Leslie Benet, PhD
Professor
Bioengineering
School of Pharmacy

He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and University of Lisbon, Portugal (Ph.D., 2016). His research interests, more than 620 publications, 7 books and 12 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Clarivate Analytics as one of the most highly cited pharmacologists worldwide with his published peer-reviewed papers cited over 33,000 times, while Google Scholar credits him with over 50,000 citations. His most recent work has addressed the deficiencies of in vitro-in vivo extrapolation (IVIVE) and different approaches to advancing our understanding and prediction of clearance processes. Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY and AAPS JOURNAL. He is a Fellow of the American Association for the Advancement of Science (AAAS), the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP) and the Controlled Release Society (CRS). In 1982, Dr. Benet received the APhA Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the National Academy of Medicine (NAM) of the U.S. National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT); in 1996, the AAPS Distinguished Service Award; and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award (repeated in 2016). In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer; in 2010, the ASCPT Hunter Memorial Award in Therapeutics; and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor and he was made an honorary member of FIP. In 2013, he was awarded the APhA Ebert Prize, the AAPS Journal Outstanding Manuscript award and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. In 2015 he received the ISSX North American Scientific Achievement award; in 2016 the Remington Honor Medal from the APhA, the highest honor in American Pharmacy; and in 2017 a full day symposium in his honor entitled “The Cutting Edge in Pharmaceutical Sciences—50 Years of Progress Celebrating Les Benet’s 80th Birthday” was held in conjunction with the Pharmaceutical Sciences World Congress in Stockholm, Sweden. In 2023 he received the Lifetime Achievement Award of the Frankfurt Foundation for the Quality of Medicines. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated NAM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and the FIP Foundation for Education and Research and as a member of the FDA Science Board, the FDA Generic Drugs Advisory Committee and the NRC Biodefense Standing Committee. He presently serves as Chair of the Board of Directors of Medicines360, a nonprofit pharmaceutical company, emphasizing products for women’s health. July 2023

• Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance.
  Pharmacology & therapeutics 2022 Pachter JA, Dill KA, Sodhi JK, Benet LZ
• State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References.
  The AAPS journal 2022 Bocci G, Oprea TI, Benet LZ
• Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?
  Drug metabolism and disposition: the biological fate of chemicals 2022 Kameyama T, Sodhi JK, Benet LZ
• Can In Vitro-In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions.
  Clinical pharmacology and therapeutics 2021 Benet LZ, Sodhi JK
• Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies.
  Pharmaceutical research 2021 Liu S, Sodhi JK, Benet LZ
• Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing.
  AAPS PharmSciTech 2021 Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ
• Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans.
  Pharmaceutical research 2021 Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM
• Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers.
  Clinical pharmacology and therapeutics 2021 Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ
• There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions.
  The AAPS journal 2021 Benet LZ, Sodhi JK, Makrygiorgos G, Mesbah A
• Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption.
  Pharmaceutical research 2021 Kou W, Sodhi JK, Wu X, Benet LZ
• Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART.
  Drug testing and analysis 2021 Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M
• Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing.
  Journal of clinical pharmacology 2021 Benet LZ
• Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization.
  Journal of medicinal chemistry 2021 Sodhi JK, Benet LZ
• Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions.
  Clinical pharmacokinetics 2021 Sodhi JK, Huang CH, Benet LZ
• Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition.
  Pharmaceutical research 2020 Sodhi JK, Liu S, Benet LZ
• Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways.
  The AAPS journal 2020 Benet LZ, Sodhi JK
• The Critical Role of Passive Permeability in Designing Successful Drugs.
  ChemMedChem 2020 Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K
• The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions.
  The AAPS journal 2020 Sodhi JK, Benet LZ
• A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs.
  Clinical pharmacology and therapeutics 2020 Sodhi JK, Benet LZ
• Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination?
  Drug metabolism and disposition: the biological fate of chemicals 2020 Sodhi JK, Wang HJ, Benet LZ
• Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System.
  Pharmacotherapy 2020 Liu W, Yan T, Chen K, Yang L, Benet LZ, Zhai S
• Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions.
  Pharmaceutical research 2020 Sodhi JK, Liu S, Benet LZ
• Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis.
  Pharmacology 2020 Sun A, Benet LZ
• Can BDDCS illuminate targets in drug design?
  Drug discovery today 2019 Bocci G, Benet LZ, Oprea TI
• Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation.
  Drug metabolism and disposition: the biological fate of chemicals 2019 Wang HJ, Benet LZ
• In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly.
  Drug metabolism and disposition: the biological fate of chemicals 2019 Bowman CM, Benet LZ
• Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial.
  Pharmaceutical research 2019 Surofchy DD, Frassetto LA, Benet LZ
• How Transporters Have Changed Basic Pharmacokinetic Understanding.
  The AAPS journal 2019 Benet LZ, Bowman CM, Sodhi JK
• The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats.
  Drug metabolism and disposition: the biological fate of chemicals 2019 Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ
• Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties.
  Pharmaceutical research 2019 Bowman CM, Benet LZ
• Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs.
  Journal of pharmacokinetics and pharmacodynamics 2019 Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK
• In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction.
  Journal of pharmaceutical sciences 2019 Bowman CM, Benet LZ
• Characterization of Fasiglifam-Related Liver Toxicity in Dogs.
  Drug metabolism and disposition: the biological fate of chemicals 2019 Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ
• The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.
  Drug metabolism and disposition: the biological fate of chemicals 2019 Bowman CM, Okochi H, Benet LZ
• Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence?
  Clinical pharmacology and therapeutics 2019 Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E
• Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs.
  Clinical pharmacology and therapeutics 2019 Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ
• TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.
  International journal for parasitology. Drugs and drug resistance 2018 Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR
• The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses.
  Pharmaceutical research 2018 Benet LZ, Bowman CM, Liu S, Sodhi JK
• Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
  Redox biology 2018 Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ
• Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence.
  EClinicalMedicine 2018 Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M
• An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation.
  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2018 Bowman CM, Benet LZ
• Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification.
  Toxicology research 2018 Chan R, Benet LZ
• Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype.
  Journal of clinical pharmacology 2018 Benet LZ
• Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI.
  Toxicological sciences : an official journal of the Society of Toxicology 2018 Chan R, Benet LZ
• A Drug-drug Interaction Between Cyclosporine and Nystatin.
  Clinical therapeutics 2018 Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S
• Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry.
  Rapid communications in mass spectrometry : RCM 2018 Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H
• Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations.
  The AAPS journal 2018 Parasrampuria DA, Benet LZ, Sharma A
• Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer.
  Scientific reports 2018 Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN
• Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M
• The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio.
  Clinical pharmacology and therapeutics 2017 Benet LZ, Liu S, Wolfe AR
• Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide".
  Clinical and translational science 2017 Morrissey KM, Benet LZ, Ware JA
• Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics.
  Journal of pharmaceutical sciences 2017 Benet LZ, Wu HF
• Cellular Uptake of Levocetirizine by Organic Anion Transporter 4.
  Journal of pharmaceutical sciences 2017 Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M
• Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.
  Journal of pharmaceutical sciences 2017 Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ
• Evaluation of DILI Predictive Hypotheses in Early Drug Development.
