Linda Kachuri, PhD
Employee of Contracting Firm
Medicine
School of Medicine

Awards

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• Scholar in Training Award, American Association for Cancer Research, 2020
• Charles J. Epstein Trainee Award for Excellence in Human Genetics Research, American Society of Human Genetics, 2019
• Gordon Cressy Student Leadership Award, University of Toronto, 2017
• Scholar in Training Award, American Association for Cancer Research, 2016

Education & Training

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• Postdoc Genetic Epidemiology University of California San Francisco 2022
• PhD Epidemiology Dalla Lana School of Public Health, University of Toronto 2018
• MPH Epidemiology Dalla Lana School of Public Health, University of Toronto 2012
• BSc Psychology McGill University 2010

Websites

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• @@Linda_Kachuri on Twitter (twitter.com)

Grants and Projects

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• Comprehensive Investigation of Multiple Myeloma Genetic Susceptibility in African Americans, NIH, 2020-2022

Publications (48)

Top publication keywords:
Occupational DiseasesVehicle EmissionsGenetic Predisposition to DiseaseLeukocytesChromosomes, Human, Pair 5TelomereGasolineOccupational ExposureLymphoma, FollicularLung NeoplasmsMendelian Randomization AnalysisPesticidesMultifactorial InheritanceSilicon DioxideTelomere Homeostasis

• Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
  Nature genetics 2023 Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, Darst BF, Sheng X, Xu Y, Chou AJ, Benlloch S, Dadaev T, Brook MN, Plym A, Sahimi A, Hoffman TJ, Takahashi A, Matsuda K, Momozawa Y, …
• Clinical consequences of a genetic predisposition toward higher benign prostate-specific antigen levels.
  EBioMedicine 2023 Shi M, Shelley JP, Schaffer KR, Tosoian JJ, Bagheri M, Witte JS, Kachuri L, Mosley JD
• Inherited polymorphisms in the Human Leukocyte Antigen Region modify the association between varicella-zoster virus antibody reactivity and glioma prognosis.
  Neuro-oncology 2023 Francis SS, Guerra G, Hansen HM, Wendt G, Kachuri L, Wiencke JK, Wrensch M
• Principles and methods for transferring polygenic risk scores across global populations.
  Nature reviews. Genetics 2023 Kachuri L, Chatterjee N, Hirbo J, Schaid DJ, Martin I, Kullo IJ, Kenny EE, Pasaniuc B, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group, Witte JS, Ge T
• Genetically adjusted PSA levels for prostate cancer screening.
  Nature medicine 2023 Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Easterlin R, Goodman PJ, Till C, Thompson I, Lilja H, Van Den Eeden SK, Chanock SJ, …

