Licia Selleri, PhD, MD
Professor
Orofacial Sciences
School of Dentistry

Department of Anatomy Institute of Human Genetics Eli and Edythe Broad Center of Regeneration Medicine & Stem Cell Research

Genetic and regulatory control of morphogenesis in embryonic development, evolution, and disease The laboratory studies the genetic and regulatory basis of how elaborately patterned tissues form during embryonic development and evolution. The laboratory combines different genetic approaches, using the mouse as a model, to understand the mechanisms underpinning basic developmental processes related to cranial and appendicular morphogenesis. They discovered that homeodomain-containing transcription factors of the Pbx family, also known as Hox-cofactors, are critical developmental regulators through the transcriptional control of target genes within tissue-specific regulatory networks. The lab uses genetically-engineered and ethylnitrosourea (ENU)-mutagenized mouse lines. Recently they utilize additional animal models, such as jerboas and primates, with the ultimate goal to identify novel genes and regulatory networks underlying morphogenesis of embryonic structures, morphological variation, and evolution. Focus is also given to how perturbation of these regulatory networks can result in human congenital disease.

• A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis.
  eLife 2024 Mohammed J, Arora N, Matthews HS, Hansen K, Bader M, Walsh S, Shaffer JR, Weinberg SM, Swigut T, Claes P, Selleri L, Wysocka J
• Conserved enhancers control notochord expression of vertebrate Brachyury.
  Nature communications 2023 Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C…
• ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.
  Developmental biology 2023 Hermosilla Aguayo V, Martin P, Tian N, Zheng J, Aho R, Losa M, Selleri L
• A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.
  Nature communications 2023 Losa M, Barozzi I, Osterwalder M, Hermosilla-Aguayo V, Morabito A, Chacón BH, Zarrineh P, Girdziusaite A, Benazet JD, Zhu J, Mackem S, Capellini TD, Dickel D, Bobola N, Zuniga A, Visel A, Zeller R, …
• Shaping faces: genetic and epigenetic control of craniofacial morphogenesis.
  Nature reviews. Genetics 2023 Selleri L, Rijli FM
• Conserved enhancer logic controls the notochord expression of vertebrate Brachyury.
  bioRxiv : the preprint server for biology 2023 Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C…
• Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.
  bioRxiv : the preprint server for biology 2023 Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F
• The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
  The EMBO journal 2021 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC
• Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.
  Cell stem cell 2020 Long HK, Osterwalder M, Welsh IC, Hansen K, Davies JOJ, Liu YE, Koska M, Adams AT, Aho R, Arora N, Ikeda K, Williams RM, Sauka-Spengler T, Porteus MH, Mohun T, Dickel DE, Swigut T, Hughes JR, Higgs DR…
• FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.
  Development (Cambridge, England) 2020 Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD…
• A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.
  Developmental cell 2020 Cozzitorto C, Mueller L, Ruzittu S, Mah N, Willnow D, Darrigrand JF, Wilson H, Khosravinia D, Mahmoud AA, Risolino M, Selleri L, Spagnoli FM
• Ubiquitous overexpression of CXCL12 confers radiation protection and enhances mobilization of hematopoietic stem and progenitor cells.
  Stem cells (Dayton, Ohio) 2020 Rajendiran S, Smith-Berdan S, Kunz L, Risolino M, Selleri L, Schroeder T, Forsberg EC
• Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease.
  Human molecular genetics 2020 Alankarage D, Szot JO, Pachter N, Slavotinek A, Selleri L, Shieh JT, Winlaw D, Giannoulatou E, Chapman G, Dunwoodie SL
• Corrigendum: 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.
  Genes & development 2019 Selleri L, Zappavigna V, Ferretti E
• 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.
  Genes & development 2019 Selleri L, Zappavigna V, Ferretti E
• Genetics of scapula and pelvis development: An evolutionary perspective.
  Current topics in developmental biology 2019 Young M, Selleri L, Capellini TD
• Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Bolze A, Boisson B, Bosch B, Antipenko A, Bouaziz M, Sackstein P, Chaker-Margot M, Barlogis V, Briggs T, Colino E, Elmore AC, Fischer A, Genel F, Hewlett A, Jedidi M, Kelecic J, Krüger R, Ku CL, …
• Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface.
