Lewis Lanier, PhD
Professor
Microbiology and Immunology
School of Medicine

NK cells express a diverse array of inhibitory and activating receptors on their cells surface that bind to ligands expressed on the cell surface of potential target cells. When encountering healthy cells, signals transmitted by inhibitory NK receptors dominate and prevent autoimmunity, whereas the loss of ligands for the inhibitory receptors or the upregulation of ligands for the activating NK receptors on infected or transformed cells allows NK cells to kill these abnormal cells and secrete cytokine that influence the subsequent response by T cells and B cells. We have developed mouse models systems in which key signaling molecules such as DAP10 and DAP12 have been ablated to explore the physiological role of these NK receptors in resistance to viral infections (cytomegalovirus, poxviruses, and influenza) and primary tumorigenesis.

• An NKG2A biased immune response confers protection for infection, autoimmune disease, and cancer.
  Research square 2023 Heath J, Chen D, Xie J, Choi J, Ng R, Zhang R, Li S, Edmark R, Zheng H, Solomon B, Campbell K, Medina E, Ribas A, Khatri P, Lanier L, Mease P, Goldman J, Su Y
• Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
  Nature biotechnology 2023 Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, Friera AM, Young C, Wells F, Chu EY, Ito CE, Krishnapura H, Jain S, Ankala R, McGill TJ, Lin A, Egenberger K, Gagnon A, Michael Rukstalis …
• The interweaved signatures of common-gamma-chain cytokines across immunologic lineages.
  The Journal of experimental medicine 2023 Baysoy A, Seddu K, Salloum T, Dawson CA, Lee JJ, Yang L, Gal-Oz S, Ner-Gaon H, Tellier J, Millan A, Sasse A, Brown B, Lanier LL, Shay T, Nutt S, Dwyer D, Benoist C, Immunological Genome Project …
• Exhausted intratumoral Vδ2- γδ T cells in human kidney cancer retain effector function.
  Nature immunology 2023 Rancan C, Arias-Badia M, Dogra P, Chen B, Aran D, Yang H, Luong D, Ilano A, Li J, Chang H, Kwek SS, Zhang L, Lanier LL, Meng MV, Farber DL, Fong L
• CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR
• The CD16 and CD32b Fc-gamma receptors regulate antibody-mediated responses in mouse natural killer cells.
  Journal of leukocyte biology 2023 Aguilar OA, Gonzalez-Hinojosa MDR, Arakawa-Hoyt JS, Millan AJ, Gotthardt D, Nabekura T, Lanier LL
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
  Nature biotechnology 2022 Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S
• Author Correction: Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells.
  BMC biology 2022 Vallejo J, Saigusa R, Gulati R, Suthahar SSA, Suryawanshi V, Alimadadi A, Durant CP, Ghosheh Y, Roy P, Ehinger E, Pattarabanjird T, Hanna DB, Landay AL, Tracy RP, Lazar JM, Mack WJ, Weber KM, Adimora …
• Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.
  The Journal of experimental medicine 2022 Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL
• Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells.
  BMC biology 2022 Vallejo J, Saigusa R, Gulati R, Armstrong Suthahar SS, Suryawanshi V, Alimadadi A, Durant CP, Ghosheh Y, Roy P, Ehinger E, Pattarabanjird T, Hanna DB, Landay AL, Tracy RP, Lazar JM, Mack WJ, Weber KM,…
• Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells.
  International journal of molecular sciences 2022 Saigusa R, Vallejo J, Gulati R, Suthahar SSA, Suryawanshi V, Alimadadi A, Makings J, Durant CP, Freuchet A, Roy P, Ghosheh Y, Pandori W, Pattarabanjird T, Drago F, Taylor A, McNamara CA, Shemesh A, …
• Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion.
  The Journal of experimental medicine 2022 Shemesh A, Pickering H, Roybal KT, Lanier LL
• Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection.
  Journal of immunology (Baltimore, Md. : 1950) 2022 Potempa M, Aguilar OA, Gonzalez-Hinojosa MDR, Tenvooren I, Marquez DM, Spitzer MH, Lanier LL
• The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
  The Journal of experimental medicine 2022 Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL
• Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group
• Multiple early factors anticipate post-acute COVID-19 sequelae.
  Cell 2022 Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J, Li S, Hong S, Zhang R, Xie J, Kornilov SA, Scherler K, Pavlovitch-Bedzyk AJ, Dong S, Lausted C, Lee I, Fallen S, Dai CL, Baloni P, Smith B, Duvvuri VR, …
• An NK-like CAR T cell transition in CAR T cell dysfunction.
  Cell 2021 Good CR, Aznar MA, Kuramitsu S, Samareh P, Agarwal S, Donahue G, Ishiyama K, Wellhausen N, Rennels AK, Ma Y, Tian L, Guedan S, Alexander KA, Zhang Z, Rommel PC, Singh N, Glastad KM, Richardson MW, …
• NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant.
  JCI insight 2021 Pickering H, Sen S, Arakawa-Hoyt J, Ishiyama K, Sun Y, Parmar R, Ahn RS, Sunga G, Llamas M, Hoffmann A, Deng M, Bunnapradist S, Schaenman JM, Gjertson DW, Rossetti M, Lanier LL, Reed EF, CMV Systems …
• A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA
• Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S
• The SIRPα-CD47 immune checkpoint in NK cells.
  The Journal of experimental medicine 2021 Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S
• Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.
  The Journal of clinical investigation 2021 Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR
• Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells.
  Journal of immunology (Baltimore, Md. : 1950) 2020 Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC
• Immigration in science.
  The Journal of experimental medicine 2020 Casanova JL, Holtzman DM, Kaech SM, Lanier LL, Nathan CF, Rudensky AY, Tuveson D, Wolchok JD
• Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
  Cell 2020 Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai CL, Voillet V, Duvvuri VR, Scherler K, Troisch P, Baloni P, Qin G, Smith B, Kornilov SA, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, …
• Tetramer Immunization and Selection Followed by CELLISA Screening to Generate Monoclonal Antibodies against the Mouse Cytomegalovirus m12 Immunoevasin.
  Journal of immunology (Baltimore, Md. : 1950) 2020 Aguilar OA, Tanaka M, Balaji GR, Berry R, Rossjohn J, Lanier LL, Carlyle JR
• Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories.
  bioRxiv : the preprint server for biology 2020 Su Y, Chen D, Lausted C, Yuan D, Choi J, Dai C, Voillet V, Scherler K, Troisch P, Duvvuri VR, Baloni P, Qin G, Smith B, Kornilov S, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, …
• Editorial: Emerging Concepts on the NKG2D Receptor-Ligand Axis in Health and Diseases.
  Frontiers in immunology 2020 Guerra N, Lanier LL
• Tissue Determinants of Human NK Cell Development, Function, and Residence.
  Cell 2020 Dogra P, Rancan C, Ma W, Toth M, Senda T, Carpenter DJ, Kubota M, Matsumoto R, Thapa P, Szabo PA, Li Poon MM, Li J, Arakawa-Hoyt J, Shen Y, Fong L, Lanier LL, Farber DL
• Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
  Nature immunology 2019 Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, …
• A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.
  Cytometry. Part A : the journal of the International Society for Analytical Cytology 2019 Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D,…
• HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response.
  Frontiers in cellular and infection microbiology 2019 McKechnie JL, Beltrán D, Pitti A, Saenz L, Araúz AB, Vergara R, Harris E, Lanier LL, Blish CA, López-Vergès S
• Plastic fantastic innate lymphoid cells.
  The Journal of experimental medicine 2019 Lanier LL
• KLF12 Regulates Mouse NK Cell Proliferation.
  Journal of immunology (Baltimore, Md. : 1950) 2019 Lam VC, Folkersen L, Aguilar OA, Lanier LL
• Caspase-8 restricts antiviral CD8 T cell hyperaccumulation.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Feng Y, Daley-Bauer LP, Roback L, Guo H, Koehler HS, Potempa M, Lanier LL, Mocarski ES
• Caspase-8 restricts natural killer cell accumulation during MCMV Infection.