  Chemical research in toxicology 2017 Chan R, Benet LZ
• Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations.
  AIDS research and human retroviruses 2017 Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, …
• Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.
  Pharmaceutical research 2016 Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ
• Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS).
  Chinese journal of natural medicines 2016 Li J, Larregieu CA, Benet LZ
• Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial.
  Clinical pharmacology and therapeutics 2016 Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B
• Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study.
  The lancet. HIV 2016 Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM
• Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.
  Drug metabolism and disposition: the biological fate of chemicals 2016 Bowman CM, Benet LZ
• 2016 Remington Honor Medal Address: Science for the profession.
  Journal of the American Pharmacists Association : JAPhA 2016 Benet LZ
• Isoniazid hair concentrations in children with tuberculosis: a proof of concept study.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016 Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M
• BDDCS, the Rule of 5 and drugability.
  Advanced drug delivery reviews 2016 Benet LZ, Hosey CM, Ursu O, Oprea TI
• Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial.
  Clinical pharmacology and therapeutics 2016 Burmeister Getz E, Carroll KJ, Jones B, Benet LZ
• Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage.
  The AAPS journal 2016 Chan R, Wei CY, Chen YT, Benet LZ
• Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain.
  Clinical pharmacokinetics 2016 Zheng Y, Chen X, Benet LZ
• BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs.
  The AAPS journal 2015 Hosey CM, Chan R, Benet LZ
• Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS.
  Journal of pharmaceutical sciences 2015 Garrison KL, Sahin S, Benet LZ
• Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions.
  Molecular pharmaceutics 2015 Hosey CM, Benet LZ
• pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion.
  Pharmaceutical research 2015 Zheng Y, Benet LZ, Okochi H, Chen X
• A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia.
  Clinical lymphoma, myeloma & leukemia 2015 Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG
• Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful.
  Basic & clinical pharmacology & toxicology 2014 Parasrampuria DA, Benet LZ
• The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.
  The AAPS journal 2014 Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA
• Predicting when biliary excretion of parent drug is a major route of elimination in humans.
  The AAPS journal 2014 Hosey CM, Broccatelli F, Benet LZ
• Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery.
  Molecular pharmaceutics 2014 Larregieu CA, Benet LZ
• Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients.
  Transplantation 2014 Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ
• Mouse liver repopulation with hepatocytes generated from human fibroblasts.
  Nature 2014 Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S
• Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.
  Molecular pharmaceutics 2013 Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA
• Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.
  Molecular pharmaceutics 2013 Estudante M, Maya M, Morais JG, Soveral G, Benet LZ
• Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.
  Biopharmaceutics & drug disposition 2013 Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L
• Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.
  Molecular pharmaceutics 2013 Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ
• The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles.
  Drug metabolism and disposition: the biological fate of chemicals 2013 Horng H, Benet LZ
• Characterization of the acyl-adenylate linked metabolite of mefenamic Acid.
  Chemical research in toxicology 2013 Horng H, Benet LZ
• Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
  Pharmaceutical research 2013 Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB
• Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements.
  The AAPS journal 2013 Larregieu CA, Benet LZ
• The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development.
  Journal of pharmaceutical sciences 2012 Benet LZ
• A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates.
  Clinical pharmacology and therapeutics 2012 Benet LZ
• Intestinal drug transporters: an overview.
  Advanced drug delivery reviews 2012 Estudante M, Morais JG, Soveral G, Benet LZ
• Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?
  Clinical pharmacology and therapeutics 2012 Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA
• Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory.
  The AAPS journal 2012 Benet LZ
• Sotalol permeability in cultured-cell, rat intestine, and PAMPA system.
  Pharmaceutical research 2012 Liu W, Okochi H, Benet LZ, Zhai SD
• BDDCS class prediction for new molecular entities.
  Molecular pharmaceutics 2012 Broccatelli F, Cruciani G, Benet LZ, Oprea TI
• Improving the prediction of the brain disposition for orally administered drugs using BDDCS.
  Advanced drug delivery reviews 2011 Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ
• Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations.
  Pharmacotherapy 2011 Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL
• Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients.
  Drug metabolism and disposition: the biological fate of chemicals 2011 Grover A, Frassetto LA, Benet LZ, Chakkera HA
• BDDCS applied to over 900 drugs.
  The AAPS journal 2011 Benet LZ, Broccatelli F, Oprea TI
• Lead PK commentary: predicting human pharmacokinetics.
  Journal of pharmaceutical sciences 2011 Rowland M, Benet LZ
• Professor Akira Tsuji: scientist, educator, and leader.
  Journal of pharmaceutical sciences 2011 Terasaki T, Sugiyama Y, Benet LZ
• Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics.
  Journal of pharmaceutical sciences 2011 Reyes M, Benet LZ
• Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation.
  Journal of pharmacokinetics and pharmacodynamics 2011 Grover A, Benet LZ
• The BCS, BDDCS, and regulatory guidances.
  Pharmaceutical research 2011 Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX
• Is Ciprofloxacin a Substrate of P-glycoprotein?
  Archives of drug information 2011 Park MS, Okochi H, Benet LZ
• Founding figures of pharmacokinetics: tribute to Malcolm Rowland.
  Journal of pharmacokinetics and pharmacodynamics 2010 Aarons L, Benet LZ
• Clearance (née Rowland) concepts: a downdate and an update.
  Journal of pharmacokinetics and pharmacodynamics 2010 Benet LZ
• Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
  Neurotoxicology 2010 Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ
• Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.
  Clinical pharmacology and therapeutics 2010 Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ
• The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted.
  Clinical pharmacology and therapeutics 2010 Benet LZ, Larregieu CA
• Membrane transporters in drug development.
  Nature reviews. Drug discovery 2010 International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, …
• Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation.
  Clinical therapeutics 2010 Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B
• Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease.
  Clinical pharmacology and therapeutics 2010 Sun H, Frassetto LA, Huang Y, Benet LZ
• Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.
  Drug metabolism and disposition: the biological fate of chemicals 2010 Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ
• Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System.
  Basic & clinical pharmacology & toxicology 2009 Benet LZ
• Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.
  Journal of pharmaceutical sciences 2009 de Souza J, Benet LZ, Huang Y, Storpirtis S
• The drug transporter-metabolism alliance: uncovering and defining the interplay.
  Molecular pharmaceutics 2009 Benet LZ
• A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient.
  Clinical pharmacology and therapeutics 2009 Benet LZ
• The role of transporters in the pharmacokinetics of orally administered drugs.
  Pharmaceutical research 2009 Shugarts S, Benet LZ
• Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate.
  The Pediatric infectious disease journal 2009 Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ
• Effects of drug transporters on volume of distribution.
  The AAPS journal 2009 Grover A, Benet LZ
• Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women.
  Journal of acquired immune deficiency syndromes (1999) 2009 Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM, Women's Interagency HIV Study
• The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms.
  Pharmaceutical research 2008 Sahin S, Benet LZ
• Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite.
  Clinical pharmacology and therapeutics 2008 Zheng HX, Huang Y, Frassetto LA, Benet LZ
• Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4.
  Journal of infection in developing countries 2008 Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J
• Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.
  Chemical research in toxicology 2008 Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA
• The use of BDDCS in classifying the permeability of marketed drugs.
