Lin Ye, PhD
Assistant Professor
Medicine
School of Medicine

Education & Training

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• Postdoctoral Studies Graduate Division University of California, San Francisco

Publications (17)

Top publication keywords:
Induced Pluripotent Stem CellsGenetic VectorsDisease ResistanceBacteriophagesBlood CellsAnemia, Sickle CellGene Editingbeta-ThalassemiaSendai virusCellular ReprogrammingGenetic EngineeringIntegrasesSequence DeletionReceptors, CCR5Fetal Hemoglobin

• Genetically edited CD34+ cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Morvan MG, Teque F, Ye L, Moreno ME, Wang J, VandenBerg S, Stoddart CA, Kan YW, Levy JA
• CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1T315I mutation mouse model.
  Haematologica 2019 Tan YT, Ye L, Xie F, Wang J, Müschen M, Chen SJ, Kan YW, Liu H
• Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.
  Cell stem cell 2019 Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D
• Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Ye L, Wang J, Tan Y, Beyer AI, Xie F, Muench MO, Kan YW
• Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells.
  Stem cells and development 2016 Xie F, Gong K, Li K, Zhang M, Chang JC, Jiang S, Ye L, Wang J, Tan Y, Kan YW

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• 332. Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells.
  Molecular Therapy 2016 R. Geoffrey Sargent, Shingo Suzuki, Luke Gruenert, Fei Xie, Lin Ye, Yuet W. Kan, Dieter C. Gruenert
• TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.
  Molecular therapy. Nucleic acids 2016 Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M…
• Identification of small activating RNAs that enhance endogenous OCT4 expression in human mesenchymal stem cells.
  Stem cells and development 2014 Wang J, Huang V, Ye L, Bárcena A, Lin G, Lue TF, Li LC
• Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac.
  Genome research 2014 Xie F, Ye L, Chang JC, Beyer AI, Wang J, Muench MO, Kan YW
• Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW
• Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors.
  Stem cells translational medicine 2013 Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW
• Generation of induced pluripotent stem cells using site-specific integration with phage integrase.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Ye L, Chang JC, Lin C, Qi Z, Yu J, Kan YW
• Sequence-specific correction of genomic hypoxanthine-guanine phosphoribosyl transferase mutations in lymphoblasts by small fragment homologous replacement.
  Oligonucleotides 2010 Bedayat B, Abdolmohamadi A, Ye L, Maurisse R, Parsi H, Schwarz J, Emamekhoo H, Nicklas JA, O'Neill JP, Gruenert DC
• Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
• High oxygen environment during pregnancy rescues sickle cell anemia mice from prenatal death.
  Blood cells, molecules & diseases 2008 Ye L, Chang JC, Lu R, Kan YW
• Treatment of sickle cell anemia using the murine embryonic stem cell model.
  Blood Cells 2007 Judy C. Chang, Lin Ye, Yuet Wai Kan
• Correction of the sickle cell mutation in embryonic stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Chang JC, Ye L, Kan YW