  Medical microbiology and immunology 2019 Feng Y, Daley-Bauer LP, Roback L, Potempa M, Lanier LL, Mocarski ES
• Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute?
  Journal of leukocyte biology 2019 Das J, Lanier LL
• NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.
  Transplantation 2019 Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR
• Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
  Nature biotechnology 2019 Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S
• Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition.
  Nature communications 2018 Balaji GR, Aguilar OA, Tanaka M, Shingu-Vazquez MA, Fu Z, Gully BS, Lanier LL, Carlyle JR, Rossjohn J, Berry R
• Natural killer cells in lung transplantation.
  Thorax 2018 Calabrese DR, Lanier LL, Greenland JR
• Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer.
  Cold Spring Harbor perspectives in biology 2018 Sun JC, Lanier LL
• Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria.
  Science immunology 2018 Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL
• A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
  Nature medicine 2018 Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA
• Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.
  Journal of immunology (Baltimore, Md. : 1950) 2018 Nabekura T, Chen Z, Schroeder C, Park T, Vivier E, Lanier LL, Liu D
• Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729.
  Journal of immunology (Baltimore, Md. : 1950) 2018 Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T
• Natural killers join the fight against cancer.
  Science (New York, N.Y.) 2018 Cerwenka A, Lanier LL
• Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ
• FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.
  Frontiers in immunology 2017 Pan YG, Yu YL, Lin CC, Lanier LL, Chu CL
• Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data.
  Royal Society open science 2017 Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J
• Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Jensen H, Potempa M, Gotthardt D, Lanier LL
• Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Nabekura T, Gotthardt D, Niizuma K, Trsan T, Jenus T, Jonjic S, Lanier LL
• Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation.
  The Journal of experimental medicine 2017 Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R
• NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration.
  Experimental and molecular pathology 2017 Vadstrup K, Galsgaard ED, Jensen H, Lanier LL, Ryan JC, Chen SY, Nolan GP, Vester-Andersen MK, Pedersen JS, Gerwien J, Jensen T, Bendtsen F
• In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells.
  Science signaling 2017 Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J
• Chronic In Vivo Interaction of Dendritic Cells Expressing the Ligand Rae-1ε with NK Cells Impacts NKG2D Expression and Function.
  ImmunoHorizons 2017 Morvan MG, Champsaur M, Reizis B, Lanier LL
• A distinct innate lymphoid cell population regulates tumor-associated T cells.
  Nature medicine 2017 Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier…
• EBI3 regulates the NK cell response to mouse cytomegalovirus infection.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Jensen H, Chen SY, Folkersen L, Nolan GP, Lanier LL
• NK cells in host responses to viral infections.
  Current opinion in immunology 2016 Lam VC, Lanier LL
• Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection.
  The Journal of experimental medicine 2016 Nabekura T, Lanier LL
• Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
  Immunity 2016 Nabekura T, Lanier LL
• NK cells and type 1 innate lymphoid cells: partners in host defense.
  Nature immunology 2016 Spits H, Bernink JH, Lanier L
• Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials.
  Journal for immunotherapy of cancer 2016 Kohrt HE, Tumeh PC, Benson D, Bhardwaj N, Brody J, Formenti S, Fox BA, Galon J, June CH, Kalos M, Kirsch I, Kleen T, Kroemer G, Lanier L, Levy R, Lyerly HK, Maecker H, Marabelle A, Melenhorst J, …
• Natural killer cell memory in infection, inflammation and cancer.
  Nature reviews. Immunology 2016 Cerwenka A, Lanier LL
• Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide.
  The Journal of experimental medicine 2016 Madera S, Rapp M, Firth MA, Beilke JN, Lanier LL, Sun JC
• NK cells and cancer: you can teach innate cells new tricks.
  Nature reviews. Cancer 2016 Morvan MG, Lanier LL
• Sweet Is the Memory of Past Troubles: NK Cells Remember.
  Current topics in microbiology and immunology 2016 Hendricks DW, Min-Oo G, Lanier LL
• Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.
  Nature neuroscience 2015 Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI
• Natural Killer Cell Memory.
  Immunity 2015 O'Sullivan TE, Sun JC, Lanier LL
• Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.
  Cell reports 2015 Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W
• NKG2D Receptor and Its Ligands in Host Defense.
  Cancer immunology research 2015 Lanier LL
• IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Nabekura T, Girard JP, Lanier LL
• Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals.
  Immunity 2015 Lee J, Zhang T, Hwang I, Kim A, Nitschke L, Kim M, Scott JM, Kamimura Y, Lanier LL, Kim S
• β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome.
  Blood 2015 Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada …
• Homeostatic control of memory cell progenitors in the natural killer cell lineage.
  Cell reports 2015 Kamimura Y, Lanier LL
• Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection.
  The Journal of experimental medicine 2014 Min-Oo G, Lanier LL
• Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.
  The Journal of experimental medicine 2014 Nabekura T, Lanier LL
• Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis.
  Stem cells (Dayton, Ohio) 2014 Weinger JG, Plaisted WC, Maciejewski SM, Lanier LL, Walsh CM, Lane TE
• Just the FACS.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Lanier LL
• Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL
• CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells.
  Cancer immunology research 2014 Du J, Lopez-Verges S, Pitcher BN, Johnson J, Jung SH, Zhou L, Hsu K, Czuczman MS, Cheson B, Kaplan L, Lanier LL, Venstrom JM
• Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection.
  The Journal of experimental medicine 2014 Min-Oo G, Bezman NA, Madera S, Sun JC, Lanier LL
• Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B
• EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production.
  American journal of physiology. Lung cellular and molecular physiology 2014 Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL
• Rapid and sequential quantitation of salivary gland-associated mouse cytomegalovirus in oral lavage.
  Journal of virological methods 2014 Kamimura Y, Lanier LL
• Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Hendricks DW, Balfour HH, Dunmire SK, Schmeling DO, Hogquist KA, Lanier LL
• Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T,…
• Of snowflakes and natural killer cell subsets.
  Nature biotechnology 2014 Lanier LL
• Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
  Immunity 2014 Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL
• Founding father of FACS: Professor Leonard A. Herzenberg (1931–2013).
  Proceedings of the National Academy of Sciences of the United States of America 2013 Dangl JL, Lanier LL
• CD56negCD16⁺ NK cells are activated mature NK cells with impaired effector function during HIV-1 infection.
  Retrovirology 2013 Milush JM, López-Vergès S, York VA, Deeks SG, Martin JN, Hecht FM, Lanier LL, Nixon DF
• Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.
  The Journal of infectious diseases 2013 Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM
• Beyond the transcriptome: completion of act one of the Immunological Genome Project.
  Current opinion in immunology 2013 Kim CC, Lanier LL
• Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium.
  The Journal of experimental medicine 2013 Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL
• Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy.
  Biology of reproduction 2013 Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier LL, Bárcena A, Fisher SJ
• CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.
  European journal of immunology 2013 Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS
• The transcriptional landscape of αβ T cell differentiation.
  Nature immunology 2013 Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Immunological Genome Consortium, Best AJ, Knell J, …
• MicroRNA function in NK-cell biology.
  Immunological reviews 2013 Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL
• Identification of transcriptional regulators in the mouse immune system.
  Nature immunology 2013 Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Immunological Genome Project Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, …
• Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC
• Natural killer cells: walking three paths down memory lane.
  Trends in immunology 2013 Min-Oo G, Kamimura Y, Hendricks DW, Nabekura T, Lanier LL
• Shades of grey--the blurring view of innate and adaptive immunity.
  Nature reviews. Immunology 2013 Lanier LL
• Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules.
  International immunology 2013 Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, Lanier LL, Saito T, Arase H
• Skewed distribution of natural killer cells in psoriasis skin lesions.
