Lawrence Shiow, MD, PhD
Assistant Professor
Pediatrics
School of Medicine

Education & Training

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• Residency Pediatrics University of California, San Francisco 2012
• M.D. School of Medicine University of California, San Francisco 2010
• Ph.D. Biomedical Sciences (Immunology) University of California, San Francisco 2008
• Fellowship Neonatology University of California, San Francisco

Publications (16)

Top publication keywords:
Cyclooxygenase 2DinoprostoneAntigens, Differentiation, T-LymphocyteAntigens, CDReceptors, LysosphingolipidActinsLeukoencephalopathiesChromosomes, Human, Pair 16Chromosome DeletionSevere Combined ImmunodeficiencyAngelman SyndromeMicrofilament ProteinsOligodendrogliaThymus GlandWhite Matter

• Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice.
  Molecular therapy : the journal of the American Society of Gene Therapy 2024 Clarke MT, Remesal L, Lentz L, Tan DJ, Young D, Thapa S, Namuduri SR, Borges B, Kirn G, Valencia J, Lopez ME, Lui JH, Shiow LR, Dindot S, Villeda S, Sanders SJ, MacKenzie TC
• Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis.
  Science immunology 2020 Pröbstel AK, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, Sellrie K, Bischof A, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khaleghi K, Landefeld J, Kirkish …
• Neuronal vulnerability and multilineage diversity in multiple sclerosis.
  Nature 2019 Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, …
• Single-Cell Genomics Reveals Spatial and Stage-Associated Diversity in Multiple Sclerosis (P2.2-070).
  Neurology 2019 Lucas Schirmer, Dmitry Velmeshev, Diane Jung, Stephanie Vistnes, Staffan Holmqvist, Brian Tung, Nitasha Goyal, Aparna Bhaduri, Simone Mayer, Maximilian Haeussler, Dorothy Schafer, Richard Reynolds, …
• Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
  eLife 2018 Schirmer L, Möbius W, Zhao C, Cruz-Herranz A, Ben Haim L, Cordano C, Shiow LR, Kelley KW, Sadowski B, Timmons G, Pröbstel AK, Wright JN, Sin JH, Devereux M, Morrison DE, Chang SM, Sabeur K, Green AJ, …

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• Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.
  Glia 2017 Shiow LR, Favrais G, Schirmer L, Schang AL, Cipriani S, Andres C, Wright JN, Nobuta H, Fleiss B, Gressens P, Rowitch DH
• InlP, a New Virulence Factor with Strong Placental Tropism.
  Infection and immunity 2016 Faralla C, Rizzuto GA, Lowe DE, Kim B, Cooke C, Shiow LR, Bakardjiev AI
• Inhibiting the Prostaglandin Pathway for Neonatal Neuroprotection.
  Pediatrics 2016 Lawrence R. Shiow, Bobbi Fleiss, Hiroko Nobuta, Pierre Gressens, David H. Rowitch
• Erratum: Corrigendum: Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.
  Nature Neuroscience 2014 Stephen P J Fancy, Emily P Harrington, Sergio E Baranzini, John C Silbereis, Lawrence R Shiow, Tracy J Yuen, Eric J Huang, Stavros Lomvardas, David H Rowitch
• Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.
  Nature neuroscience 2014 Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH
• Severe Combined Immunodeficiency Due to Absent Coronin-1A.
  Primary Immunodeficiency Diseases 2013 Lawrence R. Shiow, Kenneth Paris, Jennifer M. Puck
• CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4.
  The Journal of biological chemistry 2010 Bankovich AJ, Shiow LR, Cyster JG
• Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.
  Clinical immunology (Orlando, Fla.) 2008 Shiow LR, Paris K, Akana MC, Cyster JG, Sorensen RU, Puck JM
• The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
  Nature immunology 2008 Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG
• CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
  Nature 2006 Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M
• High-performance multiplex SNP analysis of three hemochromatosis-related mutations with capillary array electrophoresis microplates.
  Genome research 2001 Medintz I, Wong WW, Berti L, Shiow L, Tom J, Scherer J, Sensabaugh G, Mathies RA