Lea Grinberg, MD, PhD
Professor
Neurology
School of Medicine

Currently, she is a Full Professor and a John Douglas French Alzheimer's Foundation Endowed Professor at the UCSF Memory and Aging Center, part of the Executive Board of the Global Brain Health Institute and a member of the Medical Scientific Advisory Group for the Alzheimer Association. She is also a Professor of Pathology at the University of Sao Paulo.

In 2003, Dr. Grinberg was among the founders of a brain bank in São Paulo, focusing on brain aging. This brain bank which she had since developed into an extremely prolific and highly-regarded institution, helped Dr. Grinberg prove that, contrary to what has been accepted previously, the brainstem and not the cortex, harbors the first detectable neurodegeneration in Alzheimer's disease. In 2009, she was the recipient of the UNESCO-L'Oréal Award "For Women in Science," and in 2010, she received the John Douglas French Alzheimer Foundation "Distinguished Research Scholar Award." Currently, Dr. Grinberg is the Co-Leader of the UCSF/Neurodegenerative Disease Brain Bank, where she conducts neuropathological diagnosis of neurodegenerative diseases. She also directs the Human Biology Validation Core for the NIH/U54 Tau Centers Without Walls, is a principal investigator from the Tau Consortium and co-leads the Neuropathology Core for the LEADS project.

The Grinberg Lab The Grinberg Lab at UCSF, established in 2009, is now home to almost 20 researchers, students, and staff and funded by multiple federal and foundation grants. The Lab combines classical quantitative neuropathological techniques with advanced computer vision tools and multiplex molecular probing in postmortem human tissue and neurons derived from induced pluripotent cells. The Grinberg Lab follows up on Dr. Grinberg's initial discoveries to provide an integrated picture of brainstem vulnerability in AD and FTLD, including extensive studies on the neurobiological basis of sleep disturbances in these diseases aiming to provide personalized symptomatic treatment and improve the patient quality of life. The Grinberg Lab also investigates the factors influencing the clinical expression of Alzheimer's pathology to lead to better diagnostic tools, the identification of risk factors for accelerated decline, and the therapeutic targets that minimize the clinical decline in AD.

• Sex and the Clock: Exploring Sex Differences in Chronotype and Circadian Preferences Among Cognitively Healthy Older Adults.
  medRxiv : the preprint server for health sciences 2024 Pandher NS, Yack L, Li E, Coppola Q, Cassaletto K, Grinberg LT, Neylan TC, Kramer JH, Walsh CM
• Hypertension may associate with cerebral small vessel disease and infarcts through the pathway of intracranial atherosclerosis.
  Neurobiology of aging 2024 Takahashi MKN, Paradela RS, Grinberg LT, Leite REP, Farias-Itao DS, Paes VR, Braga ME, Naslavsky MS, Zatz M, Jacob-Filho W, Nitrini R, Pasqualucci CA, Suemoto CK
• Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation.
  Acta neuropathologica 2024 Shanaki Bavarsad M, Spina S, Oehler A, Allen IE, Suemoto CK, Leite REP, Seeley WS, Green A, Jagust W, Rabinovici GD, Grinberg LT
• Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease.
  bioRxiv : the preprint server for biology 2024 Zhu B, Wangzhou A, Yu D, Li T, Schmidt R, De Florencio SL, Chao L, Perez Y, Grinberg LT, Spina S, Ransohoff RM, Kriegstein AR, Seeley WW, Nowakowski T, Piao X
• Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology.
  Movement disorders : official journal of the Movement Disorder Society 2024 Kovacs GG, Grinberg LT, Halliday G, Alafuzoff I, Dugger BN, Murayama S, Forrest SL, Martinez-Valbuena I, Tanaka H, Kon T, Yoshida K, Jaunmuktane Z, Spina S, Nelson PT, Gentleman S, Alegre-Abarrategui …
• Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics.
  Cell 2024 Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Han X, Yamakawa M, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, …
• Health literacy, but not memory, is associated with hippocampal connectivity in adults with low levels of formal education.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2024 de Paula França Resende E, Lara VP, Santiago ALC, Friedlaender CV, Rosen HJ, Brown JA, Cobigo Y, Silva LLG, Cruz de Souza L, Rincon L, Grinberg LT, Maciel FIP, Caramelli P
• Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes.
  Brain : a journal of neurology 2024 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia.
  Alzheimer's research & therapy 2024 Asken BM, Bove JM, Bauer RM, Tanner JA, Casaletto KB, Staffaroni AM, VandeVrede L, Alosco ML, Mez JB, Stern RA, Miller BL, Grinberg LT, Boxer AL, Gorno-Tempini ML, Rosen HJ, Rabinovici GD, Kramer JH
• Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
  PloS one 2024 Steinbach S, Molina M, Grinberg LT, Aring L, Guntermann A, Marcus K, Heinsen H, Paraizo Leite RE, May C
• Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Falgàs N, Peña-González M, Val-Guardiola A, Pérez-Millan A, Guillén N, Sarto J, Esteller D, Bosch B, Fernández-Villullas G, Tort-Merino A, Mayà G, Augé JM, Iranzo A, Balasa M, Lladó A, Morales-Ruiz M,…
• Comorbid neuropathology and atypical presentation of Alzheimer's disease.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2024 Pina-Escudero SD, La Joie R, Spina S, Hwang JH, Miller ZA, Huang EJ, Grant H, Mundada NS, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Rabinovici GD, Grinberg LT
• Insufficient evidence for an association between iatrogenic Alzheimer's disease and cadaveric pituitary-derived growth hormone.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Nath A, Holtzman DM, Miller BL, Grinberg LT, Leschek EW
• iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
  Molecular and cellular neurosciences 2024 Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R, Kayed R, Karch CM, Miller BL, Gestwicki JE, Gan L, Temple S, Arkin MR, Grinberg LT
• CSF Proteomics in Patients With Progressive Supranuclear Palsy.
  Neurology 2024 Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, Sivasankaran R, Palma JA, Mitic L, Heuer HW, Lario-Lago A, Staffaroni AM, Clark A, Taylor J, Ljubenkov PA, Vandevrede L, Grinberg LT, …
• Neuropathological Lesions and Cognitive Abilities in Black and White Older Adults in Brazil.
  JAMA network open 2024 Suemoto CK, Leite REP, Paes VR, Rodriguez R, Justo AFO, Naslavsky MS, Zatz M, Pasqualucci CA, Nitrini R, Ferriolli E, Jacob-Filho W, Grinberg LT
• Episodic memory improvement in illiterate adults attending late-life education irrespective of low socioeconomic status: insights from the PROAME study.
  Dementia & neuropsychologia 2024 Ruppert EP, Rocha JVF, da Silva AL, Tomaz KLDS, Friedlaender CV, Assenção JCM, Rincon LP, Ribeiro NGF, Santos DCS, Lima APZ, Allen IE, Caramelli P, Grinberg LT, Maciel FIP, Resende EPF
• Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.
  medRxiv : the preprint server for health sciences 2024 Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR…
• Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Sosa AL, Brucki SM, Crivelli L, Lopera FJ, Acosta DM, Acosta-Uribe J, Aguilar D, Aguilar-Navarro SG, Allegri RF, Bertolucci PH, Calandri IL, Carrillo MC, Mendez PAC, Cornejo-Olivas M, Custodio N, …
• The wake- and sleep-modulating neurons of the lateral hypothalamic area demonstrate a differential pattern of degeneration in Alzheimers disease.
  bioRxiv : the preprint server for biology 2024 Satpati A, Pereira FL, Soloviev AV, Mladinov M, Larsen E, Hua SL, Tu CL, Leite REP, Suemoto CK, Rodriguez RD, Paes VR, Walsh C, Spina S, Seeley WW, Pasqualucci CA, Filho WJ, Chang W, Neylan TC, …
• Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.
  medRxiv : the preprint server for health sciences 2024 Iyer AK, Vermunt L, Mirfakhar FS, Minaya M, Acquarone M, Koppisetti RK, Renganathan A, You SF, Danhash EP, Verbeck A, Galasso G, Lee SM, Marsh J, Nana AL, Spina S, Seeley WW, Grinberg LT, Temple S, …
• The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Kalaria R, Maestre G, Mahinrad S, Acosta DM, Akinyemi RO, Alladi S, Allegri RF, Arshad F, Babalola DO, Baiyewu O, Bak TH, Bellaj T, Brodie-Mends DK, Carrillo MC, Celestin KK, Damasceno A, de Silva RK,…
• SV2A PET imaging in human neurodegenerative diseases.
  Frontiers in aging neuroscience 2024 Bavarsad MS, Grinberg LT
• Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting.
  Acta neuropathologica communications 2024 Rizzi L, Grinberg LT
• Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum.
  Brain : a journal of neurology 2024 Illán-Gala I, Lorca-Puls DL, Tee BL, Ezzes Z, de Leon J, Miller ZA, Rubio-Guerra S, Santos-Santos M, Gómez-Andrés D, Grinberg LT, Spina S, Kramer JH, Wauters LD, Henry ML, Boxer AL, Rosen HJ, Miller …
• Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
  Research square 2024 Saloner R, Staffaroni A, Dammer E, Johnson ECB, Paolillo E, Wise A, Heuer H, Forsberg L, Lago AL, Webb J, Vogel J, Santillo A, Hansson O, Kramer J, Miller B, Li J, Loureiro J, Sivasankaran R, …
• Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Samudra N, Fischer DL, Lenio S, Lario Lago A, Ljubenkov PA, Rojas JC, Seeley WW, Spina S, Staffaroni AM, Tablante J, Wekselman F, Lamoureux J, Concha-Marambio L, Grinberg LT, Boxer AL, VandeVrede L
• Bearded capuchin monkeys as a model for Alzheimer's disease.