  Experimental dermatology 2013 Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier LL, Kallas EG, York VA, Chang D, Liao W, Unemori P, Leslie KS, Maurer T, Nixon DF
• Consortium biology in immunology: the perspective from the Immunological Genome Project.
  Nature reviews. Immunology 2012 Benoist C, Lanier L, Merad M, Mathis D, Immunological Genome Project
• Molecular definition of the identity and activation of natural killer cells.
  Nature immunology 2012 Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier LL, Immunological Genome Project Consortium
• Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
  Blood 2012 Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM
• NK cells are not required for spontaneous autoimmune diabetes in NOD mice.
  PloS one 2012 Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier LL
• A resource for the conditional ablation of microRNAs in the mouse.
  Cell reports 2012 Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus…
• Proinflammatory cytokine signaling required for the generation of natural killer cell memory.
  The Journal of experimental medicine 2012 Sun JC, Madera S, Bezman NA, Beilke JN, Kaplan MH, Lanier LL
• Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity.
  Blood 2012 Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL
• Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
  PloS one 2012 Nielsen N, Ødum N, Ursø B, Lanier LL, Spee P
• Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy.
  Blood 2012 Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, Ames E, Bruhn KW, Craft N, Wiltrout RH, Longo DL, Lanier LL, Blazar BR, Redelman D, Murphy WJ
• Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.
  Blood 2011 Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, Lopez-Vergès S, Lanier LL, Weisdorf D, Miller JS
• CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells.
  The Journal of experimental medicine 2011 Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS
• miR-150 regulates the development of NK and iNKT cells.
  The Journal of experimental medicine 2011 Bezman NA, Chakraborty T, Bender T, Lanier LL
• NK cell development, homeostasis and function: parallels with CD8⁺ T cells.
  Nature reviews. Immunology 2011 Sun JC, Lanier LL
• Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Lopez-Vergès S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, Houchins JP, Miller S, Kang SM, Norris PJ, Nixon DF, Lanier LL
• The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
  The Journal of experimental medicine 2011 Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, …
• CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
  Immunity 2011 Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ
• Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC.
  Blood 2011 Barao I, Alvarez M, Ames E, Orr MT, Stefanski HE, Blazar BR, Lanier LL, Anderson SK, Redelman D, Murphy WJ
• NK cells and immune "memory".
  Journal of immunology (Baltimore, Md. : 1950) 2011 Sun JC, Lopez-Verges S, Kim CC, DeRisi JL, Lanier LL
• Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.
  The Journal of experimental medicine 2011 Sun JC, Beilke JN, Bezman NA, Lanier LL
• Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases.
  Blood 2011 Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL
• PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.
  Biochemical and biophysical research communications 2011 Kogure A, Shiratori I, Wang J, Lanier LL, Arase H
• Innate or adaptive immunity? The example of natural killer cells.
  Science (New York, N.Y.) 2011 Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S
• Inhibitory Ly49 receptors on mouse natural killer cells.
  Current topics in microbiology and immunology 2011 Orr MT, Lanier LL
• Natural killer cell licensing during viral infection.
  Advances in experimental medicine and biology 2011 Orr MT, Lanier LL
• Transcriptional control of natural killer cell development and function.
  Advances in immunology 2011 Hesslein DG, Lanier LL
• Versatility in NK cell memory.
  Immunology and cell biology 2010 Sun JC, Lanier LL
• Development and function of CD94-deficient natural killer cells.
  PloS one 2010 Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL
• Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo.
  The Journal of experimental medicine 2010 Babic M, Pyzik M, Zafirova B, Mitrovic M, Butorac V, Lanier LL, Krmpotic A, Vidal SM, Jonjic S
• Natural killer cell education and tolerance.
  Cell 2010 Orr MT, Lanier LL
• Distinct requirements of microRNAs in NK cell activation, survival, and function.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Bezman NA, Cedars E, Steiner DF, Blelloch R, Hesslein DG, Lanier LL
• The requirement for NKG2D in NK cell-mediated rejection of parental bone marrow grafts is determined by MHC class I expressed by the graft recipient.
  Blood 2010 Beilke JN, Benjamin J, Lanier LL
• CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset.
  Blood 2010 Lopez-Vergès S, Milush JM, Pandey S, York VA, Arakawa-Hoyt J, Pircher H, Norris PJ, Nixon DF, Lanier LL
• Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Orr MT, Beilke JN, Proekt I, Lanier LL
• Immune memory redefined: characterizing the longevity of natural killer cells.
  Immunological reviews 2010 Sun JC, Beilke JN, Lanier LL
• Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL
• Effect of NKG2D ligand expression on host immune responses.
  Immunological reviews 2010 Champsaur M, Lanier LL
• DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG
• 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection.
  Nature immunology 2010 Orr MT, Murphy WJ, Lanier LL
• TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients.
  Neuro-oncology 2009 Crane CA, Han SJ, Barry JJ, Ahn BJ, Lanier LL, Parsa AT
• Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB.
  Journal of virology 2009 Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H
• T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
  The Journal of experimental medicine 2009 Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J
• Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.
  Blood 2009 Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF
• Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2.
  Immunology 2009 Long BR, Erickson AE, Chapman JM, Barbour JD, Vu BA, Ho EL, Lanier LL, Sauer MM, Carvalho KI, Nixon DF, Kallas EG
• Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?
  European journal of immunology 2009 Sun JC, Lanier LL
• Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Sun JC, Ma A, Lanier LL
• Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.
  The Journal of experimental medicine 2009 Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ
• Do the terms innate and adaptive immunity create conceptual barriers?
  Nature reviews. Immunology 2009 Lanier LL, Sun JC
• Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.
  The Journal of experimental medicine 2009 Orr MT, Sun JC, Hesslein DG, Arase H, Phillips JH, Takai T, Lanier LL
• Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.
  The Journal of experimental medicine 2009 Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM
• Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Buhtoiarov IN, Rakhmilevich AL, Lanier LL, Ranheim EA, Sondel PM
• Adaptive immune features of natural killer cells.
  Nature 2009 Sun JC, Beilke JN, Lanier LL
• DAP10- and DAP12-associated receptors in innate immunity.
  Immunological reviews 2009 Lanier LL
• The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors.
  Viruses 2009 Sun JC, Lanier LL
• Cutting edge: viral infection breaks NK cell tolerance to "missing self".
  Journal of immunology (Baltimore, Md. : 1950) 2008 Sun JC, Lanier LL
• Experimental malaria infection triggers early expansion of natural killer cells.
  Infection and immunity 2008 Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL
• KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Saether PC, Westgaard IH, Hoelsbrekken SE, Benjamin J, Lanier LL, Fossum S, Dissen E
• Tolerance of NK cells encountering their viral ligand during development.
  The Journal of experimental medicine 2008 Sun JC, Lanier LL
• Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Rosen DB, Cao W, Avery DT, Tangye SG, Liu YJ, Houchins JP, Lanier LL
• Up on the tightrope: natural killer cell activation and inhibition.
  Nature immunology 2008 Lanier LL
• PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.
  Cell 2008 Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H
• Evolutionary struggles between NK cells and viruses.
  Nature reviews. Immunology 2008 Lanier LL
• Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection.
  Journal of virology 2008 Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD
• A role for NKG2D in NK cell-mediated resistance to poxvirus disease.
  PLoS pathogens 2008 Fang M, Lanier LL, Sigal LJ
• An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR).
  Journal of immunology (Baltimore, Md. : 1950) 2008 Wang J, Shiratori I, Satoh T, Lanier LL, Arase H
• Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2.
  The Journal of infectious diseases 2008 Michaëlsson J, Long BR, Loo CP, Lanier LL, Spotts G, Hecht FM, Nixon DF
• Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
  European journal of immunology 2008 Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA
• NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.
  Journal of virology 2007 Walsh KB, Lanier LL, Lane TE
• Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease.
  Journal of virology 2007 Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE
• The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Kim J, Chang CK, Hayden T, Liu FC, Benjamin J, Hamerman JA, Lanier LL, Kang SM
• Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus.