  Pharmaceutical research 2008 Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX
• Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats.
  Drug metabolism and disposition: the biological fate of chemicals 2008 Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ
• HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007 Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune …
• Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.
  Advanced drug delivery reviews 2007 Custodio JM, Wu CY, Benet LZ
• Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007 Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ
• Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
  Journal of mass spectrometry : JMS 2007 Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U
• Effects of uptake and efflux transporter inhibition on erythromycin breath test results.
  Clinical pharmacology and therapeutics 2007 Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ
• Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.
  Drug metabolism and disposition: the biological fate of chemicals 2007 Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH
• effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.
  Clinical pharmacology and therapeutics 2006 Lau YY, Huang Y, Frassetto L, Benet LZ
• Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.
  The Journal of pharmacology and experimental therapeutics 2006 Lam JL, Shugarts SB, Okochi H, Benet LZ
• In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.
  Drug metabolism and disposition: the biological fate of chemicals 2006 Lam JL, Okochi H, Huang Y, Benet LZ
• Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism.
  Drug metabolism and disposition: the biological fate of chemicals 2006 Lau YY, Okochi H, Huang Y, Benet LZ
• Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
  Drug metabolism and disposition: the biological fate of chemicals 2006 Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET
• Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.
  Rapid communications in mass spectrometry : RCM 2006 Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET
• A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
  Antimicrobial agents and chemotherapy 2005 Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH
• In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats.
  Chemical research in toxicology 2005 Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ
• Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems.
  The Journal of pharmacology and experimental therapeutics 2005 Lau YY, Okochi H, Huang Y, Benet LZ
• Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.
  Molecular pharmaceutics 2005 Chang JH, Benet LZ
• Effects of renal failure on drug transport and metabolism.
  Pharmacology & therapeutics 2005 Sun H, Frassetto L, Benet LZ
• Effects of short-term alendronate on bone mineral density in haemodialysis patients.
  Nephrology (Carlton, Vic.) 2005 Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L
• Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
  Transplantation 2005 Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ
• Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.
  Journal of clinical pharmacology 2005 Putnam WS, Woo JM, Huang Y, Benet LZ
• There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found.
  Molecular interventions 2005 Benet LZ
• Basic pharmacological interactions and how they may impact on one another.
  Journal of acquired immune deficiency syndromes (1999) 2005 Benet L
• Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system.
  Pharmaceutical research 2005 Wu CY, Benet LZ
• Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes.
  Pharmaceutical research 2005 Mohri K, Okada K, Benet LZ
• Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
  Drug metabolism and disposition: the biological fate of chemicals 2004 Lam JL, Benet LZ
• Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
  Therapeutic drug monitoring 2004 Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U
• Novel percutaneous adventitial drug delivery system for regional vascular treatment.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2004 Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M
• Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.
  British journal of pharmacology 2004 Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N
• Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.
  Drug metabolism and disposition: the biological fate of chemicals 2004 Sun H, Huang Y, Frassetto L, Benet LZ
• P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro.
  Pharmaceutical research 2004 Kim WY, Benet LZ
• Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.
  International journal of pharmaceutics 2004 Benet LZ, Cummins CL, Wu CY
• Pharmacogenomics and transplantation: where are we?
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004 Frassetto LA, Benet LZ
• Biochemical mechanisms of cyclosporine neurotoxicity.
  Molecular interventions 2004 Serkova NJ, Christians U, Benet LZ
• Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.
  The Journal of pharmacology and experimental therapeutics 2003 Lau YY, Wu CY, Okochi H, Benet LZ
• Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.
  Drug metabolism and disposition: the biological fate of chemicals 2003 Wu CY, Benet LZ
• CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
  The Journal of pharmacology and experimental therapeutics 2003 Cummins CL, Jacobsen W, Christians U, Benet LZ
• Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data.
  Current drug metabolism 2003 Benet LZ, Cummins CL, Wu CY
• Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro.
  Drug metabolism and disposition: the biological fate of chemicals 2003 Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ
• In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat.
  The Journal of pharmacology and experimental therapeutics 2003 Li C, Grillo MP, Benet LZ
• In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
  The Journal of pharmacology and experimental therapeutics 2003 Cummins CL, Salphati L, Reid MJ, Benet LZ
• In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester.
  Toxicology and applied pharmacology 2003 Li C, Grillo MP, Benet LZ
• Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.
  Drug metabolism and pharmacokinetics 2003 Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC
• Pharmacokinetics of cyclosporine pre- and post-liver transplantation.
  Journal of clinical pharmacology 2003 Hebert MF, Wacher VJ, Roberts JP, Benet LZ
• Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
  Planta medica 2002 Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ
• Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
  The Journal of pharmacology and experimental therapeutics 2002 Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N
• Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?
  Pharmaceutical research 2002 Susanto M, Benet LZ
• Changes in plasma protein binding have little clinical relevance.
  Clinical pharmacology and therapeutics 2002 Benet LZ, Hoener BA
• Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002 Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U
• Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation.
  Journal of clinical pharmacology 2002 Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ
• Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
  The Journal of pharmacology and experimental therapeutics 2002 Cummins CL, Jacobsen W, Benet LZ
• Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002 Unger M, Jacobsen W, Holzgrabe U, Benet LZ
• Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro.
  Drug metabolism and disposition: the biological fate of chemicals 2002 Grillo MP, Benet LZ
• Red wine decreases cyclosporine bioavailability.
  Clinical pharmacology and therapeutics 2001 Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A
• Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
  British journal of pharmacology 2001 Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U
• Active secretion and enterocytic drug metabolism barriers to drug absorption.
  Advanced drug delivery reviews 2001 Wacher VJ, Salphati L, Benet LZ
• Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.
  Transplantation proceedings 2001 Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U
• Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2001 Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L
• A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.
  Pharmaceutical research 2001 Parasrampuria DA, Lantz MV, Benet LZ
• Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.
  Advances in experimental medicine and biology 2001 Qiu Y, Benet LZ, Burlingame AL
• The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein.
  Clinical pharmacokinetics 2001 Zhang Y, Benet LZ
• The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.
  Clinical pharmacology and therapeutics 2001 Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U
• In vitro evaluation of the disposition of A novel cysteine protease inhibitor.
  Drug metabolism and disposition: the biological fate of chemicals 2000 Jacobsen W, Christians U, Benet LZ
• Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
  Drug metabolism and disposition: the biological fate of chemicals 2000 Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U
• Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants.
  Journal of chromatography. B, Biomedical sciences and applications 2000 Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI
• Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
  The Journal of pharmacology and experimental therapeutics 2000 Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U
• Recommendations for bioequivalence testing of cyclosporine generics revisited.
  Therapeutic drug monitoring 2000 Christians U, First MR, Benet LZ
• Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
  British journal of pharmacology 2000 Soldner A, Benet LZ, Mutschler E, Christians U
• The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
  British journal of pharmacology 2000 Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U
• Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.
  Transplantation 2000 Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE
• Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism.
  Drug metabolism and disposition: the biological fate of chemicals 1999 Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ
• Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.
  Journal of controlled release : official journal of the Controlled Release Society 1999 Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ
• Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.
  The Journal of pharmacology and experimental therapeutics 1999 Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U
• Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin.
  British journal of clinical pharmacology 1999 Mizuma T, McDonagh AF, Lin ET, Benet LZ
• Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.
