Laya Ekhlaspour, MD
Assistant Professor
Pediatrics
School of Medicine

Since my training, I have focused on testing and developing novel diabetes technologies, including continuous glucose monitors and automated insulin delivery systems and have been a co-investigator on multiple NIH, JDRF, and industry-funded studies. I have received an NIH grant to address the impact of meal composition on postprandial glucose excursions in closed-loop systems.

• ISPAD Clinical Practice Consensus Guidelines 2024: Diabetes Technologies: Insulin Delivery.
  Hormone research in paediatrics 2024 Biester T, Berget C, Boughton C, Cudizio L, Ekhlaspour L, Hilliard ME, Reddy L, Sap Ngo Um S, Schoelwer M, Sherr JL, Dovc K
• Discordance Between Clinician and Person-With-Diabetes Perceptions Regarding Technology Barriers and Benefits.
  Journal of diabetes science and technology 2024 Addala A, Howard KR, Hosseinipour Y, Ekhlaspour L
• Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion.
  Journal of diabetes science and technology 2024 Klonoff DC, Ayers AT, Ho CN, Fabris C, Villa-Tamayo MF, Allen E, Cengiz E, Ekhlaspour L, Wong JC, Heineman L, Kohn MA
• Impact of Missed and Late Meal Boluses on Glycemic Outcomes in Automated Insulin Delivery-Treated Children and Adolescents with Type 1 Diabetes: A Two-Center, Population-Based Cohort Study.
  Diabetes technology & therapeutics 2024 Laugesen C, Ritschel T, Ranjan AG, Hsu L, Jørgensen JB, Svensson J, Ekhlaspour L, Buckingham B, Nørgaard K
• Safety and prescribing recommendations for verapamil in newly diagnosed pediatric type 1 diabetes (T1D): The CLVer experience.
  Journal of clinical & translational endocrinology 2024 Ekhlaspour L, Buckingham B, Bauza C, Clements M, Forlenza GP, Neyman A, Norlander L, Schamberger M, Sherr JL, Bailey R, Beck RW, Kollman C, Beasley S, Cobry E, DiMeglio LA, Paprocki E, Van Name M, …
• Corrigendum to "New therapies towards a better glycemic control in youths with type 1 diabetes" [Pharmacol. Res. 2023 Aug 3;195:106882].
  Pharmacological research 2024 Cardona-Hernandez R, Dôvc K, Biester T, Ekhlaspour L, Macedoni M, Tauschmann M, Mameli C
• The Minimally-Invasive Oral Glucose Minimal Model: Estimation of Gastric Retention, Glucose Rate of Appearance, and Insulin Sensitivity From Type 1 Diabetes Data Collected in Real-Life Conditions.
  IEEE transactions on bio-medical engineering 2024 Faggionato E, Schiavon M, Ekhlaspour L, Buckingham BA, Dalla Man C
• Patient reported outcomes (PROs) and user experiences of young children with type 1 diabetes using t:slim X2 insulin pump with control-IQ technology.
  Diabetes research and clinical practice 2024 Hood KK, Schneider-Utaka AK, Reed ZW, Buckingham BA, Cobry E, DeBoer MD, Ekhlaspour L, Schoelwer M, Paul Wadwa R, Lum J, Kollman C, Beck RW, Breton MD, PEDAP Trial Study Group
• New therapies towards a better glycemic control in youths with type 1 diabetes.
  Pharmacological research 2023 Cardona-Hernandez R, Dôvc K, Biester T, Ekhlaspour L, Macedoni M, Tauschmann M, Mameli C
• Effect of Tight Glycemic Control on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial.
  JAMA 2023 McVean J, Forlenza GP, Beck RW, Bauza C, Bailey R, Buckingham B, DiMeglio LA, Sherr JL, Clements M, Neyman A, Evans-Molina C, Sims EK, Messer LH, Ekhlaspour L, McDonough R, Van Name M, Rojas D, …
• Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial.
  JAMA 2023 Forlenza GP, McVean J, Beck RW, Bauza C, Bailey R, Buckingham B, DiMeglio LA, Sherr JL, Clements M, Neyman A, Evans-Molina C, Sims EK, Messer LH, Ekhlaspour L, McDonough R, Van Name M, Rojas D, …
• Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes.