  Clinical and vaccine immunology : CVI 2007 Long BR, Michaelsson J, Loo CP, Ballan WM, Vu BA, Hecht FM, Lanier LL, Chapman JM, Nixon DF
• Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL
• BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells.
  PLoS biology 2007 Cao W, Zhang L, Rosen DB, Bover L, Watanabe G, Bao M, Lanier LL, Liu YJ
• Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Ballan WM, Vu BA, Long BR, Loo CP, Michaëlsson J, Barbour JD, Lanier LL, Wiznia AA, Abadi J, Fennelly GJ, Rosenberg MG, Nixon DF
• Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency.
  PloS one 2007 Wu Y, Torchia J, Yao W, Lane NE, Lanier LL, Nakamura MC, Humphrey MB
• Back to the future--defining NK cells and T cells.
  European journal of immunology 2007 Lanier LL
• Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Adams EJ, Juo ZS, Venook RT, Boulanger MJ, Arase H, Lanier LL, Garcia KC
• Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Carr WH, Rosen DB, Arase H, Nixon DF, Michaelsson J, Lanier LL
• Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Kielczewska A, Kim HS, Lanier LL, Dimasi N, Vidal SM
• Natural killer or dendritic: what's in a name?
  Immunity 2007 Spits H, Lanier LL
• DAP12: an adapter protein with dual functionality.
  Immunological reviews 2006 Takaki R, Watson SR, Lanier LL
• Evidence for NK cell subsets based on chemokine receptor expression.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Berahovich RD, Lai NL, Wei Z, Lanier LL, Schall TJ
• Natural killer cells: roundup.
  Immunological reviews 2006 Lanier LL
• Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
  Nature immunology 2006 Mócsai A, Abram CL, Jakus Z, Hu Y, Lanier LL, Lowell CA
• Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL
• Viral immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling in cell transformation and cancer.
  Trends in cell biology 2006 Lanier LL
• Natural killer cells as an initial defense against pathogens.
  Current opinion in immunology 2006 Lodoen MB, Lanier LL
• Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production.
  The Journal of experimental medicine 2006 Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ
• Reprogramming of CTLs into natural killer-like cells in celiac disease.
  The Journal of experimental medicine 2006 Meresse B, Curran SA, Ciszewski C, Orbelyan G, Setty M, Bhagat G, Lee L, Tretiakova M, Semrad C, Kistner E, Winchester RJ, Braud V, Lanier LL, Geraghty DE, Green PH, Guandalini S, Jabri B
• Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL
• CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
  Nature 2006 Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M
• Inhibition of immune responses by ITAM-bearing receptors.
  Science's STKE : signal transduction knowledge environment 2006 Hamerman JA, Lanier LL
• Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity.
  Nature medicine 2006 Chan CW, Crafton E, Fan HN, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky TW, Stins MF, Lanier LL, Pardoll DM, Housseau F
• IFN-dependent down-regulation of the NKG2D ligand H60 on tumors.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Bui JD, Carayannopoulos LN, Lanier LL, Yokoyama WM, Schreiber RD
• NK cell recognition of mouse cytomegalovirus-infected cells.
  Current topics in microbiology and immunology 2006 Vidal SM, Lanier LL
• NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system.
  Advances in experimental medicine and biology 2006 Walsh KB, Lodoen MB, Lanier LL, Lane TE
• Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Rosen DB, Bettadapura J, Alsharifi M, Mathew PA, Warren HS, Lanier LL
• Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.
  The Journal of experimental medicine 2005 Chen S, Kawashima H, Lowe JB, Lanier LL, Fukuda M
• Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.
  Immunological reviews 2005 Humphrey MB, Lanier LL, Nakamura MC
• Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.
  The Journal of experimental medicine 2005 Routes JM, Ryan S, Morris K, Takaki R, Cerwenka A, Lanier LL
• NKG2D in NK and T cell-mediated immunity.
  Journal of clinical immunology 2005 Ogasawara K, Lanier LL
• TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005 Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC
• Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H
• IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Takaki R, Hayakawa Y, Nelson A, Sivakumar PV, Hughes S, Smyth MJ, Lanier LL
• Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts.
  Nature immunology 2005 Ogasawara K, Benjamin J, Takaki R, Phillips JH, Lanier LL
• Missing self, NK cells, and The White Album.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Lanier LL
• Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
  Nature immunology 2005 Hamerman JA, Tchao NK, Lowell CA, Lanier LL
• Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection.
  Nature genetics 2005 Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM
• Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Ehrlich LI, Ogasawara K, Hamerman JA, Takaki R, Zingoni A, Allison JP, Lanier LL
• First sighting of the elusive T cell antigen receptor.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Lanier LL
• NK cell regulation of T cell-mediated responses.
  Molecular immunology 2005 Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL
• NK cells in innate immunity.
  Current opinion in immunology 2005 Hamerman JA, Ogasawara K, Lanier LL
• NK cell recognition.
  Annual review of immunology 2005 Lanier LL
• NKG2D in innate and adaptive immunity.
  Advances in experimental medicine and biology 2005 Lanier LL
• Viral modulation of NK cell immunity.
  Nature reviews. Microbiology 2005 Lodoen MB, Lanier LL
• The role of innate immunity in autoimmunity.
  The Journal of experimental medicine 2004 Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG
• The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions.
  The Journal of experimental medicine 2004 Lodoen MB, Abenes G, Umamoto S, Houchins JP, Liu F, Lanier LL
• CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
  The Journal of biological chemistry 2004 Voehringer D, Rosen DB, Lanier LL, Locksley RM
• Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL
• Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.
  Immunity 2004 Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B
• A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Rosen DB, Araki M, Hamerman JA, Chen T, Yamamura T, Lanier LL
• NKG2D blockade prevents autoimmune diabetes in NOD mice.
  Immunity 2004 Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL
• The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC
• Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
  International immunology 2004 Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A
• Specific recognition of virus-infected cells by paired NK receptors.
  Reviews in medical virology 2004 Arase H, Lanier LL
• Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor.
  The Journal of experimental medicine 2004 Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H
• Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Hamerman JA, Ogasawara K, Lanier LL
• The signaling adapter protein DAP12 regulates multinucleation during osteoclast development.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003 Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier LL, Nakamura MC
• NKG2D.
  Journal of biological regulators and homeostatic agents 2003 Lanier LL
• Retraction.
  The Journal of experimental medicine 2003 Meyaard L, van der Vuurst de Vries AR, de Ruiter T, Lanier LL, Phillips JH, Clevers H
• The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.
  The Journal of experimental medicine 2003 Westgaard IH, Dissen E, Torgersen KM, Lazetic S, Lanier LL, Phillips JH, Fossum S
• Natural killer cell receptor signaling.
  Current opinion in immunology 2003 Lanier LL
• NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.
  The Journal of experimental medicine 2003 Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier LL
• NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
  Nature immunology 2003 Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F
• NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer.
  Tissue antigens 2003 Cerwenka A, Lanier LL
• Immunodeficiency disorders.
  Hematology. American Society of Hematology. Education Program 2003 Cooper MD, Lanier LL, Conley ME, Puck JM
• Impairment of NK cell function by NKG2D modulation in NOD mice.
  Immunity 2003 Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL
• Natural killer cells and cancer.
  Advances in cancer research 2003 Wu J, Lanier LL
• A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
  The Journal of experimental medicine 2002 Michaëlsson J, Teixeira de Matos C, Achour A, Lanier LL, Kärre K, Söderström K
• Virus-driven evolution of natural killer cell receptors.
  Microbes and infection 2002 Arase H, Lanier LL
• Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT, Ryan JC
• Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Cerwenka A, O'Callaghan CA, Hamerman JA, Yadav R, Ajayi W, Roopenian DC, Joyce S, Lanier LL
• High levels of RAE-1 isoforms on mouse tumor cell lines assessed by anti-"pan" RAE-1 antibody confer tumor susceptibility to NK cells.