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• Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.
  Nature genetics 2023 Kachuri L, Mak ACY, Hu D, Eng C, Huntsman S, Elhawary JR, Gupta N, Gabriel S, Xiao S, Keys KL, Oni-Orisan A, Rodríguez-Santana JR, LeNoir MA, Borrell LN, Zaitlen NA, Williams LK, Gignoux CR, Burchard …
• Development and testing of a polygenic risk score for breast cancer aggressiveness.
  NPJ precision oncology 2023 Shieh Y, Roger J, Yau C, Wolf DM, Hirst GL, Swigart LB, Huntsman S, Hu D, Nierenberg JL, Middha P, Heise RS, Shi Y, Kachuri L, Zhu Q, Yao S, Ambrosone CB, Kwan ML, Caan BJ, Witte JS, Kushi LH, 't Veer…
• Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome.
  eLife 2023 Cortez Cardoso Penha R, Smith-Byrne K, Atkins JR, Haycock PC, Kar S, Codd V, Samani NJ, Nelson C, Milojevic M, Gabriel AAG, Amos C, Brennan P, Hung RJ, Kachuri L, Mckay JD
• A Polygenic Risk Score for Prostate Cancer Risk Prediction.
  JAMA internal medicine 2023 Schaffer KR, Shi M, Shelley JP, Tosoian JJ, Kachuri L, Witte JS, Mosley JD
• Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing.
  HGG advances 2022 Sheng X, Xia L, Cahoon JL, Conti DV, Haiman CA, Kachuri L, Chiang CWK
• Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies.
  BMC medicine 2022 Cavazos TB, Kachuri L, Graff RE, Nierenberg JL, Thai KK, Alexeeff S, Van Den Eeden S, Corley DA, Kushi LH, Regeneron Genetics Center, Hoffmann TJ, Ziv E, Habel LA, Jorgenson E, Sakoda LC, Witte JS
• Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.
  Journal of the National Cancer Institute 2022 Gabriel AAG, Atkins JR, Penha RCC, Smith-Byrne K, Gaborieau V, Voegele C, Abedi-Ardekani B, Milojevic M, Olaso R, Meyer V, Boland A, Deleuze JF, Zaridze D, Mukeriya A, Swiatkowska B, Janout V, …
• Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
  Nature genetics 2022 Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z, Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov…
• The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.
  American journal of human genetics 2022 Guerra G, Kachuri L, Wendt G, Hansen HM, Mack SJ, Molinaro AM, Rice T, Bracci P, Wiencke JK, Kasahara N, Eckel-Passow JE, Jenkins RB, Wrensch M, Francis SS
• Long telomeres in need of a SNP: Germline contributions of telomere maintenance to glioma.
  Neuro-oncology 2022 Kachuri L, Walsh KM
• Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.
  BMC medicine 2022 Gormley M, Dudding T, Kachuri L, Burrows K, Chong AHW, Martin RM, Thomas SJ, Tyrrell J, Ness AR, Brennan P, Munafò MR, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Tajara EH, Severino P…
• Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment.
  HGG advances 2021 Jiang Y, Meyers TJ, Emeka AA, Cooley LF, Cooper PR, Lancki N, Helenowski I, Kachuri L, Lin DW, Stanford JL, Newcomb LF, Kolb S, Finelli A, Fleshner NE, Komisarenko M, Eastham JA, Ehdaie B, Benfante N,…
• Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
  American journal of human genetics 2021 Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
• Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.
  Nature communications 2021 Graff RE, Cavazos TB, Thai KK, Kachuri L, Rashkin SR, Hoffman JD, Alexeeff SE, Blatchins M, Meyers TJ, Leong L, Tai CG, Emami NC, Corley DA, Kushi LH, Ziv E, Van Den Eeden SK, Jorgenson E, Hoffmann TJ…
• A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.
  Cancer research 2020 Emami NC, Cavazos TB, Rashkin SR, Cario CL, Graff RE, Tai CG, Mefford JA, Kachuri L, Wan E, Wong S, Aaronson D, Presti J, Habel LA, Shan J, Ranatunga DK, Chao CR, Ghai NR, Jorgenson E, Sakoda LC, …
• Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.
  Nature communications 2020 Kachuri L, Graff RE, Smith-Byrne K, Meyers TJ, Rashkin SR, Ziv E, Witte JS, Johansson M
• The landscape of host genetic factors involved in immune response to common viral infections.
  Genome medicine 2020 Kachuri L, Francis SS, Morrison ML, Wendt GA, Bossé Y, Cavazos TB, Rashkin SR, Ziv E, Witte JS
• Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.
  Nature communications 2020 Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, …
• Insecticide use and risk of non-Hodgkin lymphoma subtypes: A subset meta-analysis of the North American Pooled Project.
  International journal of cancer 2020 Kachuri L, Beane Freeman LE, Spinelli JJ, Blair A, Pahwa M, Koutros S, Hoar Zahm S, Cantor KP, Weisenburger DD, Pahwa P, Dosman JA, McLaughlin JR, Demers PA, Harris SA
• Pesticide use and risk of Hodgkin lymphoma: results from the North American Pooled Project (NAPP).
  Cancer causes & control : CCC 2020 Latifovic L, Freeman LEB, Spinelli JJ, Pahwa M, Kachuri L, Blair A, Cantor KP, Zahm SH, Weisenburger DD, McLaughlin JR, Dosman JA, Pahwa P, Koutros S, Demers PA, Harris SA
• Silica and asbestos exposure at work and the risk of bladder cancer in Canadian men: a population-based case-control study.
  BMC cancer 2020 Latifovic L, Villeneuve PJ, Parent MÉ, Kachuri L, Canadian Cancer Registries Epidemiology Group, Harris SA
• Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.
  Nature communications 2020 Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C,…
• Exposure to crystalline silica in Canadian workplaces and the risk of kidney cancer.
  Occupational and environmental medicine 2019 Peters CE, Bogaert L, Latifovic L, Kachuri L, Harris SA, Parent ME, Villeneuve PJ, Canadian Cancer Registries Epidemiology Group
• Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
  Nature communications 2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS
• Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
  Nature communications 2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS
• Investigation of Leukocyte Telomere Length and Genetic Variants in Chromosome 5p15.33 as Prognostic Markers in Lung Cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019 Kachuri L, Helby J, Bojesen SE, Christiani DC, Su L, Wu X, Tardón A, Fernández-Tardón G, Field JK, Davies MP, Chen C, Goodman GE, Shepherd FA, Leighl NB, Tsao MS, Brhane Y, Brown MC, Boyd K, …
• Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.
  International journal of epidemiology 2019 Kachuri L, Saarela O, Bojesen SE, Davey Smith G, Liu G, Landi MT, Caporaso NE, Christiani DC, Johansson M, Panico S, Overvad K, Trichopoulou A, Vineis P, Scelo G, Zaridze D, Wu X, Albanes D, …
• Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project.
  Environment international 2019 Koutros S, Harris SA, Spinelli JJ, Blair A, McLaughlin JR, Zahm SH, Kim S, Albert PS, Kachuri L, Pahwa M, Cantor KP, Weisenburger DD, Pahwa P, Pardo LA, Dosman JA, Demers PA, Beane Freeman LE
• Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019 Zhu Y, Wei Y, Zhang R, Dong X, Shen S, Zhao Y, Bai J, Albanes D, Caporaso NE, Landi MT, Zhu B, Chanock SJ, Gu F, Lam S, Tsao MS, Shepherd FA, Tardon A, Fernández-Somoano A, Fernandez-Tardon G, Chen C,…
• Occupational Exposure to Diesel and Gasoline Engine Exhausts and the Risk of Kidney Cancer in Canadian Men.
  Annals of work exposures and health 2018 Peters CE, Parent MÉ, Harris SA, Bogaert L, Latifovic L, Kachuri L, Villeneuve PJ, Canadian Cancer Registries Epidemiology Group
• Personalized Prostate Cancer Screening Based on a Single Midlife Prostate-specific Antigen Measurement.
  European urology 2018 Graff RE, Kachuri L, Witte JS
• Workplace exposure to asbestos and the risk of kidney cancer in Canadian men.
  Canadian journal of public health = Revue canadienne de sante publique 2018 Peters CE, Parent MÉ, Harris SA, Kachuri L, Latifovic L, Bogaert L, Villeneuve PJ, Canadian Cancer Registries Epidemiology Group
• Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
  Nature genetics 2017 McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le …
• Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC).
  BMC cancer 2017 Kachuri L, Harris MA, MacLeod JS, Tjepkema M, Peters PA, Demers PA
• Systematic Review of Genetic Variation in Chromosome 5p15.33 and Telomere Length as Predictive and Prognostic Biomarkers for Lung Cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Kachuri L, Latifovic L, Liu G, Hung RJ
• Pesticide exposures and the risk of multiple myeloma in men: An analysis of the North American Pooled Project.
  International journal of cancer 2016 Presutti R, Harris SA, Kachuri L, Spinelli JJ, Pahwa M, Blair A, Zahm SH, Cantor KP, Weisenburger DD, Pahwa P, McLaughlin JR, Dosman JA, Freeman LB
• Workplace exposure to diesel and gasoline engine exhausts and the risk of colorectal cancer in Canadian men.
  Environmental health : a global access science source 2016 Kachuri L, Villeneuve PJ, Parent MÉ, Johnson KC, Canadian Cancer Registries Epidemiology Research Group, Harris SA
• Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci.
  Carcinogenesis 2015 Kachuri L, Amos CI, McKay JD, Johansson M, Vineis P, Bueno-de-Mesquita HB, Boutron-Ruault MC, Johansson M, Quirós JR, Sieri S, Travis RC, Weiderpass E, Le Marchand L, Henderson BE, Wilkens L, Goodman …
• Bladder cancer and occupational exposure to diesel and gasoline engine emissions among Canadian men.
  Cancer medicine 2015 Latifovic L, Villeneuve PJ, Parent MÉ, Johnson KC, Kachuri L, Canadian Cancer Registries Epidemiology Group, Harris SA
• Authors' response.
  Chronic diseases and injuries in Canada 2014 De P, Kachuri L, Ellison LF, Semenciw R
• Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men.
  International journal of cancer 2013 Kachuri L, Villeneuve PJ, Parent MÉ, Johnson KC, Canadian Cancer Registries Epidemiology Group, Harris SA
• Multiple pesticide exposures and the risk of multiple myeloma in Canadian men.
  International journal of cancer 2013 Kachuri L, Demers PA, Blair A, Spinelli JJ, Pahwa M, McLaughlin JR, Pahwa P, Dosman JA, Harris SA
• Cancer incidence, mortality and survival trends in Canada, 1970-2007.
  Chronic diseases and injuries in Canada 2013 Kachuri L, De P, Ellison LF, Semenciw R, Advisory Committee on Canadian Cancer Statistics