  Journal of anatomy 2018 Welsh IC, Hart J, Brown JM, Hansen K, Rocha Marques M, Aho RJ, Grishina I, Hurtado R, Herzlinger D, Ferretti E, Garcia-Garcia MJ, Selleri L
• Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion.
  Development (Cambridge, England) 2018 Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, Yang H, Choi IF, Lewicki P, Khan S, Aho R, Feenstra J, Vincent CT, Brown AMC, Ferretti E, Williams T, Selleri L
• PBX transcription factors drive pulmonary vascular adaptation to birth.
  The Journal of clinical investigation 2017 McCulley DJ, Wienhold MD, Hines EA, Hacker TA, Rogers A, Pewowaruk RJ, Zewdu R, Chesler NC, Selleri L, Sun X
• De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.
  Human molecular genetics 2017 Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG, Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G, Pachter NS, …
• Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs.
  Plastic and reconstructive surgery 2017 Dong X, Landford WN, Hart J, Risolino M, Kaymakcalan O, Jin J, Toyoda Y, Ferretti E, Selleri L, Spector JA
• A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?
  PLoS genetics 2016 Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS
• Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1.
  Cancer research 2016 Jung JG, Shih IM, Park JT, Gerry E, Kim TH, Ayhan A, Handschuh K, Davidson B, Fader AN, Selleri L, Wang TL
• Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.
  Neuron 2016 Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS
• A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.
  The EMBO journal 2016 Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lönnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L,…
• The FaceBase Consortium: a comprehensive resource for craniofacial researchers.
  Development (Cambridge, England) 2016 Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, FaceBase …
• Pbx1 is required for adult subventricular zone neurogenesis.
  Development (Cambridge, England) 2016 Grebbin BM, Hau AC, Groß A, Anders-Maurer M, Schramm J, Koss M, Wille C, Mittelbronn M, Selleri L, Schulte D
• Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
  Journal of anatomy 2016 Zewdu R, Risolino M, Barbulescu A, Ramalingam P, Butler JM, Selleri L
• Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.
  Neuron 2015 Golonzhka O, Nord A, Tang PLF, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JLR
• Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.
  Development (Cambridge, England) 2015 Hurtado R, Zewdu R, Mtui J, Liang C, Aho R, Kurylo C, Selleri L, Herzlinger D
• An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.
  Nature genetics 2015 Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A
• ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.
  Cell reports 2014 Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, …
• Pbx1 activates Fgf10 in the mesenchyme of developing lungs.
  Genesis (New York, N.Y. : 2000) 2014 Li W, Lin CY, Shang C, Han P, Xiong Y, Lin CJ, Yang J, Selleri L, Chang CP
• ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.
  Molecular and cellular biology 2013 Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP
• The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
  The EMBO journal 2012 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC
• Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex.
  Cells, tissues, organs 2011 Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB
• Control of pelvic girdle development by genes of the Pbx family and Emx2.
  Developmental dynamics : an official publication of the American Association of Anatomists 2011 Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L
• Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.
  Developmental dynamics : an official publication of the American Association of Anatomists 2011 Capellini TD, Zappavigna V, Selleri L
• Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.
  Development (Cambridge, England) 2010 Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V
• Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner.
  The International journal of developmental biology 2009 Mercader N, Selleri L, Criado LM, Pallares P, Parras C, Cleary ML, Torres M
• Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.
  Genesis (New York, N.Y. : 2000) 2008 Capellini TD, Dunn MP, Passamaneck YJ, Selleri L, Di Gregorio A
• Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.
  Circulation research 2008 Stankunas K, Shang C, Twu KY, Kao SC, Jenkins NA, Copeland NG, Sanyal M, Selleri L, Cleary ML, Chang CP
• Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.
  Developmental biology 2008 Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L
• Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.
  Immunity 2007 Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X
• Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.
  Molecular and cellular biology 2007 Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A
• Development and function of the mammalian spleen.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2007 Brendolan A, Rosado MM, Carsetti R, Selleri L, Dear TN
• B-cell development fails in the absence of the Pbx1 proto-oncogene.