  Biochemical and biophysical research communications 2002 Masuda H, Saeki Y, Nomura M, Shida K, Matsumoto M, Ui M, Lanier LL, Seya T
• Natural killer cells, viruses and cancer.
  Nature reviews. Immunology 2001 Cerwenka A, Lanier LL
• Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Cerwenka A, Baron JL, Lanier LL
• Initiative of the Council of Academic Societies. Redefining scholarship in academic radiology.
  Academic radiology 2001 Smith WL, Collins J, Lanier L, Rao VM
• Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors.
  International immunology 2001 Warren HS, Campbell AJ, Waldron JC, Lanier LL
• Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).
  Journal of immunology (Baltimore, Md. : 1950) 2001 Arase H, Saito T, Phillips JH, Lanier LL
• The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).
  The Journal of experimental medicine 2001 Meyaard L, van der Vuurst de Vries AR, de Ruiter T, Lanier LL, Phillips JH, Clevers H
• Ligands for natural killer cell receptors: redundancy or specificity.
  Immunological reviews 2001 Cerwenka A, Lanier LL
• Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells.
  The Journal of experimental medicine 2001 Kadowaki N, Antonenko S, Ho S, Rissoan MC, Soumelis V, Porcelli SA, Lanier LL, Liu YJ
• Differential expression of leukocyte receptor complex-encoded Ig-like receptors correlates with the transition from effector to memory CTL.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Young NT, Uhrberg M, Phillips JH, Lanier LL, Parham P
• The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Uhrberg M, Valiante NM, Young NT, Lanier LL, Phillips JH, Parham P
• Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.
  European journal of immunology 2001 Daws MR, Lanier LL, Seaman WE, Ryan JC
• On guard--activating NK cell receptors.
  Nature immunology 2001 Lanier LL
• The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function.
  Immunology today 2000 Lanier LL, Bakker AB
• Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes.
  Nature immunology 2000 Shibuya A, Sakamoto N, Shimizu Y, Shibuya K, Osawa M, Hiroyama T, Eyre HJ, Sutherland GR, Endo Y, Fujita T, Miyabayashi T, Sakano S, Tsuji T, Nakayama E, Phillips JH, Lanier LL, Nakauchi H
• Immune inhibitory receptors.
  Science (New York, N.Y.) 2000 Ravetch JV, Lanier LL
• DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.
  The Journal of experimental medicine 2000 Wu J, Cherwinski H, Spies T, Phillips JH, Lanier LL
• Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Tangye SG, Phillips JH, Lanier LL, Nichols KE
• DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.
  Immunity 2000 Bakker AB, Hoek RM, Cerwenka A, Blom B, Lucian L, McNeil T, Murray R, Phillips LH, Sedgwick JD, Lanier LL
• Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors.
  Experimental hematology 2000 Muench MO, Humeau L, Paek B, Ohkubo T, Lanier LL, Albanese CT, Bárcena A
• Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.
  Nature genetics 2000 Paloneva J, Kestilä M, Wu J, Salminen A, Böhling T, Ruotsalainen V, Hakola P, Bakker AB, Phillips JH, Pekkarinen P, Lanier LL, Timonen T, Peltonen L
• 2B4-mediated activation of human natural killer cells.
  Molecular immunology 2000 Tangye SG, Cherwinski H, Lanier LL, Phillips JH
• Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans.
  Immunity 2000 Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P
• Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.
  Immunity 2000 Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL
• Molecular cloning, gene structure, and expression pattern of pig immunoreceptor DAP12.
  Immunogenetics 2000 Yim D, Jie HB, Lanier LL, Kim YB
• Turning on natural killer cells.
  The Journal of experimental medicine 2000 Lanier LL
• The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells.
  Seminars in immunology 2000 Tangye SG, Phillips JH, Lanier LL
• The origin and functions of natural killer cells.
  Clinical immunology (Orlando, Fla.) 2000 Lanier LL
• Transgenic expression of Ly-49A in thymocytes alters repertoire selection.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Pauza M, Smith KM, Neal H, Reilly C, Lanier LL, Lo D
• NK cell activation: distinct stimulatory pathways counterbalancing inhibitory signals.
  Human immunology 2000 Bakker AB, Wu J, Phillips JH, Lanier LL
• Use of cDNA library expression cloning to identify components of heterodimeric receptor complexes.
  Methods in molecular biology (Clifton, N.J.) 2000 Chang C, Lanier LL
• Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Castro AG, Hauser TM, Cocks BG, Abrams J, Zurawski S, Churakova T, Zonin F, Robinson D, Tangye SG, Aversa G, Nichols KE, de Vries JE, Lanier LL, O'Garra A
• Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.
  Immunity 1999 Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A
• Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL
• Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
  Science (New York, N.Y.) 1999 Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T
• An activating immunoreceptor complex formed by NKG2D and DAP10.
  Science (New York, N.Y.) 1999 Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH
• Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips JH
• Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH
• Natural killer cells fertile with receptors for HLA-G?
  Proceedings of the National Academy of Sciences of the United States of America 1999 Lanier LL
• Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells.
  The Journal of experimental medicine 1999 Allan DS, Colonna M, Lanier LL, Churakova TD, Abrams JS, Ellis SA, McMichael AJ, Braud VM
• Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Tangye SG, Wu J, Aversa G, de Vries JE, Lanier LL, Phillips JH
• CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Tangye SG, Phillips JH, Lanier LL, de Vries JE, Aversa G
• The Ets-1 transcription factor is required for the development of natural killer cells in mice.
  Immunity 1998 Barton K, Muthusamy N, Fischer C, Ting CN, Walunas TL, Lanier LL, Leiden JM
• Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Shibuya A, Lanier LL, Phillips JH
• Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Smith KM, Wu J, Bakker AB, Phillips JH, Lanier LL
• Association of DAP12 with activating CD94/NKG2C NK cell receptors.
  Immunity 1998 Lanier LL, Corliss B, Wu J, Phillips JH
• Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Bakker AB, Phillips JH, Figdor CG, Lanier LL
• Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog.
  The Journal of experimental medicine 1998 Leong CC, Chapman TL, Bjorkman PJ, Formankova D, Mocarski ES, Phillips JH, Lanier LL
• Follow the leader: NK cell receptors for classical and nonclassical MHC class I.
  Cell 1998 Lanier LL
• HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
  Nature 1998 Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ
• Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
  Nature 1998 Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH
• Activating and inhibitory NK cell receptors.
  Advances in experimental medicine and biology 1998 Lanier LL
• Killer cell inhibitory receptor expression by T cells.
  Current topics in microbiology and immunology 1998 D'Andrea A, Lanier LL
• NK cell receptors.
  Annual review of immunology 1998 Lanier LL
• Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.
  Immunity 1997 Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P
• Human diversity in killer cell inhibitory receptor genes.
  Immunity 1997 Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P
• CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Söderström K, Corliss B, Lanier LL, Phillips JH
• LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.
  Immunity 1997 Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH
• Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Jaleco AC, Blom B, Res P, Weijer K, Lanier LL, Phillips JH, Spits H
• Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Gumperz JE, Barber LD, Valiante NM, Percival L, Phillips JH, Lanier LL, Parham P
• Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC
• Natural killer cells: from no receptors to too many.
  Immunity 1997 Lanier LL
• Arousal and inhibition of human NK cells.
  Immunological reviews 1997 Lanier LL, Corliss B, Phillips JH
• Natural killer cell receptors and MHC class I interactions.
  Current opinion in immunology 1997 Lanier LL
• The human natural killer gene complex is located on chromosome 12p12-p13.
  Immunogenetics 1997 Renedo M, Arce I, Rodríguez A, Carretero M, Lanier LL, López-Botet M, Fernández-Ruiz E
• Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.
  Journal of immunology (Baltimore, Md. : 1950) 1996 Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH
• Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLC-gamma signaling complex in human natural killer (NK) cells.
  The Journal of experimental medicine 1996 Valiante NM, Phillips JH, Lanier LL, Parham P
• Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation.
