Leslie Floren, PharmD, PhD, MA
Professor
Clinical Pharmacy
School of Pharmacy

Her teaching responsibilities for the past several years have included, primarily, teaching pharmacokinetics/pharmacodynamics, clinical pharmacology and principles of drug development and regulatory sciences to a wide variety of students, including professional students in the PharmD program, Clinical Pharmacology Fellows, junior faculty members, and working professionals from industrial backgrounds. Teaching is one of her greatest pleasures and she has been honored to receive the School of Pharmacy Dean’s Recognition for Excellence in Teaching every year since 2005 and, in 2010, she received the highest honor in the School of Pharmacy for teaching, the Long Award for Excellence in Teaching. Dr. Floren has a keen interest in curriculum development, teaching methodology and assessment, educational technology and online education and will begin training in the School of Medicine 2012-2013 Teaching Scholars Program in order to develop innovative curricula, to implement novel teaching methods and to use technology in order to “bring to life” the principles of Pharmacokinetics, Pharmacodynamics and Clinical Pharmacology for a wide variety of students within and across disciplines and, ultimately, to have a positive impact on patient health. She also plans to conduct scholarly research that will demonstrate the utility of practice-based teaching methods in order to advance interdisciplinary pharmaceutical sciences education within UCSF, our local community and across the country.

• A Mobile Learning Module to Support Interprofessional Knowledge Construction in the Health Professions.
  American journal of pharmaceutical education 2020 Floren LC, Mandal J, Dall'Era M, Shin J, Irby DM, Cate OT, O'Brien BC
• Clinical Pharmacology Education - The Decade Ahead.
  Clinical pharmacology and therapeutics 2019 Brouwer KLR, Schmidt S, Floren LC, Johnson JA
• A review of interprofessional training wards: Enhancing student learning and patient outcomes.
  Medical teacher 2018 Oosterom N, Floren LC, Ten Cate O, Westerveld HE
• Are We on the Same Page? Shared Mental Models to Support Clinical Teamwork Among Health Professions Learners: A Scoping Review.
  Academic medicine : journal of the Association of American Medical Colleges 2018 Floren LC, Donesky D, Whitaker E, Irby DM, Ten Cate O, O'Brien BC
• Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.
  Biopharmaceutics & drug disposition 2013 Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L
• Cancer Chemother Pharmacol
  Pharmacokinetic/pharmacodynamic analysis of adjuvant pegylated interferon alpha-2b in patients with resected high-risk melanoma. 2011 Daud AI, Xu C, Hwu WJ, Urbas P, Andrews S, Papadopoulos NE, Floren LC, Yver A, Deconti RC, Sondak VK.
• Br J Cancer
  Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma. 2010 DeConti RC, Algazi AP, Andrews S, Urbas P, Born O, Stoeckigt D, Floren L, Hwang J, Weber J, Sondak VK, Daud AI.
• Drug Metab Dispos
  An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing. 2009 GR Tonn, SG Wong, SC Wong, MG Johnson, J Ma, R Cho, LC Floren, K Kersey, K Berry, AP Marcus, X Wang, B Van Lengerich, JC Medina, PG Pearson, and BK Wong.
• Safety and pharmacokinetics (PK) of T138067 (T67) administered as a weekly 3-hour infusion in subjects with hepatocellular carcinoma (HCC) in a phase 1 study.
  Journal of Clinical Oncology 2004 A. P. Venook, E. K. Rowinsky, R. C. Donehower, T. Leung, L. C. Floren, M. Levy
• Safety and pharmacokinetics (PK) of T138067 (T67) administered as a weekly 3-hour infusion in subjects with hepatocellular carcinoma (HCC) in a phase 1 study.
  Journal of Clinical Oncology 2004 A. P. Venook, E. K. Rowinsky, R. C. Donehower, T. Leung, L. C. Floren, M. Levy
• Drug Metab Pharmacokinet
  Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV+ Subjects. 2003 LA Frassetto, Thai T, Aggarwal A, Bucher P, Jacobsen W, U Christians, LZ Benet, LC Floren.
• Pediatrics
  Nelfinavir pharmacokinetics in stable HIV-positive children: AIDS Clinical Trials Group Protocol 377. 2003 LC Floren, A Wiznia , SA Hayashi, A Jaywardene, K Stanley, G Johnson, S Nachman, P Krosstad, F Aweeka.
• Clin Pharmacol Ther
  The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. 2001 L Mancinelli, L Frassetto, LC Floren, D Dressler, S Carrier, I Bekersky, LZ Benet, U Christians.
• Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole.
  Clinical Pharmacology & Therapeutics 1999 L.C. Floren, U. Christians, J.J. Zimmerman, L. Neefe, R. Schorer, D. Rushworth, D. Harper, J. Renz, L.Z. Benet
• Ann Onc
  Tamoxifen in liver disease: potential exacerbation of hepatic function. 1998 LC Floren, MF Hebert, AP Venook, VC Jordan, A Cisneros, and KA Somberg.
• CJHP
  Pharmacogenetics: The clinical significance of cytochrome P450 polymorphisms. 1998 C Cheng and LC Floren.
• Pharmacol Ther
  Metabolism and drug interactions of the 3-hydroxy-3methylglutaryl Coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar? 1998 U Christians, W Jacobsen and LC Floren.
• Clin Pharmacol Ther
  Tacrolimus oral bioavailability doubles with co-administration of ketoconazole. 1997 LC Floren, I Bekersky, LZ Benet, QA Mekki, DE Dressler, JW Lee, JP Roberts, and MF Hebert.
• Transplantationsmedizen
  The clinical pharmacokinetics of macrolide immunosuppressants and its impact on the clinical management of organ transplantation. 1997 U Christians, LC Floren, G Kirchner, and K-F Sewing.
• Foscarnet Pharmacokinetics (PK) During Continuous Ambulatory Peritoneal Dialysis (CAPD).
  Clinical Pharmacology & Therapeutics 1996 L. Floren, J.G. Gambertoglio, S. Martin-Munley, F. Aweeka