  The New England journal of medicine 2023 Wadwa RP, Reed ZW, Buckingham BA, DeBoer MD, Ekhlaspour L, Forlenza GP, Schoelwer M, Lum J, Kollman C, Beck RW, Breton MD, PEDAP Trial Study Group
• Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice.
  Endocrine reviews 2023 Phillip M, Nimri R, Bergenstal RM, Barnard-Kelly K, Danne T, Hovorka R, Kovatchev BP, Messer LH, Parkin CG, Ambler-Osborn L, Amiel SA, Bally L, Beck RW, Biester S, Biester T, Blanchette JE, Bosi E, …
• Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes.
  The New England journal of medicine 2022 Bionic Pancreas Research Group, Russell SJ, Beck RW, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Calhoun P, Wadwa RP, Buckingham B, Zhou K, Daniels M, Raskin P, White PC, Lynch J, Pettus J, …
• Safety and Glycemic Outcomes With a Tubeless Automated Insulin Delivery System in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Clinical Trial.
  Diabetes care 2022 Sherr JL, Bode BW, Forlenza GP, Laffel LM, Schoelwer MJ, Buckingham BA, Criego AB, DeSalvo DJ, MacLeish SA, Hansen DW, Ly TT, Omnipod 5 in Preschoolers Study Group:, Sherr JL, Weyman K, Tichy E, …
• Outpatient Randomized Crossover Comparison of Zone Model Predictive Control Automated Insulin Delivery with Weekly Data Driven Adaptation Versus Sensor-Augmented Pump: Results from the International Diabetes Closed-Loop Trial 4.
  Diabetes technology & therapeutics 2022 Pinsker JE, Dassau E, Deshpande S, Raghinaru D, Buckingham BA, Kudva YC, Laffel LM, Levy CJ, Church MM, Desrochers H, Ekhlaspour L, Kaur RJ, Levister C, Shi D, Lum JW, Kollman C, Doyle FJ, iDCL Trial …
• Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial.
  The Lancet. Digital health 2022 Ware J, Boughton CK, Allen JM, Wilinska ME, Tauschmann M, Denvir L, Thankamony A, Campbell FM, Wadwa RP, Buckingham BA, Davis N, DiMeglio LA, Mauras N, Besser REJ, Ghatak A, Weinzimer SA, Hood KK, Fox…
• Glycemic outcomes of children 2-6 years of age with type 1 diabetes during the pediatric MiniMed™ 670G system trial.
  Pediatric diabetes 2022 Forlenza GP, Ekhlaspour L, DiMeglio LA, Fox LA, Rodriguez H, Shulman DI, Kaiserman KB, Liljenquist DR, Shin J, Lee SW, Buckingham BA
• Impact of a Novel Diabetes Support System on a Cohort of Individuals With Type 1 Diabetes Treated With Multiple Daily Injections: A Multicenter Randomized Study.
  Diabetes care 2022 Bisio A, Anderson S, Norlander L, O'Malley G, Robic J, Ogyaadu S, Hsu L, Levister C, Ekhlaspour L, Lam DW, Levy C, Buckingham B, Breton MD
• Patient-Reported Outcomes in a Randomized Trial of Closed-Loop Control: The Pivotal International Diabetes Closed-Loop Trial.
  Diabetes technology & therapeutics 2021 Kudva YC, Laffel LM, Brown SA, Raghinaru D, Pinsker JE, Ekhlaspour L, Levy CJ, Messer LH, Kovatchev BP, Lum JW, Beck RW, Gonder-Frederick L, iDCL Trial Research Group
• Adjunctive Therapies to Optimize Closed-loop Glucose Control.
  Journal of diabetes science and technology 2021 Srinivasan S, Ekhlaspour L, Cengiz E
• Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes.
  Diabetes care 2021 Brown SA, Forlenza GP, Bode BW, Pinsker JE, Levy CJ, Criego AB, Hansen DW, Hirsch IB, Carlson AL, Bergenstal RM, Sherr JL, Mehta SN, Laffel LM, Shah VN, Bhargava A, Weinstock RS, MacLeish SA, DeSalvo …
• Diabetes Technology and Therapy in the Pediatric Age Group.
  Diabetes technology & therapeutics 2021 Maahs DM, Ekhlaspour L, Shalitin S
• Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial.