  The Journal of pharmacology and experimental therapeutics 1999 Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U
• Relevance of pharmacokinetics in narrow therapeutic index drugs.
  Transplantation proceedings 1999 Benet LZ
• Understanding bioequivalence testing.
  Transplantation proceedings 1999 Benet LZ
• Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment.
  Transplantation 1999 Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE
• Grapefruit juice activates P-glycoprotein-mediated drug transport.
  Pharmaceutical research 1999 Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ
• Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite.
  Biopharmaceutics & drug disposition 1999 Mizuma T, Benet LZ, Lin ET
• In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
  Pharmacology 1999 Zhang Y, Guo X, Lin ET, Benet LZ
• Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.
  Drug metabolism and disposition: the biological fate of chemicals 1999 Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U
• Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.
  Xenobiotica; the fate of foreign compounds in biological systems 1999 Salphati L, Benet LZ
• Molecular and physical mechanisms of first-pass extraction.
  Drug metabolism and disposition: the biological fate of chemicals 1999 Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA
• Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum.
  Pharmaceutical research 1999 Flanagan SD, Benet LZ
• Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.
  Journal of chromatography. B, Biomedical sciences and applications 1998 Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U
• Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women.
  Journal of clinical pharmacology 1998 Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ
• Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
  Journal of pharmaceutical sciences 1998 Wacher VJ, Silverman JA, Zhang Y, Benet LZ
• High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide.
  Journal of chromatography. B, Biomedical sciences and applications 1998 Mizuma T, Benet LZ, Lin ET
• Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers.
  Pharmaceutical research 1998 Zhang Y, Benet LZ
• Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.
  The Journal of pharmacology and experimental therapeutics 1998 Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ
• Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation.
  Transplantation proceedings 1998 Benet LZ
• Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.
  The Journal of biological chemistry 1998 Qiu Y, Benet LZ, Burlingame AL
• Effects of ketoconazole on digoxin absorption and disposition in rat.
  Pharmacology 1998 Salphati L, Benet LZ
• Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.
  The Journal of pharmacology and experimental therapeutics 1998 Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U
• Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
  Drug metabolism and disposition: the biological fate of chemicals 1998 Zhang Y, Guo X, Lin ET, Benet LZ
• Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide.
  Drug metabolism and disposition: the biological fate of chemicals 1998 Mohri K, Okada K, Benet LZ
• Antiprogestin-mediated inactivation of cytochrome P450 3A4.
  Pharmacology 1998 Jang GR, Benet LZ
• Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry.
  Drug metabolism and disposition: the biological fate of chemicals 1998 Qiu Y, Burlingame AL, Benet LZ
• Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.
  Biochemical pharmacology 1998 Salphati L, Benet LZ
• Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides.
  Preparative biochemistry & biotechnology 1998 Mizuma T, Benet LZ, Lin ET
• Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use.
  Journal of pharmacokinetics and biopharmaceutics 1997 Jang GR, Benet LZ
• Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone.
  Drug metabolism and disposition: the biological fate of chemicals 1997 Jang GR, Benet LZ
• Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine.
  Clinical pharmacology and therapeutics 1997 Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB
• Tacrolimus oral bioavailability doubles with coadministration of ketoconazole.
  Clinical pharmacology and therapeutics 1997 Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF
• Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo.
  The Journal of pharmacology and experimental therapeutics 1997 Yuan R, Sumi M, Benet LZ
• Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection.
  Journal of chromatography. B, Biomedical sciences and applications 1997 Wu ST, Benet LZ, Lin ET
• Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization.
  Journal of chromatography. B, Biomedical sciences and applications 1997 Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET
• Evaluation of orally administered highly variable drugs and drug formulations.
  Pharmaceutical research 1996 Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL
• Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus.
  Journal of clinical pharmacology 1996 Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH
• Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.
  British journal of clinical pharmacology 1996 Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ
• Morality play.
  Science (New York, N.Y.) 1996 Benet LZ
• Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.
  Biochemical pharmacology 1996 Jang GR, Wrighton SA, Benet LZ
• In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance.
  The Journal of pharmacology and experimental therapeutics 1996 Haj-Yehia AI, Benet LZ
• Acute dose-dependent disposition studies of nicotinic acid in rats.
  Drug metabolism and disposition: the biological fate of chemicals 1996 Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ
• Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases.
  Biochemical pharmacology 1996 Kenkare SR, Benet LZ
• Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression.
  Xenobiotica; the fate of foreign compounds in biological systems 1996 Berg-Candolfi M, Candolfi E, Benet LZ
• The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics.
  Clinical pharmacology and therapeutics 1996 Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ
• Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes.
  Xenobiotica; the fate of foreign compounds in biological systems 1996 Jaeger W, Benet LZ, Bornheim LM
• The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers.
  Clinical pharmacology and therapeutics 1996 Chang T, Benet LZ, Hebert MF
• Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine.
  Clinical pharmacology and therapeutics 1995 Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ
• Kidney function and age are both predictors of pharmacokinetics of metformin.
  Journal of clinical pharmacology 1995 Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG
• Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac.
  The Biochemical journal 1995 Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ
• Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation.
  Journal of clinical pharmacology 1995 d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ
• Stereoselective disposition of naproxen glucuronide in the rat.
  Drug metabolism and disposition: the biological fate of chemicals 1995 Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ
• Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin.
  Drug metabolism and disposition: the biological fate of chemicals 1995 Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ
• Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.
  Drug metabolism and disposition: the biological fate of chemicals 1995 Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ
• Gender effects in pharmacokinetics and pharmacodynamics.
  Drugs 1995 Harris RZ, Benet LZ, Schwartz JB
• Stereoselective binding properties of naproxen glucuronide diastereomers to proteins.
  Journal of pharmacokinetics and biopharmaceutics 1995 Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ
• Bioequivalence and narrow therapeutic index drugs.
  Pharmacotherapy 1995 Benet LZ, Goyan JE
• Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.
  Molecular carcinogenesis 1995 Wacher VJ, Wu CY, Benet LZ
• The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine.
  Clinical pharmacology and therapeutics 1995 Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ
• Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals.
  Biopharmaceutics & drug disposition 1995 Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ
• 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography.
  Journal of chromatography. B, Biomedical applications 1995 Haj-Yehia AI, Benet LZ
• Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats.
  The Journal of pharmacology and experimental therapeutics 1995 Haj-Yehia AI, Benet LZ
• Basic principles of pharmacokinetics.
  Toxicologic pathology 1995 Benet LZ, Zia-Amirhosseini P
• Biliary excretion of furosemide glucuronide in rabbits.
  Biological & pharmaceutical bulletin 1995 Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ
• Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry.
  Drug metabolism and disposition: the biological fate of chemicals 1995 Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ
• Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution.
  Biological & pharmaceutical bulletin 1995 Sekikawa H, Yagi N, Lin ET, Benet LZ
• Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole.
  Pharmaceutical research 1995 Haj-Yehia AI, Benet LZ
• Hypersensitivity to nonsteroidal anti-inflammatory drugs.
  Nature medicine 1995 Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ
• Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase.
  Biochemical pharmacology 1994 Kenkare SR, Han C, Benet LZ
• Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction.
  Journal of chromatography. B, Biomedical applications 1994 Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ
• HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes.
