Ling Zhan, DDS, PhD
Professor
Orofacial Sciences
School of Dentistry

Her practice provides routine as well as complex care, including care for children with dental or medical conditions who require treatment under sedation or general anesthesia. She works closely with other dental specialties to treat children with complex dental disease, such as amenogenesis imperfecta.

In addition to patient care and education, Zhan conducts clinical and translational research projects that are focused on microbiological aspects of tooth decay; oral prevention programs guided by risk assessment; and identification of protocols to prevent or eliminate dental caries in children.

Zhan completed her pediatric dentistry residency training at UCSF. She is a member of the American Academy of Pediatric Dentistry and a diplomat of the American Board of Pediatric Dentistry.

• Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.
  NPJ biofilms and microbiomes 2024 Kuraji R, Ye C, Zhao C, Gao L, Martinez A, Miyashita Y, Radaic A, Kamarajan P, Le C, Zhan L, Range H, Sunohara M, Numabe Y, Kapila YL
• Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome.
  NPJ biofilms and microbiomes 2022 Gao L, Kuraji R, Zhang MJ, Martinez A, Radaic A, Kamarajan P, Le C, Zhan L, Ye C, Rangé H, Sailani MR, Kapila YL
• Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.
  PLoS pathogens 2021 Ganther S, Radaic A, Malone E, Kamarajan P, Chang NN, Tafolla C, Zhan L, Fenno JC, Kapila YL
• Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts.
  Frontiers in cellular and infection microbiology 2021 Malone ET, Ganther S, Mena N, Radaic A, Shariati K, Kindberg A, Tafolla C, Kamarajan P, Fenno JC, Zhan L, Kapila YL
• A Comparison of Four Caries Risk Assessment Methods.
  Frontiers in oral health 2021 Featherstone JDB, Crystal YO, Alston P, Chaffee BW, Doméjean S, Rechmann P, Zhan L, Ramos-Gomez F
• Evidence-Based Caries Management for All Ages-Practical Guidelines.
  Frontiers in oral health 2021 Featherstone JDB, Crystal YO, Alston P, Chaffee BW, Doméjean S, Rechmann P, Zhan L, Ramos-Gomez F
• Matching-adjusted indirect comparison of palbociclib versus ribociclib and abemaciclib in hormone receptor-positive/HER2-negative advanced breast cancer.
  Journal of comparative effectiveness research 2021 Rugo HS, Haltner A, Zhan L, Tran A, Bananis E, Hooper B, Mitra D, Cameron C
• Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.
  PLoS pathogens 2020 Kamarajan P, Ateia I, Shin JM, Fenno JC, Le C, Zhan L, Chang A, Darveau R, Kapila YL
• Modulation of pathogenic oral biofilms towards health with nisin probiotic.
  Journal of oral microbiology 2020 Radaic A, Ye C, Parks B, Gao L, Kuraji R, Malone E, Kamarajan P, Zhan L, Kapila YL
• Polymicrobial periodontal disease triggers a wide radius of effect and unique virome.
  NPJ biofilms and microbiomes 2020 Gao L, Kang M, Zhang MJ, Reza Sailani M, Kuraji R, Martinez A, Ye C, Kamarajan P, Le C, Zhan L, Rangé H, Ho SP, Kapila YL
• Caregivers' Knowledge of Sugar and Control Over Children's Sugar Consumption.
  Pediatric dentistry 2019 Kim J, Zhan L, Le T, Cheng J
• Pediatric Caries Risk Assessment as a Predictor of Caries Outcomes.
  Pediatric dentistry 2017 Chaffee BW, Featherstone JDB, Zhan L
• Clinical efficacy and effects of xylitol wipes on bacterial virulence.
  Advances in dental research 2012 Zhan L, Featherstone JD, Lo J, Krupansky C, Hoang N, DenBesten P, Huynh T
• Strategic protein target analysis for developing drugs to stop dental caries.
  Advances in dental research 2012 Horst JA, Pieper U, Sali A, Zhan L, Chopra G, Samudrala R, Featherstone JD
• Effects of xylitol wipes on cariogenic bacteria and caries in young children.
  Journal of dental research 2012 Zhan L, Cheng J, Chang P, Ngo M, Denbesten PK, Hoover CI, Featherstone JD
• A randomized clinical trial of anticaries therapies targeted according to risk assessment (caries management by risk assessment).
  Caries research 2012 Featherstone JD, White JM, Hoover CI, Rapozo-Hilo M, Weintraub JA, Wilson RS, Zhan L, Gansky SA
• Social inequalities in childhood dental caries: the convergent roles of stress, bacteria and disadvantage.
  Social science & medicine (1982) 2010 Boyce WT, Den Besten PK, Stamperdahl J, Zhan L, Jiang Y, Adler NE, Featherstone JD
• Horizontal transmission of mutans streptococci in children.
  Journal of dental research 2010 Doméjean S, Zhan L, DenBesten PK, Stamper J, Boyce WT, Featherstone JD
• Randomized controlled clinical trial on the evaluation of bacteriostatic and cariostatic effects of a novel povidone-iodine/fluoride foam in children with high caries risk.
  Quintessence international (Berlin, Germany : 1985) 2009 Xu X, Li JY, Zhou XD, Xie Q, Zhan L, Featherstone JD