Lenore Pereira, PhD
Professor Emeritus
Cell and Tissue Biology
School of Dentistry

Grants and Projects

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• Fetal HCMV Infection: Role of the Human Placenta, NIH, 2000-2019
• Fetal Zika virus infection: role of the human placenta, NIH, 2016-2018
• HCMV infection of human placental trophoblast and hematopoietic progenitors, NIH, 2012-2014
• HCMV infection and immune modulation in a human placentation model in SCID mice, NIH, 2010-2012
• Congenital CMV Conference: Education, Prevention and Treatment, NIH, 2008-2009
• Compensatory placental development after treatment for congenital CMV infection, NIH, 2008-2009
• Fetal CMV Infection: Role of the Human Placenta, NIH, 2000-2006
• Human Placental CMV Infection: Global Gene Expression, NIH, 2002-2005
• Role of Cmv Envelope Glycoproteins in Polarized Cells, NIH, 2001-2005
• Cmv Accessory Genes and Retinal Cell Infection, NIH, 1995-2000
• Human Cmv Infection of Retinal Cells, NIH, 1993-1999
• Cellular and Viral Protein Interactions in Hsv Infection, NIH, 1987-1996
• Interaction of Cmv with Host Cells, NIH, 1985-1991
• Glycoprotein Gb of Hsv--Oral Pathogen, NIH, 1987-1990
• Cellular and Molecular Biology Equipment, NIH, 1988-1989

Publications (34)

Top publication keywords:
PlacentationVirus ReplicationCytomegalovirusTrophoblastsZika Virus InfectionZika VirusVirus DiseasesPregnancy Trimester, FirstReceptors, VirusCytomegalovirus InfectionsDeciduaPregnancy Complications, InfectiousInfectious Disease Transmission, VerticalAntibodies, NeutralizingPlacenta

• Neutralizing Antibodies to Human Cytomegalovirus Recombinant Proteins Reduce Infection in an Ex Vivo Model of Developing Human Placentas.
  Vaccines 2022 Tabata T, Petitt M, Li J, Chi X, Chen W, Yurgelonis I, Wellnitz S, Bredl S, Vicente T, Yang X, Dormitzer PR, Pereira L
• Zika Virus Nonstructural Protein 1 Disrupts Glycosaminoglycans and Causes Permeability in Developing Human Placentas.
  The Journal of infectious diseases 2020 Puerta-Guardo H, Tabata T, Petitt M, Dimitrova M, Glasner DR, Pereira L, Harris E
• Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas.
  Vaccines 2019 Tabata T, Petitt M, Fang-Hoover J, Freed DC, Li F, An Z, Wang D, Fu TM, Pereira L
• Survey of cellular immune responses to human cytomegalovirus infection in the microenvironment of the uterine-placental interface.
  Medical microbiology and immunology 2019 Tabata T, Petitt M, Fang-Hoover J, Pereira L
• Congenital Viral Infection: Traversing the Uterine-Placental Interface.
  Annual review of virology 2018 Pereira L

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• Zika Virus Replicates in Proliferating Cells in Explants From First-Trimester Human Placentas, Potential Sites for Dissemination of Infection.
  The Journal of infectious diseases 2018 Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Harris E, Pereira L
• Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo.
  Current opinion in virology 2017 Petitt M, Tabata T, Puerta-Guardo H, Harris E, Pereira L
• Congenital cytomegalovirus infection undermines early development and functions of the human placenta.
  Placenta 2017 Pereira L, Tabata T, Petitt M, Fang-Hoover J
• Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta.
  The American journal of pathology 2016 Tabata T, Petitt M, Fang-Hoover J, Zydek M, Pereira L
• Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission.
  Cell host & microbe 2016 Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, Harris E, Pereira L
• Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
  Journal of virology 2015 Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar LM, Pereira L
• A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types.
  Antimicrobial agents and chemotherapy 2014 Kauvar LM, Liu K, Park M, DeChene N, Stephenson R, Tenorio E, Ellsworth SL, Tabata T, Petitt M, Tsuge M, Fang-Hoover J, Adler SP, Cui X, McVoy MA, Pereira L
• HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex.
  Viruses 2014 Zydek M, Petitt M, Fang-Hoover J, Adler B, Kauvar LM, Pereira L, Tabata T
• Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets.
  mAbs 2014 McCutcheon KM, Gray J, Chen NY, Liu K, Park M, Ellsworth S, Tripp RA, Tompkins SM, Johnson SK, Samet S, Pereira L, Kauvar LM
• Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection.
  The Journal of infectious diseases 2014 Pereira L, Petitt M, Fong A, Tsuge M, Tabata T, Fang-Hoover J, Maidji E, Zydek M, Zhou Y, Inoue N, Loghavi S, Pepkowitz S, Kauvar LM, Ogunyemi D
• Enveloped virus-like particle expression of human cytomegalovirus glycoprotein B antigen induces antibodies with potent and broad neutralizing activity.
  Clinical and vaccine immunology : CVI 2013 Kirchmeier M, Fluckiger AC, Soare C, Bozic J, Ontsouka B, Ahmed T, Diress A, Pereira L, Schödel F, Plotkin S, Dalba C, Klatzmann D, Anderson DE
• Cytomegalovirus infection and antibody protection of the developing placenta.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013 Pereira L, Petitt M, Tabata T
• Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model.
  The American journal of pathology 2012 Tabata T, Petitt M, Fang-Hoover J, Rivera J, Nozawa N, Shiboski S, Inoue N, Pereira L
• Have we overlooked congenital cytomegalovirus infection as a cause of stillbirth?
  The Journal of infectious diseases 2011 Pereira L
• Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection.
  The American journal of pathology 2010 Maidji E, Nigro G, Tabata T, McDonagh S, Nozawa N, Shiboski S, Muci S, Anceschi MM, Aziz N, Adler SP, Pereira L
• Screening for cytomegalovirus during pregnancy.
  American journal of obstetrics and gynecology 2010 Adler SP, Nigro G, Pereira L
• Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream.
  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2009 Nozawa N, Fang-Hoover J, Tabata T, Maidji E, Pereira L
• Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
  The American journal of pathology 2008 Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L
• Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge.
  Current topics in microbiology and immunology 2008 Pereira L, Maidji E
• Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta.
  Journal of virology 2007 Maidji E, Genbacev O, Chang HT, Pereira L
• Recent advances in the prevention and treatment of congenital cytomegalovirus infections.
  Seminars in perinatology 2007 Adler SP, Nigro G, Pereira L
• Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term.
  Endocrinology 2006 Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ
• Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis.
  The American journal of pathology 2006 Maidji E, McDonagh S, Genbacev O, Tabata T, Pereira L
• Patterns of human cytomegalovirus infection in term placentas: a preliminary analysis.
  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006 McDonagh S, Maidji E, Chang HT, Pereira L
• Insights into viral transmission at the uterine-placental interface.
  Trends in microbiology 2005 Pereira L, Maidji E, McDonagh S, Tabata T
• Viral and bacterial pathogens at the maternal-fetal interface.
  The Journal of infectious diseases 2004 McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L
• Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro.
  Journal of virology 2004 Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L
• Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity.
  Journal of virology 2003 Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S
• Transmission of human cytomegalovirus from infected uterine microvascular endothelial cells to differentiating/invasive placental cytotrophoblasts.
  Virology 2002 Maidji E, Percivalle E, Gerna G, Fisher S, Pereira L