  Immunity 1996 Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ
• Specificity of two anti-class I HLA monoclonal antibodies that block class I recognition by the NKB1 killer cell inhibitory receptor.
  Tissue antigens 1996 Gumperz JE, Paterson JC, Litwin V, Valiante N, Lanier LL, Parham P, Little AM
• CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes.
  Immunity 1996 Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL
• Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles.
  The Journal of experimental medicine 1996 D'Andrea A, Chang C, Phillips JH, Lanier LL
• The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C.
  The Journal of experimental medicine 1996 Barber LD, Percival L, Valiante NM, Chen L, Lee C, Gumperz JE, Phillips JH, Lanier LL, Bigge JC, Parekh RB, Parham P
• Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.
  The Journal of experimental medicine 1996 Fry AM, Lanier LL, Weiss A
• DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.
  Immunity 1996 Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH
• Analysis of the costimulatory role of IL-2 and IL-15 in initiating proliferation of resting (CD56dim) human NK cells.
  Journal of immunology (Baltimore, Md. : 1950) 1996 Warren HS, Kinnear BF, Kastelein RL, Lanier LL
• Unusual uniformity of the N-linked oligosaccharides of HLA-A, -B, and -C glycoproteins.
  Journal of immunology (Baltimore, Md. : 1950) 1996 Barber LD, Patel TP, Percival L, Gumperz JE, Lanier LL, Phillips JH, Bigge JC, Wormwald MR, Parekh RB, Parham P
• Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype.
  The Journal of experimental medicine 1996 Gumperz JE, Valiante NM, Parham P, Lanier LL, Tyan D
• Applications of retrovirus-mediated expression cloning.
  Experimental hematology 1996 Onishi M, Kinoshita S, Morikawa Y, Shibuya A, Phillips J, Lanier LL, Gorman DM, Nolan GP, Miyajima A, Kitamura T
• Inhibitory MHC class I receptors on NK and T cells: a standard nomenclature.
  Immunology today 1996 Long EO, Colonna M, Lanier LL
• Inhibitory MHC class I receptors on NK cells and T cells.
  Immunology today 1996 Lanier LL, Phillips JH
• NKB1: a killer cell inhibitory receptor for class I HLA-B allotypes.
  Chemical immunology 1996 D'Andrea A, Lanier LL
• The role of natural killer cells in transplantation.
  Current opinion in immunology 1995 Lanier LL
• Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.
  European journal of immunology 1995 Chang C, Rodríguez A, Carretero M, López-Botet M, Phillips JH, Lanier LL
• Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.
  Journal of immunology (Baltimore, Md. : 1950) 1995 D'Andrea A, Chang C, Franz-Bacon K, McClanahan T, Phillips JH, Lanier LL
• Development of human T and natural killer cells.
  Blood 1995 Spits H, Lanier LL, Phillips JH
• Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12.
  Journal of immunology (Baltimore, Md. : 1950) 1995 Warren HS, Kinnear BF, Phillips JH, Lanier LL
• CD28/CTLA-4 ligands: the gene encoding CD86 (B70/B7.2) maps to the same region as CD80 (B7/B7.1) gene in human chromosome 3q13-q23.
  European journal of immunology 1995 Fernández-Ruiz E, Somoza C, Sánchez-Madrid F, Lanier LL
• Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes.
  Science (New York, N.Y.) 1995 Phillips JH, Gumperz JE, Parham P, Lanier LL
• NK cell recognition of major histocompatibility complex class I molecules.
  Seminars in immunology 1995 Lanier LL, Phillips JH
• The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules.
  Journal of immunology (Baltimore, Md. : 1950) 1995 Lanier LL, Gumperz JE, Parham P, Melero I, López-Botet M, Phillips JH
• T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions.
  Research in immunology 1995 Somoza C, Lanier LL
• The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.
  The Journal of experimental medicine 1995 Gumperz JE, Litwin V, Phillips JH, Lanier LL, Parham P
• CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
  Journal of immunology (Baltimore, Md. : 1950) 1995 Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M
• The role of CD28 costimulation in the generation of cytotoxic T lymphocytes.
  Current topics in microbiology and immunology 1995 Azuma M, Lanier LL
• B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.
  The Journal of experimental medicine 1994 Caux C, Vanbervliet B, Massacrier C, Azuma M, Okumura K, Lanier LL, Banchereau J
• Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.
  The Journal of experimental medicine 1994 Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A, Testi R
• Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1994 Lanier LL, Chang C, Phillips JH
• Identification of a common T/natural killer cell progenitor in human fetal thymus.
  The Journal of experimental medicine 1994 Sánchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH
• NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.
  The Journal of experimental medicine 1994 Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL
• B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
  The Journal of experimental medicine 1994 Murphy EE, Terres G, Macatonia SE, Hsieh CS, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A
• CD40 preferentially costimulates activation of CD4+ T lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1994 Cayabyab M, Phillips JH, Lanier LL
• Human natural killer cell committed thymocytes and their relation to the T cell lineage.
  The Journal of experimental medicine 1993 Sánchez MJ, Spits H, Lanier LL, Phillips JH
• B70 antigen is a second ligand for CTLA-4 and CD28.
  Nature 1993 Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C
• Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.
  The Journal of experimental medicine 1993 Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL
• Interleukin-7 specifically induces the B7/BB1 antigen on human cord blood and peripheral blood T cells and T cell clones.
  International immunology 1993 Yssel H, Schneider PV, Lanier LL
• Distribution and function of lymphocyte surface antigens. Molecules costimulating T lymphocyte activation and effector function.
  Annals of the New York Academy of Sciences 1993 Lanier LL
• Requirements for CD28-dependent T cell-mediated cytotoxicity.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Azuma M, Cayabyab M, Phillips JH, Lanier LL
• Functional expression of B7/BB1 on activated T lymphocytes.
  The Journal of experimental medicine 1993 Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL
• CD28- T lymphocytes. Antigenic and functional properties.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Azuma M, Phillips JH, Lanier LL
• The developmental relationship between NK cells and T cells.
  Immunology today 1992 Lanier LL, Spits H, Phillips JH
• Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1992 Lanier LL, Chang C, Spits H, Phillips JH
• Human fetal liver-derived CD7+CD2lowCD3-CD56- clones that express CD3 gamma, delta, and epsilon and proliferate in response to interleukin-2 (IL-2), IL-3, IL-4, or IL-7: implications for the relationship between T and natural killer cells.
  Blood 1992 Hori T, Phillips JH, Duncan B, Lanier LL, Spits H
• Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line.
  Journal of immunology (Baltimore, Md. : 1950) 1992 Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL
• Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.
  The Journal of experimental medicine 1992 Phillips JH, Hori T, Nagler A, Bhat N, Spits H, Lanier LL
• CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.
  The Journal of experimental medicine 1992 Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL
• Natural killer cells.
  Current opinion in immunology 1992 Lanier LL, Phillips JH
• CD28 co-stimulation of T-cell-mediated cytotoxicity.
  International journal of cancer. Supplement = Journal international du cancer. Supplement 1992 Azuma M, Phillips JH, Lanier LL
• A novel beta 4, alpha 6 integrin-associated epithelial cell antigen involved in natural killer cell and antigen-specific cytotoxic T lymphocyte cytotoxicity.
  The Journal of experimental medicine 1991 Phillips JH, McKinney L, Azuma M, Spits H, Lanier LL
• Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II).
  Journal of immunology (Baltimore, Md. : 1950) 1991 Harrison D, Phillips JH, Lanier LL
• Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56).
  Journal of immunology (Baltimore, Md. : 1950) 1991 Lanier LL, Chang C, Azuma M, Ruitenberg JJ, Hemperly JJ, Phillips JH
• Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Templeton DJ, Park SH, Lanier L, Weinberg RA
• Platelet-induced expression of Fc gamma RIII (CD16) on human monocytes.
