Lennart Mucke, MD
Professor
Neurology
School of Medicine
lennart.mucke@gladstone.ucsf.edu 415-734-2504
Areas of investigation
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We study processes that result in memory loss and other major neurological deficits, with an emphasis on Alzheimerís disease (AD) and related neurodegenerative disorders. Our long-term goal is to advance the understanding of the healthy and the diseased central nervous system to a point where rational strategies can be developed for the prevention and cure of these conditions.
Significance Molecules similar to those involved in neurodegenerative diseases are highly expressed in the nervous system of diverse species and appear to function in learning, synaptic plasticity, and regeneration. We are particularly curious about the roles of amyloid precursor proteins and apolipoprotein E in AD, and a-synuclein in Parkinsonís disease (PD). AD and PD are the most frequent neurodegenerative disorders. They erode peopleís ability to think and control their movements, two of the most critical and intriguing functions of the central nervous system. Both conditions are on the rise and neither can be prevented or cured. These facts underline the significance and urgency of our research efforts.
Approaches We use transgenic mouse models and neural cultures to study potential pathogenic factors and pathways at the molecular, cellular, network, and behavioral level. Mouse models are also used to develop and evaluate novel treatment strategies. Their relevance is assessed through comparative studies of humans and postmortem tissues in collaboration with clinical programs.
Contributions In AD-related transgenic models, we discovered that amyloid-ß peptides (Aß) can damage synapses and disrupt neural memory circuits independent of their deposition into the visible amyloid plaques that form in AD brains. The plaque-independent toxicity of Aß was inhibited by apolipoprotein E3, but not E4, which may relate to the differential effects of these molecules on AD risk and age of onset. Pathogenic interactions between Aß and a-synuclein worsened cognitive and motor deficits in doubly transgenic mice, a finding of potential relevance to the frequent overlap between AD and PD. Most recently, we discovered that neural network activity in AD-related mouse models fluctuates between abnormal excitation (epilepsy-like) and abnormal inhibition. Remarkably, reducing the protein tau effectively prevented these alterations as well as Aß-induced cognitive deficits. Ongoing studies aim to determine whether such network dysfunction also contributes to cognitive deficits in AD.
Some questions addressed in ongoing studies
How does Aß affect synaptic function and neuronal survival? How does tau reduction make the brain resistant against Aß-induced deficits? Can the beneficial effect of tau reduction be exploited therapeutically? Which drugs can block the aberrant network activity that Aß triggers? Will these drugs also normalize cognitive functions and prevent neurological decline in AD? What can the selective vulnerability of specific neuronal populations to different neurodegenerative disorders teach us about the uniqueness of the affected cells and the pathogenic cascades involved?
Websites
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- Mucke Lab (muckelab.com)
- Gladstone Institute of Neurological Disease (gladstone.org)
- Lennart Mucke profile at Gladstone Institute of Neurological Disease (gladstone.org)
Grants and Projects
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- Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease, NIH, 2021-2026
- Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis, NIH, 2019-2024
- Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis, NIH/NIA, 2019-2024
- Therapeutic Potential and Mechanisms of Tau Reduction in Autism Models, NIH, 2018-2023
- Evolving CRISPR-based platforms for the discovery of Alzheimer relevant neurodegenerative pathways, NIH, 2020-2022
- Effect of Aging on Efficacy of Alzheimer-focused Therapeutic Strategies, NIH, 2016-2021
- Effect of Aging on Efficacy of Alzheimer-focused Therapeutic Strategies, NIH, 2016-2021
- Identification and Development of Tau-Lowering Small-Molecule Drugs, NIH, 2019-2021
- Contribution of DNA Repair Deficits to Alzheimer Pathogenesis, NIH, 2016-2021
- Neurobiology and Therapeutic Potential of Klotho, NIH, 2014-2019
- Synaptic Dysfunction Affecting DNA Integrity in Alzheimer's Disease, NIH, 1992-2019
- New Approaches to Dementia Heterogeneity, NIH, 2004-2019
- Behavioral Core, NIH, 2011-2016
- Kinases Linking Abeta and Tau to Synaptic Dysfunction, NIH, 2001-2016
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- Proteinopathies of the Aging Central Nervous System, NIH, 2003-2013
- Transgenic Models to Study Alzheimer's Disease, NIH, 1992-2013
- Mouse Models with Regulatable Cell Type-specific Expression of Anti-Tau shRNAs, NIH, 2011-2013
- Novel Therapeutic Approaches to Alzheimer's Disease, NIH, 2009-2012
- Aging Disease--Prion/Transgenic/Immunologic Studies, NIH, 1983-2009
- A Beta Vaccination: Mechanisms and Therapautic Impact, NIH, 2001-2007
- Aids Dementia--Molecular and Cellular Mechanisms, NIH, 1990-2001
- Therapeutic Targets in Transgenic Mice, NIH, 1997-2001
- Transgenic Models to Study Aids Dementia Complex, NIH, 1995-2000
- In Vivo Cns Effects of Hiv1 Coat Proteins and Nef, NIH, 1994-1998
Publications (170)
Top publication keywords:
GlucuronidaseAmyloid beta-Protein PrecursorAstrocytesAmyloid beta-PeptidesAlzheimer DiseaseBrainMiceMice, TransgenicNeuronstau ProteinsSynapsesMaze LearningNerve NetPlaque, AmyloidEpilepsies, Myoclonic
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CHOIR improves significance-based detection of cell types and states from single-cell data.
bioRxiv : the preprint server for biology 2024 Petersen C, Mucke L, Corces MR -
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
Neurobiology of disease 2023 Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT, Mucke L -
TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model.
Science translational medicine 2022 Shao E, Chang CW, Li Z, Yu X, Ho K, Zhang M, Wang X, Simms J, Lo I, Speckart J, Holtzman J, Yu GQ, Roberson ED, Mucke L -
Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.
JAMA neurology 2021 Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, … -
Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony.
Cell reports 2021 Chang CW, Evans MD, Yu X, Yu GQ, Mucke L
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Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models.
iScience 2021 Das M, Mao W, Shao E, Tamhankar S, Yu GQ, Yu X, Ho K, Wang X, Wang J, Mucke L -
Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice.
eNeuro 2021 Gulbranson DR, Ho K, Yu GQ, Yu X, Das M, Shao E, Kim D, Zhang WJ, Choudhary K, Thomas R, Mucke L -
Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies.
Science (New York, N.Y.) 2021 Chang CW, Shao E, Mucke L -
Tau: Enabler of diverse brain disorders and target
of rapidly evolving therapeutic strategies
Science 2021 Che-Wei Chang, Eric Shao, Lennart Mucke -
Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
Molecular neurodegeneration 2020 Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L -
A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.
Science translational medicine 2020 Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris … -
Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.
eLife 2020 Díaz-Alonso J, Morishita W, Incontro S, Simms J, Holtzman J, Gill M, Mucke L, Malenka RC, Nicoll RA -
Tau Reduction Prevents Key Features of Autism in Mouse Models.
Neuron 2020 Tai C, Chang CW, Yu GQ, Lopez I, Yu X, Wang X, Guo W, Mucke L -
Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease.
Acta neuropathologica communications 2019 Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L -
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Neuron 2019 Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K -
Klotho controls the brain-immune system interface in the choroid plexus.
Proceedings of the National Academy of Sciences of the United States of America 2018 Zhu L, Stein LR, Kim D, Ho K, Yu GQ, Zhan L, Larsson TE, Mucke L -
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
Nature immunology 2018 Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, … -
The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease.
Wellcome open research 2018 Tosh JL, Rickman M, Rhymes E, Norona FE, Clayton E, Mucke L, Isaacs AM, Fisher EMC, Wiseman FK -
The mouse as a model for neuropsychiatric drug development.
Current biology : CB 2018 Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ -
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Cell 2018 Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, … -
Neuronal levels and sequence of tau modulate the power of brain rhythms.
Neurobiology of disease 2018 Das M, Maeda S, Hu B, Yu GQ, Guo W, Lopez I, Yu X, Tai C, Wang X, Mucke L -
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.
