Lily Jan, PhD
Professor
Physiology
School of Medicine

Websites

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• Jan Lab at UCSF (physio.ucsf.edu)
• Jan Lab at UCSF (physio.ucsf.edu)

Grants and Projects

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• The TMEM16 Family of Ion Channels and Lipid Scramblases, NIH, 2021-2029
• Molecular and Genetic Studies of TMEM16C Control of Thermoregulation and Neuronal Excitability, NIH, 2020-2025
• Illuminating Druggable Dark Matter, NIH, 2017-2023
• Molecular, genetic & physiological studies of calcium-activated chloride channels, NIH, 2011-2023
• Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature, NIH, 2020-2023
• Genetic Studies of the Synapse, NIH, 2001-2021
• (PQA1) The antipsychotic thioridazine protects against medulloblastoma (MB): volu, NIH, 2014-2018
• Genetic Studies of the Synapse, NIH, 2001-2016
• Assembly and Targeting of Neural Receptors and Channels, NIH, 2001-2007
• Longterm Changes in the Mammalian Brain, NIH, 1991-2002
• Genetic Studies of the Synapse, NIH, 1980-2002
• Genetic and Immunological Studies of Neural Development, NIH, 1983-1988

Publications (425)

Top publication keywords:
Phospholipid Transfer ProteinsIon ChannelsIon Channel GatingDrosophila ProteinsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsAnoctaminsPotassium Channels, Voltage-GatedPotassium ChannelsAnoctamin-1Chloride ChannelsDendritesDrosophilaPotassium Channels, Inwardly RectifyingNeuronsDrosophila melanogaster

• A personal perspective of the voltage-gated potassium channel studies.
  Nature structural & molecular biology 2024 Jan LY, Jan YN
• Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.
  Nature cell biology 2024 Li K, Guo Y, Wang Y, Zhu R, Chen W, Cheng T, Zhang X, Jia Y, Liu T, Zhang W, Jan LY, Jan YN
• Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease.
  Brain : a journal of neurology 2023 Pinard A, Ye W, Fraser SM, Rosenfeld JA, Pichurin P, Hickey SE, Guo D, Cecchi AC, Boerio ML, Guey S, Aloui C, Lee K, Kraemer M, Alyemni SO, University of Washington Center for Mendelian Genomics, …
• Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
  Nature communications 2023 Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
• SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
  bioRxiv : the preprint server for biology 2023 Tuomivaara ST, Teo CF, Jan YN, Jan LY, Wiita AP

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• The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.
  The Journal of cell biology 2022 O'Brien CE, Younger SH, Jan LY, Jan YN
• A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Liu HH, Hsu CH, Jan LY, Jan YN
• Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Lin King YH, Chen C, Lin King JV, Simms J, Glasscock E, Yang SB, Jan YN, Jan LY
• Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes.
  Molecular cell 2022 Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH
• Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development.
  eLife 2022 Jaszczak JS, DeVault L, Jan LY, Jan YN
• Identification of a conserved drug binding pocket in TMEM16 proteins.
  Research square 2022 Cheng Y, Feng S, Puchades C, Ko J, Figueroa E, Chen Y, Wu H, Gu S, Han T, Li J, Ho B, Shoichet B, Jan YN, Jan L
• Structure, function and pharmacology of human itch GPCRs.
  Nature 2021 Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y…
• Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.
  eLife 2021 Chou SM, Li KX, Huang MY, Chen C, Lin King YH, Li GG, Zhou W, Teo CF, Jan YN, Jan LY, Yang SB
• TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY
• TMEM16K is an interorganelle regulator of endosomal sorting.
  Nature communications 2020 Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN
• Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.
  Nature physics 2020 Juan GRR, Mathijssen AJTM, He M, Jan L, Marshall W, Prakash M
• Chloride channels regulate differentiation and barrier functions of the mammalian airway.
  eLife 2020 He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY
• Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.
  Annual review of neuroscience 2020 Jin P, Jan LY, Jan YN
• Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.
  Genes & development 2019 Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN
• TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
  eLife 2019 Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY
• Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
  Cell reports 2019 Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
• Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity.
  eLife 2019 Ye W, Han TW, He M, Jan YN, Jan LY
• TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY
• Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.
  Neuron 2019 Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY
• Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
  Cell reports 2019 Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
• The multifaceted role of TMEM16A in cancer.
  Cell calcium 2019 Crottès D, Jan LY
• TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY
• Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.
  Neuron 2019 Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY
• Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN
• The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.
  Neuron 2019 Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN
• Chemically induced vesiculation as a platform for studying TMEM16F activity.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY
• Far away from the lamppost.
  PLoS biology 2018 Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT
• Activation of orexin system facilitates anesthesia emergence and pain control.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY
• Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics.
  The Journal of general physiology 2018 Jan LY, Jan YN
• Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.
  Genes & development 2018 DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN
• Force-activated ion channels in close-up.
  Nature 2018 Jan YN, Jan LY
• The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.
  Neuron 2018 Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY
• Force-activated ion channels in close-up.
  Nature 2018 Jan YN, Jan LY
• Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY
• Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
  Nature 2017 Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY
• Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.
  Proceedings of the National Academy of Sciences of the United States of America 2017 He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY
• Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.
  Cell reports 2017 Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN
• Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.
  Neuron 2017 Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H
• Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.
  Cell reports 2017 Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW
• Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
  Nature 2017 Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y
• Age-dependent diastolic heart failure in an in vivo Drosophila model.
  eLife 2017 Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN
• TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.
  Neuron 2017 Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN
• A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN
• N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.