  Scientific reports 2024 Diehl Rodriguez R, Tavares MCH, Brucki SMD, Takada LT, Otaduy MCG, da Graça Morais Martin M, Kimie Suemoto C, Grinberg LT, Leite CC, Tomaz C, Nitrini R
• Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.
  Neurology 2024 Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto …
• Surface-Based Probabilistic Fiber Tracking in Superficial White Matter.
  IEEE transactions on medical imaging 2024 Nie X, Ruan J, Otaduy MCG, Grinberg LT, Ringman J, Shi Y
• The relationship of neuropsychiatric symptoms with inflammatory markers in the hippocampus and cingulate cortex of bipolar disorder subjects: A post-mortem study.
  Journal of psychiatric research 2024 Nascimento C, Villela Nunes P, Paraizo Leite RE, Grinberg LT, Suemoto CK, Lafer B
• C9orf72 Repeat Expansion Initially Presenting as Late-Onset Bipolar Disorder With Psychosis.
  The neurologist 2024 Gaynor LS, Yadollahikhales G, Tsoy E, Hall M, Boxer AL, Miller BL, Grinberg LT
• Is Alzheimer disease a disease?
  Nature reviews. Neurology 2024 Korczyn AD, Grinberg LT
• Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting.
  Acta neuropathologica communications 2024 Rizzi L, Grinberg LT
• Associations of 24-Hour Rest-Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease.
  Annals of neurology 2024 Van Egroo M, van Someren EJW, Grinberg LT, Bennett DA, Jacobs HIL
• Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.
  The Lancet. Neurology 2024 Chapleau M, La Joie R, Yong K, Agosta F, Allen IE, Apostolova L, Best J, Boon BDC, Crutch S, Filippi M, Fumagalli GG, Galimberti D, Graff-Radford J, Grinberg LT, Irwin DJ, Josephs KA, Mendez MF, …
• KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
  The Journal of clinical investigation 2024 Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y, Le D, Spina S, Grinberg LT, Seeley WW, Kramer JH, Sacktor TC, Schilling B, Gan L, Casaletto KB, Tracy…
• Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.
  Brain : a journal of neurology 2024 Lorca-Puls DL, Gajardo-Vidal A, Mandelli ML, Illán-Gala I, Ezzes Z, Wauters LD, Battistella G, Bogley R, Ratnasiri B, Licata AE, Battista P, García AM, Tee BL, Lukic S, Boxer AL, Rosen HJ, Seeley WW, …
• Spatiotemporal characteristics of neurophysiological changes in patients with four-repeat tauopathies.
  Annals of clinical and translational neurology 2024 Samudra N, Lerner H, Yack L, Walsh CM, Kirsch HE, Kudo K, Yballa C, La Joie R, Gorno-Tempini ML, Spina S, Seeley WW, Neylan TC, Miller BL, Rabinovici GD, Boxer A, Grinberg LT, Rankin KP, Nagarajan SS,…
• Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models.
  Molecular neurodegeneration 2024 Son G, Neylan TC, Grinberg LT
• The Association Between Neuropathological Lesions and Body Mass Index Is Independent of Cognitive Abilities.
  Journal of Alzheimer's disease : JAD 2024 Ururahy RDR, do Val MS, Ciciliati AMM, Leite REP, Paes VR, Rodrigues RD, Grinberg LT, Pasqualucci CA, Jacob Filho W, Suemoto CK
• Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample.
  Acta neuropathologica communications 2023 Paradela RS, Justo AFO, Paes VR, Leite REP, Pasqualucci CA, Grinberg LT, Naslavsky MS, Zatz M, Nitrini R, Jacob-Filho W, Suemoto CK
• Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Chen Y, Spina S, Callahan P, Grinberg LT, Seeley WW, Rosen HJ, Kramer JH, Miller BL, Rankin KP
• Bearded capuchin monkey as a model for Alzheimer's disease research.
  Research square 2023 Rodriguez RD, Tavares MC, Brucki SM, Takada LT, Otaduy MC, da Graça Morais Martin M, Suemoto C, Grinberg L, Leite C, Tomaz C, Nitrini R
• Synaptic proteasome is inhibited in Alzheimer's disease models and associates with memory impairment in mice.
  Communications biology 2023 Ribeiro FC, Cozachenco D, Heimfarth L, Fortuna JTS, de Freitas GB, de Sousa JM, Alves-Leon SV, Leite REP, Suemoto CK, Grinberg LT, De Felice FG, Lourenco MV, Ferreira ST
• Mutant tau and stress lead to downregulation of long noncoding RNA, SNHG8.
  Molecular psychiatry 2023 Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM
• Synaptic Oligomers and Glial Cells in Alzheimer Disease.
  JAMA neurology 2023 Grinberg LT
• FTLD targets brain regions expressing recently evolved genes.
  medRxiv : the preprint server for health sciences 2023 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina…
• Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics.
  bioRxiv : the preprint server for biology 2023 Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski…
• The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States.
  Alzheimer's & dementia (New York, N. Y.) 2023 Simon SS, Brucki SMD, Fonseca LM, Becker J, Cappi C, Marques AH, Heyn PC, Gonçalves PD, Martins SS, Busatto G, Bertola L, Suemoto CK, Nitrini R, Caramelli P, Yassuda MS, Miotto EC, Grinberg LT, Arce …
• Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
  Molecular psychiatry 2023 Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM
• Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS).
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Cho H, Mundada NS, Apostolova LG, Carrillo MC, Shankar R, Amuiri AN, Zeltzer E, Windon CC, Soleimani-Meigooni DN, Tanner JA, Heath CL, Lesman-Segev OH, Aisen P, Eloyan A, Lee HS, Hammers DB, Kirby K, …
• Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Bushnell J, Hammers DB, Aisen P, Dage JL, Eloyan A, Foroud T, Grinberg LT, Iaccarino L, Jack CR, Kirby K, Kramer J, Koeppe R, Kukull WA, La Joie R, Mundada NS, Murray ME, Nudelman K, Rumbaugh M, …
• Apolipoprotein E ε2 allele is associated with lower risk of carotid artery obstruction in a population-based autopsy study.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Paradela RS, Farias-Itao DS, Leite REP, Pasqualucci CA, Grinberg LT, Naslavsky MS, Zatz M, Nitrini R, Jacob-Filho W, Suemoto CK
• Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Nemes S, Logan PE, Manchella MK, Mundada NS, La Joie R, Polsinelli AJ, Hammers DB, Koeppe RA, Foroud TM, Nudelman KN, Eloyan A, Iaccarino L, Dorsant-Ardón V, Taurone A, Thangarajah M, Dage JL, Aisen P…
• Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Dage JL, Eloyan A, Thangarajah M, Hammers DB, Fagan AM, Gray JD, Schindler SE, Snoddy C, Nudelman KNH, Faber KM, Foroud T, Aisen P, Griffin P, Grinberg LT, Iaccarino L, Kirby K, Kramer J, Koeppe R, …
• Neuropsychiatric symptoms and imbalance of atrophy in behavioral variant frontotemporal dementia.
  Human brain mapping 2023 Sokolowski A, Roy ARK, Goh SM, Hardy EG, Datta S, Cobigo Y, Brown JA, Spina S, Grinberg L, Kramer J, Rankin KP, Seeley WW, Sturm VE, Rosen HJ, Miller BL, Perry DC
• The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex.
  Cerebral cortex (New York, N.Y. : 1991) 2023 Castro-Fonseca E, Morais V, da Silva CG, Wollner J, Freitas J, Mello-Neto AF, Oliveira LE, de Oliveira VC, Leite REP, Alho AT, Rodriguez RD, Ferretti-Rebustini REL, Suemoto CK, Jacob-Filho W, Nitrini …
• Literacy, but not memory, is associated with hippocampal connectivity in illiterate adults.
  Research square 2023 de Paula França Resende E, Lara VP, Santiago ALC, Friedlaender CV, Rosen HJ, Brown JA, Cobigo Y, Silva LLG, de Souza LC, Rincon L, Grinberg LT, Maciel FIP, Caramelli P
• KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
  bioRxiv : the preprint server for biology 2023 Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y, Le D, Spina S, Grinberg LT, Seeley WW, Kramer JH, Sacktor TC, Schilling B, Gan L, Casaletto KB, Tracy…
• Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Hammers DB, Eloyan A, Taurone A, Thangarajah M, Beckett L, Gao S, Kirby K, Aisen P, Dage JL, Foroud T, Griffin P, Grinberg LT, Jack CR, Kramer J, Koeppe R, Kukull WA, Mundada NS, La Joie R, Soleimani-…
• Alzheimer's disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Bodart-Santos V, Pinheiro LS, da Silva-Junior AJ, Froza RL, Ahrens R, Gonçalves RA, Andrade MM, Chen Y, Alcantara CL, Grinberg LT, Leite REP, Ferreira ST, Fraser PE, De Felice FG
• Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
  Acta neuropathologica communications 2023 Davis SE, Cook AK, Hall JA, Voskobiynyk Y, Carullo NV, Boyle NR, Hakim AR, Anderson KM, Hobdy KP, Pugh DA, Murchison CF, McMeekin LJ, Simmons M, Margolies KA, Cowell RM, Nana AL, Spina S, Grinberg LT,…
• Histaminergic neurotransmission in aging and Alzheimer's disease: A review of therapeutic opportunities and gaps.
  Alzheimer's & dementia (New York, N. Y.) 2023 Satpati A, Neylan T, Grinberg LT
• Creating the Pick's disease International Consortium: Association study of MAPT H2 haplotype with risk of Pick's disease.
  medRxiv : the preprint server for health sciences 2023 Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Warner TT, …
• Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia.