  Pharmaceutical research 1994 Perotti BY, Prueksaritanont T, Benet LZ
• Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro.
  Xenobiotica; the fate of foreign compounds in biological systems 1994 Ojingwa JC, Spahn-Langguth H, Benet LZ
• Menopause: pharmacodynamics and pharmacokinetics.
  Experimental gerontology 1994 Gustavson LE, Benet LZ
• Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration.
  Biopharmaceutics & drug disposition 1994 Han C, Jung P, Sanders SW, Lin ET, Benet LZ
• Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.
  Journal of clinical pharmacology 1994 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH
• Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma.
  Journal of pharmacokinetics and biopharmaceutics 1994 Ojingwa JC, Spahn-Langguth H, Benet LZ
• Bioactivation by glucuronide-conjugate formation.
  Advances in pharmacology (San Diego, Calif.) 1994 Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ
• Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing.
  Clinical pharmacology and therapeutics 1994 Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ
• FK 506 metabolism in male and female rat liver microsomes.
  Drug metabolism and disposition: the biological fate of chemicals 1994 Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ
• Pharmacokinetic profile of etodolac in special populations.
  European journal of rheumatology and inflammation 1994 Benet LZ
• Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients.
  Journal of clinical pharmacology 1994 Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ
• Pharmacokinetics--a relevant factor for the choice of a drug?
  Alimentary pharmacology & therapeutics 1994 Benet LZ, Zech K
• Pharmacokinetics and irreversible binding of tolmetin and its glucuronic acid esters in the elderly.
  Pharmacology 1993 Munafo A, Hyneck ML, Benet LZ
• Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies.
  Journal of pharmacokinetics and biopharmaceutics 1993 Lee FW, Salmonson T, Benet LZ
• Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers.
  Journal of pharmacokinetics and biopharmaceutics 1993 Gumbleton M, Benet LZ
• Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips.
  Biochemical pharmacology 1993 Kenkare SR, Benet LZ
• Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A.
  Drug metabolism and disposition: the biological fate of chemicals 1993 Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ
• Interpretation and utilization of effect and concentration data collected in an in vivo pharmacokinetic and in vitro pharmacodynamic study.
  Pharmaceutical research 1993 Gupta SK, Hwang SS, Benet LZ, Gumbleton M
• Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ
• Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides.
  Pharmacology 1993 Spahn-Langguth H, Benet LZ
• Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.
  Journal of pharmacokinetics and biopharmaceutics 1993 Lee FW, Hu J, Metzler CH, Benet LZ
• New techniques in drug metabolism and clinical pharmacology/pharmacokinetics.
  American biotechnology laboratory 1993 Benet LZ
• In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers.
  Chirality 1993 Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H
• Pharmacokinetics of sustained-release etodolac.
  Rheumatology international 1993 Benet LZ
• Predictability of the covalent binding of acidic drugs in man.
  Life sciences 1993 Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET
• Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins.
  Clinical pharmacology and therapeutics 1992 Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF
• Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction.
  Clinical pharmacology and therapeutics 1992 Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ
• Glutathione S-transferase-mediated metabolism of glyceryl trinitrate in subcellular fractions of bovine coronary arteries.
  Pharmaceutical research 1992 Lau DT, Chan EK, Benet LZ
• Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.
  Anesthesiology 1992 Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J
• Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites.
  Journal of chromatography 1992 Han C, Gumbleton M, Lau DT, Benet LZ
• Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions.
  Drug metabolism and disposition: the biological fate of chemicals 1992 Prueksaritanont T, Hoener BA, Benet LZ
• Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.
  Journal of pharmaceutical sciences 1992 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH
• Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.
  Pharmaceutical research 1992 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH
• Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation.
  Biochemical pharmacology 1992 Lau DT, Benet LZ
• Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids.
  Biochemical pharmacology 1992 Prueksaritanont T, Koike M, Hoener BA, Benet LZ
• Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.
  Clinical pharmacology and therapeutics 1992 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH
• Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement.
  Pharmaceutical research 1992 Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH
• Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin.
  Pharmaceutical research 1992 Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH
• Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?
  Drug metabolism reviews 1992 Spahn-Langguth H, Benet LZ
• The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity.
  Pharmacology 1992 Hale VG, Benet LZ
• Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein.
  Drug metabolism and disposition: the biological fate of chemicals 1991 Volland C, Sun H, Dammeyer J, Benet LZ
• Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes.
  Journal of pharmacokinetics and biopharmaceutics 1991 Hale VG, Aizawa K, Sheiner LB, Benet LZ
• Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro.
  Pharmaceutical research 1991 Kikkoji T, Gumbleton M, Higo N, Guy RH, Benet LZ
• Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
  Drug metabolism and disposition: the biological fate of chemicals 1991 Iwakawa S, Spahn H, Benet LZ, Lin ET
• Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations.
  Biopharmaceutics & drug disposition 1991 Hammarlund-Udenaes M, Benet LZ
• Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat.
  Pharmaceutical research 1991 Nakashima E, Lau DT, Benet LZ
• Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations.
  Pharmaceutical research 1991 Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ
• Stereoselective disposition of ketoprofen in rats.
  Drug metabolism and disposition: the biological fate of chemicals 1991 Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET
• Drug metabolism and laboratory anesthetic protocols in the rat: examination of antipyrine pharmacokinetics.
  Pharmaceutical research 1991 Gumbleton M, Benet LZ
• Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat.
  Biopharmaceutics & drug disposition 1991 Lau DT, Gumbleton M, Labisch C, Benet LZ
• Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist.
  DICP : the annals of pharmacotherapy 1991 Benet LZ
• Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers.
  British journal of clinical pharmacology 1991 Gumbleton M, Benet LZ
• In vitro enantioselective glucuronidation of fenoprofen.
  Pharmacology 1991 Volland C, Benet LZ
• Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver.
  Drug metabolism and disposition: the biological fate of chemicals 1991 Hale VG, Benet LZ
• Safety and pharmacokinetics: colloidal bismuth subcitrate.
  Scandinavian journal of gastroenterology. Supplement 1991 Benet LZ
• Stereoselective analysis of fenoprofen and its metabolites.
  Journal of chromatography 1990 Volland C, Sun H, Benet LZ
• Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs.
  The Journal of pharmacology and experimental therapeutics 1990 Lee FW, Salmonson T, Metzler CH, Benet LZ
• Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism.
  Drug metabolism and disposition: the biological fate of chemicals 1990 Smith PC, Benet LZ, McDonagh AF
• Report of the workshop on in vitro and in vivo testing and correlation for oral controlled/modified-release dosage forms.
  Journal of pharmaceutical sciences 1990 Skelley JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A
• Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up.
  Transplantation proceedings 1990 Manfro RC, Pohanka E, Tomlanovich SJ, Benet LZ, Salvatierra O, Garovoy MR
• Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration.
  Journal of clinical pharmacology 1990 Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ
• Nitroglycerin metabolism in subcellular fractions of rabbit liver. Dose dependency of glyceryl dinitrate formation and possible involvement of multiple isozymes of glutathione S-transferases.
  Drug metabolism and disposition: the biological fate of chemicals 1990 Lau DT, Benet LZ
• Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses.