  The Journal of physiology 2016 Thayer DA, Yang SB, Jan YN, Jan LY
• In vivo dendrite regeneration after injury is different from dendrite development.
  Genes & development 2016 Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN
• Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z
• Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.
  Neuron 2016 Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN
• Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.
  Neuron 2016 Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN
• Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.
  Science translational medicine 2015 Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY, Perretti M
• Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.
  Cell reports 2015 Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R
• Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.
  Cell 2015 Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN
• EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
  Nature neuroscience 2015 Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, …
• Regulation of axon regeneration by the RNA repair and splicing pathway.
  Nature neuroscience 2015 Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN
• The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion.
  eLife 2015 Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN
• Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY
• Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptácek LJ
• MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.
  Neuron 2014 Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN
• Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila.
  Cell reports 2014 Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN
• Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae.
  eLife 2014 Zhang W, Yan Z, Li B, Jan LY, Jan YN
• Common variants associated with general and MMR vaccine-related febrile seizures.
  Nature genetics 2014 Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard DM, Schoggins JW, Jan LY, Melbye M, Hviid A
• Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.
  Genes & development 2014 Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN
• Targeting potassium channels in cancer.
  The Journal of cell biology 2014 Huang X, Jan LY
• A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
  eLife 2014 Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H
• Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
  Nature medicine 2014 Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM
• An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
  Nature communications 2014 Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X
• Krüppel mediates the selective rebalancing of ion channel expression.
  Neuron 2014 Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW
• Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Rumpf S, Bagley JA, Thompson-Peer KL, Zhu S, Gorczyca D, Beckstead RB, Jan LY, Jan YN
• Lily Jan.
  Current biology : CB 2014 Jan L
• Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila.
  Neuron 2014 Han C, Song Y, Xiao H, Wang D, Franc NC, Jan LY, Jan YN
• A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating.
  Neuron 2013 Kim WJ, Jan LY, Jan YN
• Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila.
  Nature neuroscience 2013 Yuan Q, Song Y, Yang CH, Jan LY, Jan YN
• Subdued, a TMEM16 family Ca²⁺-activated Cl⁻channel in Drosophila melanogaster with an unexpected role in host defense.
  eLife 2013 Wong XM, Younger S, Peters CJ, Jan YN, Jan LY
• Conduits of life's spark: a perspective on ion channel research since the birth of neuron.
  Neuron 2013 Isacoff EY, Jan LY, Minor DL
• Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.
  eLife 2013 Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S
• Making antisense of pain.
  Nature neuroscience 2013 Han TW, Jan LY
• Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Zhang W, Yan Z, Jan LY, Jan YN
• TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
  Nature neuroscience 2013 Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY
• Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).
  Proceedings of the National Academy of Sciences of the United States of America 2013 Tien J, Lee HY, Minor DL, Jan YN, Jan LY
• Increased neuronal activity fragments the Golgi complex.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Thayer DA, Jan YN, Jan LY
• Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation.
  Nature 2012 Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN
• Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons.
  Neuron 2012 Ori-McKenney KM, Jan LY, Jan YN
• TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
  Cell 2012 Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY
• Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR
• Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
  Neuron 2012 Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY
• Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
  Genes & development 2012 Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY
• Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
  Genes & development 2012 Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN
• Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals.
  Nature neuroscience 2012 Kim WJ, Jan LY, Jan YN
• Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.
  Neuron 2012 Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY
• Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.
  Current opinion in neurobiology 2012 Lee HY, Jan LY
• Local generation of glia is a major astrocyte source in postnatal cortex.
  Nature 2012 Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY
• Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
  Neuron 2012 Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN
• Voltage-gated potassium channels and the diversity of electrical signalling.
  The Journal of physiology 2012 Jan LY, Jan YN
• Ca2+-activated Cl- channels at a glance.
  Journal of cell science 2012 Berg J, Yang H, Jan LY
• Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.
  The Journal of physiology 2012 Yang SB, Mclemore KD, Tasic B, Luo L, Jan YN, Jan LY
• Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.
  Neuron 2012 Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY, Jan YN
• Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Zhu S, Barshow S, Wildonger J, Jan LY, Jan YN
• Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.
  Journal of molecular medicine (Berlin, Germany) 2011 Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY
• Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein.
  Neuron 2011 Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY
• International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels.
  Pharmacological reviews 2011 Huang F, Wong X, Jan LY
• Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Lee SB, Bagley JA, Lee HY, Jan LY, Jan YN
• Light-induced structural and functional plasticity in Drosophila larval visual system.
  Science (New York, N.Y.) 2011 Yuan Q, Xiang Y, Yan Z, Han C, Jan LY, Jan YN
• Isolation and Expression Profile of the Ca-Activated Chloride Channel-like Membrane Protein 6 Gene in Xenopus laevis.
  Laboratory animal research 2011 Lee RM, Ryu RH, Jeong SW, Oh SJ, Huang H, Han JS, Lee CH, Lee CJ, Jan LY, Jeong SM
• Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.
  Development (Cambridge, England) 2011 Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B
• Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Han C, Jan LY, Jan YN
• Cloning and heterologous expression of new xANO2 from Xenopus laevis.
  Biochemical and biophysical research communications 2011 Ryu RH, Oh SJ, Lee RM, Jeong SW, Jan LY, Lee CH, Lee CJ, Jeong SM
• Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Ye B, Kim JH, Yang L, McLachlan I, Younger S, Jan LY, Jan YN
• Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
  Development (Cambridge, England) 2011 Rumpf S, Lee SB, Jan LY, Jan YN
• Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall.
  Nature 2010 Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN
• Mechanisms of distribution and targeting of neuronal ion channels.