  JAMA neurology 2023 Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Illán-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind…
• Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
  The Journal of clinical investigation 2023 Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley WW, Miller BL, Ullian EM, Krummel MF, Kriegstein AR, …
• The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Maestre G, Carrillo M, Kalaria R, Acosta D, Adams L, Adoukonou T, Akinwande K, Akinyemi J, Akinyemi R, Akpa O, Alladi S, Allegri R, Arizaga R, Arshad F, Arulogun O, Babalola D, Baiyewu O, Bak T, …
• Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
  medRxiv : the preprint server for health sciences 2023 Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM
• Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling.
  Frontiers in molecular biosciences 2023 Minaya MA, Mahali S, Iyer AK, Eteleeb AM, Martinez R, Huang G, Budde J, Temple S, Nana AL, Seeley WW, Spina S, Grinberg LT, Harari O, Karch CM
• Alzheimer's disease phenotypes show different sleep architecture.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Falgàs N, Walsh CM, Yack L, Simon AJ, Allen IE, Kramer JH, Rosen HJ, Joie R, Rabinovici G, Miller B, Spina S, Seeley WW, Ranasinghe K, Vossel K, Neylan TC, Grinberg LT
• Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, …
• Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study.
  Molecular neurobiology 2023 Toscano ECB, Vieira ÉLM, Grinberg LT, Rocha NP, Brant JAS, Paradela RS, Giannetti AV, Suemoto CK, Leite REP, Nitrini R, Rachid MA, Teixeira AL
• Resilience of Neural Cellularity to the Influence of Low Educational Level.
  Brain sciences 2023 de Morais VAC, de Oliveira-Pinto AV, Mello Neto AF, Freitas JS, da Silva MM, Suemoto CK, Leite RP, Grinberg LT, Jacob-Filho W, Pasqualucci C, Nitrini R, Caramelli P, Lent R
• LATE-NC staging in routine neuropathologic diagnosis: an update.
  Acta neuropathologica 2022 Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, …
• Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.
  Brain : a journal of neurology 2022 Younes K, Borghesani V, Montembeault M, Spina S, Mandelli ML, Welch AE, Weis E, Callahan P, Elahi FM, Hua AY, Perry DC, Karydas A, Geschwind D, Huang E, Grinberg LT, Kramer JH, Boxer AL, Rabinovici GD…
• Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
  Nature communications 2022 Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV
• Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study.
  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2022 Paradela RS, Farias-Itao DS, Leite REP, Pasqualucci CA, Grinberg LT, Naslavsky MS, Zatz M, Nitrini R, Jacob-Filho W, Suemoto CK
• Neuropathological correlates of neuropsychiatric symptoms in dementia.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Gibson LL, Grinberg LT, Ffytche D, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Jacob-Filho W, Aarsland D, Suemoto CK
• Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample.
  Molecular psychiatry 2022 Naslavsky MS, Suemoto CK, Brito LA, Scliar MO, Ferretti-Rebustini RE, Rodriguez RD, Leite REP, Araujo NM, Borda V, Tarazona-Santos E, Jacob-Filho W, Pasqualucci C, Nitrini R, Yaffe K, Zatz M, Grinberg…
• Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
  Movement disorders : official journal of the Movement Disorder Society 2022 Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, …
• Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy.
  Acta neuropathologica 2022 Roemer SF, Grinberg LT, Crary JF, Seeley WW, McKee AC, Kovacs GG, Beach TG, Duyckaerts C, Ferrer IA, Gelpi E, Lee EB, Revesz T, White CL, Yoshida M, Pereira FL, Whitney K, Ghayal NB, Dickson DW
• Applying the Bradford Hill Criteria for Causation to Repetitive Head Impacts and Chronic Traumatic Encephalopathy.
  Frontiers in neurology 2022 Nowinski CJ, Bureau SC, Buckland ME, Curtis MA, Daneshvar DH, Faull RLM, Grinberg LT, Hill-Yardin EL, Murray HC, Pearce AJ, Suter CM, White AJ, Finkel AM, Cantu RC
• Neuropsychiatric symptoms in community-dwelling older Brazilians with mild cognitive impairment and dementia.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Suemoto CK, Nunes PV, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Rodriguez RD, Grinberg LT, Jacob-Filho W
• Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling.
  Stem cell reviews and reports 2022 Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG, Corrales CI, Nana AL, Karydas AM, Spina S, Grinberg LT, Miller B, Wyss-Coray T, Abyzov A, Goodarzi H, Seeley WW, Kao AW
• The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Duran-Aniotz C, Sanhueza J, Grinberg LT, Slachevsky A, Valcour V, Robertson I, Lawlor B, Miller B, Ibáñez A
• Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.
  Acta neuropathologica 2022 Nelson PT, Brayne C, Flanagan ME, Abner EL, Agrawal S, Attems J, Castellani RJ, Corrada MM, Cykowski MD, Di J, Dickson DW, Dugger BN, Ervin JF, Fleming J, Graff-Radford J, Grinberg LT, Hokkanen SRK, …
• Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series.
  Journal of neurotrauma 2022 Asken BM, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, …
• Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications.
  Neuropathology and applied neurobiology 2022 Theofilas P, Piergies AMH, Oh I, Lee YB, Li SH, Pereira FL, Petersen C, Ehrenberg AJ, Eser RA, Ambrose AJ, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT
• Fmr1 exon 14 skipping in late embryonic development of the rat forebrain.
  BMC neuroscience 2022 Corrêa-Velloso JC, Linardi AM, Glaser T, Velloso FJ, Rivas MP, Leite REP, Grinberg LT, Ulrich H, Akins MR, Chiavegatto S, Haddad LA
• Microcephaly measurement in adults and its association with clinical variables.
  Revista de saude publica 2022 Costa NRD, Mancine L, Salvini R, Teixeira JM, Rodriguez RD, Leite REP, Nascimento C, Pasqualucci CA, Nitrini R, Jacob-Filho W, Lafer B, Grinberg LT, Suemoto CK, Nunes PV
• Neuropathology of depression in non-demented older adults: A large postmortem study of 741 individuals.
  Neurobiology of aging 2022 Nunes PV, Suemoto CK, Rodriguez RD, Paraizo Leite RE, Nascimento C, Pasqualucci CA, Nitrini R, Jacob-Filho W, Grinberg LT, Lafer B
• Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology.
  Neurology 2022 Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici …
• Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases.
  JAMA neurology 2022 Oh JY, Walsh CM, Ranasinghe K, Mladinov M, Pereira FL, Petersen C, Falgàs N, Yack L, Lamore T, Nasar R, Lew C, Li S, Metzler T, Coppola Q, Pandher N, Le M, Heuer HW, Heinsen H, Spina S, Seeley WW, …
• Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
  Nature communications 2022 Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L
• Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.
  JAMA network open 2022 Illán-Gala I, Nigro S, VandeVrede L, Falgàs N, Heuer HW, Painous C, Compta Y, Martí MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleó A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, …
• Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Quiroz YT, Solis M, Aranda MP, Arbaje AI, Arroyo-Miranda M, Cabrera LY, Carrasquillo MM, Corrada MM, Crivelli L, Diminich ED, Dorsman KA, Gonzales M, González HM, Gonzalez-Seda AL, Grinberg LT, …
• Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration.
  Neurology 2022 Mattsson-Carlgren N, Grinberg LT, Boxer A, Ossenkoppele R, Jonsson M, Seeley W, Ehrenberg A, Spina S, Janelidze S, Rojas-Martinex J, Rosen H, La Joie R, Lesman-Segev O, Iaccarino L, Kollmorgen G, …
• Race, Genetic Admixture, and Cognitive Performance in the Cuban Population.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2022 Llibre-Guerra JJ, Li Y, Allen IE, Llibre-Guerra JC, Rodríguez Salgado AM, Peñalver AI, Almirall Sanchez A, Yokoyama JS, Grinberg L, Valcour V, Miller BL, Llibre-Rodríguez JJ
• The behavioral variant of Alzheimer's disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex.
  Alzheimer's research & therapy 2022 Singleton EH, Pijnenburg YAL, Gami-Patel P, Boon BDC, Bouwman F, Papma JM, Seelaar H, Scheltens P, Grinberg LT, Spina S, Nana AL, Rabinovici GD, Seeley WW, Ossenkoppele R, Dijkstra AA
• Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Suemoto CK, Bertola L, Grinberg LT, Leite REP, Rodriguez RD, Santana PH, Pasqualucci CA, Jacob-Filho W, Nitrini R
• Late-Onset Alcohol Abuse as a Presenting Symptom of Neurodegenerative Diseases.
  Journal of Alzheimer's disease : JAD 2022 de Paula França Resende E, Ketelle R, Karydas A, Allen I, Grinberg LT, Spina S, Seeley WW, Perry DC, Miller B, Naasan G
• Increased levels of TAR DNA-binding protein 43 in the hippocampus of subjects with bipolar disorder: a postmortem study.
  Journal of neural transmission (Vienna, Austria : 1996) 2021 Nascimento C, Nunes PV, Kim HK, Leite REP, Rodriguez RD, De Oliveira KC, Brentani HP, Jacob-Filho W, Nitrini R, Pasqualucci CA, Grinberg LT, Suemoto CK, Lafer B
• Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation.
  NeuroImage 2021 Ushizima D, Chen Y, Alegro M, Ovando D, Eser R, Lee W, Poon K, Shankar A, Kantamneni N, Satrawada S, Junior EA, Heinsen H, Tosun D, Grinberg LT
• The severity of neuropsychiatric symptoms is higher in early-onset than late-onset Alzheimer's disease.