  Blood 2007 Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML
• Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.
  Molecular and cellular biology 2006 Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC, Longobardi E, Mazzieri R, Miccio A, Micali N, Selleri L, Ferrari G, Blasi F
• Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.
  Developmental biology 2006 Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL
• Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.
  Development (Cambridge, England) 2006 Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L
• Hox cofactors in vertebrate development.
  Developmental biology 2006 Moens CB, Selleri L
• Spatio-temporal expression of Pbx3 during mouse organogenesis.
  Gene expression patterns : GEP 2006 Di Giacomo G, Koss M, Capellini TD, Brendolan A, Pöpperl H, Selleri L
• A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.
  Development (Cambridge, England) 2005 Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F, Cleary ML, Selleri L
• Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs.
  Developmental biology 2004 Manley NR, Selleri L, Brendolan A, Gordon J, Cleary ML
• Pbx3 deficiency results in central hypoventilation.
  The American journal of pathology 2004 Rhee JW, Arata A, Selleri L, Jacobs Y, Arata S, Onimaru H, Cleary ML
• The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.
  Molecular and cellular biology 2004 Selleri L, DiMartino J, van Deursen J, Brendolan A, Sanyal M, Boon E, Capellini T, Smith KS, Rhee J, Pöpperl H, Grosveld G, Cleary ML
• Pbx1 is essential for adrenal development and urogenital differentiation.
  Genesis (New York, N.Y. : 2000) 2003 Schnabel CA, Selleri L, Cleary ML
• Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
  Nature genetics 2002 Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML
• Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.
  Development (Cambridge, England) 2001 Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML
• The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.
  Blood 2001 DiMartino JF, Selleri L, Traver D, Firpo MT, Rhee J, Warnke R, O'Gorman S, Weissman IL, Cleary ML
• Expression of Pbx1b during mammalian organogenesis.
  Mechanisms of development 2001 Schnabel CA, Selleri L, Jacobs Y, Warnke R, Cleary ML
• Molecular cytogenetics localizes two new breakpoints on 11q23.3 and 21q11.2 in myelodysplastic syndrome with t(11;21) translocation.
  Genes, chromosomes & cancer 1999 Wlodarska I, Selleri L, La Starza R, Paternotte C, Evans GA, Boogaerts M, Van den Berghe H, Mecucci C
• Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.
  The Journal of biological chemistry 1997 Velcich A, Palumbo L, Selleri L, Evans G, Augenlicht L
• De novo 46,XX, dir dup (11)(q133.3-->q14.2) in a patient with mental retardation, congenital cardiopathy and thrombopenia.
  Clinical genetics 1996 Legius E, Wlodarska I, Selleri L, Evans GA, Wu R, Smet G, Fryns JP
• An STS content map of human chromosome 11: localization of 910 YAC clones and 109 islands.
  Genomics 1995 Quackenbush J, Davies C, Bailis JM, Khristich JV, Diggle K, Marchuck Y, Tobin J, Clark SP, Rodkins A, Marcano S
• A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues.
  Human molecular genetics 1995 Tsang P, Gilles F, Yuan L, Kuo YH, Lupu F, Samara G, Moosikasuwan J, Goye A, Zelenetz AD, Selleri L
• Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies.
  Leukemia 1995 Hernández JM, Mecucci C, Beverloo HB, Selleri L, Wlodarska I, Stul M, Michaux L, Verhoef G, Van Orshoven A, Cassiman JJ
• High-resolution physical mapping of a 250-kb region of human chromosome 11q24 by genomic sequence sampling (GSS).
  Genomics 1995 Selleri L, Smith MW, Holmsen AL, Romo AJ, Thomas SD, Paternotte C, Romberg LC, Wei YH, Evans GA
• Spontaneous loss of Ph chromosome with maintenance of clonal hemopoiesis in an untreated patient with myeloproliferative disease and a long survival.