  Clinical pharmacology and therapeutics 1990 Nakashima E, Rigod JF, Lin ET, Benet LZ
• Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene.
  Biopharmaceutics & drug disposition 1990 Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ
• Fetal uptake of intraamniotic digoxin in sheep.
  Pediatric research 1990 Hamamoto K, Iwamoto HS, Roman CM, Benet LZ, Rudolph AM
• Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin.
  Biochemical pharmacology 1990 Iwakawa S, Spahn H, Benet LZ, Lin ET
• Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods.
  Developmental pharmacology and therapeutics 1990 Wang LH, Rudolph AM, Benet LZ
• Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.
  The Journal of pharmacology and experimental therapeutics 1990 Smith PC, McDonagh AF, Benet LZ
• High-fat meals increase the clearance of cyclosporine.
  Pharmaceutical research 1990 Gupta SK, Benet LZ
• Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro.
  Pharmaceutical research 1990 Munafo A, McDonagh AF, Smith PC, Benet LZ
• The effect of acetaminophen on zidovudine metabolism in HIV-infected patients.
  Journal of acquired immune deficiency syndromes 1990 Steffe EM, King JH, Inciardi JF, Flynn NF, Goldstein E, Tonjes TS, Benet LZ
• An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment.
  Journal of pharmacokinetics and biopharmaceutics 1989 Nakashima E, Benet LZ
• Pharmacokinetics of nicotinic acid-salicylic acid interaction.
  Clinical pharmacology and therapeutics 1989 Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ
• Absorption kinetics of cyclosporine in healthy volunteers.
  Biopharmaceutics & drug disposition 1989 Gupta SK, Benet LZ
• Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs.
  Journal of pharmacokinetics and biopharmaceutics 1989 Watari N, Benet LZ
• Simultaneous measurement of prednisone, prednisolone and 6 beta-hydroxyprednisolone in urine by high-performance liquid chromatography using dexamethasone as the internal standard.
  Journal of chromatography 1989 Teng RL, Benet LZ
• Application of clearance concepts to the assessment of exposure to lead in drinking water.
  American journal of public health 1989 Bois FY, Tozer TN, Zeise L, Benet LZ
• Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man.
  Drug metabolism and disposition: the biological fate of chemicals 1989 Iwakawa S, Suganuma T, Lee SF, Spahn H, Benet LZ, Lin ET
• Lead exposure in children vs adults.
  American journal of public health 1989 Bois FY, Tozer TN, Benet LZ, Zeise L
• Prediction of the distribution volumes of cefazolin and tobramycin in obese children based on physiological pharmacokinetic concepts.
  Pharmaceutical research 1989 Koshida R, Nakashima E, Taniguchi N, Tsuji A, Benet LZ, Ichimura F
• Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study.
  Clinical pharmacology and therapeutics 1989 Spahn H, Spahn I, Benet LZ
• Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats.
  Journal of pharmacokinetics and biopharmaceutics 1989 Gloff CA, Benet LZ
• Cyclosporin A and prednisolone: an additive inhibitory effect of cell proliferation and interleukin-2 production.
  Transplantation proceedings 1989 Manfro RC, Pohanka E, Tomlanovich S, Benet LZ, Garovoy MR
• Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver.
  Biochemical pharmacology 1989 Lau DT, Benet LZ
• Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update.
  Journal of pharmacokinetics and biopharmaceutics 1989 Hammarlund-Udenaes M, Benet LZ
• Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides.
  Pharmaceutical research 1989 Spahn H, Iwakawa S, Lin ET, Benet LZ
• Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component.
  Journal of chromatography 1988 Spahn H, Spahn I, Pflugmann G, Mutschler E, Benet LZ
• Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing.
  Biopharmaceutics & drug disposition 1988 Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH
• General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment.
  Journal of pharmacokinetics and biopharmaceutics 1988 Nakashima E, Benet LZ
• Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite.
  Journal of chromatography 1988 Gawienowski M, Benet LZ, Fleckenstein L, Lin ET
• Disposition and irreversible plasma protein binding of tolmetin in humans.
  Clinical pharmacology and therapeutics 1988 Hyneck ML, Smith PC, Munafo A, McDonagh AF, Benet LZ
• Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics.
  Clinical pharmacology and therapeutics 1988 Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ
• Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection.
  Journal of chromatography 1988 Lee FW, Watari N, Rigod J, Benet LZ
• Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide.
  Drug metabolism and disposition: the biological fate of chemicals 1988 Hyneck ML, Munafo A, Benet LZ
• Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport.
  Pharmacology 1988 Gloff CA, Mamelok RD, Benet LZ
• High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine.
  Journal of chromatography 1987 Hyneck ML, Smith PC, Unseld E, Benet LZ
• Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration.
  Clinical pharmacology and therapeutics 1987 Noonan PK, Benet LZ
• Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products.
  Pharmaceutical research 1987 Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ
• Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin.
  Journal of pharmacokinetics and biopharmaceutics 1987 Nakashima E, Noonan PK, Benet LZ
• Pharmacokinetics and excretion of unique beta-adrenergic agonists.
  Pharmacology 1987 Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N
• Developmental alterations in hepatic UDP-glucuronosyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs.
  Biochemical pharmacology 1986 Wang LH, Zakim D, Rudolph AM, Benet LZ
• AAPS and pharmaceutical research.
  Pharmaceutical research 1986 Benet LZ
• Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function.
  Clinical pharmacology and therapeutics 1986 Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ
• Characterization of the isomeric esters of zomepirac glucuronide by proton NMR.
  Drug metabolism and disposition: the biological fate of chemicals 1986 Smith PC, Benet LZ
• Ethambutol kinetics in patients with impaired renal function.
  The American review of respiratory disease 1986 Varughese A, Brater DC, Benet LZ, Lee CS
• Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit.
  The Journal of pharmacology and experimental therapeutics 1986 Wang LH, Rudolph AM, Benet LZ
• High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride.
  Journal of chromatography 1986 Shi RJ, Benet LZ, Lin ET
• Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives.
  Clinical pharmacology and therapeutics 1986 Legler UF, Benet LZ
• Irreversible binding of zomepirac to plasma protein in vitro and in vivo.
  The Journal of clinical investigation 1986 Smith PC, McDonagh AF, Benet LZ
• The bioavailability of oral nitroglycerin.
  Journal of pharmaceutical sciences 1986 Noonan PK, Benet LZ
• Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis.
  Journal of pharmaceutical sciences 1986 Sörgel F, Ettinger B, Benet LZ
• Impairment of prednisolone disposition in women taking oral contraceptives or conjugated estrogens.
  The Journal of clinical endocrinology and metabolism 1986 Gustavson LE, Legler UF, Benet LZ
• The effect of prednisone and hydrocortisone on the plasma protein binding of prednisolone in man.
  European journal of clinical pharmacology 1986 Legler UF, Benet LZ
• The macromolecular binding of prednisone in plasma of healthy volunteers including pregnant women and oral contraceptive users.
  Journal of pharmacokinetics and biopharmaceutics 1985 Gustavson LE, Benet LZ
• Distribution and fate of acetaminophen conjugates in fetal lambs in utero.
  The Journal of pharmacology and experimental therapeutics 1985 Wang LH, Rudolph AM, Benet LZ
• Premarketing observational studies of population pharmacokinetics of new drugs.