  European journal of neurology 2021 Falgàs N, Allen IE, Spina S, Grant H, Piña Escudero SD, Merrilees J, Gearhart R, Rosen HJ, Kramer JH, Seeley WW, Neylan TC, Miller BL, Rabinovici GD, Grinberg LT, Walsh CM
• Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus.
  Aging cell 2021 Matias I, Diniz LP, Damico IV, Araujo APB, Neves LDS, Vargas G, Leite REP, Suemoto CK, Nitrini R, Jacob-Filho W, Grinberg LT, Hol EM, Middeldorp J, Gomes FCA
• Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.
  Acta neuropathologica communications 2021 Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, Huh S, Vogel H, Glabe C, Grinberg LT, Spina S, Seeley WW, Guo S, Lu B
• Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
  The Lancet. Neurology 2021 Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin…
• Clinical, neuroimaging, and neuropathological characterization of a patient with Alzheimer's disease syndrome due to Pick's pathology.
  Neurocase 2021 Toller G, Zitser J, Sukhanov P, Grant H, Miller BL, Kramer JH, Rosen HJ, Rankin KP, Grinberg LT
• Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease.
  Brain : a journal of neurology 2021 Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, Hepker M, Hwang JH, Miller ZA, Huang EJ, Karydas AM, Grant H, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, …
• Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer's disease.
  Sleep medicine reviews 2021 Lew CH, Petersen C, Neylan TC, Grinberg LT
• Specific cortical and subcortical grey matter regions are associated with insomnia severity.
  PloS one 2021 Falgàs N, Illán-Gala I, Allen IE, Mumford P, Essanaa YM, Le MM, You M, Grinberg LT, Rosen HJ, Neylan TC, Kramer JH, Walsh CM
• The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Apostolova LG, Aisen P, Eloyan A, Fagan A, Fargo KN, Foroud T, Gatsonis C, Grinberg LT, Jack CR, Kramer J, Koeppe R, Kukull WA, Murray ME, Nudelman K, Rumbaugh M, Toga A, Vemuri P, Trullinger A, …
• Severe Dementia Predicts Weight Loss by the Time of Death.
  Frontiers in neurology 2021 Ciciliati AMM, Adriazola IO, Souza Farias-Itao D, Pasqualucci CA, Leite REP, Nitrini R, Grinberg LT, Jacob-Filho W, Suemoto CK
• Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Ranasinghe KG, Petersen C, Kudo K, Mizuiri D, Rankin KP, Rabinovici GD, Gorno-Tempini ML, Seeley WW, Spina S, Miller BL, Vossel K, Grinberg LT, Nagarajan SS
• Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms.
  Brain : a journal of neurology 2021 Naasan G, Shdo SM, Rodriguez EM, Spina S, Grinberg L, Lopez L, Karydas A, Seeley WW, Miller BL, Rankin KP
• Deepen into sleep and wake patterns across Alzheimer's disease phenotypes.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Falgàs N, Walsh CM, Neylan TC, Grinberg LT
• Patterns of neuronal Rhes as a novel hallmark of tauopathies.
  Acta neuropathologica 2021 Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT
• Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration.
  JAMA network open 2021 Illán-Gala I, Falgàs N, Friedberg A, Castro-Suárez S, Keret O, Rogers N, Oz D, Nigro S, Quattrone A, Quattrone A, Wolf A, Younes K, Santos-Santos M, Borrego-Écija S, Cobigo Y, Dols-Icardo O, Lladó A, …
• Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Illán-Gala I, Casaletto KB, Borrego-Écija S, Arenaza-Urquijo EM, Wolf A, Cobigo Y, Goh SYM, Staffaroni AM, Alcolea D, Fortea J, Blesa R, Clarimon J, Iulita MF, Brugulat-Serrat A, Lladó A, Grinberg LT,…
• Are the 50's, the transition decade, in choroid plexus aging?
  GeroScience 2021 Tahira A, Marques F, Lisboa B, Feltrin A, Barbosa A, de Oliveira KC, de Bragança Pereira CA, Leite R, Grinberg L, Suemoto C, de Lucena Ferretti-Rebustini RE, Pasqualucci CA, Jacob-Filho W, Brentani H,…
• Molecular characterization of selectively vulnerable neurons in Alzheimer's disease.
  Nature neuroscience 2021 Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M
• The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease.
  Acta neuropathologica 2021 Matchett BJ, Grinberg LT, Theofilas P, Murray ME
• Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study.
  Acta neuropathologica 2021 Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K, Kovacs GG, Lee EB, Love S, McAleese KE, Nelson PT, Neumann M, Parkkinen L, Polvikoski T, Sikorska B, Smith C…
• Active lifestyle enhances protein expression profile in subjects with Lewy body pathology.
  Dementia & neuropsychologia 2021 Real CC, Suemoto CK, Binda KH, Grinberg LT, Pasqualucci CA, Jacob W, Ferretti-Rebustini REL, Nitrini R, Leite REP, de Britto LR
• B and T Lymphocyte Densities Remain Stable With Age in Human Cortex.
  ASN neuro 2021 Berry K, Farias-Itao DS, Grinberg LT, Plowey ED, Schneider JA, Rodriguez RD, Suemoto CK, Buckwalter MS
• Diagnostic Accuracy of Amyloid versus 18 F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia.
  Annals of neurology 2020 Lesman-Segev OH, La Joie R, Iaccarino L, Lobach I, Rosen HJ, Seo SW, Janabi M, Baker SL, Edwards L, Pham J, Olichney J, Boxer A, Huang E, Gorno-Tempini M, DeCarli C, Hepker M, Hwang JL, Miller BL, …
• 18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases.
  Brain : a journal of neurology 2020 Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL, Edwards L, Eser R, Gorno-Tempini ML, Jagust WJ, Janabi M, Kramer JH, Lesman-Segev OH, Mellinger T, Miller BL, Pham J, …
• Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson's Disease.
  Cells 2020 Plum S, Eggers B, Helling S, Stepath M, Theiss C, Leite REP, Molina M, Grinberg LT, Riederer P, Gerlach M, May C, Marcus K
• Dementia in Latin America: Paving the way toward a regional action plan.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, …
• Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.
  Annals of clinical and translational neurology 2020 Arrant AE, Davis SE, Vollmer RM, Murchison CF, Mobley JA, Nana AL, Spina S, Grinberg LT, Karydas AM, Miller BL, Seeley WW, Roberson ED
• Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease.
  Neurology 2020 Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, …
• Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.
  Cell 2020 Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, …
• Brain arteriolosclerosis.
  Acta neuropathologica 2020 Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, …
• Differential levels of inflammatory and neuroendocrine markers in the hippocampus and anterior cingulate cortex of bipolar disorder subjects: A post-mortem study.
  Brain, behavior, and immunity 2020 Nascimento C, Nunes PV, Suemoto CK, Rodriguez RD, Leite REP, Grinberg LT, Pasqualucci CA, Nitrini R, Jacob-Filho W, Brentani HP, Lafer B
• β-amyloid pathology is not associated with depression in a large community sample autopsy study.
  Journal of affective disorders 2020 Saldanha NM, Suemoto CK, Rodriguez RD, Leite REP, Nascimento C, Ferreti-Rebustini R, da Silva MM, Pasqualucci CA, Nitrini R, Jacob-Filho W, Lafer B, Grinberg LT, Nunes PV
• Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia.
  Cerebral cortex (New York, N.Y. : 1991) 2020 Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW
• Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.
  NeuroImage. Clinical 2020 Borghesani V, Battistella G, Mandelli ML, Welch A, Weis E, Younes K, Neuhaus J, Grinberg LT, Seeley WM, Spina S, Miller B, Miller Z, Gorno-Tempini ML
• Correction to: Relevance of biomarkers across different neurodegenerative diseases.
  Alzheimer's research & therapy 2020 Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, Mattsson-Carlgren N, …
• Relevance of biomarkers across different neurodegenerative diseases.
  Alzheimer's research & therapy 2020 Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, Mattsson-Carlgren N, …
• Similar Microglial Cell Densities across Brain Structures and Mammalian Species: Implications for Brain Tissue Function.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Dos Santos SE, Medeiros M, Porfirio J, Tavares W, Pessôa L, Grinberg L, Leite REP, Ferretti-Rebustini REL, Suemoto CK, Filho WJ, Noctor SC, Sherwood CC, Kaas JH, Manger PR, Herculano-Houzel S
• Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy.
  JAMA neurology 2020 Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici …
• Temporal variant of frontotemporal dementia in C9orf72 repeat expansion carriers: two case studies.
  Brain imaging and behavior 2020 Caso F, Agosta F, Magnani G, Cardamone R, Borghesani V, Miller Z, Riva N, La Joie R, Coppola G, Grinberg LT, Seeley WW, Miller BL, Gorno-Tempini ML, Filippi M
• Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.
  Nature medicine 2020 Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H,…
• Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
  Acta neuropathologica 2020 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
• Response letter: neuropathological lesions in the very old.
  Brain pathology (Zurich, Switzerland) 2020 Suemoto CK, Leite REP, Ferretti-Rebustini REL, Rodriguez RD, Nitrini R, Pasqualucci CA, Jacob-Filho W, Grinberg LT
• Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
  Acta neuropathologica communications 2019 Arrant AE, Roth JR, Boyle NR, Kashyap SN, Hoffmann MQ, Murchison CF, Ramos EM, Nana AL, Spina S, Grinberg LT, Miller BL, Seeley WW, Roberson ED
• B Lymphocytes and Macrophages in the Perivascular Adipose Tissue Are Associated With Coronary Atherosclerosis: An Autopsy Study.