  Genes, chromosomes & cancer 1995 Luppi M, Morselli M, Emilia G, Temperani P, Marasca R, Barozzi P, Selleri L, Torelli G
• Yeast artificial chromosome cloning of 3.2 megabases within chromosomal band 11q24 closely linking c-ets 1 and Fli-1 and encompassing the Ewing sarcoma breakpoint.
  Genomics 1994 Selleri L, Giovannini M, Hermanson GG, Romo A, Quackenbush J, Penny L, Khristich JV, Evans GA
• Cloning of the entire FLI1 gene, disrupted by the Ewing's sarcoma translocation breakpoint on 11q24, in a yeast artificial chromosome.
  Cytogenetics and cell genetics 1994 Selleri L, Giovannini M, Romo A, Zucman J, Delattre O, Thomas G, Evans GA
• A sequence-tagged site map of human chromosome 11.
  Genomics 1993 Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y
• A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
  Nature genetics 1993 Djabali M, Selleri L, Parry P, Bower M, Young B, Evans GA
• A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines.
  American journal of human genetics 1993 Saleh M, Selleri L, Evans GA
• Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint.
  Cytogenetics and cell genetics 1993 Giovannini M, Selleri L, Hermanson GG, Evans GA
• Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.
  Cytogenetics and cell genetics 1993 Giovannini M, Djabali M, McElligott D, Selleri L, Evans GA
• Isolation and expression of linked zinc finger gene clusters on human chromosome 11q.
  Genomics 1992 Saleh M, Selleri L, Little PF, Evans GA
• Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23.
  Genomics 1992 Eubanks JH, Djabali M, Selleri L, Grandy DK, Civelli O, McElligott DL, Evans GA
• Interphase cytogenetics for the detection of the t(11;22)(q24;q12) in small round cell tumors.
  The Journal of clinical investigation 1992 Giovannini M, Selleri L, Biegel JA, Scotlandi K, Emanuel BS, Evans GA
• A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
  Nature genetics 1992 Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA
• Detection and characterization of "chimeric" yeast artificial chromosome clones by fluorescent in situ suppression hybridization.
  Genomics 1992 Selleri L, Eubanks JH, Giovannini M, Hermanson GG, Romo A, Djabali M, Maurer S, McElligott DL, Smith MW, Evans GA
• Serum autoantibodies and the diagnosis of type-1 autoimmune hepatitis in Italy: a reappraisal at the light of hepatitis C virus infection.
  Gut 1992 Cassani F, Muratori L, Manotti P, Lenzi M, Fusconi M, Ballardini G, Selleri L, Volta U, Zauli D, Miniero R
• Dek-can rearrangement in translocation (6;9)(p23;q34).
  Leukemia 1992 Soekarman D, von Lindern M, van der Plas DC, Selleri L, Bartram CR, Martiat P, Culligan D, Padua RA, Hasper-Voogt KP, Hagemeijer A
• Cosmid linking clones localized to the long arm of human chromosome 11.
  Genomics 1992 Hermanson GG, Lichter P, Selleri L, Ward DC, Evans GA
• Isolation, localization, and physical mapping of a highly polymorphic locus on human chromosome 11q13.
  Genomics 1991 Eubanks JH, Selleri L, Hart R, Rosette C, Evans GA
• Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction.
  Blood 1991 Torelli G, Marasca R, Luppi M, Selleri L, Ferrari S, Narni F, Mariano MT, Federico M, Ceccherini-Nelli L, Bendinelli M
• Chromosomal in situ hybridization using yeast artificial chromosomes.
  Genetic analysis, techniques and applications 1991 Selleri L, Hermanson GG, Eubanks JH, Evans GA
• Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Selleri L, Hermanson GG, Eubanks JH, Lewis KA, Evans GA
• Sinus histiocytosis with massive lymphadenopathy: immunological, cytogenetic and molecular studies.
  Blut 1990 Sacchi S, Artusi T, Selleri L, Temperani P, Zucchini P, Vecchi A, Emilia G, Torelli U
• Ratios between the abundance of messenger RNA and the corresponding protein of two growth-related genes, c-myc and vimentin, in leukemia blast cells.
