Linda Noble, PhD
Professor Emeritus
Neurological Surgery
School of Medicine

Grants and Projects

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• Determinants of vulnerability and recovery after trauma to the developing brain, NIH, 2012-2017
• Trauma to developing brain-injury and repair mechanisms, NIH, 2004-2015
• Spinal cord injury: Targeting local inhibition to improve outcome, NIH, 2009-2012
• CNS Injury and Edema Research Center, NIH, 1978-2012
• Matrix Metalloproteinases and Spinal Cord Injury, NIH, 1999-2012
• Trauma to developing brain: model refinement and therapeutic intervention, NIH, 2009-2012
• Heme Oxygenase and Spinal Cord Injury, NIH, 2001-2005
• Trauma to Developing Brain-Oxidative Events and Recovery, NIH, 2001-2005
• Spinal Cord Injury--Alterations in Barrier Permeability, NIH, 1985-2000

Publications (65)

Top publication keywords:
Spinal CordHeme Oxygenase-1Brain Injuries, TraumaticMatrix Metalloproteinase InhibitorsIntervertebral Disc DisplacementOxidative StressNeurogenesisMatrix MetalloproteinasesMatrix Metalloproteinase 2Spinal Cord InjuriesGlutathione PeroxidaseMatrix Metalloproteinase 9Recovery of FunctionHeme Oxygenase (Decyclizing)Brain Injuries

• Ten-year outcome of early childhood traumatic brain injury: Diffusion tensor imaging of the ventral striatum in relation to executive functioning.
  Brain injury 2016 Faber J, Wilde EA, Hanten G, Ewing-Cobbs L, Aitken ME, Yallampalli R, MacLeod MC, Mullins SH, Chu ZD, Li X, Hunter JV, Noble-Haeusslein L, Levin HS
• Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury.
  Cell stem cell 2016 Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR
• Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum.
  Behavioural brain research 2016 Neumann M, Liu W, Sun C, Yang SY, Noble-Haeusslein LJ, Liu J
• Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.
  ACS chemical neuroscience 2016 Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M
• Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice.
  Developmental neuroscience 2016 Semple BD, Sadjadi R, Carlson J, Chen Y, Xu D, Ferriero DM, Noble-Haeusslein LJ