  Journal of the American Heart Association 2019 Farias-Itao DS, Pasqualucci CA, Nishizawa A, da Silva LFF, Campos FM, Bittencourt MS, da Silva KCS, Leite REP, Grinberg LT, Ferretti-Rebustini REL, Jacob-Filho W, Suemoto CK
• Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of Aβ Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model.
  Molecular neurobiology 2019 Selles MC, Fortuna JTS, Zappa-Villar MF, de Faria YPR, Souza AS, Suemoto CK, Leite REP, Rodriguez RD, Grinberg LT, Reggiani PC, Ferreira ST
• Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
  Brain communications 2019 Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML
• Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.
  Acta neuropathologica communications 2019 Lin LC, Nana AL, Hepker M, Hwang JL, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH, Coppola G, Rosen HJ, Miller BL, Seeley WW
• A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
  Stem cell reports 2019 Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, …
• 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
  Acta neuropathologica 2019 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
• Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy.
  Neuron 2019 Brown JA, Deng J, Neuhaus J, Sible IJ, Sias AC, Lee SE, Kornak J, Marx GA, Karydas AM, Spina S, Grinberg LT, Coppola G, Geschwind DH, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW
• Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.
  The Journal of biological chemistry 2019 Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M
• Evidence of corticofugal tau spreading in patients with frontotemporal dementia.
  Acta neuropathologica 2019 Kim EJ, Hwang JL, Gaus SE, Nana AL, Deng J, Brown JA, Spina S, Lee MJ, Ramos EM, Grinberg LT, Kramer JH, Boxer AL, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW
• Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.
  Brain : a journal of neurology 2019 Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, …
• Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
  Nature chemical biology 2019 Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE
• Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.
  Brain : a journal of neurology 2019 Spina S, Brown JA, Deng J, Gardner RC, Nana AL, Hwang JL, Gaus SE, Huang EJ, Kramer JH, Rosen HJ, Kornak J, Neuhaus J, Miller BL, Grinberg LT, Boxer AL, Seeley WW
• Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation.
  Acta neuropathologica 2019 Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT
• Direct Measurements of Abdominal Visceral Fat and Cognitive Impairment in Late Life: Findings From an Autopsy Study.
  Frontiers in aging neuroscience 2019 Nishizawa A, Cuelho A, de Farias-Itao DS, Campos FM, Leite REP, Ferretti-Rebustini REL, Grinberg LT, Nitrini R, Jacob-Filho W, Pasqualucci CA, Suemoto CK
• Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia.
  Neurocase 2019 De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML
• A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.
  Progress in neuro-psychopharmacology & biological psychiatry 2019 Nascimento C, Nunes VP, Diehl Rodriguez R, Takada L, Suemoto CK, Grinberg LT, Nitrini R, Lafer B
• The role of artificial intelligence and machine learning in harmonization of high-resolution post-mortem MRI (virtopsy) with respect to brain microstructure.
  Brain informatics 2019 O'Sullivan S, Heinsen H, Grinberg LT, Chimelli L, Amaro E, do Nascimento Saldiva PH, Jeanquartier F, Jean-Quartier C, da Graça Morais Martin M, Sajid MI, Holzinger A
• Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis.
  Scientific reports 2019 Lisboa BCG, Oliveira KC, Tahira AC, Barbosa AR, Feltrin AS, Gouveia G, Lima L, Feio Dos Santos AC, Martins DC, Puga RD, Moretto AC, De Bragança Pereira CA, Lafer B, Leite REP, Ferretti-Rebustini REL, …
• Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
  Acta neuropathologica 2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett …
• Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials.
  Brain : a journal of neurology 2019 Staffaroni AM, Ljubenkov PA, Kornak J, Cobigo Y, Datta S, Marx G, Walters SM, Chiang K, Olney N, Elahi FM, Knopman DS, Dickerson BC, Boeve BF, Gorno-Tempini ML, Spina S, Grinberg LT, Seeley WW, Miller…
• 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.
  Alzheimer's research & therapy 2019 Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-…
• Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.
  Acta neuropathologica 2019 Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB
• Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2019 Vinceti G, Olney N, Mandelli ML, Spina S, Hubbard HI, Santos-Santos MA, Watson C, Miller ZA, Lomen-Hoerth C, Nichelli P, Miller BL, Grinberg LT, Seeley WW, Gorno-Tempini ML
• Neuropsychiatric Inventory in Community-Dwelling Older Adults with Mild Cognitive Impairment and Dementia.
  Journal of Alzheimer's disease : JAD 2019 Nunes PV, Schwarzer MC, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Rodriguez RD, Nascimento CF, Oliveira KC, Grinberg LT, Jacob-Filho W, Lafer B, Suemoto CK
• Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.
  Acta neuropathologica 2018 Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW
• Is Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease?
  The Annals of otology, rhinology, and laryngology 2018 Godoy MDCL, Fornazieri MA, Doty RL, Pinna FR, Farfel JM, Santos GBD, Molina M, Ferretti-Rebustini REL, Leite REP, Suemoto CK, Grinberg LT, Pasqualucci CAG, Voegels RL, Nitrini R, Jacob Filho W
• Primary School Education May Be Sufficient to Moderate a Memory-Hippocampal Relationship.
  Frontiers in aging neuroscience 2018 Resende EPF, Rosen HJ, Chiang K, Staffaroni AM, Allen I, Grinberg LT, Carmona KC, Guimarães HC, Carvalho VA, Barbosa MT, de Souza LC, Caramelli P
• Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
  Acta neuropathologica 2018 Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW…
• Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe …
• Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series.
  Journal of neurology 2018 Kim EJ, Brown JA, Deng J, Hwang JL, Spina S, Miller ZA, DeMay MG, Valcour V, Karydas A, Ramos EM, Coppola G, Miller BL, Rosen HJ, Seeley WW, Grinberg LT
• Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive-compulsive disorder.
  Brain structure & function 2018 de Oliveira KC, Grinberg LT, Hoexter MQ, Brentani H, Suemoto CK, Nery FG, Lima LC, Alho ATDL, Farfel JM, Ferretti-Rebustini REL, Leite REP, Moretto AC, da Silva AV, Lafer B, Miguel EC, Nitrini R, …
• Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects.
  Neurobiology of aging 2018 Soltys DT, Pereira CPM, Rowies FT, Farfel JM, Grinberg LT, Suemoto CK, Leite REP, Rodriguez RD, Ericson NG, Bielas JH, Souza-Pinto NC
• Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
  Annals of clinical and translational neurology 2018 Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, …
• Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample.
  Journal of affective disorders 2018 Nunes PV, Nascimento CF, Kim HK, Andreazza AC, Brentani HP, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Grinberg LT, Yong LT, Jacob-Filho W, Lafer B
• A patient with posterior cortical atrophy due to Alzheimer's disease.
  Dementia & neuropsychologia 2018 de Souza RKM, Grinberg LT, Josviak ND, de Almeida DB, Ramina R, Kowacs PA, Caramelli P
• Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain.
  Neural plasticity 2018 Villela D, Suemoto CK, Leite R, Pasqualucci CA, Grinberg LT, Pearson P, Rosenberg C
• Pathoarchitectonics of the cerebral cortex in chorea-acanthocytosis and Huntington's disease.
  Neuropathology and applied neurobiology 2018 Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E, Pasqualucci CA, Rüb U, Seidel K, den Dunnen W, Arzberger T, Schmitz C, Kiessling MC, Bader B, Danek A
• Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy.
  JAMA neurology 2018 Miller ZA, Rosenberg L, Santos-Santos MA, Stephens M, Allen IE, Hubbard HI, Cantwell A, Mandelli ML, Grinberg LT, Seeley WW, Miller BL, Rabinovici GD, Gorno-Tempini ML
• Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.
  The Lancet. Neurology 2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A,…
• A case of semantic variant primary progressive aphasia with Pick's pathology.
  Neurocase 2018 Caplan A, Marx G, Elofson J, Lis C, Grinberg L, Miller B, Rosen H
• Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
  JAMA neurology 2018 Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, …
• Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.
  Neurology 2018 Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski…
• Subcortical neurodegeneration in chorea: Similarities and differences between chorea-acanthocytosis and Huntington's disease.
  Parkinsonism & related disorders 2018 Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E, Pasqualucci CA, Rüb U, den Dunnen W, Arzberger T, Schmitz C, Kiessling M, Bader B, Danek A
• Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease.
  Journal of Alzheimer's disease : JAD 2018 Ehrenberg AJ, Suemoto CK, França Resende EP, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT
• Morphometric measurements of extracranial and intracranial atherosclerotic disease: A population-based autopsy study.
  Atherosclerosis 2017 Suemoto CK, Grinberg LT, Leite REP, Ferretti-Rebustini REL, Jacob-Filho W, Yaffe K, Nitrini R, Pasqualucci CA
• Clinicopathological correlations in behavioural variant frontotemporal dementia.
  Brain : a journal of neurology 2017 Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel…
• High thickness histological sections as alternative to study the three-dimensional microscopic human sub-cortical neuroanatomy.
  Brain structure & function 2017 Alho EJL, Alho ATDL, Grinberg L, Amaro E, Dos Santos GAB, da Silva RE, Neves RC, Alegro M, Coelho DB, Teixeira MJ, Fonoff ET, Heinsen H
• Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy.
  Sleep 2017 Walsh CM, Ruoff L, Walker K, Emery A, Varbel J, Karageorgiou E, Luong PN, Mance I, Heuer HW, Boxer AL, Grinberg LT, Kramer JH, Miller BL, Neylan TC
• Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study.
  PloS one 2017 Nishizawa A, Suemoto CK, Farias-Itao DS, Campos FM, Silva KCS, Bittencourt MS, Grinberg LT, Leite REP, Ferretti-Rebustini REL, Farfel JM, Jacob-Filho W, Pasqualucci CA
• 18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.
