L
• Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
  Nature 1992 Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ
• The beta-amyloid precursor protein is not processed by the regulated secretory pathway.
  Biochemical and biophysical research communications 1991 Overly CC, Fritz LC, Lieberburg I, McConlogue L
• Overexpression of tau in a nonneuronal cell induces long cellular processes.
  The Journal of cell biology 1991 Knops J, Kosik KS, Lee G, Pardee JD, Cohen-Gould L, McConlogue L
• Isolation of baculovirus-derived secreted and full-length beta-amyloid precursor protein.
  The Journal of biological chemistry 1991 Knops J, Johnson-Wood K, Schenk DB, Sinha S, Lieberburg I, McConlogue L
• Structure-independent DNA amplification by PCR using 7-deaza-2'-deoxyguanosine.
  Nucleic acids research 1988 McConlogue L, Brow MA, Innis MA
• Mouse ornithine decarboxylase gene: cloning, structure, and expression.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Brabant M, McConlogue L, van Daalen Wetters T, Coffino P
• Amplification and expression of heterologous ornithine decarboxylase in Chinese hamster cells.
  Molecular and cellular biology 1988 Chiang TR, McConlogue L
• Multiple mechanisms are responsible for altered expression of ornithine decarboxylase in overproducing variant cells.
  Molecular and cellular biology 1986 McConlogue L, Dana SL, Coffino P
• Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells.
  Proceedings of the National Academy of Sciences of the United States of America 1985 Feinstein SC, Dana SL, McConlogue L, Shooter EM, Coffino P
• Molecular cloning and expression of the mouse ornithine decarboxylase gene.
  Proceedings of the National Academy of Sciences of the United States of America 1984 McConlogue L, Gupta M, Wu L, Coffino P
• A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.
  The Journal of biological chemistry 1983 McConlogue L, Coffino P
• Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover.
  The Journal of biological chemistry 1983 McConlogue L, Coffino P
• Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells.
  The Journal of cell biology 1983 McConlogue LC, Marton LJ, Coffino P
• Radioimmune assay of induction and removal of uv lesions in total and staphylococcal nuclease-resistant DNA of mammalian chromatin.
  Radiation research 1982 McConlogue LC, Ward JF, Lewis HL, Norman A
• Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
  Current Alzheimer's Research Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St. George-Hyslop, Eva M. Mandelkow, Christopher M. Dobson, Lisa McConlogue, Eckhard Mandelkow…