Li Wang, PhD
Postdoctoral Scholar
Regeneration Medicine
School of Medicine

I am a postdoctoral scholar in Dr. Arnold Kriegstein's lab at UCSF. Interested in applying single-cell genomics and proteomics to understand human brain development, synapse formation, cognition, and pathogenesis of neurodevelopmental disorders.

Education & Training

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• PhD Molecular and Human Genetics Baylor College of Medicine 12/2018
• BS Biological Sciences Fudan University 06/2012

Grants and Projects

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• Identifying mechanisms ofsynapse maturation at neuronal subtype resolution, NIH, 2023-2025

Publications (18)

Top publication keywords:
HaploinsufficiencyProtein StabilityProteomicsCerebral CortexMitogen-Activated Protein Kinase 1SynapsesNerve Tissue ProteinsNeurogenesisMitochondrial DynamicsPost-Synaptic DensityEpendymoglial CellsNeural Stem CellsRNA InterferenceMicrofilament ProteinsMutation, Missense

• A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Liang XG, Hoang K, Meyerink BL, Kc P, Paraiso K, Wang L, Jones IR, Zhang Y, Katzman S, Finn TS, Tsyporin J, Qu F, Chen Z, Visel A, Kriegstein A, Shen Y, Pilaz LJ, Chen B
• Single-cell analysis of prenatal and postnatal human cortical development.
  Science (New York, N.Y.) 2023 Velmeshev D, Perez Y, Yan Z, Valencia JE, Castaneda-Castellanos DR, Wang L, Schirmer L, Mayer S, Wick B, Wang S, Nowakowski TJ, Paredes M, Huang EJ, Kriegstein AR
• A cross-species proteomic map reveals neoteny of human synapse development.
  Nature 2023 Wang L, Pang K, Zhou L, Cebrián-Silla A, González-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, …
• LIF signaling regulates outer radial glial to interneuron fate during human cortical development.
  Cell stem cell 2023 Andrews MG, Siebert C, Wang L, White ML, Ross J, Morales R, Donnay M, Bamfonga G, Mukhtar T, McKinney AA, Gemenes K, Wang S, Bi Q, Crouch EE, Parikshak N, Panagiotakos G, Huang E, Bhaduri A, …
• Editorial: Identifying genetics-based mechanisms and treatments for neurodevelopmental and psychiatric disorders through data integration.
  Frontiers in genetics 2023 Pang K, Wang L, Chang S

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• Non-muscle myosins control the integrity of cortical radial glial endfeet.
  PLoS biology 2023 Wang L, Kriegstein AR
• Tropism of SARS-CoV-2 for human cortical astrocytes.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin…
• Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
  The EMBO journal 2021 Li T, Yu D, Oak HC, Zhu B, Wang L, Jiang X, Molday RS, Kriegstein A, Piao X
• Mitochondria Control Cortical Cell Fate after Mitosis.
  Developmental cell 2020 Wang L, Kriegstein A
• Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
  Cell 2020 Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR
• Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders.
  Genome research 2020 Pang K, Wang L, Wang W, Zhou J, Cheng C, Han K, Zoghbi HY, Liu Z
• Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.
  Human molecular genetics 2020 Chen CA, Wang W, Pedersen SE, Raman A, Seymour ML, Ruiz FR, Xia A, van der Heijden ME, Wang L, Yin J, Lopez J, Rech ME, Lewis RA, Wu SM, Liu Z, Pereira FA, Pautler RG, Zoghbi HY, Schaaf CP
• Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions.
  eLife 2019 Meng X, McGraw CM, Wang W, Jing J, Yeh SY, Wang L, Lopez J, Brown AM, Lin T, Chen W, Xue M, Sillitoe RV, Jiang X, Zoghbi HY
• A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability.
  Molecular psychiatry 2019 Wang L, Adamski CJ, Bondar VV, Craigen E, Collette JR, Pang K, Han K, Jain A, Y Jung S, Liu Z, Sifers RN, Holder JL, Zoghbi HY
• An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function.
  Molecular psychiatry 2019 Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL, Zoghbi HY
• PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.
  Human molecular genetics 2018 Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY
• A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures.
  Cell 2018 Gennarino VA, Palmer EE, McDonell LM, Wang L, Adamski CJ, Koire A, See L, Chen CA, Schaaf CP, Rosenfeld JA, Panzer JA, Moog U, Hao S, Bye A, Kirk EP, Stankiewicz P, Breman AM, McBride A, Kandula T, …
• Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.
  American journal of human genetics 2018 Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Liu Z, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CP