  Annals of neurology 2017 Schonhaut DR, McMillan CT, Spina S, Dickerson BC, Siderowf A, Devous MD, Tsai R, Winer J, Russell DS, Litvan I, Roberson ED, Seeley WW, Grinberg LT, Kramer JH, Miller BL, Pressman P, Nasrallah I, …
• Association between diabetes and causes of dementia: Evidence from a clinicopathological study.
  Dementia & neuropsychologia 2017 Matioli MNPDS, Suemoto CK, Rodriguez RD, Farias DS, da Silva MM, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Jacob W, Grinberg LT, Nitrini R
• Focal cerebral β-amyloid angiopathy: A distinct clinicopathologic presentation.
  Neurology. Clinical practice 2017 Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT
• Vascular cognitive impairment.
  Dementia & neuropsychologia 2017 Yassuda MS, Grinberg LT
• ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
  Nature 2017 Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, …
• Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis.
  Neuropathology and applied neurobiology 2017 Nascimento C, Di Lorenzo Alho AT, Bazan Conceição Amaral C, Leite REP, Nitrini R, Jacob-Filho W, Pasqualucci CA, Hokkanen SRK, Hunter S, Keage H, Kovacs GG, Grinberg LT, Suemoto CK
• Globular glial tauopathy presenting as non-fluent/agrammatic variant primary progressive aphasia with chorea.
  Parkinsonism & related disorders 2017 Kim EJ, Lee MJ, Lee JH, Lee YM, Shin JH, Shin MJ, Choi KU, Jung NY, Pak K, Hwang C, Ahn JW, Sung S, Spina S, Grinberg LT, Seeley WW, Huh GY
• Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).
  Journal of neuropathology and experimental neurology 2017 Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts …
• Precipitous Deterioration of Motor Function, Cognition, and Behavior.
  JAMA neurology 2017 Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD
• Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.
  Neuropathology and applied neurobiology 2017 Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, …
• Typical and atypical pathology in primary progressive aphasia variants.
  Annals of neurology 2017 Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, …
• Magnetic resonance diffusion tensor imaging for the pedunculopontine nucleus: proof of concept and histological correlation.
  Brain structure & function 2017 Alho ATDL, Hamani C, Alho EJL, da Silva RE, Santos GAB, Neves RC, Carreira LL, Araújo CMM, Magalhães G, Coelho DB, Alegro MC, Martin MGM, Grinberg LT, Pasqualucci CA, Heinsen H, Fonoff ET, Amaro E
• Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding.
  Journal of neuroscience methods 2017 Alegro M, Theofilas P, Nguy A, Castruita PA, Seeley W, Heinsen H, Ushizima DM, Grinberg LT
• Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study.
  International journal of geriatric psychiatry 2017 Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Farfel JM, de Oliveira KC, Grinberg LT, da Costa NR, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob-Filho W, …
• Diabetes is Not Associated with Alzheimer's Disease Neuropathology.
  Journal of Alzheimer's disease : JAD 2017 Dos Santos Matioli MNP, Suemoto CK, Rodriguez RD, Farias DS, da Silva MM, Leite REP, Ferretti-Rebustini REL, Farfel JM, Pasqualucci CA, Jacob Filho W, Arvanitakis Z, Naslavsky MS, Zatz M, Grinberg LT,…
• Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB
• Perivascular Adipose Tissue Inflammation and Coronary Artery Disease: An Autopsy Study Protocol.
  JMIR research protocols 2016 Farias-Itao DS, Pasqualucci CA, Nishizawa A, Silva LF, Campos FM, Silva KC, Leite RE, Grinberg LT, Ferretti-Rebustini RE, Jacob Filho W, Suemoto CK
• Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.
  NeuroImage. Clinical 2016 Seo SW, Ayakta N, Grinberg LT, Villeneuve S, Lehmann M, Reed B, DeCarli C, Miller BL, Rosen HJ, Boxer AL, O'Neil JP, Jin LW, Seeley WW, Jagust WJ, Rabinovici GD
• Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Miller ZA, Sturm VE, Camsari GB, Karydas A, Yokoyama JS, Grinberg LT, Boxer AL, Rosen HJ, Rankin KP, Gorno-Tempini ML, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Graff-Radford NR, Miller BL
• GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil.
  Alzheimer disease and associated disorders 2016 Takada LT, Bahia VS, Guimarães HC, Costa TV, Vale TC, Rodriguez RD, Porto FH, Machado JC, Beato RG, Cesar KG, Smid J, Nascimento CF, Grinberg LT, Brucki SM, Maximino JR, Camargos ST, Chadi G, …
• Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.
  JAMA neurology 2016 Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W,…
• Post-mortem assessment in vascular dementia: advances and aspirations.
  BMC medicine 2016 McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kövari E, Love S, Popovic M, Skrobot O, Taipa R, Thal …
• Association between adiposity and systemic atherosclerosis: a protocol of a cross-sectional autopsy study.
  Open heart 2016 Nishizawa A, Suemoto CK, Farias DS, Campos FM, da Silva KC, Cuelho A, Leite RE, Ferretti-Rebustini RE, Grinberg LT, Farfel JM, Jacob-Filho W, Pasqualucci CA
• Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA…
• Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player.
  Journal of Alzheimer's disease : JAD 2016 Grinberg LT, Anghinah R, Nascimento CF, Amaro E, Leite RP, Martin Mda G, Naslavsky MS, Takada LT, Filho WJ, Pasqualucci CA, Nitrini R
• Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
  Molecular neurodegeneration 2016 Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L
• Rest-activity rhythm disruption in progressive supranuclear palsy.
  Sleep medicine 2016 Walsh CM, Ruoff L, Varbel J, Walker K, Grinberg LT, Boxer AL, Kramer JH, Miller BL, Neylan TC
• Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer's Disease?
  Frontiers in genetics 2016 Villela D, Suemoto CK, Pasqualucci CA, Grinberg LT, Rosenberg C
• Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration.
  JAMA neurology 2016 Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, Miller BL, Seeley WW, …
• Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer's Disease Individuals.
  Neural plasticity 2016 Villela D, Ramalho RF, Silva AR, Brentani H, Suemoto CK, Pasqualucci CA, Grinberg LT, Krepischi AC, Rosenberg C
• Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
  Proteomics 2016 Schrötter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT
• Consensus statement for diagnosis of subcortical small vessel disease.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V
• Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.
  Acta neuropathologica 2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi…
• Primary chronic traumatic encephalopathy in an older patient with late-onset AD phenotype.
  Neurology. Clinical practice 2015 Fredericks CA, Koestler M, Seeley W, Miller B, Boxer A, Grinberg LT
• Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies.
  Revista da Escola de Enfermagem da U S P 2015 Ferretti-Rebustini RE, Balbinotti MA, Jacob-Filho W, Rebustini F, Suemoto CK, Pasqualucci CA, Farfel JM, Leite RE, Grinberg LT, Nitrini R
• Do age and sex impact on the absolute cell numbers of human brain regions?
  Brain structure & function 2015 Oliveira-Pinto AV, Andrade-Moraes CH, Oliveira LM, Parente-Bruno DR, Santos RM, Coutinho RA, Alho AT, Leite RE, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R
• Three-dimensional and stereological characterization of the human substantia nigra during aging.
  Brain structure & function 2015 Di Lorenzo Alho AT, Suemoto CK, Polichiso L, Tampellini E, de Oliveira KC, Molina M, Santos GA, Nascimento C, Leite RE, de Lucena Ferreti-Rebustini RE, da Silva AV, Nitrini R, Pasqualucci CA, Jacob-…
• Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample.
  Brain pathology (Zurich, Switzerland) 2015 Nascimento C, Suemoto CK, Rodriguez RD, Alho AT, Leite RP, Farfel JM, Pasqualucci CA, Jacob-Filho W, Grinberg LT
• A Long Journey from Childhood to Senility: The 23rd HUPO BPP Workshop: 16-17 April 2015, São Paulo, Brazil.
  Proteomics 2015 Magraoui FE, Schrötter A, Heinsen H, Leite R, Park YM, Meyer HE, Grinberg LT
• Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K
• Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology.
  Brain pathology (Zurich, Switzerland) 2015 Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB, den Dunnen W, Rüb U
• Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series.
  Neurology. Clinical practice 2015 Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD
• The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
  Brain : a journal of neurology 2015 Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel …
• Alzheimer and vascular brain diseases: Focal and diffuse subforms.
  Dementia & neuropsychologia 2015 Engelhardt E, Grinberg LT
• Enrichment of single neurons and defined brain regions from human brain tissue samples for subsequent proteome analysis.
  Journal of neural transmission (Vienna, Austria : 1996) 2015 Molina M, Steinbach S, Park YM, Yun SY, Di Lorenzo Alho AT, Heinsen H, Grinberg LT, Marcus K, Leite RE, May C
• Amyloid in dementia associated with familial FTLD: not an innocent bystander.
  Neurocase 2015 Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang …
• Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.
  Brain : a journal of neurology 2015 Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin …
• d-serine levels in Alzheimer's disease: implications for novel biomarker development.
  Translational psychiatry 2015 Madeira C, Lourenco MV, Vargas-Lopes C, Suemoto CK, Brandão CO, Reis T, Leite RE, Laks J, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Ferreira ST, Panizzutti R
• Neuroproteomics: applications in neuroscience and neurology.
  Biochimica et biophysica acta 2015 Grinberg LT, Jimenez CR, Li KW
• A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques.
  Acta neuropathologica communications 2015 Moreno F, Rabinovici GD, Karydas A, Miller Z, Hsu SC, Legati A, Fong J, Schonhaut D, Esselmann H, Watson C, Stephens ML, Kramer J, Wiltfang J, Seeley WW, Miller BL, Coppola G, Grinberg LT
• Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment.