  Diabetes technology & therapeutics 2021 O'Malley G, Messer LH, Levy CJ, Pinsker JE, Forlenza GP, Isganaitis E, Kudva YC, Ekhlaspour L, Raghinaru D, Lum J, Brown SA, iDCL Trial Research Group
• Predictors of Time-in-Range (70-180 mg/dL) Achieved Using a Closed-Loop Control System.
  Diabetes technology & therapeutics 2021 Schoelwer MJ, Kanapka LG, Wadwa RP, Breton MD, Ruedy KJ, Ekhlaspour L, Forlenza GP, Cobry EC, Messer LH, Cengiz E, Jost E, Carria L, Emory E, Hsu LJ, Weinzimer SA, Buckingham BA, Lal RA, Oliveri MC, …
• Health-Related Quality of Life and Treatment Satisfaction in Parents and Children with Type 1 Diabetes Using Closed-Loop Control.
  Diabetes technology & therapeutics 2021 Cobry EC, Kanapka LG, Cengiz E, Carria L, Ekhlaspour L, Buckingham BA, Hood KK, Hsu LJ, Messer LH, Schoelwer MJ, Emory E, Ruedy KJ, Beck RW, Wadwa RP, Gonder-Frederick L, iDCL Trial Research Group
• Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial.
  Diabetes technology & therapeutics 2021 Isganaitis E, Raghinaru D, Ambler-Osborn L, Pinsker JE, Buckingham BA, Wadwa RP, Ekhlaspour L, Kudva YC, Levy CJ, Forlenza GP, Beck RW, Kollman C, Lum JW, Brown SA, Laffel LM, iDCL Trial Research …
• First Outpatient Evaluation of a Tubeless Automated Insulin Delivery System with Customizable Glucose Targets in Children and Adults with Type 1 Diabetes.
  Diabetes technology & therapeutics 2021 Forlenza GP, Buckingham BA, Brown SA, Bode BW, Levy CJ, Criego AB, Wadwa RP, Cobry EC, Slover RJ, Messer LH, Berget C, McCoy S, Ekhlaspour L, Kingman RS, Voelmle MK, Boyd J, O'Malley G, Grieme A, …
• Fast-Acting Insulin Aspart Use with the MiniMedTM 670G System.
  Diabetes technology & therapeutics 2021 Hsu L, Buckingham B, Basina M, Ekhlaspour L, von Eyben R, Wang J, Lal RA
• Extended Use of the Control-IQ Closed-Loop Control System in Children With Type 1 Diabetes.
  Diabetes care 2020 Kanapka LG, Wadwa RP, Breton MD, Ruedy KJ, Ekhlaspour L, Forlenza GP, Cengiz E, Schoelwer MJ, Jost E, Carria L, Emory E, Hsu LJ, Weinzimer SA, DeBoer MD, Buckingham BA, Oliveri M, Kollman C, Dokken BB…
• Safety and Performance of the Tandem t:slim X2 with Control-IQ Automated Insulin Delivery System in Toddlers and Preschoolers.
  Diabetes technology & therapeutics 2020 Ekhlaspour L, Schoelwer MJ, Forlenza GP, DeBoer MD, Norlander L, Hsu L, Kingman R, Boranian E, Berget C, Emory E, Buckingham BA, Breton MD, Wadwa RP
• A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.
  The New England journal of medicine 2020 Breton MD, Kanapka LG, Beck RW, Ekhlaspour L, Forlenza GP, Cengiz E, Schoelwer M, Ruedy KJ, Jost E, Carria L, Emory E, Hsu LJ, Oliveri M, Kollman CC, Dokken BB, Weinzimer SA, DeBoer MD, Buckingham BA,…
• Glycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial.
  Diabetes care 2020 Brown SA, Beck RW, Raghinaru D, Buckingham BA, Laffel LM, Wadwa RP, Kudva YC, Levy CJ, Pinsker JE, Dassau E, Doyle FJ, Ambler-Osborn L, Anderson SM, Church MM, Ekhlaspour L, Forlenza GP, Levister C, …
• Erratum. Randomized Controlled Trial of Mobile Closed-Loop Control. Diabetes Care 2020;43:607-615.