Neuron 2018 Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ -
Istradefylline reduces memory deficits in aging mice with amyloid pathology.
Neurobiology of disease 2017 Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L -
Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.
Molecular neurodegeneration 2017 Miyamoto T, Stein L, Thomas R, Djukic B, Taneja P, Knox J, Vossel K, Mucke L -
Network abnormalities and interneuron dysfunction in Alzheimer disease.
Nature reviews. Neuroscience 2016 Palop JJ, Mucke L -
Incidence and impact of subclinical epileptiform activity in Alzheimer's disease.
Annals of neurology 2016 Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, … -
Tau Phosphorylation-Much More than a Biomarker.
Neuron 2016 Maeda S, Mucke L -
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
EMBO reports 2016 Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L -
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
Nature communications 2015 Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L -
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
The Journal of biological chemistry 2015 Miyamoto T, Kim D, Knox JA, Johnson E, Mucke L -
Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
Annals of clinical and translational neurology 2015 Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L -
Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.
Nature neuroscience 2015 Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L -
Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
The Journal of cell biology 2015 Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L -
Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.
Cell death & disease 2015 Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K -
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L -
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
Nature neuroscience 2015 Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L -
Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.
PloS one 2014 Cheng JS, Craft R, Yu GQ, Ho K, Wang X, Mohan G, Mangnitsky S, Ponnusamy R, Mucke L -
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
Nature medicine 2014 Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L -
Tau reduction prevents disease in a mouse model of Dravet syndrome.
Annals of neurology 2014 Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L -
Life extension factor klotho enhances cognition.
Cell reports 2014 Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, … -
Seizures and epileptiform activity in the early stages of Alzheimer disease.
JAMA neurology 2013 Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L -
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Nature neuroscience 2013 Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L -
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice.
Neurobiology of aging 2013 Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L -
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
PloS one 2012 Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L -
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
Proceedings of the National Academy of Sciences of the United States of America 2012 Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L -
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.
Cold Spring Harbor perspectives in medicine 2012 Mucke L, Selkoe DJ -
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.
Cell 2012 Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ -
Alzheimer mechanisms and therapeutic strategies.
Cell 2012 Huang Y, Mucke L -
Selective targeting of microglia by quantum dots.
Journal of neuroinflammation 2012 Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L -
Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.
PloS one 2011 Morris M, Koyama A, Masliah E, Mucke L -
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Cissé M, Sanchez PE, Kim DH, Ho K, Yu GQ, Mucke L -
The many faces of tau.
Neuron 2011 Morris M, Maeda S, Vossel K, Mucke L -
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L -
Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling.
Methods in molecular biology (Clifton, N.J.) 2011 Palop JJ, Mucke L, Roberson ED -
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
Nature 2010 Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L -
Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.
Neuron 2010 Harris JA, Devidze N, Verret L, Ho K, Halabisky B, Thwin MT, Kim D, Hamto P, Lo I, Yu GQ, Palop JJ, Masliah E, Mucke L -
Tau reduction prevents Abeta-induced defects in axonal transport.
Science (New York, N.Y.) 2010 Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L -
Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.
Nature neuroscience 2010 Palop JJ, Mucke L -
Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.
The American journal of pathology 2010 Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L -
Phospholipase A2 and arachidonic acid in Alzheimer's disease.
Biochimica et biophysica acta 2010 Sanchez-Mejia RO, Mucke L -
Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L -
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
Cell stem cell 2009 Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L -
Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?
Neuromolecular medicine 2009 Palop JJ, Mucke L -
Neuroscience: Alzheimer's disease.
Nature 2009 Mucke L -
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009 Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, Deves A, Ferris S, Greenberg … -
Alzheimer's disease: A prion protein connection.
Nature 2009 Cisse M, Mucke L -
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L -
Epilepsy and cognitive impairments in Alzheimer disease.
Archives of neurology 2009 Palop JJ, Mucke L -
Collagen VI protects neurons against Abeta toxicity.
Nature neuroscience 2009 Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L -
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
Nature neuroscience 2008 Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L -
Genes contributing to prion pathogenesis.
The Journal of general virology 2008 Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz… -
Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L -
Paths of convergence: sirtuins in aging and neurodegeneration.
Neuron 2008 Gan L, Mucke L -
Abnormal social behaviors in mice lacking Fgf17.
Genes, brain, and behavior 2007 Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L -
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Neuron 2007 Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L -
Spatial cognition and the human navigation network in AD and MCI.
Neurology 2007 deIpolyi AR, Rankin KP, Mucke L, Miller BL, Gorno-Tempini ML -
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
The Journal of biological chemistry 2007 Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L -
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Science (New York, N.Y.) 2007 Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L -
Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L -
Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice.
Neurobiology of aging 2006 Deipolyi AR, Fang S, Palop JJ, Yu GQ, Wang X, Mucke L -
100 years and counting: prospects for defeating Alzheimer's disease.
Science (New York, N.Y.) 2006 Roberson ED, Mucke L -
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.
The Journal of clinical investigation 2006 Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T -
A network dysfunction perspective on neurodegenerative diseases.
Nature 2006 Palop JJ, Chin J, Mucke L -
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
Neuron 2006 Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L -
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2006 Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO -
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L -
Alzheimer's disease: A needle from the haystack.
Nature 2006 Morris R, Mucke L -
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L -
Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L -
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
The Journal of biological chemistry 2005 Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L -
High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.
The Journal of biological chemistry 2005 Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E -
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Journal of neurochemistry 2004 Esposito L, Gan L, Yu GQ, Essrich C, Mucke L -
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
Nature medicine 2004 Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L -
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
The EMBO journal 2004 Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du … -
Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.
Neuron 2004 Mucke L, Pitas RE -
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L -
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y -
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004 Huang Y, Weisgraber KH, Mucke L, Mahley RW -
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003 Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y -
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.
Proceedings of the National Academy of Sciences of the United States of America 2003 Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L -
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L -
Inflammation in neurodegenerative disease--a double-edged sword.
Neuron 2002 Wyss-Coray T, Mucke L -
Androgens protect against apolipoprotein E4-induced cognitive deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Raber J, Bongers G, LeFevour A, Buttini M, Mucke L -
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001 Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L -
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
Nature medicine 2001 Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L -
Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.
The American journal of pathology 2000 Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E -
Ibuprofen, inflammation and Alzheimer disease.
Nature medicine 2000 Wyss-Coray T, Mucke L -
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L -
Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates.
Annals of the New York Academy of Sciences 2000 Wyss-Coray T, Lin C, von Euw D, Masliah E, Mucke L, Lacombe P -
Apolipoprotein E and cognitive performance.
Nature 2000 Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L -
Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, Mucke L -
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.
Science (New York, N.Y.) 2000 Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L -
Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.
The American journal of pathology 2000 Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E -
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
Neuroscience 2000 Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L -
Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120.
The European journal of neuroscience 1999 D'hooge R, Franck F, Mucke L, De Deyn PP -
Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors.
The American journal of pathology 1999 Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L -
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1999 Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L -
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW -
Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice.
Neuron 1999 Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV -
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.
Proceedings of the National Academy of Sciences of the United States of America 1999 Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L -
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
Proceedings of the National Academy of Sciences of the United States of America 1998 Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L -
Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis.
The Journal of biological chemistry 1998 Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, Mucke L -
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.
Cell 1998 Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV -
Novel role of human CD4 molecule identified in neurodegeneration.
Nature medicine 1998 Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L -
Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus.
Neuroscience 1998 Krucker T, Toggas SM, Mucke L, Siggins GR -
Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli.
Proceedings of the National Academy of Sciences of the United States of America 1997 Xu X, Raber J, Yang D, Su B, Mucke L -
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
The EMBO journal 1997 Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B -
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
Nature 1997 Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L -
Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice .
Journal of neuroimmunology 1997 Wyss-Coray T, Borrow P, Brooker MJ, Mucke L -
Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects.
The Journal of biological chemistry 1997 Raber J, Chen S, Mucke L, Feng L -
Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.
Neuroscience 1997 Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L -
Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease.
Brain research. Brain research reviews 1997 Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L -
Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.
Virology 1996 Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L -
Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes.