  Cerebral cortex (New York, N.Y. : 1991) 2015 Grothe MJ, Heinsen H, Amaro E, Grinberg LT, Teipel SJ
• Alzheimer and vascular brain disease: Senile dementia.
  Dementia & neuropsychologia 2015 Engelhardt E, Grinberg LT
• Factors associated with morphometric brain changes in cognitively normal aging.
  Dementia & neuropsychologia 2015 Ferretti-Rebustini REL, Jacob-Filho W, Suemoto CK, Farfel JM, Leite REP, Grinberg LT, Pasqualucci CA, Nitrini R
• Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography.
  Alzheimer's research & therapy 2015 Sha SJ, Ghosh PM, Lee SE, Corbetta-Rastelli C, Jagust WJ, Kornak J, Rankin KP, Grinberg LT, Vinters HV, Mendez MF, Dickson DW, Seeley WW, Gorno-Tempini M, Kramer J, Miller BL, Boxer AL, Rabinovici GD
• Criminal behavior in frontotemporal dementia and Alzheimer disease.
  JAMA neurology 2015 Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, Grinberg LT, Seeley WW, Englund E, Miller BL
• New milestones in the development of characterization tools for neurodegenerative diseases in proteomics: 22nd HUPO BPP Workshop 7 October 2014, Madrid, Spain.
  Proteomics 2015 Schrötter A, Magraoui FE, Marcus K, Park YM, Meyer HE, Grinberg LT
• Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain.
  Dementia & neuropsychologia 2015 Engelhardt E, Grinberg LT
• Argyrophilic grain disease: An underestimated tauopathy.
  Dementia & neuropsychologia 2015 Rodriguez RD, Grinberg LT
• Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis.
  Journal of Alzheimer's disease : JAD 2015 Theofilas P, Dunlop S, Heinsen H, Grinberg LT
• Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.
  BioMed research international 2014 Corradini BR, Iamashita P, Tampellini E, Farfel JM, Grinberg LT, Moreira-Filho CA
• Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males.
  PloS one 2014 Oliveira-Pinto AV, Santos RM, Coutinho RA, Oliveira LM, Santos GB, Alho AT, Leite RE, Farfel JM, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R
• Primary age-related tauopathy (PART): a common pathology associated with human aging.
  Acta neuropathologica 2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, …
• Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.
  Journal of geriatric psychiatry and neurology 2014 Shinagawa S, Naasan G, Karydas AM, Coppola G, Pribadi M, Seeley WW, Trojanowski JQ, Miller BL, Grinberg LT
• Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction.
  Journal of neural transmission (Vienna, Austria : 1996) 2014 Nascimento C, Kim HK, Young LT, Mendonça KM, Grinberg LT, Lafer B, Andreazza AC
• Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene.
  Molecular neurodegeneration 2014 van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam …
• The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.
  Brain pathology (Zurich, Switzerland) 2014 Seidel K, Mahlke J, Siswanto S, Krüger R, Heinsen H, Auburger G, Bouzrou M, Grinberg LT, Wicht H, Korf HW, den Dunnen W, Rüb U
• A microdeletion in Alzheimer's disease disrupts NAMPT gene.
  Journal of genetics 2014 Villela D, Schlesinger D, Suemoto CK, Grinberg LT, Rosenberg C
• Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.
  PloS one 2014 Silva AR, Santos AC, Farfel JM, Grinberg LT, Ferretti RE, Campos AH, Cunha IW, Begnami MD, Rocha RM, Carraro DM, de Bragança Pereira CA, Jacob-Filho W, Brentani H
• Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan.
  Proteomics 2014 Schrötter A, El Magraoui F, Gröttrup B, Heinsen H, Marcus K, Meyer HE, Park YM, Grinberg LT
• Distinct tau prion strains propagate in cells and mice and define different tauopathies.
  Neuron 2014 Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI
• Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers.
  Neurobiology of aging 2014 van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, …
• Developing new methods to answer old and new questions in neurodegenerative diseases: 21(st) Workshop of the HUPO Brain Proteome Project (HBPP) 23-24 January 2014, Honolulu, Hawaii.
  Proteomics 2014 El Magraoui F, Eisenacher M, Schrötter A, Kuhlmann K, Heinsen H, Andrén P, Nilsson P, Häggmark A, Schmitz G, Verhaert P, Borchers C, Yoo JS, Lee BH, Meyer HE, Grinberg LT
• A novel approach for integrative studies on neurodegenerative diseases in human brains.
  Journal of neuroscience methods 2014 Theofilas P, Polichiso L, Wang X, Lima LC, Alho ATL, Leite REP, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H, Brazilian Aging Brain Study Group, Grinberg LT
• TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.
  Acta neuropathologica 2014 van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, …
• Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration.
  Annals of neurology 2014 Scherling CS, Hall T, Berisha F, Klepac K, Karydas A, Coppola G, Kramer JH, Rabinovici G, Ahlijanian M, Miller BL, Seeley W, Grinberg LT, Rosen H, Meredith J, Boxer AL
• Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study.
  Journal of Alzheimer's disease : JAD 2014 Kilimann I, Grothe M, Heinsen H, Alho EJ, Grinberg L, Amaro E, Dos Santos GA, da Silva RE, Mitchell AJ, Frisoni GB, Bokde AL, Fellgiebel A, Filippi M, Hampel H, Klöppel S, Teipel SJ
• In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology.
  Neurology 2013 Caso F, Mandelli ML, Henry M, Gesierich B, Bettcher BM, Ogar J, Filippi M, Comi G, Magnani G, Sidhu M, Trojanowski JQ, Huang EJ, Grinberg LT, Miller BL, Dronkers N, Seeley WW, Gorno-Tempini ML
• Practical utility of amyloid and FDG-PET in an academic dementia center.
  Neurology 2013 Sánchez-Juan P, Ghosh PM, Hagen J, Gesierich B, Henry M, Grinberg LT, O'Neil JP, Janabi M, Huang EJ, Trojanowski JQ, Vinters HV, Gorno-Tempini M, Seeley WW, Boxer AL, Rosen HJ, Kramer JH, Miller BL, …
• Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus.
  Psychiatry research 2013 Teipel SJ, Flatz W, Ackl N, Grothe M, Kilimann I, Bokde AL, Grinberg L, Amaro E, Kljajevic V, Alho E, Knels C, Ebert A, Heinsen H, Danek A
• Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene.
  Genetics and molecular biology 2013 Villela D, Kimura L, Schlesinger D, Gonçalves A, Pearson PL, Suemoto CK, Pasqualucci C, Krepischi AC, Grinberg LT, Rosenberg C
• Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease.
  Neurobiology of aging 2013 Teipel S, Heinsen H, Amaro E, Grinberg LT, Krause B, Grothe M, Alzheimer's Disease Neuroimaging Initiative
• Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles.
  Brain : a journal of neurology 2013 Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, da Silva CG, Guimarães DM, Szczupak D, Parente-Bruno DR, Carvalho LR, Polichiso L, Gomes BV, Oliveira LM, Rodriguez RD, Leite RE, Ferretti-…
• Early diagnosis of neurodegenerative diseases - the long awaited Holy Grail and bottleneck of modern brain research - 19th HUPO BPP workshop: May 22-24, 2013, Dortmund, Germany.
  Proteomics 2013 Schrötter A, Magraoui FE, Gröttrup B, Wiltfang J, Heinsen H, Marcus K, Meyer HE, Grinberg LT, Park YM
• The human cerebral cortex is neither one nor many: neuronal distribution reveals two quantitatively different zones in the gray matter, three in the white matter, and explains local variations in cortical folding.
  Frontiers in neuroanatomy 2013 Ribeiro PF, Ventura-Antunes L, Gabi M, Mota B, Grinberg LT, Farfel JM, Ferretti-Rebustini RE, Leite RE, Filho WJ, Herculano-Houzel S
• Combined enrichment of neuromelanin granules and synaptosomes from human substantia nigra pars compacta tissue for proteomic analysis.
  Journal of proteomics 2013 Plum S, Helling S, Theiss C, Leite REP, May C, Jacob-Filho W, Eisenacher M, Kuhlmann K, Meyer HE, Riederer P, Grinberg LT, Gerlach M, Marcus K
• Very low levels of education and cognitive reserve: a clinicopathologic study.
  Neurology 2013 Farfel JM, Nitrini R, Suemoto CK, Grinberg LT, Ferretti RE, Leite RE, Tampellini E, Lima L, Farias DS, Neves RC, Rodriguez RD, Menezes PR, Fregni F, Bennett DA, Pasqualucci CA, Jacob Filho W, …
• Progranulin mutations as risk factors for Alzheimer disease.
  JAMA neurology 2013 Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G
• TDP-43 frontotemporal lobar degeneration and autoimmune disease.
  Journal of neurology, neurosurgery, and psychiatry 2013 Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, Boxer AL, Rosen HJ, …
• Challenges in modern biomarker discovery--17th HUPO BPP workshop: May 24-25, 2012, Sao Paulo, Brazil.
  Proteomics 2013 Gröttrup B, Esselmann H, May C, Schrötter A, Woitalla D, Heinsen H, Marcus K, Wiltfang J, Meyer HE, Grinberg LT, Park YM
• Prevalence of dementia subtypes in a developing country: a clinicopathological study.
  Clinics (Sao Paulo, Brazil) 2013 Grinberg LT, Nitrini R, Suemoto CK, Lucena Ferretti-Rebustini RE, Leite RE, Farfel JM, Santos E, Andrade MP, Alho AT, Lima Mdo C, Oliveira KC, Tampellini E, Polichiso L, Santos GB, Rodriguez RD, Ueda …
• Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA.