  Current opinion in drug discovery & development 2010 Thayer DA, Jan LY
• The role of the TRP channel NompC in Drosophila larval and adult locomotion.
  Neuron 2010 Cheng LE, Song W, Looger LL, Jan LY, Jan YN
• A twist on potassium channel gating.
  Cell 2010 Zhou W, Jan L
• Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Young DM, Schenk AK, Yang SB, Jan YN, Jan LY
• Branching out: mechanisms of dendritic arborization.
  Nature reviews. Neuroscience 2010 Jan YN, Jan LY
• Studies on expression and function of the TMEM16A calcium-activated chloride channel.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY
• The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons.
  Neuron 2009 Parrish JZ, Xu P, Kim CC, Jan LY, Jan YN
• Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex.
  Neuron 2009 Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH
• Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Lee HH, Jan LY, Jan YN
• A gate keeper for axonal transport.
  Cell 2009 Xiao S, Jan LY
• Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
  Neuron 2009 Yang CH, Rumpf S, Xiang Y, Gordon MD, Song W, Jan LY, Jan YN
• G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Chung HJ, Ge WP, Qian X, Wiser O, Jan YN, Jan LY
• Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Chung HJ, Qian X, Ehlers M, Jan YN, Jan LY
• Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Ge WP, Zhou W, Luo Q, Jan LY, Jan YN
• Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.
  Cell 2008 Schroeder BC, Cheng T, Jan YN, Jan LY
• The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.
  Genes & development 2008 Wildonger J, Jan LY, Jan YN
• Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.
  Nature cell biology 2008 Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN
• Thrilling moment of an inhibitory channel.
  Neuron 2008 Yang SB, Jan LY
• Genetic and physiologic dissection of the vertebrate cardiac conduction system.
  PLoS biology 2008 Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY
• Drosophila egg-laying site selection as a system to study simple decision-making processes.
  Science (New York, N.Y.) 2008 Yang CH, Belawat P, Hafen E, Jan LY, Jan YN
• Stoichiometry of Kir channels with phosphatidylinositol bisphosphate.
  Channels (Austin, Tex.) 2008 Jin T, Sui JL, Rosenhouse-Dantsker A, Chan KW, Jan LY, Logothetis DE
• Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.
  Genes & development 2008 Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY
• Retrospective: Seymour Benzer (1921-2007).
  Science (New York, N.Y.) 2008 Jan YN, Jan L
• Identification of yeast proteins necessary for cell-surface function of a potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M
• Growing dendrites and axons differ in their reliance on the secretory pathway.
  Cell 2007 Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN
• Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.
  The Journal of biological chemistry 2007 Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D
• Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
  Nature neuroscience 2007 Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N
• Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.
  Neuron 2007 Soba P, Zhu S, Emoto K, Younger S, Yang SJ, Yu HH, Lee T, Jan LY, Jan YN
• Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
  Genes & development 2007 Parrish JZ, Emoto K, Jan LY, Jan YN
• Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Song W, Onishi M, Jan LY, Jan YN
• Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling.
  The Journal of biological chemistry 2007 Gong Q, Weide M, Huntsman C, Xu Z, Jan LY, Ma D
• Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions.
  Cell 2007 Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY
• HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients.
  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007 Katarina K, Daniela P, Peter N, Marianna R, Pavlina C, Stepanka P, Jan L, Ludmila T, Michal A, Marie C
• Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.
  Development (Cambridge, England) 2007 Grueber WB, Ye B, Yang CH, Younger S, Borden K, Jan LY, Jan YN
• Structure prediction for the down state of a potassium channel voltage sensor.
  Nature 2006 Grabe M, Lai HC, Jain M, Jan YN, Jan LY
• Channeling to the nucleus.
  Neuron 2006 Chung HJ, Jan LY
• Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.
  Cell 2006 Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN
• The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.
  Neuron 2006 Gu C, Zhou W, Puthenveedu MA, Xu M, Jan YN, Jan LY
• SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Fay AJ, Qian X, Jan YN, Jan LY
• Turning G proteins on and off using peptide ligands.
  ACS chemical biology 2006 Ja WW, Wiser O, Austin RJ, Jan LY, Roberts RW
• The secretory pathway and neuron polarization.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Ye B, Zhang YW, Jan LY, Jan YN
• Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
  Science (New York, N.Y.) 2006 Raab-Graham KF, Haddick PC, Jan YN, Jan LY
• The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons.
  Genes & development 2006 Kim MD, Jan LY, Jan YN
• Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Bichet D, Grabe M, Jan YN, Jan LY
• K+ channel selectivity depends on kinetic as well as thermodynamic factors.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Grabe M, Bichet D, Qian X, Jan YN, Jan LY
• The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.
  Nature 2006 Emoto K, Parrish JZ, Jan LY, Jan YN
• Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning.
  Neuron 2006 Kuo CT, Zhu S, Younger S, Jan LY, Jan YN
• The distribution and targeting of neuronal voltage-gated ion channels.
  Nature reviews. Neuroscience 2006 Lai HC, Jan LY
• Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Chung HJ, Jan YN, Jan LY
• Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN.
  Neuron 2006 Wiser O, Qian X, Ehlers M, Ja WW, Roberts RW, Reuveny E, Jan YN, Jan LY
• Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.
  Genes & development 2006 Parrish JZ, Kim MD, Jan LY, Jan YN
• International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
  Pharmacological reviews 2005 Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA
• Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Surti TS, Huang L, Jan YN, Jan LY, Cooper EC
• Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.