  European journal of immunology 1991 Phillips JH, Chang CW, Lanier LL
• Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Lanier LL, Yu G, Phillips JH
• Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo.
  The Journal of experimental medicine 1990 Nagler A, Lanier LL, Phillips JH
• Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid.
  Science (New York, N.Y.) 1989 Lanier LL, Cwirla S, Yu G, Testi R, Phillips JH
• Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.
  Nature 1989 Lanier LL, Yu G, Phillips JH
• Comparative studies of human FcRIII-positive and negative natural killer cells.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Nagler A, Lanier LL, Cwirla S, Phillips JH
• T cell activation via Leu-23 (CD69).
  Journal of immunology (Baltimore, Md. : 1950) 1989 Testi R, Phillips JH, Lanier LL
• Activation of natural killer cells via the p75 interleukin 2 receptor.
  The Journal of experimental medicine 1989 Phillips JH, Takeshita T, Sugamura K, Lanier LL
• Report from Vienna: in search of all surface molecules expressed on human leukocytes.
  Journal of clinical immunology 1989 Clark EA, Lanier LL
• Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.
  The Journal of experimental medicine 1989 Lanier LL, Testi R, Bindl J, Phillips JH
• Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.
  The Journal of experimental medicine 1989 Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB
• Membrane anchoring and spontaneous release of CD16 (FcR III) by natural killer cells and granulocytes.
  European journal of immunology 1989 Lanier LL, Phillips JH, Testi R
• Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Testi R, Phillips JH, Lanier LL
• Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain.
  Science (New York, N.Y.) 1989 Loh EY, Elliott JF, Cwirla S, Lanier LL, Davis MM
• Functional expression of CD28 on T cell antigen receptor gamma/delta-bearing T lymphocytes.
  European journal of immunology 1989 Testi R, Lanier LL
• Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Loh EY, Cwirla S, Serafini AT, Phillips JH, Lanier LL
• Structural and serological heterogeneity of gamma/delta T cell antigen receptor expression in thymus and peripheral blood.
  European journal of immunology 1988 Lanier LL, Ruitenberg J, Bolhuis RL, Borst J, Phillips JH, Testi R
• Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1988 Lanier LL, Ruitenberg JJ, Phillips JH
• Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific.
  Journal of cellular physiology 1988 Arnaout MA, Lanier LL, Faller DV
• Constitutive expression of a phosphorylated activation antigen (Leu 23) by CD3bright human thymocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1988 Testi R, Phillips JH, Lanier LL
• The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation.
  Journal of immunology (Baltimore, Md. : 1950) 1988 Nagler A, Lanier LL, Phillips JH
• Effectors, repertoire and receptors involved in lymphocyte-mediated mhc-unrestricted cytotoxicity.
  Annales de l'Institut Pasteur. Immunology 1988 Lanier LL, Phillips JH
• The effects of recombinant interleukin 2-activated natural killer cells on autologous peripheral blood hematopoietic progenitors.
  The Journal of experimental medicine 1988 Nagler A, Greenberg PL, Lanier LL, Phillips JH
• Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen.
  The Journal of experimental medicine 1988 Lanier LL, Buck DW, Rhodes L, Ding A, Evans E, Barney C, Phillips JH
• Selective generation of erythroid burst-promoting activity by recombinant interleukin 2-stimulated human T lymphocytes and natural killer cells.
  Blood 1988 Skettino S, Phillips J, Lanier L, Nagler A, Greenberg P
• Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Richie ER, McEntire B, Crispe N, Kimura J, Lanier LL, Allison JP
• Identification and sequence of a fourth human T cell antigen receptor chain.
  Nature 1987 Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A
• In vivo and in vitro activation of natural killer cells in advanced cancer patients undergoing combined recombinant interleukin-2 and LAK cell therapy.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987 Phillips JH, Gemlo BT, Myers WW, Rayner AA, Lanier LL
• Functional competency of T cell antigen receptors in human thymus.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL
• Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines.
  The Journal of experimental medicine 1987 Phillips JH, Weiss A, Gemlo BT, Rayner AA, Lanier LL
• The gamma T-cell antigen receptor.
  Journal of clinical immunology 1987 Lanier LL, Serafini AT, Ruitenberg JJ, Cwirla S, Federspiel NA, Phillips JH, Allison JP, Weiss A
• Acquisition of non-MHC restricted cytotoxic function by IL 2 activated thymocytes with an "immature" antigenic phenotype.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Phillips JH, Lanier LL
• Expression of Leu-19 (NKH-1) antigen on IL 2-dependent cytotoxic and non-cytotoxic T cell lines.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Lanier LL, Le AM, Ding A, Evans EL, Krensky AM, Clayberger C, Phillips JH
• The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
  The Journal of experimental medicine 1987 Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A
• Comparison of T cell receptor gene rearrangements in patients with large granular T cell leukemia and Felty's syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Freimark B, Lanier L, Phillips J, Quertermous T, Fox R
• Identification of a novel T cell surface disulfide-bonded dimer distinct from the alpha/beta antigen receptor.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Nagasawa R, Gross J, Kanagawa O, Townsend K, Lanier LL, Chiller J, Allison JP
• Lymphokine-activated killer cell activity Characteristics of effector cells and their progenitors in blood and spleen.
  Immunology today 1987 Herberman RB, Hiserodt J, Vujanovic N, Balch C, Lotzova E, Bolhuis R, Golub S, Lanier LL, Phillips JH, Riccardi C, Ritz J, Santoni A, Schmidt RE, Uchida A
• Structure, function, and serology of the T-cell antigen receptor complex.
  Annual review of immunology 1987 Allison JP, Lanier LL
• The T-cell antigen receptor gamma gene: rearrangement and cell lineages.
  Immunology today 1987 Allison JP, Lanier LL
• Genomic organization of T cell gamma genes in human peripheral blood natural killer cells.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lanier LL, Cwirla S, Phillips JH
• Antigenic, functional, and molecular genetic studies of human natural killer cells and cytotoxic T lymphocytes not restricted by the major histocompatibility complex.
  Federation proceedings 1986 Lanier LL, Le AM, Cwirla S, Federspiel N, Phillips JH
• Natural killer cells: definition of a cell type rather than a function.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lanier LL, Phillips JH, Hackett J, Tutt M, Kumar V
• Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus.
  Nature 1986 Lanier LL, Weiss A
• Bacterial activation of human natural killer cells. Characteristics of the activation process and identification of the effector cell.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Tarkkanen J, Saksela E, Lanier LL
• Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lanier LL, Allison JP, Phillips JH
• Distinct epitopes on the T cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lanier LL, Ruitenberg JJ, Allison JP, Weiss A
• Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.
  The Journal of experimental medicine 1986 Phillips JH, Lanier LL
• Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens.
  The Journal of experimental medicine 1986 Lanier LL, Ruitenberg JJ, Phillips JH
• The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lanier LL, Le AM, Civin CI, Loken MR, Phillips JH
• Evidence for three types of human cytotoxic lymphocyte.
  Immunology today 1986 Lanier LL, Phillips JH
• NK cell function in a patient with IgM monoclonal antibody against myelin-associated glycoprotein.
  Neurology 1986 Sriram S, Lanier L
• Function and cell distribution of KC-1, a novel natural killer cell-associated antigen.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Clayberger C, Dyer B, McIntyre B, Koller TD, Hardy B, Parham P, Lanier LL, Krensky AM
• Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Phillips JH, Lanier LL
• Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor beta chain genes.
  The Journal of experimental medicine 1986 Lanier LL, Cwirla S, Federspiel N, Phillips JH
• Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes.
  Medical oncology and tumor pharmacotherapy 1986 Lanier LL, Phillips JH
• Ontogeny of natural killer cells.
  Nature 1986 Lanier LL, Phillips JH
• Functional properties of a unique subset of cytotoxic CD3+ T lymphocytes that express Fc receptors for IgG (CD16/Leu-11 antigen).