  Cancer research 1990 Ferrari S, Tagliafico E, D'Incá M, Ceccherelli G, Manfredini R, Selleri L, Donelli A, Sacchi S, Torelli G, Torelli U
• [Mitochondrial DNA deletion in a case of progressive ophthalmoplegia].
  Medicina (Florence, Italy) 1990 Luppi M, Marasca R, Sola P, Corradi M, Fancinelli M, Montorsi M, Manfredini R, Selleri L
• Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript.
  Blood 1990 Selleri L, von Lindern M, Hermans A, Meijer D, Torelli G, Grosveld G
• Chronic myelogenous leukemia with typical clinical and morphological features can be Philadelphia chromosome negative and "bcr negative".
  Hematologic pathology 1990 Selleri L, Emilia G, Luppi M, Temperani P, Zucchini P, Tagliafico E, Artusi T, Sarti M, Donelli A, Castoldi GL
• Extramedullary pleural blast crisis in chronic myelogenous leukemia: cytogenetic and molecular study.
  Acta haematologica 1990 Sacchi S, Temperani P, Selleri L, Zucchini P, Morselli S, Vecchi A, Longo R, Torelli G, Emilia G, Torelli U
• [Identification of human herpesvirus HHV-6 sequence in a case of Hodgkin's disease by polymerase chain reaction].
  Medicina (Florence, Italy) 1990 Marasca R, Luppi M, Montorsi M, Fancinelli M, Sabbatini R, Mariano MT, Selleri L
• Serum antibodies to thymus epithelial cells in non-A, non-B and cryptogenic chronic liver disease.
  Liver 1989 Cassani F, Tremolada F, Bianchi FB, Baffoni L, Selleri L, Benvegnu L, Craxi A, Realdi G, Zauli D, Pisi E
• Philadelphia-positive chronic myelogenous leukemia with typical bcr/abl molecular features and atypical, prolonged survival.
  Leukemia 1989 Selleri L, Emilia G, Temperani P, Grassilli E, Zucchini P, Tagliafico E, Bonati A, Venezia L, Ferrari S, Torelli U
• Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes.
  Leukemia 1989 Ferrari S, Tagliafico E, Ceccherelli G, Selleri L, Calabretta B, Donelli A, Temperani P, Sarti M, Sacchi S, Emilia G
• Cytogenetic and molecular studies in primary myelofibrosis.
  Cancer genetics and cytogenetics 1989 Emilia G, Temperani P, Ferrari S, Zucchini P, Tagliafico E, Selleri L, Torelli G, Artusi T, Torelli U
• Isodicentric X chromosome in myeloproliferative disorders.
  Acta haematologica 1989 Temperani P, Zucchini P, Emilia G, Sacchi S, Selleri L, Torelli U
• [Polymerase chain reaction for the diagnostic identification of HIV infection].
  Medicina (Florence, Italy) 1989 Selleri L, Grassilli E, Tagliafico E, Corradi M, Luppi M, Ceccherelli G, Borghi V
• Absence of alternative splicing in bcr-abl mRNA in chronic myeloid leukemia cell lines.
  Blood 1988 Hermans A, Selleri L, Gow J, Grosveld GC
• Expression of oncogenes and cell cycle related genes in acute and chronic leukemias.
  Leukemia 1988 Ferrari S, Calabretta B, Selleri L, Ceccherelli G, Torelli G, Torelli U
• [Possible correlations between proliferation and differentiation of blast cells in acute promyelocytic leukemia: a molecular study].
  Medicina (Florence, Italy) 1988 Tagliafico E, Manfredini R, Selleri L, Zucchini P, Ceccherelli G
• bcr-abl oncogene activation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
  Leukemia 1988 Hermans A, Gow J, Selleri L, von Lindern M, Hagemeijer A, Wiedemann LM, Grosveld G
• Myeloperoxidase gene expression in blast cells with a lymphoid phenotype in cases of acute lymphoblastic leukemia.
  Blood 1988 Ferrari S, Mariano MT, Tagliafico E, Sarti M, Ceccherelli G, Selleri L, Merli F, Narni F, Donelli A, Torelli G
• Prognostic significance of "short-term" effects of chemotherapy on MYC and histone H3 mRNA levels in acute leukemia patients.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Venturelli D, Lange B, Narni F, Selleri L, Mariano MT, Torelli U, Gewirtz AM, Calabretta B
• Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region.