  Cell 2005 Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, Jan LY
• Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Kuo CT, Jan LY, Jan YN
• The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.
  Neuron 2005 Lai HC, Grabe M, Jan YN, Jan LY
• A potassium channel, the M-channel, as a therapeutic target.
  Current opinion in investigational drugs (London, England : 2000) 2005 Surti TS, Jan LY
• Mammalian electrophysiology on a microfluidic platform.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP
• Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
  Molecular biology of the cell 2005 Roegiers F, Jan LY, Jan YN
• A fluorescent probe designed for studying protein conformational change.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff EY, Jan LY
• Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.
  Genes & development 2004 Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN
• A quantitative assessment of models for voltage-dependent gating of ion channels.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Grabe M, Lecar H, Jan YN, Jan LY
• APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.
  Current biology : CB 2004 Shi SH, Cheng T, Jan LY, Jan YN
• Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.
  Cell 2004 Emoto K, He Y, Ye B, Grueber WB, Adler PN, Jan LY, Jan YN
• Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1).
  Proceedings of the National Academy of Sciences of the United States of America 2004 Shi SH, Cox DN, Wang D, Jan LY, Jan YN
• The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Shi SH, Cheng T, Jan LY, Jan YN
• NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Lin YF, Raab-Graham K, Jan YN, Jan LY
• Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY
• Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification.
  Genes & development 2004 Moore AW, Roegiers F, Jan LY, Jan YN
• Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.
  Current biology : CB 2004 Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN
• Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.
  Neuron 2003 Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN
• International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.
  Pharmacological reviews 2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, …
• Merging functional studies with structures of inward-rectifier K(+) channels.
  Nature reviews. Neuroscience 2003 Bichet D, Haass FA, Jan LY
• Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Hong Y, Ackerman L, Jan LY, Jan YN
• The control of dendrite development.
  Neuron 2003 Jan YN, Jan LY
• Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons.
  Neuron 2003 Rothenberg ME, Rogers SL, Vale RD, Jan LY, Jan YN
• A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.
  Science (New York, N.Y.) 2003 Gu C, Jan YN, Jan LY
• Answers and questions from the KvAP structures.
  Neuron 2003 Cohen BE, Grabe M, Jan LY
• Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T
• ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C.
  Neuron 2003 Hu K, Huang CS, Jan YN, Jan LY
• Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage.
  Current biology : CB 2003 Justice N, Roegiers F, Jan LY, Jan YN
• Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion.
  Current biology : CB 2003 Grueber WB, Ye B, Moore AW, Jan LY, Jan YN
• M-channels: neurological diseases, neuromodulation, and drug development.
  Archives of neurology 2003 Cooper EC, Jan LY
• Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons.
  Cell 2003 Grueber WB, Jan LY, Jan YN
• Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
  Cancer cell 2003 Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S
• The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.
  Developmental cell 2003 Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN
• Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.
  Cell 2003 Shi SH, Jan LY, Jan YN
• Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI
• Probing protein electrostatics with a synthetic fluorescent amino acid.
  Science (New York, N.Y.) 2002 Cohen BE, McAnaney TB, Park ES, Jan YN, Boxer SG, Jan LY
• Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.
  Neuron 2002 Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY
• M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Cooper EC, Harrington E, Jan YN, Jan LY
• Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.
  Nature 2001 Hong Y, Stronach B, Perrimon N, Jan LY, Jan YN
• Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Cox DN, Seyfried SA, Jan LY, Jan YN
• Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Roegiers F, Younger-Shepherd S, Jan LY, Jan YN
• Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Margeta-Mitrovic M, Jan YN, Jan LY
• Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Margeta-Mitrovic M, Jan YN, Jan LY
• Asymmetric cell division in the Drosophila nervous system.
  Nature reviews. Neuroscience 2001 Jan YN, Jan LY
• Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila.
  Developmental cell 2001 Brenman JE, Gao FB, Jan LY, Jan YN
• Dendrites.
  Genes & development 2001 Jan YN, Jan LY
• Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster.
  TheScientificWorldJournal 2001 Zou S, Meadows S, Sharp L, Jan LY, Jan YN
• Controlling potassium channel activities: Interplay between the membrane and intracellular factors.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Yi BA, Minor DL, Lin YF, Jan YN, Jan LY
• Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Ruan Y, Tecott L, Jiang MM, Jan LY, Jan YN
• Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.
  Nature neuroscience 2001 Lu T, Ting AY, Mainland J, Jan LY, Schultz PG, Yang J
• Yeast screen for constitutively active mutant G protein-activated potassium channels.
  Neuron 2001 Yi BA, Lin YF, Jan YN, Jan LY
• Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Zerangue N, Malan MJ, Fried SR, Dazin PF, Jan YN, Jan LY, Schwappach B
• Role of ER export signals in controlling surface potassium channel numbers.
  Science (New York, N.Y.) 2001 Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY
• Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.
  Nature cell biology 2001 Roegiers F, Younger-Shepherd S, Jan LY, Jan YN
• Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Zou S, Meadows S, Sharp L, Jan LY, Jan YN
• Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons.
  Neuron 2000 Gao FB, Kohwi M, Brenman JE, Jan LY, Jan YN
• Signalling mechanisms: a decade of signalling.
  Current opinion in neurobiology 2000 Jan LY, Stevens CF
• A genomewide survey of basic helix-loop-helix factors in Drosophila.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Moore AW, Barbel S, Jan LY, Jan YN
• Heartfelt crosstalk: desensitization of the GIRK current.
  Nature cell biology 2000 Jan LY, Jan YN
• Taking apart the gating of voltage-gated K+ channels.
  Neuron 2000 Yi BA, Jan LY
• The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
  Cell 2000 Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM
• A trafficking checkpoint controls GABA(B) receptor heterodimerization.
  Neuron 2000 Margeta-Mitrovic M, Jan YN, Jan LY
• Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Sun Y, Jan LY, Jan YN
• Mouse numb is an essential gene involved in cortical neurogenesis.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Zhong W, Jiang MM, Schonemann MD, Meneses JJ, Pedersen RA, Jan LY, Jan YN
• A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ.
  Genetics 2000 Abdelilah-Seyfried S, Chan YM, Zeng C, Justice NJ, Younger-Shepherd S, Sharp LE, Barbel S, Meadows SA, Jan LY, Jan YN
• Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY
• Molecular basis for K(ATP) assembly: transmembrane interactions mediate association of a K+ channel with an ABC transporter.
  Neuron 2000 Schwappach B, Zerangue N, Jan YN, Jan LY
• An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Zerangue N, Jan YN, Jan LY
• Polarity in cell division: what frames thy fearful asymmetry?
  Cell 2000 Jan YN, Jan LY
• Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.
  The EMBO journal 2000 Lin YF, Jan YN, Jan LY
• Control of cell divisions in the nervous system: symmetry and asymmetry.
  Annual review of neuroscience 2000 Lu B, Jan L, Jan YN
• Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division.
  Molecular cell 1999 Lu B, Ackerman L, Jan LY, Jan YN
• Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.
  Current biology : CB 1999 Lu B, Usui T, Uemura T, Jan L, Jan YN
• Genes regulating dendritic outgrowth, branching, and routing in Drosophila.
  Genes & development 1999 Gao FB, Brenman JE, Jan LY, Jan YN
• Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.
  Neuron 1999 Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M
• Asymmetry across species.
  Nature cell biology 1999 Jan YN, Jan LY
• Ion channel genes and human neurological disease: recent progress, prospects, and challenges.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Cooper EC, Jan LY
• Transmembrane structure of an inwardly rectifying potassium channel.
  Cell 1999 Minor DL, Masseling SJ, Jan YN, Jan LY
• Immunohistochemical localization of GABA(B) receptors in the rat central nervous system.
  The Journal of comparative neurology 1999 Margeta-Mitrovic M, Mitrovic I, Riley RC, Jan LY, Basbaum AI
• A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
  Neuron 1999 Zerangue N, Schwappach B, Jan YN, Jan LY
• Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.
  Current biology : CB 1999 Knoblich JA, Jan LY, Jan YN
• Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors.
  Cell 1998 Lu B, Rothenberg M, Jan LY, Jan YN
• Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Chuang HH, Yu M, Jan YN, Jan LY
• The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Zeng C, Justice NJ, Abdelilah S, Chan YM, Jan LY, Jan YN
• Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.
  Development (Cambridge, England) 1998 Sun Y, Jan LY, Jan YN
• Asymmetric cell division: lessons from flies and worms.
  Current opinion in genetics & development 1998 Lu B, Jan LY, Jan YN
• Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.
  Genes & development 1998 Shen CP, Knoblich JA, Chan YM, Jiang MM, Jan LY, Jan YN
• Molecular basis for interactions of G protein betagamma subunits with effectors.
  Science (New York, N.Y.) 1998 Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE
• Asymmetric cell division.
  Nature 1998 Jan YN, Jan LY
• G-protein signaling: fine-tuning signaling kinetics.
  Current biology : CB 1998 Zerangue N, Jan LY
• Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.
  Genes & development 1998 Zeng C, Younger-Shepherd S, Jan LY, Jan YN
• Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH
• Epilepsy genes: excitement traced to potassium channels.
  Nature genetics 1998 Stoffel M, Jan LY
• Humble starts and conserved themes in neurogenetic studies.
  Harvey lectures 1998 Jan YN, Jan LY
• Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.
  Molecular and cellular biology 1998 Chien CT, Wang S, Rothenberg M, Jan LY, Jan YN
• Serendipity, the principle of limited sloppiness, and neural development.
  The International journal of developmental biology 1998 Jan YN, Jan LY
• Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.
  The Journal of biological chemistry 1997 Vivaudou M, Chan KW, Sui JL, Jan LY, Reuveny E, Logothetis DE
• Ways and means for left shifts in the MaxiK channel.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Jan LY, Jan YN
• Voltage-gated and inwardly rectifying potassium channels.
  The Journal of physiology 1997 Jan LY, Jan YN
• Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Luo L, Lee T, Tsai L, Tang G, Jan LY, Jan YN
• The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Knoblich JA, Jan LY, Jan YN
• Breaking symmetry in the CNS.
  Trends in cell biology 1997 Li P, Yang X, Wasser M, Cai Y, Chia W, Shen CP, Jan LY, Jan YN
• Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.
  Development (Cambridge, England) 1997 Wang S, Younger-Shepherd S, Jan LY, Jan YN
• Xath5 participates in a network of bHLH genes in the developing Xenopus retina.
  Neuron 1997 Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter ML
• Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Slesinger PA, Stoffel M, Jan YN, Jan LY
• The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.
  Development (Cambridge, England) 1997 Doherty D, Jan LY, Jan YN
• G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons.
  Neuron 1997 Lüscher C, Jan LY, Stoffel M, Malenka RC, Nicoll RA
• Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila.
  Cell 1997 Shen CP, Jan LY, Jan YN
• Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium.
  Cell 1997 Chuang H, Jan YN, Jan LY
• Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Collins A, Chuang H, Jan YN, Jan LY
• Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.
  Development (Cambridge, England) 1997 Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN
• Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.
  FEBS letters 1997 Huang CL, Jan YN, Jan LY
• Receptor-regulated ion channels.
  Current opinion in cell biology 1997 Jan LY, Jan YN
• Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Yang J, Yu M, Jan YN, Jan LY
• Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Signorini S, Liao YJ, Duncan SA, Jan LY, Stoffel M
• Rho family GTP-binding proteins in growth cone signalling.
  Current opinion in neurobiology 1997 Luo L, Jan LY, Jan YN
• Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations.
  Cold Spring Harbor symposia on quantitative biology 1997 Knoblich JA, Jan LY, Jan YN
• Cloned potassium channels from eukaryotes and prokaryotes.
  Annual review of neuroscience 1997 Jan LY, Jan YN
• Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle.
  Development (Cambridge, England) 1997 Clark IE, Jan LY, Jan YN
• Regions responsible for the assembly of inwardly rectifying potassium channels.
  Cell 1996 Tinker A, Jan YN, Jan LY
• Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 Liao YJ, Jan YN, Jan LY
• Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Chien CT, Hsiao CD, Jan LY, Jan YN
• frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance.
  Cell 1996 Kolodziej PA, Timpe LC, Mitchell KJ, Fried SR, Goodman CS, Jan LY, Jan YN
• The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Frise E, Knoblich JA, Younger-Shepherd S, Jan LY, Jan YN
• Role of inscuteable in orienting asymmetric cell divisions in Drosophila.
  Nature 1996 Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA
• Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.
  The EMBO journal 1996 Fakler B, Schultz JH, Yang J, Schulte U, Brandle U, Zenner HP, Jan LY, Ruppersberg JP
• Membrane permeability.
  Current opinion in cell biology 1996 Jan LY, Jan YN
• Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.
  Neuron 1996 Zhong W, Feder JN, Jiang MM, Jan LY, Jan YN
• Control of daughter cell fates during asymmetric division: interaction of Numb and Notch.
  Neuron 1996 Guo M, Jan LY, Jan YN
• Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.
  Nature 1996 Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN
• Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.
  Genes & development 1996 Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN
• Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation.
  Biophysical journal 1996 Reuveny E, Jan YN, Jan LY
• Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.
  Neuron 1996 Slesinger PA, Patil N, Liao YJ, Jan YN, Jan LY, Cox DR
• A strongly inwardly rectifying K+ channel that is sensitive to ATP.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 Collins A, German MS, Jan YN, Jan LY, Zhao B
• Small GTPases in axon outgrowth.
  Perspectives on developmental neurobiology 1996 Luo L, Jan L, Jan YN
• Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.
  Neuron 1995 Yang J, Jan YN, Jan LY
• Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.
  Neuron 1995 Huang CL, Slesinger PA, Casey PJ, Jan YN, Jan LY
• Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.
  Neuron 1995 Slesinger PA, Reuveny E, Jan YN, Jan LY
• dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.
  The EMBO journal 1995 Feger G, Vaessin H, Su TT, Wolff E, Jan LY, Jan YN
• Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.
  The Journal of biological chemistry 1995 Xu J, Yu W, Jan YN, Jan LY, Li M
• Asymmetric segregation of Numb and Prospero during cell division.
  Nature 1995 Knoblich JA, Jan LY, Jan YN
• Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo.
  Neuron 1995 Kolodziej PA, Jan LY, Jan YN
• Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
  Biochemical and biophysical research communications 1995 Stoffel M, Tokuyama Y, Trabb JB, German MS, Tsaar ML, Jan LY, Polonsky KS, Bell GI
• Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors.
  Development (Cambridge, England) 1995 Jarman AP, Sun Y, Jan LY, Jan YN
• The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Klumpp DJ, Song EJ, Ito S, Sheng MH, Jan LY, Pinto LH
• Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
  Neuron 1995 Yang J, Jan YN, Jan LY
• tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.
  Neuron 1995 Guo M, Bier E, Jan LY, Jan YN
• Maggot's hair and bug's eye: role of cell interactions and intrinsic factors in cell fate specification.
  Neuron 1995 Jan YN, Jan LY
• The molecular organization of voltage-dependent K+ channels in vivo.
  Progress in brain research 1995 Sheng M, Jan YN, Jan L
• Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.
  Genes & development 1994 Jongens TA, Ackerman LD, Swedlow JR, Jan LY, Jan YN
• Potassium channels and their evolving gates.
  Nature 1994 Jan LY, Jan YN
• Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI
• Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
  Genes & development 1994 Luo L, Liao YJ, Jan LY, Jan YN
• Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.
  Nature 1994 Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY
• Atonal is the proneural gene for Drosophila photoreceptors.
  Nature 1994 Jarman AP, Grell EH, Ackerman L, Jan LY, Jan YN
• lola encodes a putative transcription factor required for axon growth and guidance in Drosophila.
  Development (Cambridge, England) 1994 Giniger E, Tietje K, Jan LY, Jan YN
• Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1994 Sheng M, Tsaur ML, Jan YN, Jan LY
• Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.
  Current biology : CB 1994 Clark I, Giniger E, Ruohola-Baker H, Jan LY, Jan YN
• daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.
  Development (Cambridge, England) 1994 Vaessin H, Brand M, Jan LY, Jan YN
• Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.
  Nature 1994 Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY
• Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.
  Genomics 1994 Feder JN, Li L, Jan LY, Jan YN
• The role of gene cassettes in axis formation during Drosophila oogenesis.