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• Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord.
  Experimental neurology 2016 Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ
• Social dysfunction after pediatric traumatic brain injury: A translational perspective.
  Neuroscience and biobehavioral reviews 2016 Ryan NP, Catroppa C, Godfrey C, Noble-Haeusslein LJ, Shultz SR, O'Brien TJ, Anderson V, Semple BD
• Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice.
  PloS one 2016 Bajwa NM, Halavi S, Hamer M, Semple BD, Noble-Haeusslein LJ, Baghchechi M, Hiroto A, Hartman RE, Obenaus A
• Pediatric Rodent Models of Traumatic Brain Injury.
  Methods in molecular biology (Clifton, N.J.) 2016 Semple BD, Carlson J, Noble-Haeusslein LJ
• Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse.
  PloS one 2015 Semple BD, Noble-Haeusslein LJ, Gooyit M, Tercovich KG, Peng Z, Nguyen TT, Schroeder VA, Suckow MA, Chang M, Raber J, Trivedi A
• Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories.
  Journal of neurotrauma 2015 Smith DH, Hicks RR, Johnson VE, Bergstrom DA, Cummings DM, Noble LJ, Hovda D, Whalen M, Ahlers ST, LaPlaca M, Tortella FC, Duhaime AC, Dixon CE
• Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies.
  Frontiers in neurology 2015 Semple BD, Lee S, Sadjadi R, Fritz N, Carlson J, Griep C, Ho V, Jang P, Lamb A, Popolizio B, Saini S, Bazarian JJ, Prins ML, Ferriero DM, Basso DM, Noble-Haeusslein LJ
• Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.
  Neuroscience and biobehavioral reviews 2014 Bondi CO, Semple BD, Noble-Haeusslein LJ, Osier ND, Carlson SW, Dixon CE, Giza CC, Kline AE
• Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.
  Neurobiology of disease 2014 Semple BD, Trivedi A, Gimlin K, Noble-Haeusslein LJ
• Sociosexual and communication deficits after traumatic injury to the developing murine brain.
  PloS one 2014 Semple BD, Noble-Haeusslein LJ, Jun Kwon Y, Sam PN, Gibson AM, Grissom S, Brown S, Adahman Z, Hollingsworth CA, Kwakye A, Gimlin K, Wilde EA, Hanten G, Levin HS, Schenk AK
• Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.
  PloS one 2014 Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ
• Traumatic injury to the immature frontal lobe: a new murine model of long-term motor impairment in the absence of psychosocial or cognitive deficits.
  Developmental neuroscience 2013 Chen CY, Noble-Haeusslein LJ, Ferriero D, Semple BD
• Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Hansen CN, Fisher LC, Deibert RJ, Jakeman LB, Zhang H, Noble-Haeusslein L, White S, Basso DM
• Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species.
  Progress in neurobiology 2013 Semple BD, Blomgren K, Gimlin K, Ferriero DM, Noble-Haeusslein LJ
• Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice.
  Journal of neurotrauma 2012 Semple BD, Canchola SA, Noble-Haeusslein LJ
• A call for transparent reporting to optimize the predictive value of preclinical research.
  Nature 2012 Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK…
• RIGOR guidelines: escalating STAIR and STEPS for effective translational research.
  Translational stroke research 2012 Lapchak PA, Zhang JH, Noble-Haeusslein LJ
• Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ
• Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury.
  Journal of neurotrauma 2011 Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ
• Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2011 Zhang H, Chang M, Hansen CN, Basso DM, Noble-Haeusslein LJ
• Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research.
  Journal of neurotrauma 2011 Levine JM, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ
• Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors.
  Experimental neurology 2011 Semple BD, Noble-Haeusslein LJ
• Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury.
  Journal of neurotrauma 2011 Wang Y, Neumann M, Hansen K, Hong SM, Kim S, Noble-Haeusslein LJ, Liu J
• Pediatric traumatic brain injury. Preface.
  Developmental neuroscience 2011 McKenna MC, Noble-Haeusslein LJ, Robertson CL
• Characterization and functionality of proliferative human Sertoli cells.
  Cell transplantation 2010 Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh AL, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM
• Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury.
  Developmental neuroscience 2010 Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ
• Finite element analysis of controlled cortical impact-induced cell loss.
  Journal of neurotrauma 2010 Mao H, Jin X, Zhang L, Yang KH, Igarashi T, Noble-Haeusslein LJ, King AI
• Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes.
  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2010 Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ
• Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain.
  Developmental neuroscience 2010 Yoneyama-Sarnecky T, Olivas AD, Azari S, Ferriero DM, Manvelyan HM, Noble-Haeusslein LJ
• Long-term neurologic outcomes after traumatic brain injury.
  The Journal of head trauma rehabilitation 2009 Bazarian JJ, Cernak I, Noble-Haeusslein L, Potolicchio S, Temkin N
• Traumatic brain injury: an overview of pathobiology with emphasis on military populations.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Cernak I, Noble-Haeusslein LJ
• Models of traumatic cerebellar injury.
  Cerebellum (London, England) 2009 Potts MB, Adwanikar H, Noble-Haeusslein LJ
• Combination therapies for traumatic brain injury: prospective considerations.
  Journal of neurotrauma 2009 Margulies S, Hicks R, Combination Therapies for Traumatic Brain Injury Workshop Leaders
• Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain.
  Journal of neuroscience research 2009 Potts MB, Rola R, Claus CP, Ferriero DM, Fike JR, Noble-Haeusslein LJ
• Glutathione peroxidase activity modulates recovery in the injured immature brain.
  Annals of neurology 2009 Tsuru-Aoyagi K, Potts MB, Trivedi A, Pfankuch T, Raber J, Wendland M, Claus CP, Koh SE, Ferriero D, Noble-Haeusslein LJ
• Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ
• Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system.
  Journal of neuroscience research 2007 Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS
• Inflammation and Spinal Cord Injury: Infiltrating Leukocytes as Determinants of Injury and Repair Processes.
  Clinical neuroscience research 2006 Trivedi A, Olivas AD, Noble-Haeusslein LJ
• Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006 Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ
• Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury.
  Experimental neurology 2006 Igarashi T, Potts MB, Noble-Haeusslein LJ
• Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ
• Alterations in hippocampal neurogenesis following traumatic brain injury in mice.
  Experimental neurology 2006 Rola R, Mizumatsu S, Otsuka S, Morhardt DR, Noble-Haeusslein LJ, Fishman K, Potts MB, Fike JR
• Phospholipase A2 and spinal cord injury: a novel target for therapeutic intervention.
  Annals of neurology 2006 Olivas AD, Noble-Haeusslein LJ
• Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets.
  NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006 Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ
• Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord.
  Experimental neurology 2006 Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ
• Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments.
  Developmental neuroscience 2006 Pullela R, Raber J, Pfankuch T, Ferriero DM, Claus CP, Koh SE, Yamauchi T, Rola R, Fike JR, Noble-Haeusslein LJ
• Heme regulation in traumatic brain injury: relevance to the adult and developing brain.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005 Chang EF, Claus CP, Vreman HJ, Wong RJ, Noble-Haeusslein LJ
• Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress.
  Developmental neuroscience 2005 McLean CW, Mirochnitchenko O, Claus CP, Noble-Haeusslein LJ, Ferriero DM
• Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase.
  Brain research 2004 Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ
• Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord.
  Journal of neurotrauma 2004 Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ
• Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse.
  Journal of neuroscience research 2004 Fiore C, Inman DM, Hirose S, Noble LJ, Igarashi T, Compagnone NA
• Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing.
  Journal of neuroscience research 2003 Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ
• The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord.
  Journal of neuroscience methods 2003 Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ
• Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing.
  Journal of neurosurgery 2003 Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ
• Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury.
  Journal of neuroscience research 2003 Luk HW, Noble LJ, Werb Z
• Age-dependent differences in glutathione peroxidase activity after traumatic brain injury.
  Journal of neurotrauma 2003 Fan P, Yamauchi T, Noble LJ, Ferriero DM
• Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ
• Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase.
  Neuroscience letters 2003 Weinzierl M, Mautes AE, Lin Y, Noble LJ
• Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability.
  Experimental neurology 2002 Tong W, Igarashi T, Ferriero DM, Noble LJ
• Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model.
  Neuroscience 1989 McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL