Lee Chen, PhD, MD
Postdoctoral Scholar
Neurological Surgery
School of Medicine

Publications (17)

Top publication keywords:
PyrrolidinesPurine-Nucleoside PhosphorylaseIsocitrate DehydrogenaseGlioblastomaGliomaPhthalazinesAminopyridinesProtein Phosphatase 2CMutationGene Expression Regulation, Neoplasticpara-AminobenzoatesProto-Oncogene Proteins c-mdm2Loss of Function MutationBrain Stem NeoplasmsGenes, Neoplasm

• The integrated genomic and epigenomic landscape of brainstem glioma.
  Nature communications 2020 Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, …
• Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
  Nature genetics 2014 Zhang L, Chen LH, Wan H, Yang R, Wang Z, Feng J, Yang S, Jones S, Wang S, Zhou W, Zhu H, Killela PJ, Zhang J, Wu Z, Li G, Hao S, Wang Y, Webb JB, Friedman HS, Friedman AH, McLendon RE, He Y, Reitman …
• Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells.
  Biomedicines 2022 Singh SX, Yang R, Roso K, Hansen LJ, Du C, Chen LH, Greer PK, Pirozzi CJ, He Y
• MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.
  Scientific reports 2022 Hansen LJ, Yang R, Roso K, Wang W, Chen L, Yang Q, Pirozzi CJ, He Y
• TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
  Acta neuropathologica communications 2021 Xu C, Liu H, Pirozzi CJ, Chen LH, Greer PK, Diplas BH, Zhang L, Waitkus MS, He Y, Yan H

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• Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
  Molecular cancer research : MCR 2020 Wang Z, Xu C, Diplas BH, Moure CJ, Chen CJ, Chen LH, Du C, Zhu H, Greer PK, Zhang L, He Y, Waitkus MS, Yan H
• CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
  Molecular cancer research : MCR 2019 Moure CJ, Diplas BH, Chen LH, Yang R, Pirozzi CJ, Wang Z, Spasojevic I, Waitkus MS, He Y, Yan H
• MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
  Cancer research 2019 Hansen LJ, Sun R, Yang R, Singh SX, Chen LH, Pirozzi CJ, Moure CJ, Hemphill C, Carpenter AB, Healy P, Ruger RC, Chen CJ, Greer PK, Zhao F, Spasojevic I, Grenier C, Huang Z, Murphy SK, McLendon RE, …
• Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.
  Scientific reports 2018 Lei K, Sun R, Chen LH, Diplas BH, Moure CJ, Wang W, Hansen LJ, Tao Y, Chen X, Chen CJ, Greer PK, Zhao F, Yan H, Bigner DD, Huang J, He Y
• The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
  Nature communications 2018 Diplas BH, He X, Brosnan-Cashman JA, Liu H, Chen LH, Wang Z, Moure CJ, Killela PJ, Loriaux DB, Lipp ES, Greer PK, Yang R, Rizzo AJ, Rodriguez FJ, Friedman AH, Friedman HS, Wang S, He Y, McLendon RE, …
• Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
  Cancer research 2017 Yang R, Chen LH, Hansen LJ, Carpenter AB, Moure CJ, Liu H, Pirozzi CJ, Diplas BH, Waitkus MS, Greer PK, Zhu H, McLendon RE, Bigner DD, He Y, Yan H
• Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.
  Molecular cancer research : MCR 2017 Pirozzi CJ, Carpenter AB, Waitkus MS, Wang CY, Zhu H, Hansen LJ, Chen LH, Greer PK, Feng J, Wang Y, Bock CB, Fan P, Spasojevic I, McLendon RE, Bigner DD, He Y, Yan H
• SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women.
  Journal of biomedical science 2014 Lai LC, Tsai MH, Chen PC, Chen LH, Hsiao JH, Chen SK, Lu TP, Lee JM, Hsu CP, Hsiao CK, Chuang EY
• KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.
  Oncotarget 2013 Guo C, Chen LH, Huang Y, Chang CC, Wang P, Pirozzi CJ, Qin X, Bao X, Greer PK, McLendon RE, Yan H, Keir ST, Bigner DD, He Y
• Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y
• Mutant IDH1 is required for IDH1 mutated tumor cell growth.
  Oncotarget 2012 Jin G, Pirozzi CJ, Chen LH, Lopez GY, Duncan CG, Feng J, Spasojevic I, Bigner DD, He Y, Yan H
• Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.
  PloS one 2011 Chen LH, Kuo WH, Tsai MH, Chen PC, Hsiao CK, Chuang EY, Chang LY, Hsieh FJ, Lai LC, Chang KJ