  Proteomics 2013 Gröttrup B, May C, Meyer HE, Grinberg LT, Park YM
• Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease.
  PloS one 2012 Silva AR, Grinberg LT, Farfel JM, Diniz BS, Lima LA, Silva PJ, Ferretti RE, Rocha RM, Filho WJ, Carraro DM, Brentani H
• Cerebral amyloid angiopathy impact on endothelium.
  Experimental gerontology 2012 Grinberg LT, Korczyn AD, Heinsen H
• A 44-year-old man with profound behavioural changes.
  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2012 Laforce R, Kerchner GA, Rabinovici GD, Fong JC, Miller BL, Seeley WW, Grinberg LT
• Vascular dementia: Current concepts and nomenclature harmonization.
  Dementia & neuropsychologia 2012 Grinberg LT
• Depression and cardiovascular risk factors: evidence from a large postmortem sample.
  International journal of geriatric psychiatry 2012 Suemoto CK, Damico MV, Ferretti RE, Grinberg LT, Farfel JM, Leite RE, Nitrini R, Lafer B, Jacob-Filho W, Pasqualucci CA, Brazilian Aging Brain Study Group
• Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain.
  Experimental gerontology 2012 Thal DR, Grinberg LT, Attems J
• Vascular dementia.
  Journal of the neurological sciences 2012 Korczyn AD, Vakhapova V, Grinberg LT
• Translational proteomics in neurodegenerative diseases--16th HUPO BPP workshop September 5, 2011 Geneva, Switzerland.
  Proteomics 2012 Gröttrup B, Böckmann M, Stephan C, Marcus K, Grinberg LT, Meyer HE, Park YM
• Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.
  Neurology 2011 Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML…
• Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany.
  Proteomics 2011 Gröttrup B, Böckmann M, Marcus K, Wiltfang J, Grinberg LT, Meyer HE, Park YM
• Neuropathologic features associated with Alzheimer disease diagnosis: age matters.
  Neurology 2011 Middleton LE, Grinberg LT, Miller B, Kawas C, Yaffe K
• Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury.
  Journal of photochemistry and photobiology. B, Biology 2011 Moreira MS, Velasco IT, Ferreira LS, Ariga SK, Abatepaulo F, Grinberg LT, Marques MM
• Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries.
  Stroke 2011 Suemoto CK, Nitrini R, Grinberg LT, Ferretti RE, Farfel JM, Leite RE, Menezes PR, Fregni F, Jacob-Filho W, Pasqualucci CA, Brazilian Aging Brain Study Group
• Creating a human brain proteome atlas--14th HUPO BPP workshop September 20-21, 2010, Sydney, Australia.
  Proteomics 2011 Gröttrup B, Marcus K, Grinberg LT, Lee SK, Meyer HE, Park YM
• Creating a human brain proteome atlas--13th HUPO BPP Workshop March 30-31, 2010, Ochang, Korea.
  Proteomics 2011 Gröttrup B, Stephan C, Marcus K, Grinberg LT, Wiltfang J, Lee SK, Kim YH, Meyer HE, Park YM
• Staging Alzheimer's disease progression with multimodality neuroimaging.
  Progress in neurobiology 2011 Ewers M, Frisoni GB, Teipel SJ, Grinberg LT, Amaro E, Heinsen H, Thompson PM, Hampel H
• Brazilian psychiatric brain bank: a new contribution tool to network studies.
  Cell and tissue banking 2011 de Oliveira KC, Nery FG, Ferreti RE, Lima MC, Cappi C, Machado-Lima A, Polichiso L, Carreira LL, Ávila C, Alho AT, Brentani HP, Miguel EC, Heinsen H, Jacob-Filho W, Pasqualucci CA, Lafer B, Grinberg …
• Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis.
  The international journal of neuropsychopharmacology 2010 Gigante AD, Young LT, Yatham LN, Andreazza AC, Nery FG, Grinberg LT, Heinsen H, Lafer B
• Morphometric brain changes during aging: Results from a Brazilian necropsy sample.
  Dementia & neuropsychologia 2010 Ferretti REL, Jacob-Filho W, Grinberg LT, Leite REP, Farfel JM, Suemoto CK, Saldiva PHN, Rosemberg S, Pasqualucci CA, Nitrini R
• The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study.
  Human brain mapping 2010 Teipel SJ, Meindl T, Grinberg L, Grothe M, Cantero JL, Reiser MF, Möller HJ, Heinsen H, Hampel H
• Post-Mortem diagnosis of dementia by informant interview.
  Dementia & neuropsychologia 2010 Ferretti REL, Damin AE, Brucki SMD, Morillo LS, Perroco TR, Campora F, Moreira EG, Balbino ÉS, Lima MDCA, Battela C, Ruiz L, Grinberg LT, Farfel JM, Leite REP, Suemoto CK, Pasqualucci CA, Rosemberg S,…
• Association between cardiovascular disease and dementia.
  Dementia & neuropsychologia 2009 Suemoto CK, Ferretti RE, Grinberg LT, de Oliveira KC, Farfel JM, Leite REP, Nitrini R, Jacob Filho W, Pasqualucci CA, Brazilian Aging Brain Study Group
• Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study.
  Dementia & neuropsychologia 2009 Takada LT, Camiz P, Grinberg LT, Leite CDC
• Brainstem pathology and non-motor symptoms in PD.
  Journal of the neurological sciences 2009 Grinberg LT, Rueb U, Alho AT, Heinsen H
• Toward a Successful Clinical Neuroproteomics The 11th HUPO Brain Proteome Project Workshop 3 March, 2009, Kolymbari, Greece.
  Proteomics. Clinical applications 2009 Kim YH, Marcus K, Grinberg LT, Goehler H, Wiltfang J, Stephan C, Eisenacher M, Hardt T, Martens L, J Dunn M, Park YM, Meyer HE
• The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
  Neuropathology and applied neurobiology 2009 Grinberg LT, Rüb U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H, Brazilian Brain Bank Study Group
• Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology.
  Journal of the neurological sciences 2009 Grinberg LT, Amaro Junior E, da Silva AV, da Silva RE, Sato JR, dos Santos DD, de Paula Pacheco S, de Lucena Ferretti RE, Paraizo Leite RE, Pasqualucci CA, Teipel SJ, Flatz WH, Brazilian Aging Brain …
• Argyrophilic grain disease: an update about a frequent cause of dementia.
  Dementia & neuropsychologia 2009 Grinberg LT, Heinsen H
• Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity.
  The international journal of biochemistry & cell biology 2008 Paula-Lima AC, Tricerri MA, Brito-Moreira J, Bomfim TR, Oliveira FF, Magdesian MH, Grinberg LT, Panizzutti R, Ferreira ST
• How to run a brain bank--revisited.
  Cell and tissue banking 2008 Ravid R, Grinberg LT
• Clinico-pathological discrepancies in the diagnoses of solid malignancies.
  Pathology, research and practice 2008 Grinberg LT, Ferraz da Silva LF, Galtarossa Xavier AC, Nascimento Saldiva PH, Mauad T
• ALS and FTLD: two faces of TDP-43 proteinopathy.
  European journal of neurology 2008 Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ
• Assessment of factors that confound MRI and neuropathological correlation of human postmortem brain tissue.
  Cell and tissue banking 2008 Grinberg LT, Amaro E, Teipel S, dos Santos DD, Pasqualucci CA, Leite RE, Camargo CR, Gonçalves JA, Sanches AG, Santana M, Ferretti RE, Jacob-Filho W, Nitrini R, Heinsen H, Brazilian Aging Brain Study …
• Novel MRI techniques in the assessment of dementia.
  European journal of nuclear medicine and molecular imaging 2008 Teipel SJ, Meindl T, Grinberg L, Heinsen H, Hampel H
• Clinicopathological correlates of Alzheimer's disease in a general autopsy series from Brazil.
  Dementia & neuropsychologia 2007 Grinberg LT, Ferretti REL, Leite REP, Farfel JM, Pacheco SP, Alho ATDL, Grisoli RP, Matos HTM, Moreira EG, Balbino ES, Oliveira KC, Rosemberg S, Carvalho HB, Pasquallucci CAG, Saldiva PHN, Jacob-Filho…
• Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.
  Acta neuropathologica 2007 Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, …
• Computer-assisted 3D reconstruction of the human basal forebrain complex.
  Dementia & neuropsychologia 2007 Grinberg LT, Heinsen H
• Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation.
  Alzheimer disease and associated disorders 2007 Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, Cairns NJ
• Brain bank of the Brazilian aging brain study group - a milestone reached and more than 1,600 collected brains.
  Cell and tissue banking 2006 Grinberg LT, Ferretti RE, Farfel JM, Leite R, Pasqualucci CA, Rosemberg S, Nitrini R, Saldiva PH, Filho WJ, Brazilian Aging Brain Study Group
• Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma.
  American journal of respiratory and critical care medicine 2004 Mauad T, Silva LF, Santos MA, Grinberg L, Bernardi FD, Martins MA, Saldiva PH, Dolhnikoff M
• Enhanced protective antibody responses to PspA after intranasal or subcutaneous injections of PspA genetically fused to granulocyte-macrophage colony-stimulating factor or interleukin-2.
  Infection and immunity 1998 Wortham C, Grinberg L, Kaslow DC, Briles DE, McDaniel LS, Lees A, Flora M, Snapper CM, Mond JJ
• Policy statement on FDA reform. Food and Drug Administration.
  BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation 1995 Baker R, Delaney M, Getty J, Grinberg L, Levin J
• On a specific aspect of countertransference due to the patient's projective identification.
  The International journal of psycho-analysis 1962 GRINBERG L