  Diabetes care 2020 Kovatchev B, Anderson SM, Raghinaru D, Kudva YC, Laffel LM, Levy C, Pinsker JE, Wadwa RP, Buckingham B, Doyle FJ, Brown SA, Church MM, Dadlani V, Dassau E, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam…
• Randomized Controlled Trial of Mobile Closed-Loop Control.
  Diabetes care 2020 Kovatchev B, Anderson SM, Raghinaru D, Kudva YC, Laffel LM, Levy C, Pinsker JE, Wadwa RP, Buckingham B, Doyle FJ, Brown SA, Church MM, Dadlani V, Dassau E, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam…
• Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes.
  Endocrine reviews 2019 Lal RA, Ekhlaspour L, Hood K, Buckingham B
• Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions.
  Diabetes technology & therapeutics 2019 Sherr JL, Buckingham BA, Forlenza GP, Galderisi A, Ekhlaspour L, Wadwa RP, Carria L, Hsu L, Berget C, Peyser TA, Lee JB, O'Connor J, Dumais B, Huyett LM, Layne JE, Ly TT
• Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting.
  Journal of diabetes science and technology 2019 Ekhlaspour L, Nally LM, El-Khatib FH, Ly TT, Clinton P, Frank E, Tanenbaum ML, Hanes SJ, Selagamsetty RR, Hood K, Damiano ER, Buckingham BA
• Task-related fMRI BOLD response to hyperinsulinemia in healthy older adults.
  JCI insight 2019 Williams VJ, Trombetta BA, Jafri RZ, Koenig AM, Wennick CD, Carlyle BC, Ekhlaspour L, Ahima RS, Russell SJ, Salat DH, Arnold SE
• A Review of Continuous Glucose Monitoring Data Interpretation in the Age of Automated Insulin Delivery.
  Journal of diabetes science and technology 2019 Ekhlaspour L, Tabatabai I, Buckingham B
• Closed loop control in adolescents and children during winter sports: Use of the Tandem Control-IQ AP system.
  Pediatric diabetes 2019 Ekhlaspour L, Forlenza GP, Chernavvsky D, Maahs DM, Wadwa RP, Deboer MD, Messer LH, Town M, Pinnata J, Kruse G, Kovatchev BP, Buckingham BA, Breton MD
• Successful At-Home Use of the Tandem Control-IQ Artificial Pancreas System in Young Children During a Randomized Controlled Trial.
  Diabetes technology & therapeutics 2019 Forlenza GP, Ekhlaspour L, Breton M, Maahs DM, Wadwa RP, DeBoer M, Messer LH, Town M, Pinnata J, Kruse G, Buckingham BA, Cherñavvsky D
• Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial.
  Diabetes care 2018 Forlenza GP, Li Z, Buckingham BA, Pinsker JE, Cengiz E, Wadwa RP, Ekhlaspour L, Church MM, Weinzimer SA, Jost E, Marcal T, Andre C, Carria L, Swanson V, Lum JW, Kollman C, Woodall W, Beck RW
• Predictive hyperglycemia and hypoglycemia minimization: In-home double-blind randomized controlled evaluation in children and young adolescents.
  Pediatric diabetes 2017 Forlenza GP, Raghinaru D, Cameron F, Wayne Bequette B, Peter Chase H, Paul Wadwa R, Maahs DM, Jost E, Ly TT, Wilson DM, Norlander L, Ekhlaspour L, Min H, Clinton P, Njeru N, Lum JW, Kollman C, Beck RW…
• Biopsychosocial Aspects of Weight Management in Type 1 Diabetes: a Review and Next Steps.
  Current diabetes reports 2017 Driscoll KA, Corbin KD, Maahs DM, Pratley R, Bishop FK, Kahkoska A, Hood KK, Mayer-Davis E, Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON)
• In-Home Closed Loop Control for Artificial Pancreas: Patient and Provider Perspective.
  Diabetes technology & therapeutics 2017 Ekhlaspour L, Maahs DM
• Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders.
  Journal of autism and developmental disorders 2016 Ekhlaspour L, Baskaran C, Campoverde KJ, Sokoloff NC, Neumeyer AM, Misra M
• Comparative Accuracy of 17 Point-of-Care Glucose Meters.
  Journal of diabetes science and technology 2016 Ekhlaspour L, Mondesir D, Lautsch N, Balliro C, Hillard M, Magyar K, Radocchia LG, Esmaeili A, Sinha M, Russell SJ