  Trends in genetics : TIG 1994 Ruohola-Baker H, Jan LY, Jan YN
• Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.
  Cell 1994 Rhyu MS, Jan LY, Jan YN
• Images of purified Shaker potassium channels.
  Current biology : CB 1994 Li M, Unwin N, Stauffer KA, Jan YN, Jan LY
• Neuronal cell fate specification in Drosophila.
  Current opinion in neurobiology 1994 Jan YN, Jan LY
• Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.
  Nature 1994 Lopez GA, Jan YN, Jan LY
• Genetic control of cell fate specification in Drosophila peripheral nervous system.
  Annual review of genetics 1994 Jan YN, Jan LY
• Assembly of potassium channels.
  Annals of the New York Academy of Sciences 1993 Li M, Isacoff E, Jan YN, Jan LY
• HLH proteins, fly neurogenesis, and vertebrate myogenesis.
  Cell 1993 Jan YN, Jan LY
• pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.
  Development (Cambridge, England) 1993 Siegel V, Jongens TA, Jan LY, Jan YN
• The S4-S5 loop contributes to the ion-selective pore of potassium channels.
  Neuron 1993 Slesinger PA, Jan YN, Jan LY
• Functional gene cassettes in development.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Jan YN, Jan LY
• Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.
  Nature 1993 Sheng M, Liao YJ, Jan YN, Jan LY
• The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.
  Development (Cambridge, England) 1993 Jarman AP, Brand M, Jan LY, Jan YN
• asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.
  Development (Cambridge, England) 1993 Brand M, Jarman AP, Jan LY, Jan YN
• Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
  Nature 1993 Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY
• A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.
  Roux's archives of developmental biology : the official organ of the EDBO 1993 Bodmer R, Jan LY, Jan YN
• atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system.
  Cell 1993 Jarman AP, Grau Y, Jan LY, Jan YN
• Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis.
  Cell 1993 Ruohola-Baker H, Grell E, Chou TB, Baker D, Jan LY, Jan YN
• The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.
  The EMBO journal 1993 Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN
• Cell interactions and gene interactions in peripheral neurogenesis.
  Genes & development 1993 Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN
• Primary structure and functional expression of a mouse inward rectifier potassium channel.
  Nature 1993 Kubo Y, Baldwin TJ, Jan YN, Jan LY
• Tracing neurons with a kinesin-β-galactosidase fusion protein.
  Roux's archives of developmental biology : the official organ of the EDBO 1993 Giniger E, Wells W, Jan LY, Jan YN
• A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila.
  Nature 1993 Crowley TE, Hoey T, Liu JK, Jan YN, Jan LY, Tjian R
• Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila.
  Development (Cambridge, England) 1993 Blochlinger K, Jan LY, Jan YN
• Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch.
  Development (Cambridge, England) 1993 Giniger E, Jan LY, Jan YN
• A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.
  Molecular and cellular biology 1993 Feder JN, Jan LY, Jan YN
• Molecular basis of K+ channel inactivation gating.
  EXS 1993 Isacoff EY, Jan YN, Jan LY
• deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.
  Genes & development 1992 Bier E, Vaessin H, Younger-Shepherd S, Jan LY, Jan YN
• deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination.
  Cell 1992 Younger-Shepherd S, Vaessin H, Bier E, Jan LY, Jan YN
• The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.
  Development (Cambridge, England) 1992 Rao Y, Bodmer R, Jan LY, Jan YN
• Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel.
  Science (New York, N.Y.) 1992 Li M, Jan YN, Jan LY
• The germ cell-less gene product: a posteriorly localized component necessary for germ cell development in Drosophila.
  Cell 1992 Jongens TA, Hay B, Jan LY, Jan YN
• Neuronal specification.
  Current opinion in genetics & development 1992 Jan YN, Jan LY
• Subcellular segregation of two A-type K+ channel proteins in rat central neurons.
  Neuron 1992 Sheng M, Tsaur ML, Jan YN, Jan LY
• Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures.
  Neuron 1992 Tsaur ML, Sheng M, Lowenstein DH, Jan YN, Jan LY
• Tracing the roots of ion channels.
  Cell 1992 Jan LY, Jan YN
• Elucidation of biophysical and biological properties of voltage-gated potassium channels.
  Cold Spring Harbor symposia on quantitative biology 1992 Baldwin TJ, Isacoff E, Li M, Lopez GA, Sheng M, Tsaur ML, Yan YN, Jan LY
• Structural elements involved in specific K+ channel functions.
  Annual review of physiology 1992 Jan LY, Jan YN
• prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila.
  Cell 1991 Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN
• The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.
  The EMBO journal 1991 Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN
• Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel.
  Nature 1991 Isacoff EY, Jan YN, Jan LY
• Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel.
  Neuron 1991 Baldwin TJ, Tsaur ML, Lopez GA, Jan YN, Jan LY
• Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.
  Genes & development 1991 Rao Y, Vaessin H, Jan LY, Jan YN
• Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila.
  Cell 1991 Ruohola H, Bremer KA, Baker D, Swedlow JR, Jan LY, Jan YN
• Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.
  Neuron 1991 Lopez GA, Jan YN, Jan LY
• Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.
  Genes & development 1991 Blochlinger K, Jan LY, Jan YN
• Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.
  Nature 1991 Papazian DM, Timpe LC, Jan YN, Jan LY
• Genes required for specifying cell fates in Drosophila embryonic sensory nervous system.
  Trends in neurosciences 1990 Jan YN, Jan LY
• A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila.