  Blood 1987 Selleri L, Narni F, Emilia G, Colò A, Zucchini P, Venturelli D, Donelli A, Torelli U, Torelli G
• Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa.
  Cancer research 1987 Torelli G, Venturelli D, Coló A, Zanni C, Selleri L, Moretti L, Calabretta B, Torelli U
• Establishment and characterization of a human IgA-kappa-secreting plasma cell line (MT3).
  International journal of cancer 1987 Donelli A, Narni F, Tabilio A, Emilia G, Selleri L, Colo A, Zucchini P, Montagnani G, Torelli G, Torelli U
• Immunoglobulin and T-cell receptor beta chain gene rearrangements as lineage markers in human leukemias: a study of 78 cases.
  Haematologica 1987 Narni F, Colò A, Venturelli D, Selleri L, Donelli A, Tabilio A, Artusi T, Di Prisco U, Torelli G, Torelli U
• Promyelocytic crisis of chronic myeloid leukaemia.
  British journal of haematology 1987 Emilia G, Sacchi S, Selleri L, Zucchini P, Artusi T, Torelli U
• Molecular study of the Philadelphia translocation in chronic myelogenous leukemia in different stages of disease.
  Haematologica 1987 Torelli G, Selleri L, Emilia G, Narni F, Colò A, Zucchini P, Donelli A, Venturelli D, Torelli U
• Simultaneously increased expression of the c-myc and mu chain genes in the acute blastic transformation of a chronic lymphocytic leukaemia.
  British journal of haematology 1987 Torelli UL, Torelli GM, Emilia G, Selleri L, Venturelli D, Artusi T, Donelli A, Colò A, Fornieri C
• Clinical subsets of scleroderma: relevance of fluorescent and precipitating antinuclear antibodies.
  Clinical and experimental rheumatology 1987 Cassani F, Tosti A, Bianchi FB, Fusconi M, Selleri L, Baffoni L, Veronesi S, Volta U, Lenzi M, Pisi E
• Nuclear protrusions and marker chromosomes in lymphocytes of two patients with cutaneous T-cell lymphoma.
  Acta haematologica 1987 Emilia G, Torelli G, Sacchi S, Zucchini P, Selleri L, Temperani P, Torelli U
• Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells.
  Cancer research 1986 Calabretta B, Kaczmarek L, Selleri L, Torelli G, Ming PM, Ming SC, Mercer WE
• Cellular levels of mRNA from c-myc, c-myb and c-fes onc-genes in normal myeloid and erythroid precursors of human bone marrow: an in situ hybridization study.
  British journal of haematology 1986 Emilia G, Donelli A, Ferrari S, Torelli U, Selleri L, Zucchini P, Moretti L, Venturelli D, Ceccherelli G, Torelli G
• Differential patterns of expression of cell cycle-related genes in blast cells of acute myeloid leukemia.
  Leukemia research 1986 Torelli U, Selleri L, Venturelli D, Donelli A, Emilia G, Ceccherelli G, Turchi L, Torelli G
• Activation of c-myb expression by phytohemagglutinin stimulation in normal human T lymphocytes.
  Molecular and cellular biology 1985 Torelli G, Selleri L, Donelli A, Ferrari S, Emilia G, Venturelli D, Moretti L, Torelli U
• Expression of human c-fes onc-gene occurs at detectable levels in myeloid but not in lymphoid cell populations.
  British journal of haematology 1985 Ferrari S, Torelli U, Selleri L, Donelli A, Venturelli D, Moretti L, Torelli G
• Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage.
  Leukemia research 1985 Ferrari S, Torelli U, Selleri L, Donelli A, Venturelli D, Narni F, Moretti L, Torelli G
• Low-dose intravenous pepsin-treated gammaglobulin for idiopathic thrombocytopenic purpura in adults.
  British journal of haematology 1984 Emilia G, Sacchi S, Torelli G, Selleri L, Torelli U