  Clinical pharmacology and therapeutics 1985 Sheiner LB, Benet LZ
• Mean residence time in the body versus mean residence time in the central compartment.
  Journal of pharmacokinetics and biopharmaceutics 1985 Benet LZ
• Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac.
  Clinical pharmacology and therapeutics 1985 Smith PC, Langendijk PN, Bosso JA, Benet LZ
• Peptides and proteins as drugs.
  Pharmaceutical research 1985 Ferraiolo BL, Benet LZ
• Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers.
  Journal of pharmacokinetics and biopharmaceutics 1985 Noonan PK, Williams RL, Benet LZ
• Pharmacokinetics and metabolism of bepridil.
  The American journal of cardiology 1985 Benet LZ
• Immunosuppressive activity of prednisone and prednisolone and their metabolic interconversion in the mixed lymphocyte reaction.
  International journal of immunopharmacology 1985 Tsang SY, Garovoy MR, Benet LZ
• Incomplete and delayed bioavailability of sublingual nitroglycerin.
  The American journal of cardiology 1985 Noonan PK, Benet LZ
• Pharmacokinetics of drugs and metabolites in the maternal-placental-fetal unit: general principles.
  NIDA research monograph 1985 Wang LH, Rudolph AM, Benet LZ
• Stability of acyl glucuronides in blood, plasma, and urine: studies with zomepirac.
  Drug metabolism and disposition: the biological fate of chemicals 1985 Smith PC, Hasegawa J, Langendijk PN, Benet LZ
• Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered.
  Journal of pharmacokinetics and biopharmaceutics 1984 Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ
• Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide.
  The American journal of medicine 1984 Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ
• Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection.
  Journal of pharmaceutical sciences 1984 Noonan PK, Kanfer I, Riegelman S, Benet LZ
• Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine.
  Journal of pharmaceutical sciences 1984 Sörgel F, Lin ET, Hasegawa J, Benet LZ
• Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine.
  Journal of chromatography 1984 Langendijk PN, Smith PC, Hasegawa J, Benet LZ
• High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine.
  Journal of chromatography 1984 Smith PC, Benet LZ
• Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies.
  Pharmacology 1984 Chiang CW, Benet LZ
• Pharmacokinetic parameters: which are necessary to define a drug substance?
  European journal of respiratory diseases. Supplement 1984 Benet LZ
• Unchanged absorption of digoxin tablets in patients with cardiac failure.
  Pharmacology 1984 Meister W, Benowitz NL, Benet LZ
• Dose-dependent bioavailability of prazosin in beagle dogs.
  Journal of cardiovascular pharmacology 1983 Baughman RA, Sorgel F, Mico BA, Benet LZ
• Oral bioavailability and intravenous pharmacokinetics of amrinone in humans.
  Journal of pharmaceutical sciences 1983 Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J
• Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases.
  Journal of dental research 1983 Lozada F, Frey FJ, Benet LZ
• Furosemide assays and disposition in healthy volunteers and renal transplant patients.
  Federation proceedings 1983 Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG
• The bioavailability and disposition of tiodazosin levulinate in beagle dogs with a comparison to prazosin hydrochloride.
  Drug metabolism and disposition: the biological fate of chemicals 1983 Baughman RA, Mico BA, Benet LZ
• Biotransformation of furosemide in kidney transplant patients.
  European journal of clinical pharmacology 1983 Smith DE, Benet LZ
• Plasma protein binding of furosemide in kidney transplant patients.
  Journal of pharmacokinetics and biopharmaceutics 1982 Smith DE, Benet LZ
• Endogenous and exogenous glucocorticoids in cushingoid patients.
  Drug intelligence & clinical pharmacy 1982 Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM
• Disposition of zomepirac sodium in man.
  Journal of clinical pharmacology 1982 O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ
• Pharmacokinetics of triamterene and its metabolite in man.
  Journal of pharmacokinetics and biopharmaceutics 1982 Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ
• Prednisolone clearance at steady state in man.
  The Journal of clinical endocrinology and metabolism 1982 Legler UF, Frey FJ, Benet LZ
• Apparent intramolecular acyl migration of zomepirac glucuronide.
  Drug metabolism and disposition: the biological fate of chemicals 1982 Hasegawa J, Smith PC, Benet LZ
• Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography.
  Journal of chromatography 1982 Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ
• Determination of tiodazosin in plasma and whole blood by high-performance liquid chromatography.
  Journal of chromatography 1982 Mico BA, Baughman RA, Benet LZ
• Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction.
  Transplantation 1982 Frey BM, Frey FJ, Holford NH, Lozada F, Benet LZ
• Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol.
  Journal of pharmaceutical sciences 1982 Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ
• Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin.
  Journal of clinical pharmacology 1982 Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ
• Nonlinear plasma protein binding and haemodialysis clearance of prednisolone.
  European journal of clinical pharmacology 1982 Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ
• Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals.
  Journal of clinical pharmacology 1981 Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ
• Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone.
  The Journal of clinical endocrinology and metabolism 1981 Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ
• Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica.
  Journal of neurochemistry 1981 Mamelok RD, Macrae DR, Benet LZ, Prusiner SB
• Saturable kinetics of intravenous chlorothiazide in the rhesus monkey.
  Journal of pharmacokinetics and biopharmaceutics 1981 Gustafson JH, Benet LZ
• Furosemide kinetics and dynamics after kidney transplant.
  Clinical pharmacology and therapeutics 1981 Smith DE, Gambertoglio JG, Vincenti F, Benet LZ
• A standard approach to compiling clinical pharmacokinetic data.
  Journal of pharmacokinetics and biopharmaceutics 1981 Sheiner LB, Benet LZ, Pagliaro LA
• Dose-dependent kinetics of probenecid in rhesus monkeys-intravenous bolus studies.
  Pharmacology 1981 Chiang CW, Benet LZ
• Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients.
  European journal of clinical pharmacology 1981 Frey FJ, Amend WJ, Lozada F, Frey BM, Holford NH, Benet LZ
• Induction kinetics of human suppressor cells in the mixed lymphocyte reaction and influence of prednisolone on their genesis.
  Cellular immunology 1980 Frey BM, Frey FJ, Cochrum KC, Benet LZ
• Prednisolone clearance at steady state in dogs.
  The Journal of pharmacology and experimental therapeutics 1980 Frey FJ, Frey BM, Greither A, Benet LZ
• Renal excretion of pseudoephedrine.
  Clinical pharmacology and therapeutics 1980 Brater DC, Kaojarern S, Benet LZ, Lin ET, Lockwood T, Morris RC, McSherry EJ, Melmon KL
• High-performance liquid chromatographic determination of prazosin in human plasma, whole blood and urine.
  Journal of chromatography 1980 Lin ET, Baughman RA, Benet LZ
• Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay.
  Drug metabolism and disposition: the biological fate of chemicals 1980 Smith DE, Lin ET, Benet LZ
• Disposition kinetics of ethambutol in man.
  Journal of pharmacokinetics and biopharmaceutics 1980 Lee CS, Brater DC, Gambertoglio JG, Benet LZ
• Altered prazosin pharmacokinetics in congestive heart failure.