  The Journal of experimental medicine 1985 Lanier LL, Kipps TJ, Phillips JH
• Lymphocyte surface antigens. Introduction.
  Federation proceedings 1985 Lanier L
• Molecular characterization of the murine T cell antigen receptor and associated structures.
  Federation proceedings 1985 Allison JP, McIntyre BW, Ridge LL, Gross-Pelose J, Lanier LL
• Antigens associated with the activation of murine mononuclear phagocytes in vivo: differential expression of lymphocyte function-associated antigen in the several stages of development.
  Cellular immunology 1985 Strassmann G, Springer TA, Haskill SJ, Miraglia CC, Lanier LL, Adams DO
• Salivary gland lymphocytes in primary Sjogren's syndrome lack lymphocyte subsets defined by Leu-7 and Leu-11 antigens.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Fox RI, Hugli TE, Lanier LL, Morgan EL, Howell F
• Terminology in T gamma lymphoproliferative disease.
  Blood 1985 Ault KA, Lanier LL
• p150/95, Third member of the LFA-1/CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody.
  European journal of immunology 1985 Lanier LL, Arnaout MA, Schwarting R, Warner NL, Ross GD
• A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562.
  The Journal of experimental medicine 1985 Phillips JH, Lanier LL
• Identification of antigen receptor-associated structures on murine T cells.
  Nature 1985 Allison JP, Lanier LL
• Phenotypic variation in clonal Abelson virus lymphoma cells.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Green PL, Lamph WW, Dudley J, Arfsten A, Risser R, Lanier LL, Warner NL, Tung JS, Scheid MP
• Recombinant interleukin 2 enhanced natural killer cell-mediated cytotoxicity in human lymphocyte subpopulations expressing the Leu 7 and Leu 11 antigens.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Lanier LL, Benike CJ, Phillips JH, Engleman EG
• Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker.
  Science (New York, N.Y.) 1985 Waldor MK, Sriram S, Hardy R, Herzenberg LA, Herzenberg LA, Lanier L, Lim M, Steinman L
• Influence of racial background on the distribution of T-cell subsets and Leu 11-positive lymphocytes in healthy blood donors.
  Diagnostic immunology 1985 Prince HE, Hirji K, Waldbeser LS, Plaeger-Marshall S, Kleinman S, Lanier LL
• Lymphocyte subsets and surface molecules in man.
  Clinical immunology reviews 1985 Krensky AM, Lanier LL, Engleman EG
• The murine T cell antigen receptor and associated structures.
  Immunological reviews 1984 Allison JP, Ridge L, Lund J, Gross-Pelose J, Lanier L, McIntyre BW
• Characterization and expression of the HLA-DC antigens defined by anti-Leu 10.
  Human immunology 1984 Chen YX, Evans RL, Pollack MS, Lanier LL, Phillips JH, Rousso C, Warner NL, Brodsky FM
• The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1984 Perussia B, Trinchieri G, Jackson A, Warner NL, Faust J, Rumpold H, Kraft D, Lanier LL
• Regulation of expression of class II major histocompatibility antigens on human peripheral blood monocytes and Langerhans cells by interferon.
  Human immunology 1984 Basham T, Smith W, Lanier L, Morhenn V, Merigan T
• Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens.
  The Journal of experimental medicine 1984 Phillips JH, Le AM, Lanier LL
• A human natural killer cell-associated antigen defined by monoclonal antibody anti-Leu (NKP-15): functional and two-color flow cytometry analysis.
  Journal of leukocyte biology 1984 Lanier LL, Phillips JH, Warner NL, Babcock GF
• Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu-2, Leu-3, Leu-7, Leu-8, and Leu-11 cell surface antigen expression.
  Journal of immunology (Baltimore, Md. : 1950) 1984 Lanier LL, Loken MR
• Location of Ly-7 on mouse chromosome 12.
  Immunogenetics 1984 Hogarth PM, McKenzie IF, Lanier L, Bailey DW, Taylor BA
• Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens.
  Journal of immunology (Baltimore, Md. : 1950) 1983 Lanier LL, Le AM, Phillips JH, Warner NL, Babcock GF
• Correlation of biophysical properties and cell surface antigenic profile of Percoll gradient-separated human natural killer cells.
  Natural immunity and cell growth regulation 1983 Phillips JH, Warner NL, Lanier LL
• Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry.
  Immunological reviews 1983 Lanier LL, Engleman EG, Gatenby P, Babcock GF, Warner NL, Herzenberg LA
• Expression of Ly-1 and Ly-2 on a spontaneous AKR B-cell lymphoma.
  Immunogenetics 1983 Lanier LL, Richie ER, Howell AL, Allison JP
• Lym 7.3: new murine specificity defining third allele of the Ly 7 locus.
  Hybridoma 1983 Lanier LL, Warner NL
• Activation of murine B cell lymphomas. I. Influence of lipopolysaccharide.
  Journal of immunology (Baltimore, Md. : 1950) 1982 Lanier LL
• Characterization and functional properties of tumor cell lines in accessory cell replacement assays.
  Journal of immunology (Baltimore, Md. : 1950) 1982 Walker EB, Lanier LL, Warner NL
• Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line.
  The Journal of experimental medicine 1982 Walker EB, Lanier LL, Warner NL
• Lym 7.2: monoclonal antibody defining an alloantigen similar or identical to Ly 7.2.
  Hybridoma 1982 Lanier LL, Warner NL
• Monoclonal antibodies against rat immunoglobulin kappa chains.
  Hybridoma 1982 Lanier LL, Gutman GA, Lewis DE, Griswold ST, Warner NL
• Transplantable B-cell lymphomas in B10. H-2aH-4bp/Wts mice.
  Immunogenetics 1982 Lanier LL, Arnold LW, Raybourne RB, Russell S, Lynes MA, Warner NL, Haughton G
• Quantitative immunofluorescent analysis of surface phenotypes of murine B cell lymphomas and plasmacytomas with monoclonal antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1981 Lanier LL, Warner NL, Ledbetter JA, Herzenberg LA
• Expression of Lyt-1 antigen on certain murine B cell lymphomas.
  The Journal of experimental medicine 1981 Lanier LL, Warner NL, Ledbetter JA, Herzenberg LA
• Cell cycle related heterogeneity of Ia antigen expression on a murine B lymphoma cell line:analysis by flow cytometry.
  Journal of immunology (Baltimore, Md. : 1950) 1981 Lanier LL, Warner NL
• Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry (FACS) analysis.
  Journal of immunological methods 1981 Lanier LL, Warner NL
• Mechanism of B cell lymphoma immunotherapy with passive xenogeneic anti-idiotype serum.
  Journal of immunology (Baltimore, Md. : 1950) 1980 Lanier LL, Babcock GF, Raybourne RB, Arnold LW, Warner NL, Haughton G
• Antigen-induced murine B-cell lymphomas. III. Passive anti-idiotype serum therapy and its combined effect with chemotherapy.
  Journal of the National Cancer Institute 1979 Lanier LL, Babcock GF, Lynes MA, Haughton G
• Early detection of the CH1 murine lymphoma by tumor-associated idiotype in the serum.
  International journal of cancer 1979 Lanier LL, Babcock GF, Lynes MA, Haughton G
• Tolerance to non-H-2 histocompatibility antigens. Transplantation tolerance to the H-4 and H-7 histocompatibility antigens.
  Transplantation 1979 Lanier LL, Haughton G
• Antigen-induced murine B cell lymphomas. II. Exploitation of the surface idiotype as tumor specific antigen.
  Journal of immunology (Baltimore, Md. : 1950) 1978 Haughton G, Lanier LL, Babcock GF, Lynes MA
• The murine kappa light chain shift.
  Nature 1978 Haughton G, Lanier LL, Babcock GF
• Novel type of murine B-cell lymphoma.
  Nature 1978 Lanier LL, Lynes M, Haughton G, Wettstein PJ