The Journal of biological chemistry 1996 Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L -
Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.
Neuroreport 1996 D'Hooge R, Nagels G, Westland CE, Mucke L, De Deyn PP -
Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D -
Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule L1 by mouse astrocytes.
The European journal of neuroscience 1996 Mohajeri MH, Bartsch U, van der Putten H, Sansig G, Mucke L, Schachner M -
Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis.
The Journal of clinical investigation 1996 Wyss-Coray T, Masliah E, Toggas SM, Rockenstein EM, Brooker MJ, Lee HS, Mucke L -
Neurotrophic and neuroprotective effects of hAPP in transgenic mice.
Annals of the New York Academy of Sciences 1996 Mucke L, Abraham CR, Masliah E -
Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.
Brain research 1996 Toggas SM, Masliah E, Mucke L -
Pathogenesis of HIV-1 associated neurodegeneration.
Critical reviews in neurobiology 1996 Masliah E, Ge N, Mucke L -
Transgenic models in the study of AIDS dementia complex.
Current topics in microbiology and immunology 1996 Toggas SM, Mucke L -
Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.
The Journal of biological chemistry 1995 Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L -
Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo.
The Journal of experimental medicine 1995 Rall GF, Mucke L, Oldstone MB -
Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent.
Neuron 1995 Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, Oldstone MB -
Immunization-induced inflammatory infiltration of the central nervous system in transgenic mice expressing a microbial antigen in astrocytes.
Journal of neuroimmunology 1995 Borrow P, Cornell JL, Ruppe MD, Mucke L -
Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.
The American journal of pathology 1995 Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L -
Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and Müller cells.
Investigative ophthalmology & visual science 1995 Verderber L, Johnson W, Mucke L, Sarthy V -
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.
The Journal of experimental medicine 1995 Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E -
gp120 and neurotoxicity in vivo.
Trends in pharmacological sciences 1995 Lipton SA, Brenneman DE, Silverstein FS, Masliah E, Mucke L -
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Glia 1995 Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, Mucke L -
Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines.
Current topics in microbiology and immunology 1995 Mucke L, Masliah E, Campbell IL -
Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice.
Brain research 1994 Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR -
A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes.
Journal of neuroimmunology 1994 Rall GF, Mucke L, Nerenberg M, Oldstone MB -
Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.
Nature 1994 Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L -
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Proceedings of the National Academy of Sciences of the United States of America 1993 Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L -
Astrocytes in infectious and immune-mediated diseases of the central nervous system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993 Mucke L, Eddleston M -
Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes.
Brain research 1993 Abraham CR, Kanemaru K, Mucke L -
Molecular profile of reactive astrocytes--implications for their role in neurologic disease.
Neuroscience 1993 Eddleston M, Mucke L -
Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein.
Annals of the New York Academy of Sciences 1992 Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L -
The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV).
Journal of neuroimmunology 1992 Mucke L, Oldstone MB -
Viral persistence in neurons explained by lack of major histocompatibility class I expression.
Science (New York, N.Y.) 1991 Joly E, Mucke L, Oldstone MB -
Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury.
The New biologist 1991 Mucke L, Oldstone MB, Morris JC, Nerenberg MI -
Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM -
Prolonged survival and partial recovery in AIDS-associated progressive multifocal leukoencephalopathy.
Neurology 1988 Berger JR, Mucke L -
Anterior ectosylvian visual area (AEV) of the cat: physiological properties.
Progress in brain research 1988 Benedek G, Mucke L, Norita M, Albowitz B, Creutzfeldt OD -
Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization.
Acta physiologica Scandinavica 1987 Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH -
Clinical management of neuropathic pain.
Neurologic clinics 1987 Mucke L, Maciewicz R -
Connections of the anterior ectosylvian visual area (AEV).
Experimental brain research 1986 Norita M, Mucke L, Benedek G, Albowitz B, Katoh Y, Creutzfeldt OD -
Physiologic and anatomic investigation of a visual cortical area situated in the ventral bank of the anterior ectosylvian sulcus of the cat.
Experimental brain research 1982 Mucke L, Norita M, Benedek G, Creutzfeldt O