  European journal of clinical pharmacology 1980 Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL
• Preliminary evaluation of furosemide-probenecid interaction in humans.
  Journal of pharmaceutical sciences 1980 Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ
• Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol.
  Journal of pharmacokinetics and biopharmaceutics 1980 Lee CS, Marbury TC, Benet LZ
• Inhibition by indomethacin of the glycemic response to arginine in man.
  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1980 Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH
• Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review.
  Journal of pharmacokinetics and biopharmaceutics 1980 Gambertoglio JG, Amend WJ, Benet LZ
• Drug pharmacokinetics in cardiac and hepatic disease.
  Annual review of pharmacology and toxicology 1980 Williams RL, Benet LZ
• Renal excretion of pseudoephedrine in the rat.
  The Journal of pharmacology and experimental therapeutics 1979 Till AE, Benet LZ
• Cefamandole kinetics in uremic patients undergoing hemodialysis.
  Clinical pharmacology and therapeutics 1979 Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ
• Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey.
  Drug metabolism and disposition: the biological fate of chemicals 1979 Ding TL, Benet LZ
• Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma.
  Clinical chemistry 1979 Frey FJ, Frey BM, Benet LZ
• Attenuation of prazosin effect on cardiac output in chronic heart failure.
  Annals of internal medicine 1979 Arnold SB, Williams RL, Ports TA, Baughman RA, Benet LZ, Parmley WW, Chatterjee K
• Noncompartmental determination of the steady-state volume of distribution.
  Journal of pharmaceutical sciences 1979 Benet LZ, Galeazzi RL
• Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography.
  Journal of chromatography 1979 Ding TL, Benet LZ
• High-performance liquid chromatographic assays for furosemide in plasma and urine.
  Journal of chromatography 1979 Lin ET, Smith DE, Benet LZ, Hoener BA
• Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation.
  Journal of pharmacokinetics and biopharmaceutics 1979 Smith DE, Brater DC, Lin ET, Benet LZ
• Pharmacokinetics/pharmacodynamics of furosemide in man: a review.
  Journal of pharmacokinetics and biopharmaceutics 1979 Benet LZ
• Pharmacokinetics of furosemide in patients with congestive heart failure.
  Pharmacology 1979 Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K
• Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique.
  Pharmacology 1979 Till AE, Benet LZ
• Relationship between urinary excretion rate, steady-state plasma levels and diuretic response of furosemide in the rat.
  Pharmacology 1979 Smith DE, Benet LZ
• Effect of route of administration and distribution on drug action.
  Journal of pharmacokinetics and biopharmaceutics 1978 Benet LZ
• Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat.
  Anesthesiology 1978 Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL
• Micro and macro GLC determination of ethambutol in biological fluids.
  Journal of pharmaceutical sciences 1978 Lee CS, Benet LZ
• Pharmacokinetics of cefamandole using a HPLC assay.
  Journal of pharmacokinetics and biopharmaceutics 1978 Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ
• Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis.
  Journal of clinical pharmacology 1978 Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ
• Ascorbate stimulation of salicylate absorption in isolated rat intestine.
  Journal of pharmaceutical sciences 1978 Barnett G, Lockwood T, Arancibia A, Benet LZ
• The reversible biotransformation of N-acetylprocainamide in the rhesus monkey.
  Arzneimittel-Forschung 1978 Ding TL, Lin ET, Benet LZ
• Kinetics of oral ethambutol in the normal subject.
  Clinical pharmacology and therapeutics 1977 Lee CS, Gambertoglio JG, Brater DC, Benet LZ
• Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urine.
  Journal of chromatography 1977 Lin ET, Brater DC, Benet LZ
• The pharmacokinetics of d-tubocurarine in man with and without renal failure.
  The Journal of pharmacology and experimental therapeutics 1977 Miller RD, Matteo RS, Benet LZ, Sohn YJ
• Interpretation of plasma concentration-time curves after oral dosing.
  Journal of pharmaceutical sciences 1977 Ronfeld RA, Benet LZ
• Gas-liquid chromatographic determination of ethambutol in plasma and urine of man and monkey.
  Journal of chromatography 1976 Lee CS, Benet LZ
• Relationship between the pharmacokinetics and pharmacodynamics of procainamide.
  Clinical pharmacology and therapeutics 1976 Galeazzi RL, Benet LZ, Sheiner LB
• Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems.
  Journal of pharmacokinetics and biopharmaceutics 1976 Galeazzi RL, Benet LZ
• Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities.
  Journal of pharmaceutical sciences 1976 Gustafson JH, Schoenwald RD, Benet LZ
• Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.
  Journal of pharmacokinetics and biopharmaceutics 1975 Pagliaro LA, Benet LZ
• The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies.
  The American journal of digestive diseases 1975 Orr JM, Benet LZ
• An integrated approach to the pharmacokinetic analysis of drug absorption.
  Journal of pharmacokinetics and biopharmaceutics 1974 Till AE, Benet LZ, Kwan KC
• Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration.
  The Journal of pharmacy and pharmacology 1974 Gustafson JH, Benet LZ
• Use of the unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs.
  Journal of pharmacokinetics and biopharmaceutics 1974 Nayak RK, Benet LZ
• Clearance concepts in pharmacokinetics.
  Journal of pharmacokinetics and biopharmaceutics 1973 Rowland M, Benet LZ, Graham GG
• Drug transfer across intact rat intestinal mucosa following surgical removal of serosa and muscularis externa.
  Journal of pharmaceutical sciences 1973 Wolfe DL, Forland SC, Benet LZ
• Gastrointestinal absorption of iopanoic acid.
  Investigative radiology 1973 Nelson JA, Moss AA, Goldberg HI, Benet LZ, Amberg J
• General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.
  Journal of pharmaceutical sciences 1972 Benet LZ
• Drug transfer across rat intestinal musculature after edetic acid treatment.
  Journal of pharmaceutical sciences 1971 Nayak RK, Benet LZ
• Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis.
  Journal of pharmaceutical sciences 1971 Benet LZ, Turi JS
• Effect of buffer constituents and time on drug transfer across in vitro rat intestine.
  Journal of pharmaceutical sciences 1971 Benet LZ, Orr JM, Turner RH, Webb HS
• Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies.
  Journal of pharmaceutical sciences 1970 Turner RH, Mehta CS, Benet LZ
• Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics.
  Journal of pharmaceutical sciences 1970 Rowland M, Benet LZ, Riegelman S
• Volume terms in pharmacokinetics.
  Journal of pharmaceutical sciences 1969 Benet LZ, Ronfeld RA
• Potentiometric determination of dissociation constants.
  Journal of pharmaceutical sciences 1967 Benet LZ, Goyan JE
• Thermodynamics of chelation by tetracyclines.
  Journal of pharmaceutical sciences 1966 Benet LZ, Goyan JE
• Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates.
  Journal of pharmaceutical sciences 1966 Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN
• Nonlogarithmic titration curves for the determination of dissociation constants and purity.
  Journal of pharmaceutical sciences 1965 Benet LZ, Goyan JE
• Determination of the stability constants of tetracycline complexes.
  Journal of pharmaceutical sciences 1965 Benet LZ, Goyan JE