  Development (Cambridge, England) 1990 Bodmer R, Jan LY, Jan YN
• How might the diversity of potassium channels be generated?
  Trends in neurosciences 1990 Jan LY, Jan YN
• Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.
  Neuron 1990 Klaiber K, Williams N, Roberts TM, Papazian DM, Jan LY, Miller C
• Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.
  Genes & development 1990 Blochlinger K, Bodmer R, Jan LY, Jan YN
• A superfamily of ion channels.
  Nature 1990 Jan LY, Jan YN
• Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes.
  Nature 1990 Isacoff EY, Jan YN, Jan LY
• Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity.
  Development (Cambridge, England) 1990 Hay B, Jan LY, Jan YN
• Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.
  Nature 1990 Rao Y, Jan LY, Jan YN
• rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
  Genes & development 1990 Bier E, Jan LY, Jan YN
• Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila.
  Neuron 1990 Schwarz TL, Papazian DM, Carretto RC, Jan YN, Jan LY
• Molecular studies of voltage-gated potassium channels.
  Cold Spring Harbor symposia on quantitative biology 1990 Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY
• Role of helix-loop-helix proteins in Drosophila neurogenesis.
  Cold Spring Harbor symposia on quantitative biology 1990 Vaessin H, Caudy M, Bier E, Jan LY, Jan YN
• Spider toxins selectively block calcium currents in Drosophila.
  Neuron 1989 Leung HT, Branton WD, Phillips HS, Jan L, Byerly L
• Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.
  Cell 1989 Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB
• numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos.
  Cell 1989 Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN
• Voltage-sensitive ion channels.
  Cell 1989 Jan LY, Jan YN
• daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.
  Cell 1988 Caudy M, Vässin H, Brand M, Tuma R, Jan LY, Jan YN
• A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.
  Cell 1988 Hay B, Jan LY, Jan YN
• Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.
  Neuron 1988 Timpe LC, Jan YN, Jan LY
• Identification of a component of Drosophila polar granules.
  Development (Cambridge, England) 1988 Hay B, Ackerman L, Barbel S, Jan LY, Jan YN
• The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.
  Genes & development 1988 Caudy M, Grell EH, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN
• Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila.
  Nature 1988 Blochlinger K, Bodmer R, Jack J, Jan LY, Jan YN
• Identification and characterization of a neuron-specific nuclear antigen in Drosophila.
  Science (New York, N.Y.) 1988 Bier E, Ackerman L, Barbel S, Jan L, Jan YN
• Cloning of a probable potassium channel gene from mouse brain.
  Nature 1988 Tempel BL, Jan YN, Jan LY
• Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.
  Nature 1988 Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY
• Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.
  Nature 1988 Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY
• Ion channels in Drosophila.
  Annual review of physiology 1988 Papazian DM, Schwarz TL, Tempel BL, Timpe LC, Jan LY
• Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1987 Branton WD, Kolton L, Jan YN, Jan LY
• The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.
  Cell 1987 Royden CS, Pirrotta V, Jan LY
• Transformation of sensory organs by mutations of the cut locus of D. melanogaster.
  Cell 1987 Bodmer R, Barbel S, Sheperd S, Jack JW, Jan LY, Jan YN
• Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.
  Science (New York, N.Y.) 1987 Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY
• Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.
  Science (New York, N.Y.) 1987 Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY
• Gene dosage and complementation analysis of the Shaker locus in Drosophila.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1987 Timpe LC, Jan LY
• Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Bowers CW, Phillips HS, Lee P, Jan YN, Jan LY
• Muscle connections between imaginal discs in Drosophila.
  Developmental biology 1986 Dambly-Chaudière C, Ghysen A, Jan YN, Jan LY
• Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1985 Jan YN, Ghysen A, Christoph I, Barbel S, Jan LY
• Segmental determination in Drosophila central nervous system.
  Cell 1985 Ghysen A, Jan LY, Jan YN
• Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila.
  Cold Spring Harbor symposia on quantitative biology 1983 Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN
• Peptides in neuronal function: studies using frog autonomic ganglia.
  Cold Spring Harbor symposia on quantitative biology 1983 Jan YN, Bowers CW, Branton D, Evans L, Jan LY
• Some features of peptidergic transmission.
  Progress in brain research 1983 Jan YN, Jan LY
• Peptidergic transmission in sympathetic ganglia of the frog.
  The Journal of physiology 1982 Jan LY, Jan YN
• Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.
  Proceedings of the National Academy of Sciences of the United States of America 1982 Jan LY, Jan YN
• Segmental differences in the protein content of Drosophila imaginal discs.
  The EMBO journal 1982 Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN
• Role of an LHRH-like peptide as a neurotransmitter is sympathetic ganglia of the frog.
  Federation proceedings 1981 Jan LY, Jan YN
• Peptidergic transmitters in synaptic boutons of sympathetic ganglia.
  Nature 1980 Jan LY, Jan YN, Brownfield MS
• Further evidence for peptidergic transmission in sympathetic ganglia.
  Proceedings of the National Academy of Sciences of the United States of America 1980 Jan YN, Jan LY, Kuffler SW
• Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.
  The Journal of cell biology 1979 Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L, Evans L
• A Drosophila mutant with a temperature-sensitive block in nerve conduction.
  Proceedings of the National Academy of Sciences of the United States of America 1978 Wu CF, Ganetzky B, Jan LY, Jan YN, Benzer S
• L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction.
  The Journal of physiology 1976 Jan LY, Jan YN
• Ultrastructural localization of rhodopsin in the vertebrate retina.
  The Journal of cell biology 1974 Jan LY, Revel JP