Lisa Chesner, PhD
Assistant Professor
Urology
School of Medicine

Awards

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• Career Enhancement Program Award, UCSF Prostate Cancer SPORE, 2025
• Pilot Research Award, UCSF Prostate Cancer Program, 2024
• Early Investigator Research Award, Department of Defense Prostate Cancer Research Program, 2020-2023
• Young Investigator Award, Prostate Cancer Foundation, 2020-2023
• Dr. Marvin and Hadassah Bananer Research Award, University of Minnesota, 2018
• Honorable Mention, 3 Minute Thesis, University of Minnesota, 2018
• Milne and Brandenburg Award, University of Minnesota, 2018
• NHLBI T32 Training Grant, University of Minnesota, 2016-2018

Education & Training

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• PhD Pharmacology University of Minnesota-Twin Cities 2018
• MS Pharmacology University of Minnesota-Twin Cities 08/2014
• BS Biology University of Wisconsin-Eau Claire 06/2011

Publications (17)

Top publication keywords:
DNA, MitochondrialDNA AdductsCricetulusDNAEpoxy Compounds5-MethylcytosineRecombinational DNA RepairDNA RepairProstatic NeoplasmsPlasmidsAndrogen Receptor AntagonistsMitochondriaReceptors, AndrogenHistocompatibility Antigens Class IRad51 Recombinase

• Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer.
  Nature genetics 2025 Li H, Melnyk JE, Fu BXH, Shrestha R, Zhang M, Sjöström M, Feng S, Anderson JA, Han W, Chesner LN, Shin HJ, Farsh T, Suarez HJ, Nath S, Chou J, Das R, Egusa EA, Calvert M, Kishishita A, Barpanda A, Zhu…
• HLA class I expression shapes the tumor immune microenvironment and influences prognosis in prostate cancer.
  Prostate cancer and prostatic diseases 2025 Likasitwatanakul P, Besonen C, Tsai AK, Sadeghipour N, Elliott A, Arafa AT, Passow R, Chesner L, Felices M, Kennedy PR, Patnaik A, Narayan V, Hamrick J, Sena LA, Zorko NA, Hwang JH, Antonarakis ES
• Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator.
  bioRxiv : the preprint server for biology 2025 Li H, Melnyk JE, Fu BXH, Shrestha R, Zhang M, Sjöström M, Feng S, Anderson JA, Han W, Chesner LN, Shin HJ, Farsh T, Suarez HJ, Nath S, Chou J, Das R, Egusa EA, Zhu J, Winters A, Maheshwari A, Hua JT, …
• Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer.
  bioRxiv : the preprint server for biology 2025 Li H, Younger NS, Malik B, Shin HJ, Zhang C, Niknafs Y, Zhao SG, Wilder-Romans K, Pitchiaya S, Han S, Barnard T, Lloyd P, Zhang M, Chesner LN, Calvert M, Egusa EA, Zhu J, Chou J, Das R, Kothari V, …
• Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer.
  Cancer discovery 2025 Chesner LN, Polesso F, Graff JN, Hawley JE, Smith AK, Lundberg A, Das R, Shenoy T, Sjöström M, Zhao F, Hu YM, Linder S, Chen WS, Hawkins RM, Shrestha R, Zhu X, Foye A, Li H, Kim LM, Bhalla M, O'…

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• Personalized Medicine: Leave no Patient Behind; Report From the 2024 Coffey-Holden Prostate Cancer Academy Meeting.
  The Prostate 2024 Miyahira AK, Sharifi M, Chesner LN, El-Kenawi A, Haas R, Sena LA, Tewari AK, Pienta KJ, Soule HR
• An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor Progression.
  Cancer research 2024 Shrestha R, Chesner LN, Zhang M, Zhou S, Foye A, Lundberg A, Weinstein AS, Sjöström M, Zhu X, Moreno-Rodriguez T, Li H, SU2C/PCF West Coast Prostate Cancer Dream Team, Alumkal JJ, Aggarwal R, Small EJ…
• Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.
  Nature genetics 2024 Zhao SG, Bootsma M, Zhou S, Shrestha R, Moreno-Rodriguez T, Lundberg A, Pan C, Arlidge C, Hawley JR, Foye A, Weinstein AS, Sjöström M, Zhang M, Li H, Chesner LN, Rydzewski NR, Helzer KT, Shi Y, West …
• Ubiquitin signaling and the proteasome drive human DNA-protein crosslink repair.
  Nucleic acids research 2023 Essawy M, Chesner L, Alshareef D, Ji S, Tretyakova N, Campbell C
• The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
  Cancer research 2022 Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, …
• An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.
  Nature communications 2021 Das R, Sjöström M, Shrestha R, Yogodzinski C, Egusa EA, Chesner LN, Chen WS, Chou J, Dang DK, Swinderman JT, Ge A, Hua JT, Kabir S, Quigley DA, Small EJ, Ashworth A, Feng FY, Gilbert LA
• DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria.
  DNA repair 2020 Chesner LN, Essawy M, Warner C, Campbell C
• The DNA methylation landscape of advanced prostate cancer.
  Nature genetics 2020 Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, …
• A Simple, Rapid, and Quantitative Assay to Measure Repair of DNA-protein Crosslinks on Plasmids Transfected into Mammalian Cells.
  Journal of visualized experiments : JoVE 2018 Chesner LN, Campbell C
• A quantitative PCR-based assay reveals that nucleotide excision repair plays a predominant role in the removal of DNA-protein crosslinks from plasmids transfected into mammalian cells.
  DNA repair 2018 Chesner LN, Campbell C
• Cellular Repair of DNA-DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane.
  International journal of molecular sciences 2017 Chesner LN, Degner A, Sangaraju D, Yomtoubian S, Wickramaratne S, Malayappan B, Tretyakova N, Campbell C
• Spectral and copper binding properties of methanobactin from the facultative methanotroph Methylocystis strain SB2.
  Journal of inorganic biochemistry 2012 Bandow N, Gilles VS, Freesmeier B, Semrau JD, Krentz B, Gallagher W, McEllistrem MT, Hartsel SC, Choi DW, Hargrove MS, Heard TM, Chesner LN, Braunreiter KM, Cao BV, Gavitt MM, Hoopes JZ, Johnson JM, …